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The map label for this gene is poxB [H]

Identifier: 62391449

GI number: 62391449

Start: 2750074

End: 2751813

Strand: Reverse

Name: poxB [H]

Synonym: cg2891

Alternate gene names: 62391449

Gene position: 2751813-2750074 (Counterclockwise)

Preceding gene: 62391453

Following gene: 62391448

Centisome position: 83.83

GC content: 52.24

Gene sequence:

>1740_bases
ATGGCACACAGCTACGCAGAACAATTAATTGACACTTTGGAAGCTCAAGGTGTGAAGCGAATTTATGGTTTGGTGGGTGA
CAGCCTTAATCCGATCGTGGATGCTGTCCGCCAATCAGATATTGAGTGGGTGCACGTTCGAAATGAGGAAGCGGCGGCGT
TTGCAGCCGGTGCGGAATCGTTGATCACTGGGGAGCTGGCAGTATGTGCTGCTTCTTGTGGTCCTGGAAACACACACCTG
ATTCAGGGTCTTTATGATTCGCATCGAAATGGTGCGAAGGTGTTGGCCATCGCTAGCCATATTCCGAGTGCCCAGATTGG
TTCGACGTTCTTCCAGGAAACGCATCCGGAGATTTTGTTTAAGGAATGCTCTGGTTACTGCGAGATGGTGAATGGTGGTG
AGCAGGGTGAACGCATTTTGCATCACGCGATTCAGTCCACCATGGCGGGTAAAGGTGTGTCGGTGGTAGTGATTCCTGGT
GATATCGCTAAGGAAGACGCAGGTGACGGTACTTATTCCAATTCCACTATTTCTTCTGGCACTCCTGTGGTGTTCCCGGA
TCCTACTGAGGCTGCAGCGCTGGTGGAGGCGATTAACAACGCTAAGTCTGTCACTTTGTTCTGCGGTGCGGGCGTGAAGA
ATGCTCGCGCGCAGGTGTTGGAGTTGGCGGAGAAGATTAAATCACCGATCGGGCATGCGCTGGGTGGTAAGCAGTACATC
CAGCATGAGAATCCGTTTGAGGTCGGCATGTCTGGCCTGCTTGGTTACGGCGCCTGCGTGGATGCGTCCAATGAGGCGGA
TCTGCTGATTCTATTGGGTACGGATTTCCCTTATTCTGATTTCCTTCCTAAAGACAACGTTGCCCAGGTGGATATCAACG
GTGCGCACATTGGTCGACGTACCACGGTGAAGTATCCGGTGACCGGTGATGTTGCTGCAACAATCGAAAATATTTTGCCT
CATGTGAAGGAAAAAACAGATCGTTCCTTCCTTGATCGGATGCTCAAGGCACACGAGCGTAAGTTGAGCTCGGTGGTAGA
GACGTACACACATAACGTCGAGAAGCATGTGCCTATTCACCCTGAATACGTTGCCTCTATTTTGAACGAGCTGGCGGATA
AGGATGCGGTGTTTACTGTGGATACCGGCATGTGCAATGTGTGGCATGCGAGGTACATCGAGAATCCGGAGGGAACGCGC
GACTTTGTGGGTTCATTCCGCCACGGCACGATGGCTAATGCGTTGCCTCATGCGATTGGTGCGCAAAGTGTTGATCGAAA
CCGCCAGGTGATCGCGATGTGTGGCGATGGTGGTTTGGGCATGCTGCTGGGTGAGCTTCTGACCGTTAAGCTGCACCAAC
TTCCGCTGAAGGCTGTGGTGTTTAACAACAGTTCTTTGGGCATGGTGAAGTTGGAGATGCTCGTGGAGGGACAGCCAGAA
TTTGGTACTGACCATGAGGAAGTGAATTTCGCAGAGATTGCGGCGGCTGCGGGTATCAAATCGGTACGCATCACCGATCC
GAAGAAAGTTCGCGAGCAGCTAGCTGAGGCATTGGCATATCCTGGACCTGTACTGATCGATATCGTCACGGATCCTAATG
CGCTGTCGATCCCACCAACCATCACGTGGGAACAGGTCATGGGATTCAGCAAGGCGGCCACCCGAACCGTCTTTGGTGGA
GGAGTAGGAGCGATGATCGATCTGGCCCGTTCGAACATAAGGAATATTCCTACTCCATGA

Upstream 100 bases:

>100_bases
CTGGCAGGCGGGCGAAGCGTGGCAACAACTGGAATTTAAGAGCACAATTGAAGTCGCACCAAGTTAGGCAACACAATAGC
CATAACGTTGAGGAGTTCAG

Downstream 100 bases:

>100_bases
TGATTGATACACCTGCTGTTCTCATTGACCGCGAGCGCTTAACTGCCAACATTTCCAGGATGGCAGCTCACGCCGGTGCC
CATGAGATTGCCCTGCGTCC

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: Pyruvate oxidase; POX [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MAHSYAEQLIDTLEAQGVKRIYGLVGDSLNPIVDAVRQSDIEWVHVRNEEAAAFAAGAESLITGELAVCAASCGPGNTHL
IQGLYDSHRNGAKVLAIASHIPSAQIGSTFFQETHPEILFKECSGYCEMVNGGEQGERILHHAIQSTMAGKGVSVVVIPG
DIAKEDAGDGTYSNSTISSGTPVVFPDPTEAAALVEAINNAKSVTLFCGAGVKNARAQVLELAEKIKSPIGHALGGKQYI
QHENPFEVGMSGLLGYGACVDASNEADLLILLGTDFPYSDFLPKDNVAQVDINGAHIGRRTTVKYPVTGDVAATIENILP
HVKEKTDRSFLDRMLKAHERKLSSVVETYTHNVEKHVPIHPEYVASILNELADKDAVFTVDTGMCNVWHARYIENPEGTR
DFVGSFRHGTMANALPHAIGAQSVDRNRQVIAMCGDGGLGMLLGELLTVKLHQLPLKAVVFNNSSLGMVKLEMLVEGQPE
FGTDHEEVNFAEIAAAAGIKSVRITDPKKVREQLAEALAYPGPVLIDIVTDPNALSIPPTITWEQVMGFSKAATRTVFGG
GVGAMIDLARSNIRNIPTP

Sequences:

>Translated_579_residues
MAHSYAEQLIDTLEAQGVKRIYGLVGDSLNPIVDAVRQSDIEWVHVRNEEAAAFAAGAESLITGELAVCAASCGPGNTHL
IQGLYDSHRNGAKVLAIASHIPSAQIGSTFFQETHPEILFKECSGYCEMVNGGEQGERILHHAIQSTMAGKGVSVVVIPG
DIAKEDAGDGTYSNSTISSGTPVVFPDPTEAAALVEAINNAKSVTLFCGAGVKNARAQVLELAEKIKSPIGHALGGKQYI
QHENPFEVGMSGLLGYGACVDASNEADLLILLGTDFPYSDFLPKDNVAQVDINGAHIGRRTTVKYPVTGDVAATIENILP
HVKEKTDRSFLDRMLKAHERKLSSVVETYTHNVEKHVPIHPEYVASILNELADKDAVFTVDTGMCNVWHARYIENPEGTR
DFVGSFRHGTMANALPHAIGAQSVDRNRQVIAMCGDGGLGMLLGELLTVKLHQLPLKAVVFNNSSLGMVKLEMLVEGQPE
FGTDHEEVNFAEIAAAAGIKSVRITDPKKVREQLAEALAYPGPVLIDIVTDPNALSIPPTITWEQVMGFSKAATRTVFGG
GVGAMIDLARSNIRNIPTP
>Mature_578_residues
AHSYAEQLIDTLEAQGVKRIYGLVGDSLNPIVDAVRQSDIEWVHVRNEEAAAFAAGAESLITGELAVCAASCGPGNTHLI
QGLYDSHRNGAKVLAIASHIPSAQIGSTFFQETHPEILFKECSGYCEMVNGGEQGERILHHAIQSTMAGKGVSVVVIPGD
IAKEDAGDGTYSNSTISSGTPVVFPDPTEAAALVEAINNAKSVTLFCGAGVKNARAQVLELAEKIKSPIGHALGGKQYIQ
HENPFEVGMSGLLGYGACVDASNEADLLILLGTDFPYSDFLPKDNVAQVDINGAHIGRRTTVKYPVTGDVAATIENILPH
VKEKTDRSFLDRMLKAHERKLSSVVETYTHNVEKHVPIHPEYVASILNELADKDAVFTVDTGMCNVWHARYIENPEGTRD
FVGSFRHGTMANALPHAIGAQSVDRNRQVIAMCGDGGLGMLLGELLTVKLHQLPLKAVVFNNSSLGMVKLEMLVEGQPEF
GTDHEEVNFAEIAAAAGIKSVRITDPKKVREQLAEALAYPGPVLIDIVTDPNALSIPPTITWEQVMGFSKAATRTVFGGG
VGAMIDLARSNIRNIPTP

Specific function: Unknown

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=569, Percent_Identity=23.5500878734622, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1787096, Length=574, Percent_Identity=46.3414634146341, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1790104, Length=540, Percent_Identity=28.5185185185185, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87081685, Length=536, Percent_Identity=26.4925373134328, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786717, Length=561, Percent_Identity=23.1729055258467, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788716, Length=551, Percent_Identity=20.3266787658802, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531299, Length=475, Percent_Identity=23.3684210526316, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17531301, Length=475, Percent_Identity=23.3684210526316, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323755, Length=564, Percent_Identity=22.8723404255319, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320816, Length=487, Percent_Identity=22.9979466119097, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922626, Length=581, Percent_Identity=22.8915662650602, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.5.1 [H]

Molecular weight: Translated: 61951; Mature: 61820

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHSYAEQLIDTLEAQGVKRIYGLVGDSLNPIVDAVRQSDIEWVHVRNEEAAAFAAGAES
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHCCHH
LITGELAVCAASCGPGNTHLIQGLYDSHRNGAKVLAIASHIPSAQIGSTFFQETHPEILF
HHHCHHHHEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHH
KECSGYCEMVNGGEQGERILHHAIQSTMAGKGVSVVVIPGDIAKEDAGDGTYSNSTISSG
HHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
TPVVFPDPTEAAALVEAINNAKSVTLFCGAGVKNARAQVLELAEKIKSPIGHALGGKQYI
CCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
QHENPFEVGMSGLLGYGACVDASNEADLLILLGTDFPYSDFLPKDNVAQVDINGAHIGRR
CCCCCHHHHHHHHHHCCEEECCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCE
TTVKYPVTGDVAATIENILPHVKEKTDRSFLDRMLKAHERKLSSVVETYTHNVEKHVPIH
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEYVASILNELADKDAVFTVDTGMCNVWHARYIENPEGTRDFVGSFRHGTMANALPHAIG
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHC
AQSVDRNRQVIAMCGDGGLGMLLGELLTVKLHQLPLKAVVFNNSSLGMVKLEMLVEGQPE
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEEECCCCC
FGTDHEEVNFAEIAAAAGIKSVRITDPKKVREQLAEALAYPGPVLIDIVTDPNALSIPPT
CCCCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
ITWEQVMGFSKAATRTVFGGGVGAMIDLARSNIRNIPTP
CCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AHSYAEQLIDTLEAQGVKRIYGLVGDSLNPIVDAVRQSDIEWVHVRNEEAAAFAAGAES
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHCCHH
LITGELAVCAASCGPGNTHLIQGLYDSHRNGAKVLAIASHIPSAQIGSTFFQETHPEILF
HHHCHHHHEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHH
KECSGYCEMVNGGEQGERILHHAIQSTMAGKGVSVVVIPGDIAKEDAGDGTYSNSTISSG
HHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
TPVVFPDPTEAAALVEAINNAKSVTLFCGAGVKNARAQVLELAEKIKSPIGHALGGKQYI
CCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
QHENPFEVGMSGLLGYGACVDASNEADLLILLGTDFPYSDFLPKDNVAQVDINGAHIGRR
CCCCCHHHHHHHHHHCCEEECCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCE
TTVKYPVTGDVAATIENILPHVKEKTDRSFLDRMLKAHERKLSSVVETYTHNVEKHVPIH
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEYVASILNELADKDAVFTVDTGMCNVWHARYIENPEGTRDFVGSFRHGTMANALPHAIG
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHC
AQSVDRNRQVIAMCGDGGLGMLLGELLTVKLHQLPLKAVVFNNSSLGMVKLEMLVEGQPE
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEEECCCCC
FGTDHEEVNFAEIAAAAGIKSVRITDPKKVREQLAEALAYPGPVLIDIVTDPNALSIPPT
CCCCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
ITWEQVMGFSKAATRTVFGGGVGAMIDLARSNIRNIPTP
CCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3016647; 8905232; 9278503; 2663858; 3902830; 8022274 [H]