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The map label for this gene is gpx [H]

Identifier: 62391430

GI number: 62391430

Start: 2726633

End: 2727112

Strand: Reverse

Name: gpx [H]

Synonym: cg2867

Alternate gene names: 62391430

Gene position: 2727112-2726633 (Counterclockwise)

Preceding gene: 62391432

Following gene: 62391429

Centisome position: 83.08

GC content: 51.25

Gene sequence:

>480_bases
ATGACTTCTATTCATGACATCAGCGTAACTCTCAACGACGGCACAGAAACCACCATGGCGGATTGGGCGGGCCACCTTTT
GCTCATCGTGAACGTGGCATCCAAGTGCGGACTCACGCCACAGTATGAAGGGCTTCAAAAACTGTATGAGGAATACCAAG
ATCGAGGCTTCTTTGTCATTGGCGTGCCCTGCAATCAATTCAACGGCCAGGAACCTGGAACCGACGCTGAGGTGTGTGCT
TTCGCGCAAAATCAGTACGACGTCACCTTCCCGCTCTTGAGCAAAACCGAGGTGAATGGGGAGGGTGCCCACCCCCTGTA
CAAGGTGCTCAAAGAGGCAACTGATGGTAGCGAAATCGAGTGGAATTTTGAGAAATTCCTGGTAGATGCAGAAGGTAATA
CGATTAAGCGCTTTGCTCCTCGGACGGAACCATCTGCAGCTGAGGTAGTGGAAGCAATCGAGGAGAATCTCCCTATCTAA

Upstream 100 bases:

>100_bases
CGACCTGGCAGTTCACCTTTGGTCTCACCAAAGTTCACCTATTAGCTGACCTTTATTTAGATGATGCACTAAATCCTCCC
CCTCAACTAGGGTTGCGATT

Downstream 100 bases:

>100_bases
GGGCTGGCTAGGTTTGACCAGTGGCAACAGTTACACTTGTGCTCGTAAAACATTGTCCTCCCCATTTCTTGAGTAAGGGA
AAATACCGTGGCCCGTGTAG

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MTSIHDISVTLNDGTETTMADWAGHLLLIVNVASKCGLTPQYEGLQKLYEEYQDRGFFVIGVPCNQFNGQEPGTDAEVCA
FAQNQYDVTFPLLSKTEVNGEGAHPLYKVLKEATDGSEIEWNFEKFLVDAEGNTIKRFAPRTEPSAAEVVEAIEENLPI

Sequences:

>Translated_159_residues
MTSIHDISVTLNDGTETTMADWAGHLLLIVNVASKCGLTPQYEGLQKLYEEYQDRGFFVIGVPCNQFNGQEPGTDAEVCA
FAQNQYDVTFPLLSKTEVNGEGAHPLYKVLKEATDGSEIEWNFEKFLVDAEGNTIKRFAPRTEPSAAEVVEAIEENLPI
>Mature_158_residues
TSIHDISVTLNDGTETTMADWAGHLLLIVNVASKCGLTPQYEGLQKLYEEYQDRGFFVIGVPCNQFNGQEPGTDAEVCAF
AQNQYDVTFPLLSKTEVNGEGAHPLYKVLKEATDGSEIEWNFEKFLVDAEGNTIKRFAPRTEPSAAEVVEAIEENLPI

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=162, Percent_Identity=38.2716049382716, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI90903240, Length=162, Percent_Identity=38.2716049382716, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI15618997, Length=138, Percent_Identity=39.8550724637681, Blast_Score=109, Evalue=8e-25,
Organism=Homo sapiens, GI192455698, Length=141, Percent_Identity=36.1702127659575, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=38.4615384615385, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI4557629, Length=170, Percent_Identity=32.3529411764706, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI6006001, Length=171, Percent_Identity=34.5029239766082, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI41406084, Length=159, Percent_Identity=32.7044025157233, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI33186887, Length=148, Percent_Identity=34.4594594594595, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI32967607, Length=171, Percent_Identity=32.7485380116959, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1788003, Length=179, Percent_Identity=45.2513966480447, Blast_Score=150, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17535473, Length=149, Percent_Identity=42.9530201342282, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17506887, Length=163, Percent_Identity=41.1042944785276, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193210707, Length=164, Percent_Identity=37.8048780487805, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71993584, Length=136, Percent_Identity=38.9705882352941, Blast_Score=106, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI193209493, Length=183, Percent_Identity=34.9726775956284, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550320, Length=184, Percent_Identity=33.695652173913, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319721, Length=151, Percent_Identity=46.3576158940397, Blast_Score=153, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6322228, Length=161, Percent_Identity=45.9627329192547, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322826, Length=161, Percent_Identity=40.9937888198758, Blast_Score=130, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24656767, Length=161, Percent_Identity=42.2360248447205, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24656772, Length=161, Percent_Identity=42.2360248447205, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24656777, Length=161, Percent_Identity=42.2360248447205, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI85726443, Length=146, Percent_Identity=45.2054794520548, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17589; Mature: 17458

Theoretical pI: Translated: 4.06; Mature: 4.06

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIHDISVTLNDGTETTMADWAGHLLLIVNVASKCGLTPQYEGLQKLYEEYQDRGFFVI
CCCEEEEEEEECCCCCCHHHHHHCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHCCEEEE
GVPCNQFNGQEPGTDAEVCAFAQNQYDVTFPLLSKTEVNGEGAHPLYKVLKEATDGSEIE
EECCCCCCCCCCCCCHHHEEEECCCCEEEEECCCCEECCCCCCCHHHHHHHHCCCCCEEE
WNFEKFLVDAEGNTIKRFAPRTEPSAAEVVEAIEENLPI
EEHHHEEEECCCCEEEECCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSIHDISVTLNDGTETTMADWAGHLLLIVNVASKCGLTPQYEGLQKLYEEYQDRGFFVI
CCEEEEEEEECCCCCCHHHHHHCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHCCEEEE
GVPCNQFNGQEPGTDAEVCAFAQNQYDVTFPLLSKTEVNGEGAHPLYKVLKEATDGSEIE
EECCCCCCCCCCCCCHHHEEEECCCCEEEEECCCCEECCCCCCCHHHHHHHHCCCCCEEE
WNFEKFLVDAEGNTIKRFAPRTEPSAAEVVEAIEENLPI
EEHHHEEEECCCCEEEECCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]