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The map label for this gene is purL [H]

Identifier: 62391427

GI number: 62391427

Start: 2723332

End: 2725620

Strand: Reverse

Name: purL [H]

Synonym: cg2862

Alternate gene names: 62391427

Gene position: 2725620-2723332 (Counterclockwise)

Preceding gene: 62391428

Following gene: 62391426

Centisome position: 83.03

GC content: 58.76

Gene sequence:

>2289_bases
ATGAGCACTTTTGTCAATGACACCGTCGAAGACGCAATCAAGACCCCTGAGCTGGATCAGCCATTTGAGGCTCTTGGTCT
GAAAGACGACGAGTACGCGCGCATCAAGGAAATCCTTGGCCGCCGCCCAACCGACGCCGAGCTGACCGTTTACTCCGTCA
TGTGGTCGGAGCACTGCTCCTACAAGTCCTCCAAGGTTCACCTGCGTTACTTCGGTGAAACCACCACTGAGGAAATGGCT
TCCAAGATTCTTGCCGGCATCGGCGAGAACGCTGGTGTGGTCGACATCGGAGACGGCAACGCCGTGACCTTCCGCGTGGA
GTCCCACAACCACCCATCCTTCGTAGAGCCACACCAGGGCGCTGCGACCGGCGTCGGCGGCATCGTCCGCGACATTATGG
CTATGGGCGCACGCCCAATCGCTGTGATGGATCAGCTGCGTTTCGGTGCACTGGACAACCCAGACACCCAGCGTGTGCTT
CCTGGCGTTGTTGACGGCATTTCCCACTACGGCAACTGCCTCGGCCTGCCAAACATCGGTGGCGAAACCGTCTTCGACGA
TTCCTACGCAGGTAACCCACTGGTCAACGCACTGTGCGTGGGTACCCTCAAGGTGGAAGACCTCAAGCTTGCATTCGCAT
CCGGCACCGGCAACAAGGTGATCCTGTTCGGTTCCCGCACCGGCCTTGATGGCATCGGTGGCGTGTCCGTCCTGGGTTCC
GCATCCTTCGAAGAAGGCGAAGAGCGCAAGCTCCCAGCTGTTCAGGTTGGCGATCCTTTCGCAGAGAAGGTACTCATCGA
GTGCTGCCTCGAGCTGTACAAGGCTGGCGTCGTGGTCGGTATTCAGGACCTCGGTGGCGGCGGACTTGCGTGTGCAACCT
CTGAGCTGGCAGCCGCAGGCGACGGCGGCATGCGCGTCAACCTAGACAACGTCCCACTGCGCGCAGAGAACATGTCTGCA
GCTGAAATCCTGGCTTCCGAGTCCCAGGAGCGCATGTGTGCTGTTGTCACCCCTGAAAACGTTGAGCGTTTCCTCGAGAT
CTGTGCAAAGTGGGATGTCACCTGCGCAGAAATCGGCGAAGTTACCGACGAGAAGGACCGCTACGTTGTGGTCCACAACG
GTGAAGTTGTTATCGACGCACCTCCATCAACCATCGATGAAGGCCCTGTCTACAACCGCCCAGTTGCTCGCCCTGAGAAC
CAGGACGAACTGCAGCTCGAAGGCGAGATCGCTCGCCCAGTCGACGTTGAAGAGATCAAGGCTGCTTGGCTGAAGCTTGT
CGCTTCACCAGCACTTGCATCCCGCGCGTTTATCACCGAGCAGTACGACCGCTACGTCCGCGGCAACACCGTTCAGGCAA
AGAACGCCAATGCTGGCGTCTTGCGTATCGACGAAGAGACCAACCGTGGCGTTGCGATCTCCGCCGACGCATCCGGCCGT
TACACCAAGCTCGAGCCAAACACTGGCGCGCAGCTTGCACTGGCTGAGGCTTACCGCAACGTGGTCTCCACCGGTGCACG
CCCAGTGGCTGTCACCAACTGCCTGAACTTCGGTTCCCCAGAAAACGCTGGTGTTATGTGGCAGTTCAAGGAAGCAGTCC
ACGGTCTGGCAGACGGATCCAAGCTTTTGGGCATTCCAGTGTCCGGCGGTAACGTCTCCTTCTACAACCAGACTGGTGAC
GAGCCCATCCTGCCAACCCCAGTCGTGGGTGTTTTGGGAGTCTTGGACAACGTCGAGCAGAGCATCGGCAACGTCCTCCC
ATCCGAGGACAACGATCTCTACCTCCTGGGTGAGACCTTCGATGAGTTCGGTGGCTCCATCTGGCAGCAGGTTTCTGGCG
CTGGCCTCAACGGTCTGCCACCAGTAGTTGACCTGCTCAACGAGCAGCGTCTTGCAGACCTGTTCGTCGGTTCTGATCTG
TTTGCTGCATCCCACGATCTGTCTGAGGGCGGCCTTGGCCAGACCCTCGCAGAGCTTGCGATCCACGCAGACAAGGGCAT
GGATGTTGATCTCTCCCAGATCCACCCATCCCTGTTCACCTCACTGTTTGCTGAGTCCGCTTCCCGCATCGTGGTTGCAA
CCAACCGCGGCGAAGAGTTGGAAAAGCGCGCAGCAGAGCTGGGTGTTCCAGTGTTCAAGCTGGGCTGCACCAACGATTCA
GCCGTCATCGCTGTCAAGGGCGCAGACGTTGAGTTCACTGTTTCCGTGGAGGAACTCCGCGAAGCATGGACCAACACTTT
GCCTGAGGCCTTCGGTCACGCAGTTGGAGCTAACGCAGTAGTTGCATAA

Upstream 100 bases:

>100_bases
ACCCGGAACATGCCGTCGAAAAGCTAACCGGCCCATCTATTGATGGCCTGGAGCTGTTCCTGTCCGCCGTTGGCACCATC
GCGGCTTAAGAGGAGTAAAT

Downstream 100 bases:

>100_bases
TTTTCTGCTGTGAAGCCGGGTTTCGTTTTCGCAAAGCCCGGCTTTTGCTCTTTCTTCCACTAGATTGGATACAACAAGTC
AGGGAAGAAAGAAGCGTGAA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MSTFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCSYKSSKVHLRYFGETTTEEMA
SKILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQGAATGVGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVL
PGVVDGISHYGNCLGLPNIGGETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGS
ASFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAGDGGMRVNLDNVPLRAENMSA
AEILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGEVTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPEN
QDELQLEGEIARPVDVEEIKAAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGR
YTKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGSKLLGIPVSGGNVSFYNQTGD
EPILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETFDEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDL
FAASHDLSEGGLGQTLAELAIHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGCTNDS
AVIAVKGADVEFTVSVEELREAWTNTLPEAFGHAVGANAVVA

Sequences:

>Translated_762_residues
MSTFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCSYKSSKVHLRYFGETTTEEMA
SKILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQGAATGVGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVL
PGVVDGISHYGNCLGLPNIGGETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGS
ASFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAGDGGMRVNLDNVPLRAENMSA
AEILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGEVTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPEN
QDELQLEGEIARPVDVEEIKAAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGR
YTKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGSKLLGIPVSGGNVSFYNQTGD
EPILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETFDEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDL
FAASHDLSEGGLGQTLAELAIHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGCTNDS
AVIAVKGADVEFTVSVEELREAWTNTLPEAFGHAVGANAVVA
>Mature_761_residues
STFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCSYKSSKVHLRYFGETTTEEMAS
KILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQGAATGVGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVLP
GVVDGISHYGNCLGLPNIGGETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGSA
SFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAGDGGMRVNLDNVPLRAENMSAA
EILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGEVTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPENQ
DELQLEGEIARPVDVEEIKAAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGRY
TKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGSKLLGIPVSGGNVSFYNQTGDE
PILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETFDEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDLF
AASHDLSEGGLGQTLAELAIHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGCTNDSA
VIAVKGADVEFTVSVEELREAWTNTLPEAFGHAVGANAVVA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=736, Percent_Identity=24.320652173913, Blast_Score=110, Evalue=7e-24,
Organism=Escherichia coli, GI48994899, Length=832, Percent_Identity=26.3221153846154, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321498, Length=826, Percent_Identity=23.365617433414, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80843; Mature: 80711

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCS
CCCCCCHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEEEHHHHCC
YKSSKVHLRYFGETTTEEMASKILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQG
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCC
AATGVGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVLPGVVDGISHYGNCLGLPNIG
CCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGS
CCCEECCCCCCCHHHHHHEEEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHCCC
ASFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAG
CCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEHHHHHHHCC
DGGMRVNLDNVPLRAENMSAAEILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGE
CCCEEEEECCCCCCCCCCCHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHC
VTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPENQDELQLEGEIARPVDVEEIK
CCCCCCCEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
AAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGR
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCEEEEECCCCC
YTKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGS
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCCEEEEEHHHHHHHCCCC
KLLGIPVSGGNVSFYNQTGDEPILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETF
EEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCH
DEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDLFAASHDLSEGGLGQTLAELA
HHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHH
IHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGCTNDS
HHCCCCCCCCHHHHCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEEECCCCC
AVIAVKGADVEFTVSVEELREAWTNTLPEAFGHAVGANAVVA
EEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STFVNDTVEDAIKTPELDQPFEALGLKDDEYARIKEILGRRPTDAELTVYSVMWSEHCS
CCCCCHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEEEHHHHCC
YKSSKVHLRYFGETTTEEMASKILAGIGENAGVVDIGDGNAVTFRVESHNHPSFVEPHQG
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCC
AATGVGGIVRDIMAMGARPIAVMDQLRFGALDNPDTQRVLPGVVDGISHYGNCLGLPNIG
CCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GETVFDDSYAGNPLVNALCVGTLKVEDLKLAFASGTGNKVILFGSRTGLDGIGGVSVLGS
CCCEECCCCCCCHHHHHHEEEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHCCC
ASFEEGEERKLPAVQVGDPFAEKVLIECCLELYKAGVVVGIQDLGGGGLACATSELAAAG
CCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEHHHHHHHCC
DGGMRVNLDNVPLRAENMSAAEILASESQERMCAVVTPENVERFLEICAKWDVTCAEIGE
CCCEEEEECCCCCCCCCCCHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCHHHHHC
VTDEKDRYVVVHNGEVVIDAPPSTIDEGPVYNRPVARPENQDELQLEGEIARPVDVEEIK
CCCCCCCEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
AAWLKLVASPALASRAFITEQYDRYVRGNTVQAKNANAGVLRIDEETNRGVAISADASGR
HHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCEEEEECCCCC
YTKLEPNTGAQLALAEAYRNVVSTGARPVAVTNCLNFGSPENAGVMWQFKEAVHGLADGS
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCCEEEEEHHHHHHHCCCC
KLLGIPVSGGNVSFYNQTGDEPILPTPVVGVLGVLDNVEQSIGNVLPSEDNDLYLLGETF
EEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCH
DEFGGSIWQQVSGAGLNGLPPVVDLLNEQRLADLFVGSDLFAASHDLSEGGLGQTLAELA
HHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHH
IHADKGMDVDLSQIHPSLFTSLFAESASRIVVATNRGEELEKRAAELGVPVFKLGCTNDS
HHCCCCCCCCHHHHCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEEECCCCC
AVIAVKGADVEFTVSVEELREAWTNTLPEAFGHAVGANAVVA
EEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA