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The map label for this gene is actA [H]

Identifier: 62391407

GI number: 62391407

Start: 2701046

End: 2702554

Strand: Reverse

Name: actA [H]

Synonym: cg2840

Alternate gene names: 62391407

Gene position: 2702554-2701046 (Counterclockwise)

Preceding gene: 62391410

Following gene: 62391406

Centisome position: 82.33

GC content: 56.33

Gene sequence:

>1509_bases
ATGTCTGATCGCATTGCTTCAGAAAAGCTGCGCTCCAAGCTCATGTCCGCCGACGAGGCGGCACAGTTTGTTAACCACGG
TGACAAGGTTGGTTTCTCCGGCTTCACCGGCGCTGGCTACCCAAAGGCACTGCCTACGGCAATCGCTAACCGGGCTAAAG
AAGCACACGGTGCAGGCAACGACTACGCAATCGACCTGTTCACTGGCGCATCGACCGCCCCTGACTGCGATGGCGTACTT
GCAGAAGCTGACGCTATCCGCTGGCGCATGCCATACGCATCTGATCCAATCATGCGTAACAAGATCAACTCCGGCTCCAT
GGGATACTCCGATATCCACCTGTCCCACTCCGGCCAGCAGGTTGAAGAGGGCTTCTTCGGCCAGCTCAACGTAGCTGTCA
TTGAAATCACCCGCATCACTGAAGAGGGCTACATCATCCCTTCTTCCTCCGTGGGTAACAACGTTGAGTGGCTCAACGCT
GCAGAGAAGGTCATCCTCGAGGTTAACTCTTGGCAGTCTGAAGACCTCGAAGGTATGCACGACATCTGGTCTGTTCCTGC
CCTGCCAAACCGCATTGCCGTGCCAATCAACAAGCCAGGCGACCGCATCGGTAAGACCTACATCGAGTTCGACACCGACA
AGGTTGTTGCTGTTGTTGAGACCAACACCGCAGACCGCAACGCACCATTCAAGCCTGTCGACGACATCTCTAAGAAGATC
GCTGGCAACTTCCTCGACTTCCTGGAAAGCGAAGTTGCTGCAGGTCGCCTGTCCTACGACGGCTACATCATGCAGTCCGG
CGTGGGCAACGTGCCAAACGCGGTGATGGCAGGCCTGCTGGAATCCAAGTTTGAGAACATCCAGGCCTACACCGAAGTTA
TCCAGGACGGCATGGTGGACCTCATCGACGCCGGCAAGATGACCGTTGCATCCGCAACTTCCTTCTCCCTGTCTCCTGAG
TACGCAGAGAAGATGAACAACGAGGCTAAGCGTTACCGCGAGTCCATTATCCTGCGCCCACAGCAGATCTCTAACCACCC
AGAGGTCATCCGCCGCGTTGGCCTGATCGCCACCAACGGTCTCATCGAGGCTGACATTTACGGCAACGTCAACTCCACCA
ACGTTTCTGGCTCCCGCGTCATGAACGGCATCGGCGGCTCCGGCGACTTCACCCGTAACGGCTACATCTCCAGCTTCATC
ACCCCTTCAGAGGCAAAGGGCGGCGCAATCTCTGCGATCGTTCCTTTCGCATCCCACATCGACCACACCGAGCACGATGT
CATGGTTGTTATCTCTGAGTACGGTTACGCAGACCTTCGTGGTCTGGCTCCACGTGAGCGCGTTGCCAAGATGATCGGCC
TGGCTCACCCTGATTACCGCCCACTGCTCGAGGAGTACTACGCTCGCGCAACCTCCGGTGACAACAAGTACATGCAGACC
CCTCATGATCTTGCAACCGCGTTTGATTTCCACATCAACCTGGCTAAGAACGGCTCCATGAAGGCATAA

Upstream 100 bases:

>100_bases
GTCGCATTCTGCTTGCTGAAGTGGCACACCTATGTGTTCTGCTTGGGTATAGCAGTGCGGGAAAAATTTGAAAAAGTCCG
ATTACCTGAGGAGGTATTCA

Downstream 100 bases:

>100_bases
GTTTTTTCTTGGTTTAGAAACCGCCGCCTCGACAACATTTCGAGGCGGCGGTTTCTTTTATTACCTGGGTTTTGAGCGTT
AAATTAGACCAGGTCAGGCT

Product: butyryl-COA:acetate coenzyme A transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSDRIASEKLRSKLMSADEAAQFVNHGDKVGFSGFTGAGYPKALPTAIANRAKEAHGAGNDYAIDLFTGASTAPDCDGVL
AEADAIRWRMPYASDPIMRNKINSGSMGYSDIHLSHSGQQVEEGFFGQLNVAVIEITRITEEGYIIPSSSVGNNVEWLNA
AEKVILEVNSWQSEDLEGMHDIWSVPALPNRIAVPINKPGDRIGKTYIEFDTDKVVAVVETNTADRNAPFKPVDDISKKI
AGNFLDFLESEVAAGRLSYDGYIMQSGVGNVPNAVMAGLLESKFENIQAYTEVIQDGMVDLIDAGKMTVASATSFSLSPE
YAEKMNNEAKRYRESIILRPQQISNHPEVIRRVGLIATNGLIEADIYGNVNSTNVSGSRVMNGIGGSGDFTRNGYISSFI
TPSEAKGGAISAIVPFASHIDHTEHDVMVVISEYGYADLRGLAPRERVAKMIGLAHPDYRPLLEEYYARATSGDNKYMQT
PHDLATAFDFHINLAKNGSMKA

Sequences:

>Translated_502_residues
MSDRIASEKLRSKLMSADEAAQFVNHGDKVGFSGFTGAGYPKALPTAIANRAKEAHGAGNDYAIDLFTGASTAPDCDGVL
AEADAIRWRMPYASDPIMRNKINSGSMGYSDIHLSHSGQQVEEGFFGQLNVAVIEITRITEEGYIIPSSSVGNNVEWLNA
AEKVILEVNSWQSEDLEGMHDIWSVPALPNRIAVPINKPGDRIGKTYIEFDTDKVVAVVETNTADRNAPFKPVDDISKKI
AGNFLDFLESEVAAGRLSYDGYIMQSGVGNVPNAVMAGLLESKFENIQAYTEVIQDGMVDLIDAGKMTVASATSFSLSPE
YAEKMNNEAKRYRESIILRPQQISNHPEVIRRVGLIATNGLIEADIYGNVNSTNVSGSRVMNGIGGSGDFTRNGYISSFI
TPSEAKGGAISAIVPFASHIDHTEHDVMVVISEYGYADLRGLAPRERVAKMIGLAHPDYRPLLEEYYARATSGDNKYMQT
PHDLATAFDFHINLAKNGSMKA
>Mature_501_residues
SDRIASEKLRSKLMSADEAAQFVNHGDKVGFSGFTGAGYPKALPTAIANRAKEAHGAGNDYAIDLFTGASTAPDCDGVLA
EADAIRWRMPYASDPIMRNKINSGSMGYSDIHLSHSGQQVEEGFFGQLNVAVIEITRITEEGYIIPSSSVGNNVEWLNAA
EKVILEVNSWQSEDLEGMHDIWSVPALPNRIAVPINKPGDRIGKTYIEFDTDKVVAVVETNTADRNAPFKPVDDISKKIA
GNFLDFLESEVAAGRLSYDGYIMQSGVGNVPNAVMAGLLESKFENIQAYTEVIQDGMVDLIDAGKMTVASATSFSLSPEY
AEKMNNEAKRYRESIILRPQQISNHPEVIRRVGLIATNGLIEADIYGNVNSTNVSGSRVMNGIGGSGDFTRNGYISSFIT
PSEAKGGAISAIVPFASHIDHTEHDVMVVISEYGYADLRGLAPRERVAKMIGLAHPDYRPLLEEYYARATSGDNKYMQTP
HDLATAFDFHINLAKNGSMKA

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=488, Percent_Identity=46.3114754098361, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17538151, Length=399, Percent_Identity=25.062656641604, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32563853, Length=249, Percent_Identity=28.9156626506024, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319456, Length=515, Percent_Identity=39.4174757281553, Blast_Score=360, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 54518; Mature: 54387

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRIASEKLRSKLMSADEAAQFVNHGDKVGFSGFTGAGYPKALPTAIANRAKEAHGAGN
CCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
DYAIDLFTGASTAPDCDGVLAEADAIRWRMPYASDPIMRNKINSGSMGYSDIHLSHSGQQ
CEEEEEEECCCCCCCCCCHHHCCCCEEEECCCCCCCHHHCCCCCCCCCCEEEEECCCCCH
VEEGFFGQLNVAVIEITRITEEGYIIPSSSVGNNVEWLNAAEKVILEVNSWQSEDLEGMH
HHCCCCCCEEEEEEEEEEECCCCEEEECCCCCCCCHHHHHHHHEEEEECCCCCCCHHHHH
DIWSVPALPNRIAVPINKPGDRIGKTYIEFDTDKVVAVVETNTADRNAPFKPVDDISKKI
HHHCCCCCCCCEEEECCCCCHHHCCEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHH
AGNFLDFLESEVAAGRLSYDGYIMQSGVGNVPNAVMAGLLESKFENIQAYTEVIQDGMVD
HHHHHHHHHHHHHCCEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LIDAGKMTVASATSFSLSPEYAEKMNNEAKRYRESIILRPQQISNHPEVIRRVGLIATNG
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHEECC
LIEADIYGNVNSTNVSGSRVMNGIGGSGDFTRNGYISSFITPSEAKGGAISAIVPFASHI
EEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCEEEHHHHHHHHC
DHTEHDVMVVISEYGYADLRGLAPRERVAKMIGLAHPDYRPLLEEYYARATSGDNKYMQT
CCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
PHDLATAFDFHINLAKNGSMKA
CHHHHHEEEEEEEEECCCCCCC
>Mature Secondary Structure 
SDRIASEKLRSKLMSADEAAQFVNHGDKVGFSGFTGAGYPKALPTAIANRAKEAHGAGN
CCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
DYAIDLFTGASTAPDCDGVLAEADAIRWRMPYASDPIMRNKINSGSMGYSDIHLSHSGQQ
CEEEEEEECCCCCCCCCCHHHCCCCEEEECCCCCCCHHHCCCCCCCCCCEEEEECCCCCH
VEEGFFGQLNVAVIEITRITEEGYIIPSSSVGNNVEWLNAAEKVILEVNSWQSEDLEGMH
HHCCCCCCEEEEEEEEEEECCCCEEEECCCCCCCCHHHHHHHHEEEEECCCCCCCHHHHH
DIWSVPALPNRIAVPINKPGDRIGKTYIEFDTDKVVAVVETNTADRNAPFKPVDDISKKI
HHHCCCCCCCCEEEECCCCCHHHCCEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHH
AGNFLDFLESEVAAGRLSYDGYIMQSGVGNVPNAVMAGLLESKFENIQAYTEVIQDGMVD
HHHHHHHHHHHHHCCEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LIDAGKMTVASATSFSLSPEYAEKMNNEAKRYRESIILRPQQISNHPEVIRRVGLIATNG
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHEECC
LIEADIYGNVNSTNVSGSRVMNGIGGSGDFTRNGYISSFITPSEAKGGAISAIVPFASHI
EEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCEEEHHHHHHHHC
DHTEHDVMVVISEYGYADLRGLAPRERVAKMIGLAHPDYRPLLEEYYARATSGDNKYMQT
CCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
PHDLATAFDFHINLAKNGSMKA
CHHHHHEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]