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The map label for this gene is dtxR [H]

Identifier: 62391367

GI number: 62391367

Start: 2647914

End: 2648576

Strand: Reverse

Name: dtxR [H]

Synonym: cg2784

Alternate gene names: 62391367

Gene position: 2648576-2647914 (Counterclockwise)

Preceding gene: 62391368

Following gene: 62391364

Centisome position: 80.68

GC content: 53.09

Gene sequence:

>663_bases
TTGACGCAGTGGGGTAATTCGAATGTTGTGGAGGACTATCTCACAGCACTTTTCCGTGCAGAAGAATGGGATGAGGAACC
AACAACAGGAAAACTCGCTGAAGTAATTGGAGTTACCGCATCAACGGTGTCGGCGACGCTCAAAAAACTCAACCCTGAGG
GCTTCGTCAATTACCGTCCCTACGGGGACATCGAGCTGACGCCCGCAGGTCGAGACATCGCCATCAACGTGATCAGGCGG
CGCCGGATCATTGAGACCTATCTGTCTGAGAAGCTTGGATTAGGCGCTCATGAACTACACGGCGAGGCAGATTTATTAGA
GCACGCAGTGTCTCCACTGGTGTTGGAGAAGATGTTTCAGGCAGTGGGCTATCCAACGTTGGATCCTCACGGGGATCCCA
TCCCCACCGAATCTGGGGAGATGACCATCAATGATGGACTCATGCTTTTGGGACTAAAAGCTGGCGCATCTGCCACGGTT
ACACGTGTTAGGGACGGAAACCCATCAGTGGTTCGGTACCTCACTGGAGTGGGAATTACCGTGGGCACAACGGTCACGGT
CGTTGAAGCTCTTAGCGATATTGCCACACTGCGCCTGCAGATCGGGGAAATGTTTCAAGACATTCCCCTTGCAGTGGCAA
ACGCAGTGCGCGTATCACGTTAG

Upstream 100 bases:

>100_bases
GGCCTTGCTTGCGTTAGTTGCAGTGCTTCCTGAATATGCTTCTGAAACGGTTGTCGAGCACACTTATCAAACATCGGCGG
CGAATTAAGAAGGTGAACAG

Downstream 100 bases:

>100_bases
TTCAGCGTGCCCAGCGCGCTGCGCACCTCATTGAGGATGTTTCGGGACGCAGTTTCTGCGGCGTCGGCGTCGCGGTTAAG
GAGGGCGTCGGCAAGCTTAT

Product: metal-dependent transcriptional regulator

Products: NA

Alternate protein names: Iron-dependent diphtheria tox regulatory element; Tox regulatory factor [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTQWGNSNVVEDYLTALFRAEEWDEEPTTGKLAEVIGVTASTVSATLKKLNPEGFVNYRPYGDIELTPAGRDIAINVIRR
RRIIETYLSEKLGLGAHELHGEADLLEHAVSPLVLEKMFQAVGYPTLDPHGDPIPTESGEMTINDGLMLLGLKAGASATV
TRVRDGNPSVVRYLTGVGITVGTTVTVVEALSDIATLRLQIGEMFQDIPLAVANAVRVSR

Sequences:

>Translated_220_residues
MTQWGNSNVVEDYLTALFRAEEWDEEPTTGKLAEVIGVTASTVSATLKKLNPEGFVNYRPYGDIELTPAGRDIAINVIRR
RRIIETYLSEKLGLGAHELHGEADLLEHAVSPLVLEKMFQAVGYPTLDPHGDPIPTESGEMTINDGLMLLGLKAGASATV
TRVRDGNPSVVRYLTGVGITVGTTVTVVEALSDIATLRLQIGEMFQDIPLAVANAVRVSR
>Mature_219_residues
TQWGNSNVVEDYLTALFRAEEWDEEPTTGKLAEVIGVTASTVSATLKKLNPEGFVNYRPYGDIELTPAGRDIAINVIRRR
RIIETYLSEKLGLGAHELHGEADLLEHAVSPLVLEKMFQAVGYPTLDPHGDPIPTESGEMTINDGLMLLGLKAGASATVT
RVRDGNPSVVRYLTGVGITVGTTVTVVEALSDIATLRLQIGEMFQDIPLAVANAVRVSR

Specific function: Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess [H]

COG id: COG1321

COG function: function code K; Mn-dependent transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH dtxR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007167
- InterPro:   IPR001367
- InterPro:   IPR022689
- InterPro:   IPR022687
- InterPro:   IPR008988
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02742 Fe_dep_repr_C; PF01325 Fe_dep_repress; PF04023 FeoA [H]

EC number: NA

Molecular weight: Translated: 23798; Mature: 23667

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50944 HTH_DTXR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQWGNSNVVEDYLTALFRAEEWDEEPTTGKLAEVIGVTASTVSATLKKLNPEGFVNYRP
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
YGDIELTPAGRDIAINVIRRRRIIETYLSEKLGLGAHELHGEADLLEHAVSPLVLEKMFQ
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHH
AVGYPTLDPHGDPIPTESGEMTINDGLMLLGLKAGASATVTRVRDGNPSVVRYLTGVGIT
HHCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHCCCH
VGTTVTVVEALSDIATLRLQIGEMFQDIPLAVANAVRVSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQWGNSNVVEDYLTALFRAEEWDEEPTTGKLAEVIGVTASTVSATLKKLNPEGFVNYRP
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
YGDIELTPAGRDIAINVIRRRRIIETYLSEKLGLGAHELHGEADLLEHAVSPLVLEKMFQ
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHH
AVGYPTLDPHGDPIPTESGEMTINDGLMLLGLKAGASATVTRVRDGNPSVVRYLTGVGIT
HHCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHCCCH
VGTTVTVVEALSDIATLRLQIGEMFQDIPLAVANAVRVSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]