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The map label for this gene is lmrB [H]

Identifier: 62391331

GI number: 62391331

Start: 2606836

End: 2608263

Strand: Reverse

Name: lmrB [H]

Synonym: cg2739

Alternate gene names: 62391331

Gene position: 2608263-2606836 (Counterclockwise)

Preceding gene: 62391333

Following gene: 62391330

Centisome position: 79.45

GC content: 55.18

Gene sequence:

>1428_bases
TTGTCTTCCTCCAGCAATCCCACAACGGAGCAGGTTGGGATCCCGAGAAATGTTGTCATCATCTTGGCTGTATTAGTTTT
TACAGCCTTTGTCATGATGTTGAATGAGACTACTCTGGCAGTCGCGTTGCCGTCGATCATGGCGGACTTTGACATTGAGG
CGAATACTGCGCAGTGGTTGCTCACTGGTTTTATGTTGACCATGGCTGTGGTTCTTCCAGCTACTGGTTGGATGTTGGAA
CGTTTTACCACTCGTAGTGTGTTTATTTTCGCCACGGTGGTCTTCCTGATCGGTACTGTGACGGCTGCGTTGTCTCCTAC
TTTTGCGATTATGCTTGCAGCCCGCGTCGCTCAGGCGATTGGTACCGCTGTGATCATGCCGCTGCTGATGACTGTCGCGA
TGACCGTTGTTCCTCCAGAGCGCCGTGGCGCCGTCATGGGTTTGATTGCGGTCGTGATGGCCGTTGGTCCTGCTCTTGGA
CCTAGTGTGGCTGGTTTCGTACTCAGCTTGTCTTCGTGGCACGCGATTTTCTGGGTCATGGTTCCGTTGGTGTTTGTGGC
AAGCCTGATCGGTACCCTGCGTCTGACCAACGTCAGTGAGCCTAAAAAGACTCCTTTGGATGTTATTTCCTTCCTGATTT
CCGCAGTGGCTTTCGGTGGCCTTGTGTACGCCTTGAGCTCGATTGGCATCATTTTGGAAGGTGACAGAAGCGCTTTGGTC
GTGTTGGCTGTCGGCATCATTGCGTTGGTGGTGTTTGTGTGGCGCCAGATTGCCATGGGTAAGCAGGATAAGGCGCTGTT
GGATCTGCGTCCGTTGGCGATTCGTGAGTACACCATTCCGCTGGTTGTGCTTTTGACGCTGTTCGGTGCGCTGCTCGGTG
TCATGAATACACTGCCGCTCTACCTGCAGGGATCCTTGATGGTCACCGCCTTGGTCGCGGGTCTAGTGCTGTTGCCAGGT
GGTCTTTTGGAAGGTGTGCTGTCGCCATTTGTGGGTCGAATTTATGATCGTCATGGTCCACGCGGACTCGTGATCGGCGG
TATGTCACTCGTTGTGATCTCCCTGTTTGCACTGTCCACCGTCGATGAGTTCGCCAACGTGTGGTTCATCATCGGCGTAC
ACATCGTGTTCTCCATCGGCCTTGCGCTGCTGTTCACCCCACTGATGACAGTCGCGCTCGCATCCGTCCCCGACAACATG
TACGGCCACGGCTCCGCGATCCTCAACACCCTCCAACAGCTCGCCGGCGCCGCAGGCACCGCGGTCATGATTGCGGTTTA
TTCCACCGTCAGCAACAACGCGCTTATCGACGGCGCAACCCAACAAACCGCCCTCGCCGACGGCGCCAACTCTGCATTCT
TCGCCTCAGCGTGCGTGGCAGTGTTTGCACTGATCGTGGGCTTCTTTGTAAAGAGGCCAGCCCGCTAA

Upstream 100 bases:

>100_bases
TAAGCAAGTATCCGCCCCGTTTTCTGCACGATGCAGGAACTGGGGCGGTATGCATTTACCTCGCGATAGCGCCCTTTGAT
TCGAGAAAGGAGCTGGAGCC

Downstream 100 bases:

>100_bases
GCTAGGTCGCATGATCAGCATTGGAACCGACCTCGTTCACATTTCGGCGTTCGCAGAGCAGCTTGCACAGCCGGGAAGTT
CCTTCATGGAGGTGTTTTCC

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSSSSNPTTEQVGIPRNVVIILAVLVFTAFVMMLNETTLAVALPSIMADFDIEANTAQWLLTGFMLTMAVVLPATGWMLE
RFTTRSVFIFATVVFLIGTVTAALSPTFAIMLAARVAQAIGTAVIMPLLMTVAMTVVPPERRGAVMGLIAVVMAVGPALG
PSVAGFVLSLSSWHAIFWVMVPLVFVASLIGTLRLTNVSEPKKTPLDVISFLISAVAFGGLVYALSSIGIILEGDRSALV
VLAVGIIALVVFVWRQIAMGKQDKALLDLRPLAIREYTIPLVVLLTLFGALLGVMNTLPLYLQGSLMVTALVAGLVLLPG
GLLEGVLSPFVGRIYDRHGPRGLVIGGMSLVVISLFALSTVDEFANVWFIIGVHIVFSIGLALLFTPLMTVALASVPDNM
YGHGSAILNTLQQLAGAAGTAVMIAVYSTVSNNALIDGATQQTALADGANSAFFASACVAVFALIVGFFVKRPAR

Sequences:

>Translated_475_residues
MSSSSNPTTEQVGIPRNVVIILAVLVFTAFVMMLNETTLAVALPSIMADFDIEANTAQWLLTGFMLTMAVVLPATGWMLE
RFTTRSVFIFATVVFLIGTVTAALSPTFAIMLAARVAQAIGTAVIMPLLMTVAMTVVPPERRGAVMGLIAVVMAVGPALG
PSVAGFVLSLSSWHAIFWVMVPLVFVASLIGTLRLTNVSEPKKTPLDVISFLISAVAFGGLVYALSSIGIILEGDRSALV
VLAVGIIALVVFVWRQIAMGKQDKALLDLRPLAIREYTIPLVVLLTLFGALLGVMNTLPLYLQGSLMVTALVAGLVLLPG
GLLEGVLSPFVGRIYDRHGPRGLVIGGMSLVVISLFALSTVDEFANVWFIIGVHIVFSIGLALLFTPLMTVALASVPDNM
YGHGSAILNTLQQLAGAAGTAVMIAVYSTVSNNALIDGATQQTALADGANSAFFASACVAVFALIVGFFVKRPAR
>Mature_474_residues
SSSSNPTTEQVGIPRNVVIILAVLVFTAFVMMLNETTLAVALPSIMADFDIEANTAQWLLTGFMLTMAVVLPATGWMLER
FTTRSVFIFATVVFLIGTVTAALSPTFAIMLAARVAQAIGTAVIMPLLMTVAMTVVPPERRGAVMGLIAVVMAVGPALGP
SVAGFVLSLSSWHAIFWVMVPLVFVASLIGTLRLTNVSEPKKTPLDVISFLISAVAFGGLVYALSSIGIILEGDRSALVV
LAVGIIALVVFVWRQIAMGKQDKALLDLRPLAIREYTIPLVVLLTLFGALLGVMNTLPLYLQGSLMVTALVAGLVLLPGG
LLEGVLSPFVGRIYDRHGPRGLVIGGMSLVVISLFALSTVDEFANVWFIIGVHIVFSIGLALLFTPLMTVALASVPDNMY
GHGSAILNTLQQLAGAAGTAVMIAVYSTVSNNALIDGATQQTALADGANSAFFASACVAVFALIVGFFVKRPAR

Specific function: Proton-dependent transporter. May mediate the efflux of lincomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=404, Percent_Identity=25.990099009901, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788710, Length=440, Percent_Identity=24.5454545454545, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789042, Length=425, Percent_Identity=24.9411764705882, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI87081983, Length=399, Percent_Identity=27.5689223057644, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788392, Length=448, Percent_Identity=25.2232142857143, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325455, Length=147, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49937; Mature: 49805

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSSNPTTEQVGIPRNVVIILAVLVFTAFVMMLNETTLAVALPSIMADFDIEANTAQWL
CCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHH
LTGFMLTMAVVLPATGWMLERFTTRSVFIFATVVFLIGTVTAALSPTFAIMLAARVAQAI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTAVIMPLLMTVAMTVVPPERRGAVMGLIAVVMAVGPALGPSVAGFVLSLSSWHAIFWVM
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VPLVFVASLIGTLRLTNVSEPKKTPLDVISFLISAVAFGGLVYALSSIGIILEGDRSALV
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHH
VLAVGIIALVVFVWRQIAMGKQDKALLDLRPLAIREYTIPLVVLLTLFGALLGVMNTLPL
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLQGSLMVTALVAGLVLLPGGLLEGVLSPFVGRIYDRHGPRGLVIGGMSLVVISLFALST
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
VDEFANVWFIIGVHIVFSIGLALLFTPLMTVALASVPDNMYGHGSAILNTLQQLAGAAGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCH
AVMIAVYSTVSNNALIDGATQQTALADGANSAFFASACVAVFALIVGFFVKRPAR
HHHHHHHHHHCCCCEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSSSNPTTEQVGIPRNVVIILAVLVFTAFVMMLNETTLAVALPSIMADFDIEANTAQWL
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHH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HHHHHHHHHHCCCCEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]