Click here to switch to the map view.

The map label for this gene is mdh [H]

Identifier: 62391223

GI number: 62391223

Start: 2493938

End: 2494924

Strand: Reverse

Name: mdh [H]

Synonym: cg2613

Alternate gene names: 62391223

Gene position: 2494924-2493938 (Counterclockwise)

Preceding gene: 62391225

Following gene: 62391222

Centisome position: 76.0

GC content: 55.72

Gene sequence:

>987_bases
ATGAATTCCCCGCAGAACGTCTCCACCAAGAAGGTCACCGTCACCGGCGCAGCTGGTCAAATCTCTTATTCACTGTTGTG
GCGCATCGCCAACGGTGAAGTATTCGGCACCGACACCCCTGTAGAACTGAAACTTCTGGAGATCCCTCAGGCTCTTGGCG
GGGCAGAGGGTGTGGCTATGGAACTTCTGGATTCTGCCTTCCCCCTCCTGCGAAACATCACCATCACCGCGGATGCCAAT
GAGGCATTCGACGGCGCTAATGCGGCGTTTTTGGTCGGTGCGAAGCCTCGCGGAAAAGGCGAAGAGCGCGCAGATTTGCT
GGCTAACAACGGCAAGATTTTCGGACCTCAAGGTAAAGCTATCAATGACAACGCCGCAGATGACATTCGTGTCCTAGTTG
TTGGAAACCCAGCGAACACCAACGCGTTGATTGCTTCAGCTGCGGCCCCAGATGTTCCAGCATCCCGCTTCAACGCAATG
ATGCGCCTTGATCACAACCGTGCGATCTCCCAGCTGGCCACCAAGCTTGGCCGTGGATCTGCGGAATTTAACAACATTGT
GGTCTGGGGAAATCACTCCGCAACCCAGTTCCCAGACATCACCTACGCAACCGTTGGTGGAGAAAAGGTCACTGACCTGG
TTGATCACGATTGGTATGTGGAGGAGTTCATTCCTCGCGTGGCTAACCGTGGCGCTGAAATCATTGAGGTCCGTGGAAAG
TCTTCTGCAGCTTCTGCAGCATCCTCTGCGATTGATCACATGCGCGATTGGGTACAGGGCACCGAGGCGTGGTCCTCTGC
GGCAATTCCTTCCACCGGTGCATACGGCATTCCTGAGGGCATTTTTGTCGGTCTGCCAACCGTATCCCGCAACGGTGAGT
GGGAAATCGTTGAAGGCCTGGAGATTTCCGATTTCCAGCGCGCCCGCATCGACGCGAATGCTCAGGAATTGCAGGCCGAG
CGCGAGGCAGTGCGCGACTTGCTCTAA

Upstream 100 bases:

>100_bases
TGCAGTATCGTCAAGATCACCCAAAACTGGTGGCTGTTCTCTTTTAAGCGGGATAGCATGGGTTCTTAGAGGACCCCCTA
CAAGGATTGAGGATTGTTTA

Downstream 100 bases:

>100_bases
TCTTTAACGCATGACTTCGCTTTTCGACGCCCCAACCCTCCAACGCGTCACCGTTTTCACGGGCTCGGCGCTCGGCAGTT
CCTCGCTGTACACGCAAGCG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MNSPQNVSTKKVTVTGAAGQISYSLLWRIANGEVFGTDTPVELKLLEIPQALGGAEGVAMELLDSAFPLLRNITITADAN
EAFDGANAAFLVGAKPRGKGEERADLLANNGKIFGPQGKAINDNAADDIRVLVVGNPANTNALIASAAAPDVPASRFNAM
MRLDHNRAISQLATKLGRGSAEFNNIVVWGNHSATQFPDITYATVGGEKVTDLVDHDWYVEEFIPRVANRGAEIIEVRGK
SSAASAASSAIDHMRDWVQGTEAWSSAAIPSTGAYGIPEGIFVGLPTVSRNGEWEIVEGLEISDFQRARIDANAQELQAE
REAVRDLL

Sequences:

>Translated_328_residues
MNSPQNVSTKKVTVTGAAGQISYSLLWRIANGEVFGTDTPVELKLLEIPQALGGAEGVAMELLDSAFPLLRNITITADAN
EAFDGANAAFLVGAKPRGKGEERADLLANNGKIFGPQGKAINDNAADDIRVLVVGNPANTNALIASAAAPDVPASRFNAM
MRLDHNRAISQLATKLGRGSAEFNNIVVWGNHSATQFPDITYATVGGEKVTDLVDHDWYVEEFIPRVANRGAEIIEVRGK
SSAASAASSAIDHMRDWVQGTEAWSSAAIPSTGAYGIPEGIFVGLPTVSRNGEWEIVEGLEISDFQRARIDANAQELQAE
REAVRDLL
>Mature_328_residues
MNSPQNVSTKKVTVTGAAGQISYSLLWRIANGEVFGTDTPVELKLLEIPQALGGAEGVAMELLDSAFPLLRNITITADAN
EAFDGANAAFLVGAKPRGKGEERADLLANNGKIFGPQGKAINDNAADDIRVLVVGNPANTNALIASAAAPDVPASRFNAM
MRLDHNRAISQLATKLGRGSAEFNNIVVWGNHSATQFPDITYATVGGEKVTDLVDHDWYVEEFIPRVANRGAEIIEVRGK
SSAASAASSAIDHMRDWVQGTEAWSSAAIPSTGAYGIPEGIFVGLPTVSRNGEWEIVEGLEISDFQRARIDANAQELQAE
REAVRDLL

Specific function: Catalyzes the reversible oxidation of malate to oxaloacetate [H]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. MDH type 2 family [H]

Homologues:

Organism=Homo sapiens, GI5174539, Length=326, Percent_Identity=46.0122699386503, Blast_Score=291, Evalue=4e-79,
Organism=Homo sapiens, GI89886456, Length=322, Percent_Identity=24.8447204968944, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561064, Length=320, Percent_Identity=50.625, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI32566798, Length=261, Percent_Identity=52.4904214559387, Blast_Score=237, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI32566800, Length=170, Percent_Identity=47.0588235294118, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24583394, Length=325, Percent_Identity=47.6923076923077, Blast_Score=288, Evalue=4e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR010945
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 34908; Mature: 34908

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPQNVSTKKVTVTGAAGQISYSLLWRIANGEVFGTDTPVELKLLEIPQALGGAEGVAM
CCCCCCCCCEEEEEECCCCCEEEEEEEEEECCEEECCCCCCEEEEEECHHHHCCCCHHHH
ELLDSAFPLLRNITITADANEAFDGANAAFLVGAKPRGKGEERADLLANNGKIFGPQGKA
HHHHHHHHHHHCEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCEEECCCCCC
INDNAADDIRVLVVGNPANTNALIASAAAPDVPASRFNAMMRLDHNRAISQLATKLGRGS
CCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
AEFNNIVVWGNHSATQFPDITYATVGGEKVTDLVDHDWYVEEFIPRVANRGAEIIEVRGK
CCCCCEEEECCCCCCCCCCEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCC
SSAASAASSAIDHMRDWVQGTEAWSSAAIPSTGAYGIPEGIFVGLPTVSRNGEWEIVEGL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECC
EISDFQRARIDANAQELQAEREAVRDLL
CCCCCHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSPQNVSTKKVTVTGAAGQISYSLLWRIANGEVFGTDTPVELKLLEIPQALGGAEGVAM
CCCCCCCCCEEEEEECCCCCEEEEEEEEEECCEEECCCCCCEEEEEECHHHHCCCCHHHH
ELLDSAFPLLRNITITADANEAFDGANAAFLVGAKPRGKGEERADLLANNGKIFGPQGKA
HHHHHHHHHHHCEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCEEECCCCCC
INDNAADDIRVLVVGNPANTNALIASAAAPDVPASRFNAMMRLDHNRAISQLATKLGRGS
CCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
AEFNNIVVWGNHSATQFPDITYATVGGEKVTDLVDHDWYVEEFIPRVANRGAEIIEVRGK
CCCCCEEEECCCCCCCCCCEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCC
SSAASAASSAIDHMRDWVQGTEAWSSAAIPSTGAYGIPEGIFVGLPTVSRNGEWEIVEGL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECC
EISDFQRARIDANAQELQAEREAVRDLL
CCCCCHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA