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The map label for this gene is ycdW [C]

Identifier: 62391198

GI number: 62391198

Start: 2467370

End: 2468284

Strand: Reverse

Name: ycdW [C]

Synonym: cg2587

Alternate gene names: 62391198

Gene position: 2468284-2467370 (Counterclockwise)

Preceding gene: 62391199

Following gene: 62391197

Centisome position: 75.19

GC content: 53.99

Gene sequence:

>915_bases
ATGAAGTTTGTTATGTATCCGCATTTGTGGGAGTCCACGACCGCTGTCATTGAGGGTGGCGGACATGAGCGGGTTGAGGA
TATTAAAGATGCAGACTTCATTTTCTTTAATGGTTCAGCGCCGGAGTTCCCGGATTTGCCGGAGAACATCAAGTTCGTGC
AGGCCTCCATGGCGGGTATTGATGCGCTGGTCAAGCGTGGTGTCGTCAATGAGAAGGCACGTTGGGCAAACGCGGCTGGC
CTGTACGCTGACACCGTTGCTGAGTCCACCATTGGTTTAATTCTGGCGCAGATGCACATGCATGCGACGACTCGTTTGGC
TAAGTCGTGGAGCGTGCGGCCTGAGGTGGAAAACAACAAGTCATGGCTGCATGACAATAAAACTGTCGCTATTTTGGGCG
CCGGTGGCATTGGCGTGCGTCTGCTGGAAATGCTCAAGCCGTTCAACGTGAAGACCATTGCGGTTAATAACTCTGGTCGT
CCGGTGGAAGGTGCAGATGAAACCTTCGCCATGGATAAGGCTGAGCACGTGTGGGCTGAGGCTGATGTGTTTGTGCTCAT
CCTGCCGCTGACTGATGCCACTTATCAGATCGTCAATGCAGAAACTTTGGGCAAGATGAAGCCTTCTGCCGTGGTGGTCA
ATGTGGGGCGTGGCCCGCTGATCAACACCGATGATCTGGTGGATGCATTGAACAACGGCACCATTGCGGGTGCTGCGCTG
GACGTTACCGATCCTGAGCCACTTCCTGACAGCCACCCGCTGTGGGAGATGGACAATGTGGTTATCACTCCTCATACTGC
AAACACGAATGAGAGGATTCGTGCTTTGACCGGCGAACTCACCTTGCGCAACATTGAGTTGTTTGAGGCAGGCGAGCAGA
TGGCCACCGAGGTCGATGTGGTGGCTGGCTACTAG

Upstream 100 bases:

>100_bases
TGCATGCAGATTATCTGTCCAACTACGCCAGCCGCGCGTAAAGCGCGGGCCTGCTGGTGGCGGGTGGCGTCGAAAAGCAT
TTTTAAAGGAGTTTAAGACG

Downstream 100 bases:

>100_bases
GCCTTTTATGGTGTGATCCGACACTGTTGCTTCTTAAGGGTCTGTATAGTGGGCAACCATGAGTTCAACGACCCTAACTG
ATGACCAAATTCGCGACAAT

Product: phosphoglycerate dehydrogenase or related dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKFVMYPHLWESTTAVIEGGGHERVEDIKDADFIFFNGSAPEFPDLPENIKFVQASMAGIDALVKRGVVNEKARWANAAG
LYADTVAESTIGLILAQMHMHATTRLAKSWSVRPEVENNKSWLHDNKTVAILGAGGIGVRLLEMLKPFNVKTIAVNNSGR
PVEGADETFAMDKAEHVWAEADVFVLILPLTDATYQIVNAETLGKMKPSAVVVNVGRGPLINTDDLVDALNNGTIAGAAL
DVTDPEPLPDSHPLWEMDNVVITPHTANTNERIRALTGELTLRNIELFEAGEQMATEVDVVAGY

Sequences:

>Translated_304_residues
MKFVMYPHLWESTTAVIEGGGHERVEDIKDADFIFFNGSAPEFPDLPENIKFVQASMAGIDALVKRGVVNEKARWANAAG
LYADTVAESTIGLILAQMHMHATTRLAKSWSVRPEVENNKSWLHDNKTVAILGAGGIGVRLLEMLKPFNVKTIAVNNSGR
PVEGADETFAMDKAEHVWAEADVFVLILPLTDATYQIVNAETLGKMKPSAVVVNVGRGPLINTDDLVDALNNGTIAGAAL
DVTDPEPLPDSHPLWEMDNVVITPHTANTNERIRALTGELTLRNIELFEAGEQMATEVDVVAGY
>Mature_304_residues
MKFVMYPHLWESTTAVIEGGGHERVEDIKDADFIFFNGSAPEFPDLPENIKFVQASMAGIDALVKRGVVNEKARWANAAG
LYADTVAESTIGLILAQMHMHATTRLAKSWSVRPEVENNKSWLHDNKTVAILGAGGIGVRLLEMLKPFNVKTIAVNNSGR
PVEGADETFAMDKAEHVWAEADVFVLILPLTDATYQIVNAETLGKMKPSAVVVNVGRGPLINTDDLVDALNNGTIAGAAL
DVTDPEPLPDSHPLWEMDNVVITPHTANTNERIRALTGELTLRNIELFEAGEQMATEVDVVAGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

Homologues:

Organism=Homo sapiens, GI6912396, Length=263, Percent_Identity=33.0798479087452, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI23308577, Length=268, Percent_Identity=25.7462686567164, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87082289, Length=220, Percent_Identity=32.2727272727273, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87081824, Length=198, Percent_Identity=30.3030303030303, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787645, Length=287, Percent_Identity=24.390243902439, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789279, Length=95, Percent_Identity=35.7894736842105, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=220, Percent_Identity=29.0909090909091, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25147481, Length=225, Percent_Identity=29.7777777777778, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=29.2181069958848, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=263, Percent_Identity=26.9961977186312, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=150, Percent_Identity=30.6666666666667, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=167, Percent_Identity=32.9341317365269, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=225, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320925, Length=179, Percent_Identity=27.3743016759777, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574286, Length=224, Percent_Identity=36.1607142857143, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI45552429, Length=290, Percent_Identity=31.0344827586207, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585514, Length=288, Percent_Identity=31.25, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574282, Length=288, Percent_Identity=31.25, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45551003, Length=288, Percent_Identity=30.9027777777778, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574284, Length=288, Percent_Identity=30.9027777777778, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=32, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI28571528, Length=173, Percent_Identity=36.4161849710983, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921140, Length=150, Percent_Identity=36, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2355_CORGL (P0C1E8)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927155
- RefSeq:   NP_601556.1
- RefSeq:   YP_226600.1
- ProteinModelPortal:   P0C1E8
- SMR:   P0C1E8
- GeneID:   1020306
- GeneID:   3344875
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2587
- KEGG:   cgl:NCgl2273
- HOGENOM:   HBG731446
- OMA:   KARWANA
- PhylomeDB:   P0C1E8
- ProtClustDB:   CLSK633764
- BioCyc:   CGLU196627:CG2587-MONOMER
- InterPro:   IPR006140
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF02826 2-Hacid_dh_C

EC number: NA

Molecular weight: Translated: 33053; Mature: 33053

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 217-217 ACT_SITE 246-246 ACT_SITE 265-265 BINDING 241-241

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVMYPHLWESTTAVIEGGGHERVEDIKDADFIFFNGSAPEFPDLPENIKFVQASMAGI
CEEEECCCCCCCCEEEEECCCCHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHH
DALVKRGVVNEKARWANAAGLYADTVAESTIGLILAQMHMHATTRLAKSWSVRPEVENNK
HHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SWLHDNKTVAILGAGGIGVRLLEMLKPFNVKTIAVNNSGRPVEGADETFAMDKAEHVWAE
CEEECCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCHHHHEEC
ADVFVLILPLTDATYQIVNAETLGKMKPSAVVVNVGRGPLINTDDLVDALNNGTIAGAAL
CCEEEEEEECCCCEEEEECHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEEEE
DVTDPEPLPDSHPLWEMDNVVITPHTANTNERIRALTGELTLRNIELFEAGEQMATEVDV
ECCCCCCCCCCCCCEECCCEEEECCCCCCCHHHEEEECCEEEEEEEEHHCCHHHHHEEEE
VAGY
EECC
>Mature Secondary Structure
MKFVMYPHLWESTTAVIEGGGHERVEDIKDADFIFFNGSAPEFPDLPENIKFVQASMAGI
CEEEECCCCCCCCEEEEECCCCHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHH
DALVKRGVVNEKARWANAAGLYADTVAESTIGLILAQMHMHATTRLAKSWSVRPEVENNK
HHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SWLHDNKTVAILGAGGIGVRLLEMLKPFNVKTIAVNNSGRPVEGADETFAMDKAEHVWAE
CEEECCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCHHHHEEC
ADVFVLILPLTDATYQIVNAETLGKMKPSAVVVNVGRGPLINTDDLVDALNNGTIAGAAL
CCEEEEEEECCCCEEEEECHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEEEE
DVTDPEPLPDSHPLWEMDNVVITPHTANTNERIRALTGELTLRNIELFEAGEQMATEVDV
ECCCCCCCCCCCCCEECCCEEEECCCCCCCHHHEEEECCEEEEEEEEHHCCHHHHHEEEE
VAGY
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626