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The map label for this gene is lysA [C]

Identifier: 62390971

GI number: 62390971

Start: 2225768

End: 2228422

Strand: Reverse

Name: lysA [C]

Synonym: cg2343

Alternate gene names: 62390971

Gene position: 2228422-2225768 (Counterclockwise)

Preceding gene: 62390972

Following gene: 62390970

Centisome position: 67.88

GC content: 49.94

Gene sequence:

>2655_bases
ATGGGTGGAGGAAAACCTTTGTTCAAGGTAGCTATCATTGGTGGCGGACCGCGCGGGTTGTGGGCTGCTGAAGAATTACT
AGCTCTTGCTAGGGAGAGAGGAGCCAGCATTGATCTTCATGTTTTTAATGATGGTCTCGGTGTGGCATATCAACCTGATC
AGCCTGAAGAATGGCTGATAAATGTACGATCTTCCACGATTAATACACAGTTCAGCGACTTCAGTCAATGGCTACGAAAA
CGCAATGTAGATTCATCTTTCCCACCTCGACGATTAGTAGGGGAGTTCCTGGAAGAATCTTGGGATGCGCTTCTTGAATA
TGTACCTCAGGGGTGTTCTCTTACGATGCACACTAAACATGTAGACACAATCAAACCCTGCGGTAAAAAGAGTGAACGTT
GGTTAGTGCAGGAACAAGAGTTTGATGAAATTCTTTTAGCTACTGGACATGCACACGATTGGCCTGGATCCTTATCGCAA
GAAGATTTCCCCGGGTCAGTGCGTCTGATCGCATCTCCTTATCCTGCTAATAATCTAGACGGGATCAAGTCCACAGACAG
AGTGTTAGTGCGTGGGGCAGCTCTCACTTTCATCGACATCACTCGAGTATGCTCACCGGCCGTATTCATTCCAATAACCC
GCACAGGGAAACTAATGATACCGAAGCCCGACGTGACCGACTTATATTTAGAGGACCTCTTAAATGAGGGTTCGGAAAAG
ATTCGGTCCGCCAAGGATCTTTCCGAACTTAGGACAGTTCTAAAAGAGGTTTCCTCCCAAATTCAGGAACGAGCTGGGAA
AAAAGATGAAGAATGGGGAATGGGGGCCACTTGGCGGGAGCTGTACCCCAGCATCGTGGAACGCGCTTCCTACGAAGGGC
GTGACAGCCTAATCGGATTTGATCACTTAGCCCGGGAAATGGAAAGATTAGCCTTCGGCCCACCATCCGAAAGTTTTGAA
TACCTCCAAGAACTCGTAAAATCCGGAGTGGTAGACATCACTCACCTGCATCGTGGCCGGGAACCACTGACAGATTTAGT
TCGTGAACTTGAAATAACTGTGGTGATAGACGCTGTTCTTCCCCCGCCGGGAGTAGTGCCAGGCACATTGGTGCACAATT
TGGTAAAAGAGGGATATGCCAGAATGCGTCCTGGGACTCGGGGGTTAGATGTAGCGGCTGACGGCACCGTTCAAGGGCAA
CGACATTTGGCTGCAGTCGGACGGATGACGGAAGATGTGGTTTTGGGTAATGACACATTGTCGCGATCATTACATGACAT
AATCCCGAAGTGGGCTCGTCGAGTTATCCGCGACGCGAGCACGTATCCCGATAGGGTACATGGTACTCCACCGCTTCCGG
CACGGTTGGAACCCTGGGCGGAAAAGCTCACTTCAGATCCGGCCACATGCCGCCACCTGATTGAAGAATTCGGGAGTCCT
GTGAATGTACTCCATTCAGGTTCTATGCCTCGTAATATAAATGAGTTGGTTGACGCCGGCATTCAGATGGGGGTGGATAC
TCGAATATTTTTTGCCCGCAAAGCGAATAAGGGTCTTACCTTCGTTGATGCCGTTAAAGACACCGGTCATGGTGTAGATG
TAGCCAGTGAACGAGAGTTATCTCAGGTGCTTAATCGTGGAGTCCCAGGAGAGCGGATCATTCTATCCGCAGCTATCAAA
CCGGACAGACTATTGGCATTAGCGATCGAAAATGGCGTGATCATCTCTGTGGATTCGCGTGATGAATTAGATCGCATTTC
GGCTTTGGTTGGTGACCGCGTTGCACGAGTTGCGCCTAGAGTAGCTCCAGATCCTGCAGTCTTACCTCCAACTAGATTTG
GTGAGCGTGCTGCAGACTGGGGTAATCGGCTTACCGAGGTGATACCCGGCGTGGATATTGTGGGTCTTCACGTTCACCTC
CATGGCTATGCTGCAAAAGACCGTGCTCTGGCTCTGCAGGAATGTTGCCAACTCGTCGATTCTCTCAGAGAATGCGGGCA
TTCCCCACAGTTTATTGACCTTGGAGGAGGGGTGCCTATGAGCTACATTGAATCTGAGGAAGATTGGATCCGTTATCAAT
CCGCTAAATCTGCGACTTCAGCCGGGTATGCCGAATCCTTTACGTGGAAAGACGATCCGTTATCTAATACGTACCCGTTC
TATCAGACCCCAGTGCGCGGTAATTGGTTGAAAGACGTGCTTTCTAAGGGGGTAGCTCAGATGCTCATTGACCGGGGATT
GCGGTTACACCTAGAGCCTGGTCGAAGTTTACTAGATGGGTGTGGCGTCACTCTTGCCGAAGTTGCTTTTGTGAAAACCC
GAAGTGACGGGTTGCCTCTAGTGGGACTGGCTATGAACCGAACGCAGTGCCGGACTACATCCGATGATTTTCTCATTGAT
CCCCTGCATATCACTGACGGTGATGTAGGCGAGGAAATCGAAGCATATCTAGTGGGTGCCTACTGCATCGAAGATGAGCT
GATTTTACGCCGGCGAATCCGCTTCCCGAGAGGAGTCAAACCAGGAGATATCATCGGAATTCCTAACACCGCAGGATACT
TCATGCATATCTTGGAAAGTGCATCGCACCAAATCCCGTTGGCGAAAAATGTAGTGTGGCCGGAGGGGCAGTTAGACGAT
ATCGATGCGGATTAA

Upstream 100 bases:

>100_bases
CTATGGAGATATTACGCCCCGACATCCCTGCGGGTAGCAATGTAGTAGTAATTCTTCATGATGACGGAAATAAGTATTTA
GATACGATTTATAACGACGA

Downstream 100 bases:

>100_bases
GACATAACCATTCGCTAATCTTTCGACGCCCCTTCTGAGGTGGGGATTTCTTTTCATCCCCTTTAATTATTTTCGGAAAT
TTATACAGCAATCCTCGAAA

Product: decarboxylase

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 884; Mature: 883

Protein sequence:

>884_residues
MGGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLINVRSSTINTQFSDFSQWLRK
RNVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKHVDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQ
EDFPGSVRLIASPYPANNLDGIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEK
IRSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLIGFDHLAREMERLAFGPPSESFE
YLQELVKSGVVDITHLHRGREPLTDLVRELEITVVIDAVLPPPGVVPGTLVHNLVKEGYARMRPGTRGLDVAADGTVQGQ
RHLAAVGRMTEDVVLGNDTLSRSLHDIIPKWARRVIRDASTYPDRVHGTPPLPARLEPWAEKLTSDPATCRHLIEEFGSP
VNVLHSGSMPRNINELVDAGIQMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASERELSQVLNRGVPGERIILSAAIK
PDRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPRVAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHL
HGYAAKDRALALQECCQLVDSLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPF
YQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPLVGLAMNRTQCRTTSDDFLID
PLHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGVKPGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDD
IDAD

Sequences:

>Translated_884_residues
MGGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLINVRSSTINTQFSDFSQWLRK
RNVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKHVDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQ
EDFPGSVRLIASPYPANNLDGIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEK
IRSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLIGFDHLAREMERLAFGPPSESFE
YLQELVKSGVVDITHLHRGREPLTDLVRELEITVVIDAVLPPPGVVPGTLVHNLVKEGYARMRPGTRGLDVAADGTVQGQ
RHLAAVGRMTEDVVLGNDTLSRSLHDIIPKWARRVIRDASTYPDRVHGTPPLPARLEPWAEKLTSDPATCRHLIEEFGSP
VNVLHSGSMPRNINELVDAGIQMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASERELSQVLNRGVPGERIILSAAIK
PDRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPRVAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHL
HGYAAKDRALALQECCQLVDSLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPF
YQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPLVGLAMNRTQCRTTSDDFLID
PLHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGVKPGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDD
IDAD
>Mature_883_residues
GGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLINVRSSTINTQFSDFSQWLRKR
NVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKHVDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQE
DFPGSVRLIASPYPANNLDGIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEKI
RSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLIGFDHLAREMERLAFGPPSESFEY
LQELVKSGVVDITHLHRGREPLTDLVRELEITVVIDAVLPPPGVVPGTLVHNLVKEGYARMRPGTRGLDVAADGTVQGQR
HLAAVGRMTEDVVLGNDTLSRSLHDIIPKWARRVIRDASTYPDRVHGTPPLPARLEPWAEKLTSDPATCRHLIEEFGSPV
NVLHSGSMPRNINELVDAGIQMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASERELSQVLNRGVPGERIILSAAIKP
DRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPRVAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHLH
GYAAKDRALALQECCQLVDSLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPFY
QTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPLVGLAMNRTQCRTTSDDFLIDP
LHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGVKPGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDDI
DAD

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG4529

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 97622; Mature: 97491

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLI
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEECCCCCHHHHE
NVRSSTINTQFSDFSQWLRKRNVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKH
EEHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
VDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQEDFPGSVRLIASPYPANNLD
CCHHCCCCCCCHHCCCCHHHHHHHEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
GIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEK
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCHHHHHHHHHHHCCHHH
IRSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLIGF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCH
DHLAREMERLAFGPPSESFEYLQELVKSGVVDITHLHRGREPLTDLVRELEITVVIDAVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEHHHHHCCCCHHHHHHHHHEEEEEEEECC
PPPGVVPGTLVHNLVKEGYARMRPGTRGLDVAADGTVQGQRHLAAVGRMTEDVVLGNDTL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHCCHHCEEECCHHH
SRSLHDIIPKWARRVIRDASTYPDRVHGTPPLPARLEPWAEKLTSDPATCRHLIEEFGSP
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCC
VNVLHSGSMPRNINELVDAGIQMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASEREL
EEEHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEHHHCCCCCCCCCCHHHH
SQVLNRGVPGERIILSAAIKPDRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPR
HHHHHCCCCCCEEEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
VAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHLHGYAAKDRALALQECCQLVD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHH
SLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPF
HHHHHCCCCCEEECCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
YQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPL
EECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCHHHHHHHHHEECCCCCCE
VGLAMNRTQCRTTSDDFLIDPLHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGVK
EEEECCCCCCCCCCCCEEEECEECCCCCCCHHHHHHEEEHHHHHHHHHHHHHHCCCCCCC
PGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDDIDAD
CCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GGGKPLFKVAIIGGGPRGLWAAEELLALARERGASIDLHVFNDGLGVAYQPDQPEEWLI
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEECCCCCHHHHE
NVRSSTINTQFSDFSQWLRKRNVDSSFPPRRLVGEFLEESWDALLEYVPQGCSLTMHTKH
EEHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
VDTIKPCGKKSERWLVQEQEFDEILLATGHAHDWPGSLSQEDFPGSVRLIASPYPANNLD
CCHHCCCCCCCHHCCCCHHHHHHHEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
GIKSTDRVLVRGAALTFIDITRVCSPAVFIPITRTGKLMIPKPDVTDLYLEDLLNEGSEK
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCHHHHHHHHHHHCCHHH
IRSAKDLSELRTVLKEVSSQIQERAGKKDEEWGMGATWRELYPSIVERASYEGRDSLIGF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCH
DHLAREMERLAFGPPSESFEYLQELVKSGVVDITHLHRGREPLTDLVRELEITVVIDAVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEHHHHHCCCCHHHHHHHHHEEEEEEEECC
PPPGVVPGTLVHNLVKEGYARMRPGTRGLDVAADGTVQGQRHLAAVGRMTEDVVLGNDTL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHCCHHCEEECCHHH
SRSLHDIIPKWARRVIRDASTYPDRVHGTPPLPARLEPWAEKLTSDPATCRHLIEEFGSP
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCC
VNVLHSGSMPRNINELVDAGIQMGVDTRIFFARKANKGLTFVDAVKDTGHGVDVASEREL
EEEHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEHHHCCCCCCCCCCHHHH
SQVLNRGVPGERIILSAAIKPDRLLALAIENGVIISVDSRDELDRISALVGDRVARVAPR
HHHHHCCCCCCEEEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
VAPDPAVLPPTRFGERAADWGNRLTEVIPGVDIVGLHVHLHGYAAKDRALALQECCQLVD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHH
SLRECGHSPQFIDLGGGVPMSYIESEEDWIRYQSAKSATSAGYAESFTWKDDPLSNTYPF
HHHHHCCCCCEEECCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
YQTPVRGNWLKDVLSKGVAQMLIDRGLRLHLEPGRSLLDGCGVTLAEVAFVKTRSDGLPL
EECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCHHHHHHHHHEECCCCCCE
VGLAMNRTQCRTTSDDFLIDPLHITDGDVGEEIEAYLVGAYCIEDELILRRRIRFPRGVK
EEEECCCCCCCCCCCCEEEECEECCCCCCCHHHHHHEEEHHHHHHHHHHHHHHCCCCCCC
PGDIIGIPNTAGYFMHILESASHQIPLAKNVVWPEGQLDDIDAD
CCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]