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The map label for this gene is map2 [H]

Identifier: 62390847

GI number: 62390847

Start: 2090406

End: 2091290

Strand: Reverse

Name: map2 [H]

Synonym: cg2198

Alternate gene names: 62390847

Gene position: 2091290-2090406 (Counterclockwise)

Preceding gene: 62390848

Following gene: 62390841

Centisome position: 63.71

GC content: 53.11

Gene sequence:

>885_bases
ATGGTGACCATGTCTAAAATGCGCGCACCACTTGTACCCGGAATTCCTACCCCAATCAGGGAAGTACCTGCACATATTGA
ACGTCCAGAATATGTGTGGAAGGACGAAGTCCAAGAAGCAATCGGTGAGCCTTTTGTGCAGGCCCCTGAGGTCATCGAGA
AGATGCGTGAGACATCTCGCATCGCTGCAAACTCACTGAAAATCGCGGGCGAAGCCGTCAAGCCAGGCGTGACCACTGAT
GAACTTGATCGCATTGTGCATGAGTACACCTGCGATATGGGCGCATACCCTTCAGATCTTGGTTACCGGGGATTCACCAA
GTCCTCATGCATTTCCCTCAATGAGATCGTGTGCCACGGTATTCCTGATTCCACCGTCATTGAAGAGGGCGATATTGTTA
ACATCGATGTCACCGCGTTCAAGCACGGCGTCCACGGCGACTGCAATGCCACCTTCTTAGCGGGTGATGTTTCTGAAGAA
CACCGCCTGCTGGTTGAGCGCACCGAAGAAGCCATGATGCGTTCCATCCGTGCAGCAAAGCCTGGACGTGAAATCAACGT
CATTGGGCGTGTCATTGAGTCTTACGCCAAGCGTTTTGGCTACAACGTGGTCCGCGATTTCACCGGACACGGCATCGGCC
CAACTTTCCACAACGGCCTTGTGGTGCTGCACTACGACAACACTCAGTACCGCGATCTGCTCGTGCCAGGCATGACCTTG
ACCATCGAGCCAATGATCAACCTTGGTTCCCTCGACTACGAGATCTGGGAAGATGATTGGACTGTCCAAAACGTTGACCG
TAAGTTCAGCGCGCAGTTCGAGCACACCATTGTCATCACCGAAGACGGCAATGAGATCCTCACCCTCCCAGACGATTCCG
TCTAA

Upstream 100 bases:

>100_bases
GGGGGAGAAGTTGCAGTCAGTGAAGCTGAAGAGCAGCCAGTCGGCTAAAAAATAGCCTCCATCCAACCCGCTTTACCTGT
CATCGCTTCAGGCGACTAGC

Downstream 100 bases:

>100_bases
AAACGCCTAGGCCACAAGCCTGCGACCGTCGCAAGAACCCCGGCAATCATAAAACCCCATGCGACCGTCGTGGGCTGCAG
CCACAGCAAACCCGGCGCCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MVTMSKMRAPLVPGIPTPIREVPAHIERPEYVWKDEVQEAIGEPFVQAPEVIEKMRETSRIAANSLKIAGEAVKPGVTTD
ELDRIVHEYTCDMGAYPSDLGYRGFTKSSCISLNEIVCHGIPDSTVIEEGDIVNIDVTAFKHGVHGDCNATFLAGDVSEE
HRLLVERTEEAMMRSIRAAKPGREINVIGRVIESYAKRFGYNVVRDFTGHGIGPTFHNGLVVLHYDNTQYRDLLVPGMTL
TIEPMINLGSLDYEIWEDDWTVQNVDRKFSAQFEHTIVITEDGNEILTLPDDSV

Sequences:

>Translated_294_residues
MVTMSKMRAPLVPGIPTPIREVPAHIERPEYVWKDEVQEAIGEPFVQAPEVIEKMRETSRIAANSLKIAGEAVKPGVTTD
ELDRIVHEYTCDMGAYPSDLGYRGFTKSSCISLNEIVCHGIPDSTVIEEGDIVNIDVTAFKHGVHGDCNATFLAGDVSEE
HRLLVERTEEAMMRSIRAAKPGREINVIGRVIESYAKRFGYNVVRDFTGHGIGPTFHNGLVVLHYDNTQYRDLLVPGMTL
TIEPMINLGSLDYEIWEDDWTVQNVDRKFSAQFEHTIVITEDGNEILTLPDDSV
>Mature_294_residues
MVTMSKMRAPLVPGIPTPIREVPAHIERPEYVWKDEVQEAIGEPFVQAPEVIEKMRETSRIAANSLKIAGEAVKPGVTTD
ELDRIVHEYTCDMGAYPSDLGYRGFTKSSCISLNEIVCHGIPDSTVIEEGDIVNIDVTAFKHGVHGDCNATFLAGDVSEE
HRLLVERTEEAMMRSIRAAKPGREINVIGRVIESYAKRFGYNVVRDFTGHGIGPTFHNGLVVLHYDNTQYRDLLVPGMTL
TIEPMINLGSLDYEIWEDDWTVQNVDRKFSAQFEHTIVITEDGNEILTLPDDSV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=296, Percent_Identity=42.5675675675676, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI40385867, Length=292, Percent_Identity=39.7260273972603, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=47.3895582329317, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1789275, Length=277, Percent_Identity=28.5198555956679, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=289, Percent_Identity=42.560553633218, Blast_Score=226, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323273, Length=278, Percent_Identity=41.726618705036, Blast_Score=224, Evalue=1e-59,
Organism=Drosophila melanogaster, GI21355531, Length=289, Percent_Identity=42.9065743944637, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24583427, Length=276, Percent_Identity=43.4782608695652, Blast_Score=228, Evalue=4e-60,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32872; Mature: 32872

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTMSKMRAPLVPGIPTPIREVPAHIERPEYVWKDEVQEAIGEPFVQAPEVIEKMRETSR
CCCHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
IAANSLKIAGEAVKPGVTTDELDRIVHEYTCDMGAYPSDLGYRGFTKSSCISLNEIVCHG
HHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHHCCC
IPDSTVIEEGDIVNIDVTAFKHGVHGDCNATFLAGDVSEEHRLLVERTEEAMMRSIRAAK
CCCCCEECCCCEEEEEHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
PGREINVIGRVIESYAKRFGYNVVRDFTGHGIGPTFHNGLVVLHYDNTQYRDLLVPGMTL
CCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEECCCCEE
TIEPMINLGSLDYEIWEDDWTVQNVDRKFSAQFEHTIVITEDGNEILTLPDDSV
EEECCCCCCCCCEEEECCCCEEHHHHHHHCCCEEEEEEEEECCCEEEECCCCCC
>Mature Secondary Structure
MVTMSKMRAPLVPGIPTPIREVPAHIERPEYVWKDEVQEAIGEPFVQAPEVIEKMRETSR
CCCHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
IAANSLKIAGEAVKPGVTTDELDRIVHEYTCDMGAYPSDLGYRGFTKSSCISLNEIVCHG
HHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHHCCC
IPDSTVIEEGDIVNIDVTAFKHGVHGDCNATFLAGDVSEEHRLLVERTEEAMMRSIRAAK
CCCCCEECCCCEEEEEHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
PGREINVIGRVIESYAKRFGYNVVRDFTGHGIGPTFHNGLVVLHYDNTQYRDLLVPGMTL
CCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEECCCCEE
TIEPMINLGSLDYEIWEDDWTVQNVDRKFSAQFEHTIVITEDGNEILTLPDDSV
EEECCCCCCCCCEEEECCCCEEHHHHHHHCCCEEEEEEEEECCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]