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The map label for this gene is clpE [H]

Identifier: 62390641

GI number: 62390641

Start: 1860235

End: 1862202

Strand: Direct

Name: clpE [H]

Synonym: cg1982

Alternate gene names: 62390641

Gene position: 1860235-1862202 (Clockwise)

Preceding gene: 62390640

Following gene: 62390642

Centisome position: 56.67

GC content: 49.85

Gene sequence:

>1968_bases
GTGAACTCTCGCGGATTGCCACACACCACCAACCACTACAAGAAAGAACCCCCTACCGTGCCTTTTCACGATTTCACTGA
CCCTGATAGCGATCCTAGGCAAAATGCACCAGCTAACCCCACCGCTCAACCGCCATCTGCCCCCACCTCACACTCATCAC
AGCAGGGTCTCCCTCCGGGCGCCATTATGATCCCTTTTCCAGGGCAACCGCAGCAGCAAAGCGCACCCAATGACGAGACC
CGTTTCATCGACCTTAACGAACGTCATAAAGATGATGAACCAGCCCTGTTTCGCGATGATGTTATTGATCAAACTCTCGC
TATTTTGATCAGTAAAAATAAGCCCAATGCGCTACTCGTTGGGCCTGCCGGTACAGGTAAATCCCGTATCGCAGAAGATA
TTGCGCGCCGCCTTGCCAATGATGACGTATCTATTCCCGATCAGCTTGTCGGCCACCGTATTCTTGATGTCTCCATTGCA
GAGCTTGTTGCTGGTGCTGGCGTTGTTGGTCAGCTCGAAGAACGCATTCTGGATCTCATCAAGTATGCGACCGACCCGAG
TAACAAAGTCATTATCTTTATTGACGAGATTCACCAAATTGCTGGTGATCAGTCCAGTCACAGTGGATCGCAAGCCAAAG
TTGCTCAGATTCTCAAACCCTATCTTGCCCGTGGTGACCTTCGTGTTATTGGTGCCACCACCACCCAGGAAGCTCGTGAC
TTCGATCATGATCCAGCCCTCAAACGCCGTTTTAGCAGAGTAAATGTCGATGAATTTGATCGAGATCAAACGCTCACTAT
TCTTCATGCTGCACGTGATGGTTACCTCAAACATTTCAACAACGCTGTCACGGTATCTGACGACGTACTGGGCTATGTCT
ACACCTACTCGCAGCAATTCAACCCAGGCAATACAGCACAACCTGATGCAGCACTGACGCTGTTTGATAAGGCGTTGGCT
TCCCTAACTATGGAGAAACAGCGTCTGATCAACAACCATGTCATTGCGCCGTCGCTCAAGTTCCCTGTGTCAGAAAGGCA
CATCCATAACACCGCTCGCAAACTTGCCTTTGGCTCTCAAGTGCCAGCCTCCATCAATACTGATGATGCTCGTGACAAAC
TCGAAACGTTGTTTGGTCAAGATCATATTATTGAGCCAGTACTCACCGCTATCAAGCGTGAACAGCTTGGTATTTTCCCT
CGCACCAAACCATTGAGCTGGGTGTTTGCTGGTTCATCTGGTGTGGGTAAAACAGAAATGGCGCGTATTCTCTCTCGCGC
CATTAATGGCGGCGATCCCATCATTATCAATGGTCCCGAATACATTAGTCCTGAGTCCATTACTGGCCTTATCGGATCAT
CCGATGGCTATATCGGCTCTAATTCTAAGCGTGCTAAACCACTCGACCCGCTGATTTCTAATCCGCGTCAGGTGATTGTG
CTCGATGAATTTGAGAAGTCTCACCCTCATTTCCAGCAATTGTTCATGGCAGCTCTTGATACAGGCACTATGGCGATGGC
TAATGGCACGACATTGAATTTCTCTCAGGCCATTATCATTGCCACCACCAATGCAGCCCGCGACAAAATCGGTCGTGACA
GCTTTGGATTCGATTCAGATAATTCAGGTGTCCTCGGTTCTGCTCAAGCAGCAACTGATCCGCGTGCACAGGAACGCCTC
AAGTCACTGATGTCCAAGGATTTCCCTGTTGAACTGCTCAACCGTTTCCAGAATATCTTTGCCTTCAACCGCATTGATGC
AGGCACCTACCGTGAGATTCTGGACAATCTCTACCAGCGTCGCCGTGACGCCGTGCTGCTTAGCCACCCGCATTACGCAG
CACAGATCCCTGCAGATATTGATTCAGACACTCTTGATCAGCTGGTGGAAACCACCTTTATCTCAGATTTTGGTGCACGT
CCTGCTGCACGCACCATCGAAGACCACATCGCATCCTTGCTGATGTGA

Upstream 100 bases:

>100_bases
TATGTCTCATTTCGCAAATGAAATGGTTGACTTCGACCCCTATATCCACAGCCGACTACTCGGCGTACACGGAAAATAGC
AGCTGATCCATCTAGGGTCA

Downstream 100 bases:

>100_bases
CCAACCTTTTAGGAGTACATCATGATTGATACCACTGCTAACAGCACCTCAGGCACCCTACCTACACTCACTGCTGACCA
AGCTGCGTTTATCACCGGTT

Product: ATPase with chaperone activity, ATP-binding subunit

Products: NA

Alternate protein names: ATPase ClpE; Heat shock protein HSP1 [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MNSRGLPHTTNHYKKEPPTVPFHDFTDPDSDPRQNAPANPTAQPPSAPTSHSSQQGLPPGAIMIPFPGQPQQQSAPNDET
RFIDLNERHKDDEPALFRDDVIDQTLAILISKNKPNALLVGPAGTGKSRIAEDIARRLANDDVSIPDQLVGHRILDVSIA
ELVAGAGVVGQLEERILDLIKYATDPSNKVIIFIDEIHQIAGDQSSHSGSQAKVAQILKPYLARGDLRVIGATTTQEARD
FDHDPALKRRFSRVNVDEFDRDQTLTILHAARDGYLKHFNNAVTVSDDVLGYVYTYSQQFNPGNTAQPDAALTLFDKALA
SLTMEKQRLINNHVIAPSLKFPVSERHIHNTARKLAFGSQVPASINTDDARDKLETLFGQDHIIEPVLTAIKREQLGIFP
RTKPLSWVFAGSSGVGKTEMARILSRAINGGDPIIINGPEYISPESITGLIGSSDGYIGSNSKRAKPLDPLISNPRQVIV
LDEFEKSHPHFQQLFMAALDTGTMAMANGTTLNFSQAIIIATTNAARDKIGRDSFGFDSDNSGVLGSAQAATDPRAQERL
KSLMSKDFPVELLNRFQNIFAFNRIDAGTYREILDNLYQRRRDAVLLSHPHYAAQIPADIDSDTLDQLVETTFISDFGAR
PAARTIEDHIASLLM

Sequences:

>Translated_655_residues
MNSRGLPHTTNHYKKEPPTVPFHDFTDPDSDPRQNAPANPTAQPPSAPTSHSSQQGLPPGAIMIPFPGQPQQQSAPNDET
RFIDLNERHKDDEPALFRDDVIDQTLAILISKNKPNALLVGPAGTGKSRIAEDIARRLANDDVSIPDQLVGHRILDVSIA
ELVAGAGVVGQLEERILDLIKYATDPSNKVIIFIDEIHQIAGDQSSHSGSQAKVAQILKPYLARGDLRVIGATTTQEARD
FDHDPALKRRFSRVNVDEFDRDQTLTILHAARDGYLKHFNNAVTVSDDVLGYVYTYSQQFNPGNTAQPDAALTLFDKALA
SLTMEKQRLINNHVIAPSLKFPVSERHIHNTARKLAFGSQVPASINTDDARDKLETLFGQDHIIEPVLTAIKREQLGIFP
RTKPLSWVFAGSSGVGKTEMARILSRAINGGDPIIINGPEYISPESITGLIGSSDGYIGSNSKRAKPLDPLISNPRQVIV
LDEFEKSHPHFQQLFMAALDTGTMAMANGTTLNFSQAIIIATTNAARDKIGRDSFGFDSDNSGVLGSAQAATDPRAQERL
KSLMSKDFPVELLNRFQNIFAFNRIDAGTYREILDNLYQRRRDAVLLSHPHYAAQIPADIDSDTLDQLVETTFISDFGAR
PAARTIEDHIASLLM
>Mature_655_residues
MNSRGLPHTTNHYKKEPPTVPFHDFTDPDSDPRQNAPANPTAQPPSAPTSHSSQQGLPPGAIMIPFPGQPQQQSAPNDET
RFIDLNERHKDDEPALFRDDVIDQTLAILISKNKPNALLVGPAGTGKSRIAEDIARRLANDDVSIPDQLVGHRILDVSIA
ELVAGAGVVGQLEERILDLIKYATDPSNKVIIFIDEIHQIAGDQSSHSGSQAKVAQILKPYLARGDLRVIGATTTQEARD
FDHDPALKRRFSRVNVDEFDRDQTLTILHAARDGYLKHFNNAVTVSDDVLGYVYTYSQQFNPGNTAQPDAALTLFDKALA
SLTMEKQRLINNHVIAPSLKFPVSERHIHNTARKLAFGSQVPASINTDDARDKLETLFGQDHIIEPVLTAIKREQLGIFP
RTKPLSWVFAGSSGVGKTEMARILSRAINGGDPIIINGPEYISPESITGLIGSSDGYIGSNSKRAKPLDPLISNPRQVIV
LDEFEKSHPHFQQLFMAALDTGTMAMANGTTLNFSQAIIIATTNAARDKIGRDSFGFDSDNSGVLGSAQAATDPRAQERL
KSLMSKDFPVELLNRFQNIFAFNRIDAGTYREILDNLYQRRRDAVLLSHPHYAAQIPADIDSDTLDQLVETTFISDFGAR
PAARTIEDHIASLLM

Specific function: ATPase essential both for efficient CtsR-dependent gene derepression during heat stress and for rerepression. Together with ClpP, degrades the global regulator CtsR after heat shock. Is also involved in disaggregation of heat-denatured proteins. Has thus

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=164, Percent_Identity=29.8780487804878, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1787109, Length=606, Percent_Identity=30.3630363036304, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1788943, Length=250, Percent_Identity=35.2, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6323002, Length=245, Percent_Identity=34.2857142857143, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320464, Length=235, Percent_Identity=33.1914893617021, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 71909; Mature: 71909

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSRGLPHTTNHYKKEPPTVPFHDFTDPDSDPRQNAPANPTAQPPSAPTSHSSQQGLPPG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AIMIPFPGQPQQQSAPNDETRFIDLNERHKDDEPALFRDDVIDQTLAILISKNKPNALLV
EEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCEEEE
GPAGTGKSRIAEDIARRLANDDVSIPDQLVGHRILDVSIAELVAGAGVVGQLEERILDLI
ECCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KYATDPSNKVIIFIDEIHQIAGDQSSHSGSQAKVAQILKPYLARGDLRVIGATTTQEARD
HHCCCCCCCEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHC
FDHDPALKRRFSRVNVDEFDRDQTLTILHAARDGYLKHFNNAVTVSDDVLGYVYTYSQQF
CCCCHHHHHHHHHCCHHHCCCCCEEEEEEHHHHHHHHHCCCCEEECHHHEEEEEEECCCC
NPGNTAQPDAALTLFDKALASLTMEKQRLINNHVIAPSLKFPVSERHIHNTARKLAFGSQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHCCCC
VPASINTDDARDKLETLFGQDHIIEPVLTAIKREQLGIFPRTKPLSWVFAGSSGVGKTEM
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHH
ARILSRAINGGDPIIINGPEYISPESITGLIGSSDGYIGSNSKRAKPLDPLISNPRQVIV
HHHHHHHHCCCCEEEECCCCCCCCCHHEEEECCCCCCCCCCCCCCCCCCHHHCCCCEEEE
LDEFEKSHPHFQQLFMAALDTGTMAMANGTTLNFSQAIIIATTNAARDKIGRDSFGFDSD
EECCCCCCHHHHHHHHHHHCCCCEEECCCCEEECCCEEEEEECCHHHHHCCCCCCCCCCC
NSGVLGSAQAATDPRAQERLKSLMSKDFPVELLNRFQNIFAFNRIDAGTYREILDNLYQR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RRDAVLLSHPHYAAQIPADIDSDTLDQLVETTFISDFGARPAARTIEDHIASLLM
HHCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSRGLPHTTNHYKKEPPTVPFHDFTDPDSDPRQNAPANPTAQPPSAPTSHSSQQGLPPG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AIMIPFPGQPQQQSAPNDETRFIDLNERHKDDEPALFRDDVIDQTLAILISKNKPNALLV
EEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCEEEE
GPAGTGKSRIAEDIARRLANDDVSIPDQLVGHRILDVSIAELVAGAGVVGQLEERILDLI
ECCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KYATDPSNKVIIFIDEIHQIAGDQSSHSGSQAKVAQILKPYLARGDLRVIGATTTQEARD
HHCCCCCCCEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHC
FDHDPALKRRFSRVNVDEFDRDQTLTILHAARDGYLKHFNNAVTVSDDVLGYVYTYSQQF
CCCCHHHHHHHHHCCHHHCCCCCEEEEEEHHHHHHHHHCCCCEEECHHHEEEEEEECCCC
NPGNTAQPDAALTLFDKALASLTMEKQRLINNHVIAPSLKFPVSERHIHNTARKLAFGSQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHCCCC
VPASINTDDARDKLETLFGQDHIIEPVLTAIKREQLGIFPRTKPLSWVFAGSSGVGKTEM
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHH
ARILSRAINGGDPIIINGPEYISPESITGLIGSSDGYIGSNSKRAKPLDPLISNPRQVIV
HHHHHHHHCCCCEEEECCCCCCCCCHHEEEECCCCCCCCCCCCCCCCCCHHHCCCCEEEE
LDEFEKSHPHFQQLFMAALDTGTMAMANGTTLNFSQAIIIATTNAARDKIGRDSFGFDSD
EECCCCCCHHHHHHHHHHHCCCCEEECCCCEEECCCEEEEEECCHHHHHCCCCCCCCCCC
NSGVLGSAQAATDPRAQERLKSLMSKDFPVELLNRFQNIFAFNRIDAGTYREILDNLYQR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RRDAVLLSHPHYAAQIPADIDSDTLDQLVETTFISDFGARPAARTIEDHIASLLM
HHCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]