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The map label for this gene is tesB2 [H]

Identifier: 62390545

GI number: 62390545

Start: 1766484

End: 1767332

Strand: Reverse

Name: tesB2 [H]

Synonym: cg1873

Alternate gene names: 62390545

Gene position: 1767332-1766484 (Counterclockwise)

Preceding gene: 62390547

Following gene: 62390544

Centisome position: 53.84

GC content: 50.77

Gene sequence:

>849_bases
GTGAAAACTATTGAAGATATTTTGACCTTGGAAGAAATCGACCGCGATATTTACCGTGGTCCCGTTATCGAATCTTATTT
AGCCAGGACTTTCGGTGGCCAGGTCGCTGCCCAAGCTTTAGTAGCAGCAACGCATACTGTTGATAAAGCCTTTACTGTGC
ATTCTTTGCATGGCTACTTTATAGCTCCTGGTGATCCAACAGCACCCGCAATTTATTTAGTGGATCGAGTTCGCGACGGA
AAAAGCTACGTCACCCGCTCGGTGCGTGGCATCCAAGACGGCGAAGTAATCTTCAGCATGCAGGCCAGCTTTCATCGTGG
GGATGAAGGCATTGAGCACATGGACAAGATGCGTAAAGTTCCAGCTCCTGATGAGATCAAGGGAACAGTAGAACGTATGC
CGATCTCAAGTAGGCGAGTGCTTGATGAATGGGCGGAATGGGATATCCGCGTTATTCCGCAGGATCAATTAGAACTCAGC
GATTTCACCGCTACTGAGCAAGCTGTGTGGATTCGGTGCACCGCTGATCTTCCGGATAATCCCACCTTCCACCAGTGCTC
ACTGACTTATCTGTCCGATATGACTTTGCTGCATAGTGCCCTGGTGCCACACCCAGGTGAGAAAATGCAGATGGCCTCAC
TTGATCACGCTGTGTGGTTCCTGCGTCCCTTCCGCGTCGATGAATGGTTGCTTTATGATCAGCGCTCTCCATCGGCCTCA
AGTGGGCGAGCCTTGACTCACGGGCGGCTTTTCAACCAGCAGGGAGATTTGGTCGCTATTGTCAATCAAGAGGGAATGAC
CCGCACACTCCACGAGGGTGCGCAATCAATTCCGATGCGCAAAGACTAA

Upstream 100 bases:

>100_bases
CCGTAACCTAATCGTTGAAACATCACCTTATTGCTGGGCTTTGCACGCTACTCTTTGTGAGTAACCTCACCGAAGTGCAT
AAATTAATTGGGAGTGATCA

Downstream 100 bases:

>100_bases
AATGCAGCGAACTTGAAGATCTGAATCCGGTAACGCGACAGAAATTGGTGCCCTTTAAGTTTCATCATTTGACCTTGGCG
TATACTGTTTCATCAGTTCC

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKTIEDILTLEEIDRDIYRGPVIESYLARTFGGQVAAQALVAATHTVDKAFTVHSLHGYFIAPGDPTAPAIYLVDRVRDG
KSYVTRSVRGIQDGEVIFSMQASFHRGDEGIEHMDKMRKVPAPDEIKGTVERMPISSRRVLDEWAEWDIRVIPQDQLELS
DFTATEQAVWIRCTADLPDNPTFHQCSLTYLSDMTLLHSALVPHPGEKMQMASLDHAVWFLRPFRVDEWLLYDQRSPSAS
SGRALTHGRLFNQQGDLVAIVNQEGMTRTLHEGAQSIPMRKD

Sequences:

>Translated_282_residues
MKTIEDILTLEEIDRDIYRGPVIESYLARTFGGQVAAQALVAATHTVDKAFTVHSLHGYFIAPGDPTAPAIYLVDRVRDG
KSYVTRSVRGIQDGEVIFSMQASFHRGDEGIEHMDKMRKVPAPDEIKGTVERMPISSRRVLDEWAEWDIRVIPQDQLELS
DFTATEQAVWIRCTADLPDNPTFHQCSLTYLSDMTLLHSALVPHPGEKMQMASLDHAVWFLRPFRVDEWLLYDQRSPSAS
SGRALTHGRLFNQQGDLVAIVNQEGMTRTLHEGAQSIPMRKD
>Mature_282_residues
MKTIEDILTLEEIDRDIYRGPVIESYLARTFGGQVAAQALVAATHTVDKAFTVHSLHGYFIAPGDPTAPAIYLVDRVRDG
KSYVTRSVRGIQDGEVIFSMQASFHRGDEGIEHMDKMRKVPAPDEIKGTVERMPISSRRVLDEWAEWDIRVIPQDQLELS
DFTATEQAVWIRCTADLPDNPTFHQCSLTYLSDMTLLHSALVPHPGEKMQMASLDHAVWFLRPFRVDEWLLYDQRSPSAS
SGRALTHGRLFNQQGDLVAIVNQEGMTRTLHEGAQSIPMRKD

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=292, Percent_Identity=36.3013698630137, Blast_Score=181, Evalue=8e-46,
Organism=Escherichia coli, GI1786657, Length=274, Percent_Identity=38.6861313868613, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71988741, Length=298, Percent_Identity=34.8993288590604, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17558508, Length=314, Percent_Identity=35.6687898089172, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17531889, Length=269, Percent_Identity=34.2007434944238, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI115532456, Length=269, Percent_Identity=34.2007434944238, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17531885, Length=269, Percent_Identity=34.2007434944238, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71982224, Length=300, Percent_Identity=29, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI212645202, Length=288, Percent_Identity=28.4722222222222, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 31831; Mature: 31831

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIEDILTLEEIDRDIYRGPVIESYLARTFGGQVAAQALVAATHTVDKAFTVHSLHGYF
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEECCCEE
IAPGDPTAPAIYLVDRVRDGKSYVTRSVRGIQDGEVIFSMQASFHRGDEGIEHMDKMRKV
ECCCCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCC
PAPDEIKGTVERMPISSRRVLDEWAEWDIRVIPQDQLELSDFTATEQAVWIRCTADLPDN
CCCHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCC
PTFHQCSLTYLSDMTLLHSALVPHPGEKMQMASLDHAVWFLRPFRVDEWLLYDQRSPSAS
CCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCCEEEEECCCCCCCC
SGRALTHGRLFNQQGDLVAIVNQEGMTRTLHEGAQSIPMRKD
CCCEEECCEEECCCCCEEEEECCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTIEDILTLEEIDRDIYRGPVIESYLARTFGGQVAAQALVAATHTVDKAFTVHSLHGYF
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEECCCEE
IAPGDPTAPAIYLVDRVRDGKSYVTRSVRGIQDGEVIFSMQASFHRGDEGIEHMDKMRKV
ECCCCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCC
PAPDEIKGTVERMPISSRRVLDEWAEWDIRVIPQDQLELSDFTATEQAVWIRCTADLPDN
CCCHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCC
PTFHQCSLTYLSDMTLLHSALVPHPGEKMQMASLDHAVWFLRPFRVDEWLLYDQRSPSAS
CCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCCEEEEECCCCCCCC
SGRALTHGRLFNQQGDLVAIVNQEGMTRTLHEGAQSIPMRKD
CCCEEECCEEECCCCCEEEEECCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]