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The map label for this gene is sdaA [H]

Identifier: 62390528

GI number: 62390528

Start: 1746353

End: 1747702

Strand: Direct

Name: sdaA [H]

Synonym: cg1852

Alternate gene names: 62390528

Gene position: 1746353-1747702 (Clockwise)

Preceding gene: 62390527

Following gene: 62390532

Centisome position: 53.2

GC content: 55.11

Gene sequence:

>1350_bases
ATGGCTATCAGTGTTGTTGATCTATTTAGCATCGGTATCGGACCATCATCCTCACATACCGTCGGCCCCATGAGAGCCGC
CCTCACGTATATCTCTGAATTTCCCAGCTCGCATGTCGATATCACGTTGCACGGATCCCTTGCCGCCACCGGTAAAGGCC
ACTGCACTGACCGGGCGGTATTACTGGGTCTGGTGGGATGGGAACCAACGATAGTTCCCATTGATGCTGCACCCTCACCC
GGCGCGCCGATTCCTGCGAAAGGTTCTGTGAACGGGCCAAAGGGAACGGTGTCGTATTCCCTGACGTTTGATCCTCATCC
TCTTCCAGAACACCCCAATGCCGTTACCTTTAAAGGATCAACCACAAGGACTTATTTGTCGGTGGGTGGTGGGTTCATTA
TGACGTTGGAGGATTTCCGGAAGCTGGACGATATCGGATCAGGTGTGTCAACCATTCATCCAGAGGCAGAGGTGCCTTGT
CCTTTTCAGAAGAGTTCCCAATTACTCGCATATGGTCGCGATTTTGCGGAGGTCATGAAGGATAATGAGCGCTTAATCCA
CGGGGATCTTGGCACAGTGGATGCCCATTTGGATCGAGTGTGGCAGATTATGCAGGAGTGCGTGGCACAAGGCATCGCAA
CGCCGGGGATTTTACCGGGTGGGTTGAATGTGCAACGTCGGGCGCCGCAGGTACACGCGCTGATTAGCAACGGGGATACG
TGTGAGCTGGGTGCTGATCTTGATGCTGTGGAGTGGGTGAATCTGTACGCCTTGGCGGTGAATGAAGAAAACGCCGCTGG
TGGTCGTGTGGTTACTGCTCCGACTAATGGTGCTGCGGGGATTATTCCGGCGGTGATGCACTATGCGCGGGATTTTTTGA
CAGGTTTTGGGGCGGAGCAGGCGCGGACGTTTTTGTATACCGCGGGTGCGGTGGGCATCATCATTAAGGAAAATGCCTCG
ATCTCTGGCGCGGAGGTGGGGTGTCAGGGTGAGGTTGGTTCAGCGTCCGCGATGGCGGCTGCCGGGTTGTGTGCAGTCTT
AGGTGGTTCTCCGCAACAGGTGGAAAACGCCGCGGAGATTGCGTTGGAGCACAATTTGGGATTGACGTGCGATCCGGTGG
GCGGGTTAGTGCAGATTCCGTGTATTGAACGCAACGCTATTGCTGCCATGAAGTCCATCAATGCGGCAAGGCTTGCCCGG
ATTGGTGATGGCAACAATCGCGTGAGTTTGGATGATGTGGTGGTCACGATGGCTGCCACCGGCCGGGACATGCTGACCAA
ATATAAGGAAACGTCCCTTGGTGGTTTGGCAACCACCTTGGGCTTCCCGGTGTCGATGACGGAGTGTTAG

Upstream 100 bases:

>100_bases
TTCGTGCAACTTCAGACTCTTACGGAGGCGATGGACCAAAAACAACTACAATCAAGCAGATCACCTTGTACACCACCATA
GAAAAGGCCCACCCTCAGCC

Downstream 100 bases:

>100_bases
CGGTACGGCTTTAACACGGCTTGGATTTTGTCTTGCTTGGCGAGGTAGGACTGGCACTGGGCGTCGATAAGCTCAGCTGA
CCACCCGGTGACCTGCGCCA

Product: L-serine dehydratase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAISVVDLFSIGIGPSSSHTVGPMRAALTYISEFPSSHVDITLHGSLAATGKGHCTDRAVLLGLVGWEPTIVPIDAAPSP
GAPIPAKGSVNGPKGTVSYSLTFDPHPLPEHPNAVTFKGSTTRTYLSVGGGFIMTLEDFRKLDDIGSGVSTIHPEAEVPC
PFQKSSQLLAYGRDFAEVMKDNERLIHGDLGTVDAHLDRVWQIMQECVAQGIATPGILPGGLNVQRRAPQVHALISNGDT
CELGADLDAVEWVNLYALAVNEENAAGGRVVTAPTNGAAGIIPAVMHYARDFLTGFGAEQARTFLYTAGAVGIIIKENAS
ISGAEVGCQGEVGSASAMAAAGLCAVLGGSPQQVENAAEIALEHNLGLTCDPVGGLVQIPCIERNAIAAMKSINAARLAR
IGDGNNRVSLDDVVVTMAATGRDMLTKYKETSLGGLATTLGFPVSMTEC

Sequences:

>Translated_449_residues
MAISVVDLFSIGIGPSSSHTVGPMRAALTYISEFPSSHVDITLHGSLAATGKGHCTDRAVLLGLVGWEPTIVPIDAAPSP
GAPIPAKGSVNGPKGTVSYSLTFDPHPLPEHPNAVTFKGSTTRTYLSVGGGFIMTLEDFRKLDDIGSGVSTIHPEAEVPC
PFQKSSQLLAYGRDFAEVMKDNERLIHGDLGTVDAHLDRVWQIMQECVAQGIATPGILPGGLNVQRRAPQVHALISNGDT
CELGADLDAVEWVNLYALAVNEENAAGGRVVTAPTNGAAGIIPAVMHYARDFLTGFGAEQARTFLYTAGAVGIIIKENAS
ISGAEVGCQGEVGSASAMAAAGLCAVLGGSPQQVENAAEIALEHNLGLTCDPVGGLVQIPCIERNAIAAMKSINAARLAR
IGDGNNRVSLDDVVVTMAATGRDMLTKYKETSLGGLATTLGFPVSMTEC
>Mature_448_residues
AISVVDLFSIGIGPSSSHTVGPMRAALTYISEFPSSHVDITLHGSLAATGKGHCTDRAVLLGLVGWEPTIVPIDAAPSPG
APIPAKGSVNGPKGTVSYSLTFDPHPLPEHPNAVTFKGSTTRTYLSVGGGFIMTLEDFRKLDDIGSGVSTIHPEAEVPCP
FQKSSQLLAYGRDFAEVMKDNERLIHGDLGTVDAHLDRVWQIMQECVAQGIATPGILPGGLNVQRRAPQVHALISNGDTC
ELGADLDAVEWVNLYALAVNEENAAGGRVVTAPTNGAAGIIPAVMHYARDFLTGFGAEQARTFLYTAGAVGIIIKENASI
SGAEVGCQGEVGSASAMAAAGLCAVLGGSPQQVENAAEIALEHNLGLTCDPVGGLVQIPCIERNAIAAMKSINAARLARI
GDGNNRVSLDDVVVTMAATGRDMLTKYKETSLGGLATTLGFPVSMTEC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=461, Percent_Identity=47.2885032537961, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788116, Length=465, Percent_Identity=46.0215053763441, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1789161, Length=461, Percent_Identity=45.9869848156182, Blast_Score=365, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 46563; Mature: 46432

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISVVDLFSIGIGPSSSHTVGPMRAALTYISEFPSSHVDITLHGSLAATGKGHCTDRAV
CEEEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCCCEE
LLGLVGWEPTIVPIDAAPSPGAPIPAKGSVNGPKGTVSYSLTFDPHPLPEHPNAVTFKGS
EEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEECCC
TTRTYLSVGGGFIMTLEDFRKLDDIGSGVSTIHPEAEVPCPFQKSSQLLAYGRDFAEVMK
CCEEEEEECCCEEEEHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCHHHHHCHHHHHHHC
DNERLIHGDLGTVDAHLDRVWQIMQECVAQGIATPGILPGGLNVQRRAPQVHALISNGDT
CCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCE
CELGADLDAVEWVNLYALAVNEENAAGGRVVTAPTNGAAGIIPAVMHYARDFLTGFGAEQ
EEECCCCCCEEEEEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHH
ARTFLYTAGAVGIIIKENASISGAEVGCQGEVGSASAMAAAGLCAVLGGSPQQVENAAEI
HEEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHE
ALEHNLGLTCDPVGGLVQIPCIERNAIAAMKSINAARLARIGDGNNRVSLDDVVVTMAAT
EEECCCCEEECCCCCEEEECEECCHHHHHHHHCCHHHHEEECCCCCEEEHHHEEEEEECC
GRDMLTKYKETSLGGLATTLGFPVSMTEC
CHHHHHHHHHCCCCCHHHHHCCCEEECCC
>Mature Secondary Structure 
AISVVDLFSIGIGPSSSHTVGPMRAALTYISEFPSSHVDITLHGSLAATGKGHCTDRAV
EEEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCEEECCCCCCCCCEE
LLGLVGWEPTIVPIDAAPSPGAPIPAKGSVNGPKGTVSYSLTFDPHPLPEHPNAVTFKGS
EEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEECCC
TTRTYLSVGGGFIMTLEDFRKLDDIGSGVSTIHPEAEVPCPFQKSSQLLAYGRDFAEVMK
CCEEEEEECCCEEEEHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCHHHHHCHHHHHHHC
DNERLIHGDLGTVDAHLDRVWQIMQECVAQGIATPGILPGGLNVQRRAPQVHALISNGDT
CCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCE
CELGADLDAVEWVNLYALAVNEENAAGGRVVTAPTNGAAGIIPAVMHYARDFLTGFGAEQ
EEECCCCCCEEEEEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHH
ARTFLYTAGAVGIIIKENASISGAEVGCQGEVGSASAMAAAGLCAVLGGSPQQVENAAEI
HEEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHE
ALEHNLGLTCDPVGGLVQIPCIERNAIAAMKSINAARLARIGDGNNRVSLDDVVVTMAAT
EEECCCCEEECCCCCEEEECEECCHHHHHHHHCCHHHHEEECCCCCEEEHHHEEEEEECC
GRDMLTKYKETSLGGLATTLGFPVSMTEC
CHHHHHHHHHCCCCCHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]