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The map label for this gene is nanH [H]

Identifier: 62390439

GI number: 62390439

Start: 1645782

End: 1646981

Strand: Reverse

Name: nanH [H]

Synonym: cg1756

Alternate gene names: 62390439

Gene position: 1646981-1645782 (Counterclockwise)

Preceding gene: 62390442

Following gene: 62390438

Centisome position: 50.17

GC content: 55.17

Gene sequence:

>1200_bases
ATGCTTCCAATCTGGATGGGTCTTCCATTCAAGAAAGCAGGTGCTTTGTCTCGGCGTAAAGCAGTATTCTCAGCGCTTGG
TGCAGCCGCACTCATCGGCGCAGCACTACCCACCATCCCAACGGCCCAAGCTCAAACACCCACGGGCTACGGATTCGATG
CAACAGCAAGCATCAGCGAAGAACCAGAGTTTTCAACACAACAACTCGCTGACGGCGGAACTCTCGGATTTGATTGCTAC
CGCATCCCATCGCTTGGCGTCGCACCCAACGGCAACGTCCTCGCATCGTGGGATGGTCGCCCAAACAACTGTTCAGATGC
TCCACAACCCAACTCCATCGTGGGCAAGGTATCGACCGACAACGGAGCAACCTGGGGCGAACAGCACGACATTTCCGCAG
GTATCACCGCCGAACCCAAAACTGGCTATTCCGATCCCAGCATCGTTGTGGACTGGGAGAGGGGCGATGTCTTTAACTTC
CACGTGAAGTCATTCGATGCAGGATACTTCACCTCCCAACCAGGCACGGACCCGGATGATCGCAACGTTGCCCATGTTGC
CTACGCCAAATCATCAGATAACGGCTCAACCTGGGTTGCAGACACCGTCATTACTGATCAAGTGGTTGCTGATGACACCT
GGGACAGCCGATTTGCCACATCCGGAAACGGCATCCAACTGCAATACGGCGCGTACAAGGGACGATTGGTCCAGCCATCG
GTAACTCGCATGACCAATGGTCGAGTCGCAGCAGTTGCCATGCTGAGTGATGATCACGGCGCAACGTGGTACCCCAGTGC
TCCTTGGGGAAACTCCATGGATGAAAACAAAATCGTGGAACTCAGCGATGGAACCCTGATGAACAACAGTCGTTCATCAG
GAGCCGATACTTACCGCAAGGTGTCTTATTCCACCGACGGCGGCGTCACTTGGACCGAGCCAACTCTTGATACCCAGCTG
CCGGATCCTCGCAACAATGCTTCCCTGATTCGAGTATTCCCGACAGCACCTGAGGGAAGTGCGCAGGCAAAGGTTCTGCT
GTTCTCCAACACTGCCACCACGAGTGGCCGCACCAATGGCACCGTCCGCATGTCGTGTGATGATGGTCAGACCTGGCCGG
TGTCTAAGGTGTTTGAACCAGGAGCAATCCAATATACCTCGATGGCAACGCTTCCCAACGGTGACATCGGCATGCTGTGA

Upstream 100 bases:

>100_bases
ACAGCACCGTTTTGTAGGATAAGAAAATCCCGCACACAACCCGTCCTGGTGGGTGAAGTGGGGGAGGCATGTCTATGCCC
CCAATTAGACATCTGACATC

Downstream 100 bases:

>100_bases
GAAAACAGTGGCTCAAATATCGACATCTTCTACTCACAGTTCAACCTGTCGTGGCTGGAGGCCGGCTGCATTGGTGTCGA
CGCCGATGAAACGTCCGTGA

Product: sialidase

Products: NA

Alternate protein names: Neuraminidase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLPIWMGLPFKKAGALSRRKAVFSALGAAALIGAALPTIPTAQAQTPTGYGFDATASISEEPEFSTQQLADGGTLGFDCY
RIPSLGVAPNGNVLASWDGRPNNCSDAPQPNSIVGKVSTDNGATWGEQHDISAGITAEPKTGYSDPSIVVDWERGDVFNF
HVKSFDAGYFTSQPGTDPDDRNVAHVAYAKSSDNGSTWVADTVITDQVVADDTWDSRFATSGNGIQLQYGAYKGRLVQPS
VTRMTNGRVAAVAMLSDDHGATWYPSAPWGNSMDENKIVELSDGTLMNNSRSSGADTYRKVSYSTDGGVTWTEPTLDTQL
PDPRNNASLIRVFPTAPEGSAQAKVLLFSNTATTSGRTNGTVRMSCDDGQTWPVSKVFEPGAIQYTSMATLPNGDIGML

Sequences:

>Translated_399_residues
MLPIWMGLPFKKAGALSRRKAVFSALGAAALIGAALPTIPTAQAQTPTGYGFDATASISEEPEFSTQQLADGGTLGFDCY
RIPSLGVAPNGNVLASWDGRPNNCSDAPQPNSIVGKVSTDNGATWGEQHDISAGITAEPKTGYSDPSIVVDWERGDVFNF
HVKSFDAGYFTSQPGTDPDDRNVAHVAYAKSSDNGSTWVADTVITDQVVADDTWDSRFATSGNGIQLQYGAYKGRLVQPS
VTRMTNGRVAAVAMLSDDHGATWYPSAPWGNSMDENKIVELSDGTLMNNSRSSGADTYRKVSYSTDGGVTWTEPTLDTQL
PDPRNNASLIRVFPTAPEGSAQAKVLLFSNTATTSGRTNGTVRMSCDDGQTWPVSKVFEPGAIQYTSMATLPNGDIGML
>Mature_399_residues
MLPIWMGLPFKKAGALSRRKAVFSALGAAALIGAALPTIPTAQAQTPTGYGFDATASISEEPEFSTQQLADGGTLGFDCY
RIPSLGVAPNGNVLASWDGRPNNCSDAPQPNSIVGKVSTDNGATWGEQHDISAGITAEPKTGYSDPSIVVDWERGDVFNF
HVKSFDAGYFTSQPGTDPDDRNVAHVAYAKSSDNGSTWVADTVITDQVVADDTWDSRFATSGNGIQLQYGAYKGRLVQPS
VTRMTNGRVAAVAMLSDDHGATWYPSAPWGNSMDENKIVELSDGTLMNNSRSSGADTYRKVSYSTDGGVTWTEPTLDTQL
PDPRNNASLIRVFPTAPEGSAQAKVLLFSNTATTSGRTNGTVRMSCDDGQTWPVSKVFEPGAIQYTSMATLPNGDIGML

Specific function: To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors [H]

COG id: COG4409

COG function: function code G; Neuraminidase (sialidase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 F5/8 type C domain [H]

Homologues:

Organism=Homo sapiens, GI4557791, Length=353, Percent_Identity=29.4617563739377, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018905
- InterPro:   IPR002860
- InterPro:   IPR000421
- InterPro:   IPR008979
- InterPro:   IPR013783
- InterPro:   IPR014756
- InterPro:   IPR011040
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02012 BNR; PF00754 F5_F8_type_C; PF10633 NPCBM_assoc [H]

EC number: =3.2.1.18 [H]

Molecular weight: Translated: 42347; Mature: 42347

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPIWMGLPFKKAGALSRRKAVFSALGAAALIGAALPTIPTAQAQTPTGYGFDATASISE
CCEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
EPEFSTQQLADGGTLGFDCYRIPSLGVAPNGNVLASWDGRPNNCSDAPQPNSIVGKVSTD
CCCCCHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECC
NGATWGEQHDISAGITAEPKTGYSDPSIVVDWERGDVFNFHVKSFDAGYFTSQPGTDPDD
CCCCCCCCCCCCCCCEECCCCCCCCCCEEEEECCCCEEEEEEEEECCCEECCCCCCCCCC
RNVAHVAYAKSSDNGSTWVADTVITDQVVADDTWDSRFATSGNGIQLQYGAYKGRLVQPS
CCEEEEEEEECCCCCCEEEEEEEEECEEEECCCCCCCEEECCCCEEEEECCCCCEEECCH
VTRMTNGRVAAVAMLSDDHGATWYPSAPWGNSMDENKIVELSDGTLMNNSRSSGADTYRK
HHHCCCCCEEEEEEEECCCCCEECCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCCEEE
VSYSTDGGVTWTEPTLDTQLPDPRNNASLIRVFPTAPEGSAQAKVLLFSNTATTSGRTNG
EEECCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCC
TVRMSCDDGQTWPVSKVFEPGAIQYTSMATLPNGDIGML
EEEEECCCCCCCCHHHHCCCCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MLPIWMGLPFKKAGALSRRKAVFSALGAAALIGAALPTIPTAQAQTPTGYGFDATASISE
CCEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
EPEFSTQQLADGGTLGFDCYRIPSLGVAPNGNVLASWDGRPNNCSDAPQPNSIVGKVSTD
CCCCCHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECC
NGATWGEQHDISAGITAEPKTGYSDPSIVVDWERGDVFNFHVKSFDAGYFTSQPGTDPDD
CCCCCCCCCCCCCCCEECCCCCCCCCCEEEEECCCCEEEEEEEEECCCEECCCCCCCCCC
RNVAHVAYAKSSDNGSTWVADTVITDQVVADDTWDSRFATSGNGIQLQYGAYKGRLVQPS
CCEEEEEEEECCCCCCEEEEEEEEECEEEECCCCCCCEEECCCCEEEEECCCCCEEECCH
VTRMTNGRVAAVAMLSDDHGATWYPSAPWGNSMDENKIVELSDGTLMNNSRSSGADTYRK
HHHCCCCCEEEEEEEECCCCCEECCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCCEEE
VSYSTDGGVTWTEPTLDTQLPDPRNNASLIRVFPTAPEGSAQAKVLLFSNTATTSGRTNG
EEECCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCC
TVRMSCDDGQTWPVSKVFEPGAIQYTSMATLPNGDIGML
EEEEECCCCCCCCHHHHCCCCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400240; 8591030 [H]