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The map label for this gene is xerD

Identifier: 62390303

GI number: 62390303

Start: 1497328

End: 1498242

Strand: Direct

Name: xerD

Synonym: cg1608

Alternate gene names: 62390303

Gene position: 1497328-1498242 (Clockwise)

Preceding gene: 62390302

Following gene: 62390305

Centisome position: 45.61

GC content: 56.5

Gene sequence:

>915_bases
ATGAAGGCTCGCGTTTTAGCGAAAACATGGCTGACACATTTGGCCGTGGAGCGTGGCTTGTCGGCAAATACGCTGAGTAA
TTATCGGCGCGATGTGGAACGCTATTGCGACTGGCTCGAGGCAGCTGGGCTGGATGATATTCGTGATATCACCACCGCGC
ATGTGGAAAGTTATGTCAAAGACCTGCGCCGCGGGATTGATGGACAACAAGCGTTGTCTGCGTCCTCGGCAGGTCGCGCG
CTCATCGTCGCGCGCGGGTTGCACAAGTTTGCATTGATGGAGGGCGAGGTGGCTGCGGACGTTGCGGCTGATGTGTCGCC
ACCGGCCATGGGCCGGCATTTACCTGACACGCTCAGCATCAACGAGGTAGCCCTGCTTATCGACGCGATCCCACATTCAG
ATATCGCCACTCCCGTTGATCTCCGTGACCGAGCGCTGGTGGAATTACTTTATGGAACTGGCGCGCGTATCTCTGAGGCG
ATTGGGCTGGCAGTTGATGATGTGTCGGAAATGCCTGAAGTTCTTCGCATCACGGGCAAAGGTTCCAAACAACGGATCGT
GCCTTTTGGTTCGATGGCACAACAAGCGGTCCGGGAATATTTGGTCAGAGCCAGACCCGCGTTGAGTAAGGGGAAAAGCC
ATGCGCTTTTTCTCAACCAACGCGGCGGTCCGCTATCTCGGCAATCTGCGTGGGCAGTGCTGAAGAAAACGGTTGAGCGC
GCAGGTTTAGATAAAGATATTTCTCCCCACACCCTGCGGCACAGCTTTGCCACCCATCTCCTCGAAGGTGGCGCCGATGT
CCGTGTGGTGCAGGAACTCCTGGGTCATTCTTCTGTGACGACCACTCAGATTTACACGCACATCACAGCCGATAGCTTGC
GGGAAGTGTGGCGCGGGGCTCATCCTCGTGCGTGA

Upstream 100 bases:

>100_bases
GTGCGTCTGCGCGTGCCGTCACCGCGCCGTTTACCTATCGCCCTACGGCGTTGGCGCAGCGTCGAAAAGCGCACGGCATT
GTTCCTGACATGAAAAAACT

Downstream 100 bases:

>100_bases
AAGCCCTTGCGAATTCTTAAGATTTCAACTCGATGTGCCTCCAATGAGCCGTATCGCGGAGTAGCTGTCGATCATGCGTT
ACCATGATCACTGCAGCCGC

Product: site-specific tyrosine recombinase XerD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKARVLAKTWLTHLAVERGLSANTLSNYRRDVERYCDWLEAAGLDDIRDITTAHVESYVKDLRRGIDGQQALSASSAGRA
LIVARGLHKFALMEGEVAADVAADVSPPAMGRHLPDTLSINEVALLIDAIPHSDIATPVDLRDRALVELLYGTGARISEA
IGLAVDDVSEMPEVLRITGKGSKQRIVPFGSMAQQAVREYLVRARPALSKGKSHALFLNQRGGPLSRQSAWAVLKKTVER
AGLDKDISPHTLRHSFATHLLEGGADVRVVQELLGHSSVTTTQIYTHITADSLREVWRGAHPRA

Sequences:

>Translated_304_residues
MKARVLAKTWLTHLAVERGLSANTLSNYRRDVERYCDWLEAAGLDDIRDITTAHVESYVKDLRRGIDGQQALSASSAGRA
LIVARGLHKFALMEGEVAADVAADVSPPAMGRHLPDTLSINEVALLIDAIPHSDIATPVDLRDRALVELLYGTGARISEA
IGLAVDDVSEMPEVLRITGKGSKQRIVPFGSMAQQAVREYLVRARPALSKGKSHALFLNQRGGPLSRQSAWAVLKKTVER
AGLDKDISPHTLRHSFATHLLEGGADVRVVQELLGHSSVTTTQIYTHITADSLREVWRGAHPRA
>Mature_304_residues
MKARVLAKTWLTHLAVERGLSANTLSNYRRDVERYCDWLEAAGLDDIRDITTAHVESYVKDLRRGIDGQQALSASSAGRA
LIVARGLHKFALMEGEVAADVAADVSPPAMGRHLPDTLSINEVALLIDAIPHSDIATPVDLRDRALVELLYGTGARISEA
IGLAVDDVSEMPEVLRITGKGSKQRIVPFGSMAQQAVREYLVRARPALSKGKSHALFLNQRGGPLSRQSAWAVLKKTVER
AGLDKDISPHTLRHSFATHLLEGGADVRVVQELLGHSSVTTTQIYTHITADSLREVWRGAHPRA

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerD subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=299, Percent_Identity=40.133779264214, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1790244, Length=298, Percent_Identity=36.9127516778523, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1790767, Length=179, Percent_Identity=29.0502793296089, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790768, Length=181, Percent_Identity=28.7292817679558, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERD_CORGL (Q8NQL5)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927152
- RefSeq:   NP_600637.1
- RefSeq:   YP_225705.1
- ProteinModelPortal:   Q8NQL5
- SMR:   Q8NQL5
- GeneID:   1019394
- GeneID:   3344765
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1608
- KEGG:   cgl:NCgl1364
- HOGENOM:   HBG727654
- OMA:   ISRIMVF
- PhylomeDB:   Q8NQL5
- ProtClustDB:   PRK00283
- BioCyc:   CGLU196627:CG1608-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01807
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011932
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02225

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 33135; Mature: 33135

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: ACT_SITE 156-156 ACT_SITE 180-180 ACT_SITE 250-250 ACT_SITE 253-253 ACT_SITE 276-276 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKARVLAKTWLTHLAVERGLSANTLSNYRRDVERYCDWLEAAGLDDIRDITTAHVESYVK
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
DLRRGIDGQQALSASSAGRALIVARGLHKFALMEGEVAADVAADVSPPAMGRHLPDTLSI
HHHHCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCH
NEVALLIDAIPHSDIATPVDLRDRALVELLYGTGARISEAIGLAVDDVSEMPEVLRITGK
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEECCC
GSKQRIVPFGSMAQQAVREYLVRARPALSKGKSHALFLNQRGGPLSRQSAWAVLKKTVER
CCCCEECCCHHHHHHHHHHHHHHHCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
AGLDKDISPHTLRHSFATHLLEGGADVRVVQELLGHSSVTTTQIYTHITADSLREVWRGA
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
HPRA
CCCC
>Mature Secondary Structure
MKARVLAKTWLTHLAVERGLSANTLSNYRRDVERYCDWLEAAGLDDIRDITTAHVESYVK
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
DLRRGIDGQQALSASSAGRALIVARGLHKFALMEGEVAADVAADVSPPAMGRHLPDTLSI
HHHHCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCH
NEVALLIDAIPHSDIATPVDLRDRALVELLYGTGARISEAIGLAVDDVSEMPEVLRITGK
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEECCC
GSKQRIVPFGSMAQQAVREYLVRARPALSKGKSHALFLNQRGGPLSRQSAWAVLKKTVER
CCCCEECCCHHHHHHHHHHHHHHHCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
AGLDKDISPHTLRHSFATHLLEGGADVRVVQELLGHSSVTTTQIYTHITADSLREVWRGA
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
HPRA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626