BacMap

Definition	Corynebacterium glutamicum ATCC 13032, complete genome.
Accession	NC_006958
Length	3,282,708

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The map label for this gene is dkgX [C]

Identifier: 62390240

GI number: 62390240

Start: 1420343

End: 1421218

Strand: Direct

Name: dkgX [C]

Synonym: cg1528

Alternate gene names: 62390240

Gene position: 1420343-1421218 (Clockwise)

Preceding gene: 62390239

Following gene: 62390242

Centisome position: 43.27

GC content: 53.31

Gene sequence:

>876_bases
ATGACTTTCACACTGAACAACGGACTCGCCATTCCCGACATTGGATTTGGTGTATTCCAAACCCCACCCGATGAAACCCG
AAACTCCGTTAACGCTGCTCTTGAAGCCGGCTATCGCCACATCGACACCGCCGCCGCATACGGCAATGAACGTGAAGTCG
GTGAAGCAATCGCAGCATCCGGCATTGGCCGCGACGAGATCACCATCGAAACCAAAATCTGGGTGACCGACTACGGCTTC
GAGGAAACTCTCCACGCATTCGACAAGGCCACAGGCAAGCTTGGTGTCGATACACTGGACATTTTGATCTTGCACCAGGC
AGTGCCAAGCAGCTTTGATCGCACCATCGCCGCCTACAAGGCGCTAGAGAAGCTGCTTTTCGACGGCGCGGTGCGGGCAA
TCGGAGTCAGTAATTTCATGCCAGAGCACCTGGACAAACTCCTTTTGGAAACCTCCATTGTCCCAGCTCTGAACCAAATC
GAATGCCACCCCTACTTCCAGCAGCGTGACGTGCTTGCCCGCAATGAGCAGCTTGGCATTTTGACTCAGGCGTGGTCACC
AATCGGTGGCATCACCTTCTACCGCGACGGACAGCTTCCAAGCACTCTAGAAAATGAGGTCATCGCTGGAATCGCCGCAG
AAGTTGGCAAAACACCAGCTCAAGTAATGCTGCGCTGGCACCTACAGCGTAGACGTCACGCAATTCCAAAGTCTGTGACC
CCATCACGCATTGTGGAAAACTTTGAGATCTTTGATTTCGAACTCTCCGATGAGCAACTACAGCAAATCGATGCCCTCAA
CACCGATCTGCGCGGTGGCCCAGAACCAGAGAACATCACCATGGAAAACTACTACCGAGAAATCCCAGAAGCCTAA

Upstream 100 bases:

>100_bases
CGGAAGGTTCGACATCTGCAATGAACCTTCAACTTCTGGCCAATTGGACAGGTAATGACAGCCCCTCCCTCAGCACAGAA
CTTGGTGACACTATTTAATT

Downstream 100 bases:

>100_bases
AGGCCCTTAGAGGCGAATGTAGGCCTATGTATTTTATGCCTATTCCGGCGGGATTTAGACCTGACCAGAACATGTGGCCA
ATGAGAGGGGTAAAGGGGAG

Product: 2,5-diketo-D-gluconic acid reductase

Products: morphinone; NADH; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTFTLNNGLAIPDIGFGVFQTPPDETRNSVNAALEAGYRHIDTAAAYGNEREVGEAIAASGIGRDEITIETKIWVTDYGF
EETLHAFDKATGKLGVDTLDILILHQAVPSSFDRTIAAYKALEKLLFDGAVRAIGVSNFMPEHLDKLLLETSIVPALNQI
ECHPYFQQRDVLARNEQLGILTQAWSPIGGITFYRDGQLPSTLENEVIAGIAAEVGKTPAQVMLRWHLQRRRHAIPKSVT
PSRIVENFEIFDFELSDEQLQQIDALNTDLRGGPEPENITMENYYREIPEA

Sequences:

>Translated_291_residues
MTFTLNNGLAIPDIGFGVFQTPPDETRNSVNAALEAGYRHIDTAAAYGNEREVGEAIAASGIGRDEITIETKIWVTDYGF
EETLHAFDKATGKLGVDTLDILILHQAVPSSFDRTIAAYKALEKLLFDGAVRAIGVSNFMPEHLDKLLLETSIVPALNQI
ECHPYFQQRDVLARNEQLGILTQAWSPIGGITFYRDGQLPSTLENEVIAGIAAEVGKTPAQVMLRWHLQRRRHAIPKSVT
PSRIVENFEIFDFELSDEQLQQIDALNTDLRGGPEPENITMENYYREIPEA
>Mature_290_residues
TFTLNNGLAIPDIGFGVFQTPPDETRNSVNAALEAGYRHIDTAAAYGNEREVGEAIAASGIGRDEITIETKIWVTDYGFE
ETLHAFDKATGKLGVDTLDILILHQAVPSSFDRTIAAYKALEKLLFDGAVRAIGVSNFMPEHLDKLLLETSIVPALNQIE
CHPYFQQRDVLARNEQLGILTQAWSPIGGITFYRDGQLPSTLENEVIAGIAAEVGKTPAQVMLRWHLQRRRHAIPKSVTP
SRIVENFEIFDFELSDEQLQQIDALNTDLRGGPEPENITMENYYREIPEA

Specific function: Reduction [C]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=37.2413793103448, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=37.2413793103448, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI223468663, Length=304, Percent_Identity=36.1842105263158, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI4502049, Length=292, Percent_Identity=36.6438356164384, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI93277124, Length=317, Percent_Identity=31.8611987381703, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI291291012, Length=274, Percent_Identity=35.4014598540146, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI5174695, Length=298, Percent_Identity=33.8926174496644, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI310109922, Length=281, Percent_Identity=33.0960854092527, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI5453543, Length=298, Percent_Identity=31.8791946308725, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI45446745, Length=298, Percent_Identity=31.8791946308725, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI4503285, Length=298, Percent_Identity=31.8791946308725, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI310109920, Length=298, Percent_Identity=31.8791946308725, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI24497585, Length=296, Percent_Identity=32.7702702702703, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24497583, Length=295, Percent_Identity=32.2033898305085, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI300116271, Length=277, Percent_Identity=33.2129963898917, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=32.4909747292419, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=35.7142857142857, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI310109926, Length=127, Percent_Identity=31.496062992126, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI207028673, Length=127, Percent_Identity=31.496062992126, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87082198, Length=278, Percent_Identity=39.9280575539568, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1786400, Length=264, Percent_Identity=35.6060606060606, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1788081, Length=284, Percent_Identity=28.169014084507, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787674, Length=299, Percent_Identity=26.4214046822742, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537077, Length=293, Percent_Identity=35.4948805460751, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17537075, Length=293, Percent_Identity=35.8361774744027, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71998625, Length=288, Percent_Identity=34.0277777777778, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17564128, Length=298, Percent_Identity=33.2214765100671, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=30.2013422818792, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17561298, Length=277, Percent_Identity=32.8519855595668, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17538386, Length=281, Percent_Identity=31.6725978647687, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17550248, Length=287, Percent_Identity=30.3135888501742, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17566692, Length=289, Percent_Identity=29.757785467128, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17552492, Length=278, Percent_Identity=26.6187050359712, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17561300, Length=284, Percent_Identity=29.9295774647887, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17562292, Length=284, Percent_Identity=27.112676056338, Blast_Score=104, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320576, Length=283, Percent_Identity=36.3957597173145, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324694, Length=294, Percent_Identity=34.3537414965986, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6322556, Length=271, Percent_Identity=31.3653136531365, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321896, Length=306, Percent_Identity=32.6797385620915, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319625, Length=300, Percent_Identity=30.6666666666667, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=29.5373665480427, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24644950, Length=299, Percent_Identity=35.1170568561873, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI221378297, Length=319, Percent_Identity=33.5423197492163, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24663317, Length=296, Percent_Identity=34.7972972972973, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24657054, Length=305, Percent_Identity=33.1147540983607, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24662789, Length=294, Percent_Identity=32.6530612244898, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=33.2191780821918, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=32.6460481099656, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21356425, Length=302, Percent_Identity=32.4503311258278, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24662781, Length=276, Percent_Identity=35.5072463768116, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24662785, Length=303, Percent_Identity=34.3234323432343, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI281366140, Length=257, Percent_Identity=33.0739299610895, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.1.1.218

Molecular weight: Translated: 32367; Mature: 32236

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFTLNNGLAIPDIGFGVFQTPPDETRNSVNAALEAGYRHIDTAAAYGNEREVGEAIAAS
CEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GIGRDEITIETKIWVTDYGFEETLHAFDKATGKLGVDTLDILILHQAVPSSFDRTIAAYK
CCCCCCEEEEEEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
ALEKLLFDGAVRAIGVSNFMPEHLDKLLLETSIVPALNQIECHPYFQQRDVLARNEQLGI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHCCCCCEE
LTQAWSPIGGITFYRDGQLPSTLENEVIAGIAAEVGKTPAQVMLRWHLQRRRHAIPKSVT
HHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
PSRIVENFEIFDFELSDEQLQQIDALNTDLRGGPEPENITMENYYREIPEA
HHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TFTLNNGLAIPDIGFGVFQTPPDETRNSVNAALEAGYRHIDTAAAYGNEREVGEAIAAS
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GIGRDEITIETKIWVTDYGFEETLHAFDKATGKLGVDTLDILILHQAVPSSFDRTIAAYK
CCCCCCEEEEEEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
ALEKLLFDGAVRAIGVSNFMPEHLDKLLLETSIVPALNQIECHPYFQQRDVLARNEQLGI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHCCCCCEE
LTQAWSPIGGITFYRDGQLPSTLENEVIAGIAAEVGKTPAQVMLRWHLQRRRHAIPKSVT
HHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
PSRIVENFEIFDFELSDEQLQQIDALNTDLRGGPEPENITMENYYREIPEA
HHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: morphine; NAD+; NADP+

Specific reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA