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The map label for this gene is gltX [H]

Identifier: 62390179

GI number: 62390179

Start: 1362828

End: 1364318

Strand: Direct

Name: gltX [H]

Synonym: cg1463

Alternate gene names: 62390179

Gene position: 1362828-1364318 (Clockwise)

Preceding gene: 62390177

Following gene: 62390186

Centisome position: 41.52

GC content: 56.67

Gene sequence:

>1491_bases
ATGGCCTGCATGACTGATGTTCGTGTTCGTTTCTGCCCATCGCCCACCGGCACCCCACACGTTGGACTTGTGCGCACCGC
GCTGTTCAACTGGGCATATGCTCGCCACACTGGAGGCAAGTTAGTTTTCCGCATTGAGGACACTGACGCTGCCCGCGATT
CCGAGGAGTCTTACTCCGCCATCATCGATTCCCTGCGCTGGTTGGGAATGGACTGGGATGAGGGTGTGGAAAAGGGCGGC
CCGCATGAGCCCTACCGCCAGTCGCAGCGCAAGGACATCTATCAGGATGTGTTGAAGCAGCTTATCGACGCCGGTGAAGT
CTACCCAGCTTATTCCACCGCGGAAGAGGTTGAGGAGCGACACAAGGCTGCTGGCCGCGATCCAAAGCTCGGCTACGACA
ACTTTGACCGTGATCTCACCGAAGAGCAGGTCGCAGCATTTGAGGCTGAGGGGCGTAAGCCTGTGTGGCGTCTGCGCATG
CCAGAGCAGGATTGGAAGTGGACTGACCTGGTCCGCGGTGAAGTTGAGTTCAAGTCGTTCACCCAGCCTGACTTCGTGGT
TGCTCGTTCCAACGGTGAGCCTTTGTACACCCTGGTCAACCCTGTTGATGATGCGTTGATGGAAGTCACCCATGTGCTGC
GTGGTGAGGATCTTTTGCCATCGACTCCTCGTCAGCTTGCTCTGTATGAGGCGCTCAAGCGCATTGGCGTGGCAAAGGCC
ACCCCAGCCTTTGGTCACCTGCCATTTGTGATGGGTGAGGGCAACAAGAAGCTGTCTAAGCGTGATCCACAGTCCAGCCT
GTTCAACCACCGTGACAACGGCATCATCCCAGAGGGCATGCTCAACTACCTGGCGCTGCTGGGTTGGTCACTGTCTGCTG
ATCAGGACATTTTCGGTGTCGATGAGTTGATCGCTAACTTTGATGTCGCTGACGTGTTGGGCAACCCAGCTCGCTTTGAC
CAGAAGAAGCTTGAGGCCATCAACGCGGATCACATCCGACTTCTGGAGCCTAAGGATTTCGAGGCTCGCCTGCGCGCGTA
CATGACTGAGTACACCGAGTTCCCAGCGGATTACCCAGCTGAGAAGTTTGCCATTGCTGCGGAGCTGGTTCAGACCCGCA
TCAAGGTGCTCAGCGAGGCGTGGGATCTGCTGAAGTTCCTGGTCACCGCTGACGAAGATCTGGTGTTCAATGAGAAGGCT
GCCAAGAAGAACCTCAAGGAGACCGCTGTTGAGCCTCTCAACGCCGGTATCGCAGCGCTGGAGGCAGTGGAGGAGTGGAC
CACTCCAAACATTGAAGCAGCATTGAACAAGGCTCTCATTGAGGATCTAGGCCTGAAGCCTCGCGTGGCGTTCGGTGCGT
TGCGCATTGGTATCTCCGGCGAGGCTGTATCCCCACCACTGTTTGAGTCCATGGAGCTTTTGGGCAAGGAATCCACGTTG
GTTCGTCTGAAGGTTACTCGTGAGCAGACCCCATTCGTGGTCGCTGAGTAA

Upstream 100 bases:

>100_bases
GTGTTGGGGGCAGAGGGGTTGCGGTGGGCAGACATGGTTAGCCATTCTAATCCCAGTAGAACTGGGGTAAACGCGCGGGC
GGTGGGTGCGGGCTATTAAC

Downstream 100 bases:

>100_bases
AACCTGTAGATGAACAAAAGCCCGTCTCCGTTCAGAATTTCTGAGGGAGGTGGGCTCTTTGCGTTTCGGGTTTAGTTGTG
GAGGGAGGCGTCGTAACGCA

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MACMTDVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGKLVFRIEDTDAARDSEESYSAIIDSLRWLGMDWDEGVEKGG
PHEPYRQSQRKDIYQDVLKQLIDAGEVYPAYSTAEEVEERHKAAGRDPKLGYDNFDRDLTEEQVAAFEAEGRKPVWRLRM
PEQDWKWTDLVRGEVEFKSFTQPDFVVARSNGEPLYTLVNPVDDALMEVTHVLRGEDLLPSTPRQLALYEALKRIGVAKA
TPAFGHLPFVMGEGNKKLSKRDPQSSLFNHRDNGIIPEGMLNYLALLGWSLSADQDIFGVDELIANFDVADVLGNPARFD
QKKLEAINADHIRLLEPKDFEARLRAYMTEYTEFPADYPAEKFAIAAELVQTRIKVLSEAWDLLKFLVTADEDLVFNEKA
AKKNLKETAVEPLNAGIAALEAVEEWTTPNIEAALNKALIEDLGLKPRVAFGALRIGISGEAVSPPLFESMELLGKESTL
VRLKVTREQTPFVVAE

Sequences:

>Translated_496_residues
MACMTDVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGKLVFRIEDTDAARDSEESYSAIIDSLRWLGMDWDEGVEKGG
PHEPYRQSQRKDIYQDVLKQLIDAGEVYPAYSTAEEVEERHKAAGRDPKLGYDNFDRDLTEEQVAAFEAEGRKPVWRLRM
PEQDWKWTDLVRGEVEFKSFTQPDFVVARSNGEPLYTLVNPVDDALMEVTHVLRGEDLLPSTPRQLALYEALKRIGVAKA
TPAFGHLPFVMGEGNKKLSKRDPQSSLFNHRDNGIIPEGMLNYLALLGWSLSADQDIFGVDELIANFDVADVLGNPARFD
QKKLEAINADHIRLLEPKDFEARLRAYMTEYTEFPADYPAEKFAIAAELVQTRIKVLSEAWDLLKFLVTADEDLVFNEKA
AKKNLKETAVEPLNAGIAALEAVEEWTTPNIEAALNKALIEDLGLKPRVAFGALRIGISGEAVSPPLFESMELLGKESTL
VRLKVTREQTPFVVAE
>Mature_495_residues
ACMTDVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGKLVFRIEDTDAARDSEESYSAIIDSLRWLGMDWDEGVEKGGP
HEPYRQSQRKDIYQDVLKQLIDAGEVYPAYSTAEEVEERHKAAGRDPKLGYDNFDRDLTEEQVAAFEAEGRKPVWRLRMP
EQDWKWTDLVRGEVEFKSFTQPDFVVARSNGEPLYTLVNPVDDALMEVTHVLRGEDLLPSTPRQLALYEALKRIGVAKAT
PAFGHLPFVMGEGNKKLSKRDPQSSLFNHRDNGIIPEGMLNYLALLGWSLSADQDIFGVDELIANFDVADVLGNPARFDQ
KKLEAINADHIRLLEPKDFEARLRAYMTEYTEFPADYPAEKFAIAAELVQTRIKVLSEAWDLLKFLVTADEDLVFNEKAA
KKNLKETAVEPLNAGIAALEAVEEWTTPNIEAALNKALIEDLGLKPRVAFGALRIGISGEAVSPPLFESMELLGKESTLV
RLKVTREQTPFVVAE

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=488, Percent_Identity=31.3524590163934, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1788743, Length=483, Percent_Identity=34.1614906832298, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI226510925, Length=314, Percent_Identity=28.343949044586, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71993394, Length=500, Percent_Identity=29, Blast_Score=196, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324540, Length=500, Percent_Identity=30.4, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6321192, Length=230, Percent_Identity=27.8260869565217, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24665321, Length=487, Percent_Identity=31.6221765913758, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 55697; Mature: 55565

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACMTDVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGKLVFRIEDTDAARDSEESYSA
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHH
IIDSLRWLGMDWDEGVEKGGPHEPYRQSQRKDIYQDVLKQLIDAGEVYPAYSTAEEVEER
HHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
HKAAGRDPKLGYDNFDRDLTEEQVAAFEAEGRKPVWRLRMPEQDWKWTDLVRGEVEFKSF
HHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHCCCCHHCCC
TQPDFVVARSNGEPLYTLVNPVDDALMEVTHVLRGEDLLPSTPRQLALYEALKRIGVAKA
CCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
TPAFGHLPFVMGEGNKKLSKRDPQSSLFNHRDNGIIPEGMLNYLALLGWSLSADQDIFGV
CCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
DELIANFDVADVLGNPARFDQKKLEAINADHIRLLEPKDFEARLRAYMTEYTEFPADYPA
HHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCH
EKFAIAAELVQTRIKVLSEAWDLLKFLVTADEDLVFNEKAAKKNLKETAVEPLNAGIAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHH
EAVEEWTTPNIEAALNKALIEDLGLKPRVAFGALRIGISGEAVSPPLFESMELLGKESTL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEE
VRLKVTREQTPFVVAE
EEEEEECCCCCEEEEC
>Mature Secondary Structure 
ACMTDVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGKLVFRIEDTDAARDSEESYSA
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHH
IIDSLRWLGMDWDEGVEKGGPHEPYRQSQRKDIYQDVLKQLIDAGEVYPAYSTAEEVEER
HHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
HKAAGRDPKLGYDNFDRDLTEEQVAAFEAEGRKPVWRLRMPEQDWKWTDLVRGEVEFKSF
HHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHCCCCHHCCC
TQPDFVVARSNGEPLYTLVNPVDDALMEVTHVLRGEDLLPSTPRQLALYEALKRIGVAKA
CCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
TPAFGHLPFVMGEGNKKLSKRDPQSSLFNHRDNGIIPEGMLNYLALLGWSLSADQDIFGV
CCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
DELIANFDVADVLGNPARFDQKKLEAINADHIRLLEPKDFEARLRAYMTEYTEFPADYPA
HHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCH
EKFAIAAELVQTRIKVLSEAWDLLKFLVTADEDLVFNEKAAKKNLKETAVEPLNAGIAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHH
EAVEEWTTPNIEAALNKALIEDLGLKPRVAFGALRIGISGEAVSPPLFESMELLGKESTL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEE
VRLKVTREQTPFVVAE
EEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA