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The map label for this gene is czcD [H]

Identifier: 62390167

GI number: 62390167

Start: 1346935

End: 1347909

Strand: Direct

Name: czcD [H]

Synonym: cg1447

Alternate gene names: 62390167

Gene position: 1346935-1347909 (Clockwise)

Preceding gene: 62390166

Following gene: 62390168

Centisome position: 41.03

GC content: 53.85

Gene sequence:

>975_bases
GTGTGCTTAGCTGGGGTCATGGAAAGCCACGATCTTCAGCAGCGCAGTTATGCGCACAATCCCGATGGCCACGACCACAG
CCATGACGGACTCGGACACTCACATGCTCCCAGCTCCCTCAAGGCTCTTTTTGCGGTCATCATTTTCACCTCGATCATCT
TCCTAGCGGAACTAATCGCCGGCCTTATTTCCGGATCTTTGGCACTGCTGGCTGACGCCATGCACATGCTGTCCGACTCC
ACTGGCTTGATCATTGCGGCTGTCGCCATGCTCATTGGCCGTCGGGCACGCACTTCTCGTGCGACCTACGGATACAAGCG
TGCGGAAGTCTTGGCAGCGATGGTTAACGCCACCGTTGTTACAGCACTGTCTGTGTGGATCGTCGTTGAGGCCATCATGC
GTCTGGGCAAGGACCTGGAAATCCAGACCAACCTGATGCTCATCGTCGCGGTCATTGGTTTTGTCACCAACGGAATTTCC
GCCCTGGTGTTGATGCGCCACCAAGATGGCAATATCAATATGCGTGGAGCATTCCTTCACGTTCTCAGTGACATGCTGGG
TTCCGTTGCCGTCATTATTGCGGGCCTGGTGATTCGCTACACGGGATGGATGCCGGCCGATACCATTGCTTCGATTGCGA
TTGCTGCGATTATTATTCCTCGCGCATTCAGCCTCCTGAAGGAAGCTCTCAATATCTTGTTGGAGCGTGTTCCTACAGGT
GCGGAGCCTGCAGAGGTCGACGCAGCCCTTCGTAAAGTCCCAGGTGTCAGCGATGTGCATGATCTTCACATTTGGAGCAT
TGACGGCAAGGAAATCCTGGCCACGGTGCATTTGGTGGTGGATTCGTCTACAAATCAGCTGCATAGTTGTGGCGTGTTGG
ATCGGGCAGAAGCGGAACTATCCAAACTTGGGATCTTGCACTCAACAATTCAGCTGGAAAGCGCAGATCACAGTGATCAT
GAAAGTGTGTGCTGA

Upstream 100 bases:

>100_bases
AGCAAAAGCCACTTCTTTACCACCGTGGCAGGCTTTTTCAGTGGCAAGAAGATTAATTCTCCACCCCTTCATTTTCAATA
AGCTTTCAATAAGGGGAGAA

Downstream 100 bases:

>100_bases
TATAGAGTATGTCCCATGGGGTTTTCCACACCAAGCTATCCGCTAAATGATCTGTTCGCCCGCATTGACCGAGGCGATAT
CCAACTTCCCGATTTTCAAC

Product: Co/Zn/Cd efflux system transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MCLAGVMESHDLQQRSYAHNPDGHDHSHDGLGHSHAPSSLKALFAVIIFTSIIFLAELIAGLISGSLALLADAMHMLSDS
TGLIIAAVAMLIGRRARTSRATYGYKRAEVLAAMVNATVVTALSVWIVVEAIMRLGKDLEIQTNLMLIVAVIGFVTNGIS
ALVLMRHQDGNINMRGAFLHVLSDMLGSVAVIIAGLVIRYTGWMPADTIASIAIAAIIIPRAFSLLKEALNILLERVPTG
AEPAEVDAALRKVPGVSDVHDLHIWSIDGKEILATVHLVVDSSTNQLHSCGVLDRAEAELSKLGILHSTIQLESADHSDH
ESVC

Sequences:

>Translated_324_residues
MCLAGVMESHDLQQRSYAHNPDGHDHSHDGLGHSHAPSSLKALFAVIIFTSIIFLAELIAGLISGSLALLADAMHMLSDS
TGLIIAAVAMLIGRRARTSRATYGYKRAEVLAAMVNATVVTALSVWIVVEAIMRLGKDLEIQTNLMLIVAVIGFVTNGIS
ALVLMRHQDGNINMRGAFLHVLSDMLGSVAVIIAGLVIRYTGWMPADTIASIAIAAIIIPRAFSLLKEALNILLERVPTG
AEPAEVDAALRKVPGVSDVHDLHIWSIDGKEILATVHLVVDSSTNQLHSCGVLDRAEAELSKLGILHSTIQLESADHSDH
ESVC
>Mature_324_residues
MCLAGVMESHDLQQRSYAHNPDGHDHSHDGLGHSHAPSSLKALFAVIIFTSIIFLAELIAGLISGSLALLADAMHMLSDS
TGLIIAAVAMLIGRRARTSRATYGYKRAEVLAAMVNATVVTALSVWIVVEAIMRLGKDLEIQTNLMLIVAVIGFVTNGIS
ALVLMRHQDGNINMRGAFLHVLSDMLGSVAVIIAGLVIRYTGWMPADTIASIAIAAIIIPRAFSLLKEALNILLERVPTG
AEPAEVDAALRKVPGVSDVHDLHIWSIDGKEILATVHLVVDSSTNQLHSCGVLDRAEAELSKLGILHSTIQLESADHSDH
ESVC

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=324, Percent_Identity=28.0864197530864, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21359890, Length=294, Percent_Identity=28.9115646258503, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI52352805, Length=333, Percent_Identity=27.3273273273273, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI64762489, Length=350, Percent_Identity=28.2857142857143, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI289803013, Length=286, Percent_Identity=30.4195804195804, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI289803009, Length=286, Percent_Identity=30.4195804195804, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI289803007, Length=286, Percent_Identity=30.4195804195804, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI289803003, Length=286, Percent_Identity=30.4195804195804, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI21361112, Length=309, Percent_Identity=28.8025889967638, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI52351208, Length=125, Percent_Identity=41.6, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI14210520, Length=232, Percent_Identity=27.1551724137931, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI52352803, Length=130, Percent_Identity=36.9230769230769, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI222080086, Length=124, Percent_Identity=30.6451612903226, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40255009, Length=124, Percent_Identity=30.6451612903226, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786966, Length=280, Percent_Identity=38.2142857142857, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17555794, Length=317, Percent_Identity=31.8611987381703, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17555796, Length=300, Percent_Identity=32, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193210990, Length=324, Percent_Identity=29.6296296296296, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32564488, Length=295, Percent_Identity=29.8305084745763, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550440, Length=123, Percent_Identity=37.3983739837398, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17550442, Length=123, Percent_Identity=37.3983739837398, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=127, Percent_Identity=37.007874015748, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320411, Length=176, Percent_Identity=31.25, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=146, Percent_Identity=32.8767123287671, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583858, Length=315, Percent_Identity=26.984126984127, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24585900, Length=155, Percent_Identity=30.9677419354839, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585898, Length=155, Percent_Identity=30.9677419354839, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585896, Length=155, Percent_Identity=30.9677419354839, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921672, Length=155, Percent_Identity=30.9677419354839, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24645863, Length=147, Percent_Identity=34.0136054421769, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656728, Length=157, Percent_Identity=36.3057324840764, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656724, Length=157, Percent_Identity=36.3057324840764, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656720, Length=157, Percent_Identity=36.3057324840764, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656715, Length=157, Percent_Identity=36.3057324840764, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357035, Length=157, Percent_Identity=36.3057324840764, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584409, Length=156, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574430, Length=156, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34599; Mature: 34599

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLAGVMESHDLQQRSYAHNPDGHDHSHDGLGHSHAPSSLKALFAVIIFTSIIFLAELIA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLISGSLALLADAMHMLSDSTGLIIAAVAMLIGRRARTSRATYGYKRAEVLAAMVNATVV
HHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
TALSVWIVVEAIMRLGKDLEIQTNLMLIVAVIGFVTNGISALVLMRHQDGNINMRGAFLH
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCHHHHHHH
VLSDMLGSVAVIIAGLVIRYTGWMPADTIASIAIAAIIIPRAFSLLKEALNILLERVPTG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AEPAEVDAALRKVPGVSDVHDLHIWSIDGKEILATVHLVVDSSTNQLHSCGVLDRAEAEL
CCHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHEEECCCCHHHHCCCCHHHHHHH
SKLGILHSTIQLESADHSDHESVC
HHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure
MCLAGVMESHDLQQRSYAHNPDGHDHSHDGLGHSHAPSSLKALFAVIIFTSIIFLAELIA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLISGSLALLADAMHMLSDSTGLIIAAVAMLIGRRARTSRATYGYKRAEVLAAMVNATVV
HHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
TALSVWIVVEAIMRLGKDLEIQTNLMLIVAVIGFVTNGISALVLMRHQDGNINMRGAFLH
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCHHHHHHH
VLSDMLGSVAVIIAGLVIRYTGWMPADTIASIAIAAIIIPRAFSLLKEALNILLERVPTG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AEPAEVDAALRKVPGVSDVHDLHIWSIDGKEILATVHLVVDSSTNQLHSCGVLDRAEAEL
CCHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHEEECCCCHHHHCCCCHHHHHHH
SKLGILHSTIQLESADHSDHESVC
HHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]