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The map label for this gene is ggtB [H]

Identifier: 62389846

GI number: 62389846

Start: 1013264

End: 1014967

Strand: Reverse

Name: ggtB [H]

Synonym: cg1090

Alternate gene names: 62389846

Gene position: 1014967-1013264 (Counterclockwise)

Preceding gene: 62389848

Following gene: 62389841

Centisome position: 30.92

GC content: 54.05

Gene sequence:

>1704_bases
ATGACCCCTGTTCAAACCCAAGGTTATGCGGTGGCAACTGCAAACCCCATCGCTTCTGAAGCAGCCTGCGCGGTGTTAAG
AGAAGGCGGCACTGCAGCTGATGCTCTTGTCACCGCGCAGTTTGTTTTGGGACTGACGGAACCGCAGTCGTCTGGCCTTG
GTGGTGGCGGATACATTCTGTACTACGACGCCGAAGCCAATGCGGTGACAGCCATTGATGGCCGTGAAACAGCGCCAGTT
GCTGCTGATGAAAACTATCTCATTCATGTTTCTGCAGAGGATCAAACGGCACCTGTTCCTGATGCCCGACGTTCCGGCAG
GTCAATTGGTGTGCCAGGAATCGTGGCAGCCCTTGGACAGCTGCATGATTCATTCGGAAAGACCTCCTGGCAGGACGTGC
TGACAACTCCGCAGCAGCTCGCAACTGATGGTTTTTCCATCAGCCCTCGCATGTCAGCATCAATTGCTAACTCCGCTGAG
GATCTCTCCCACGATCCGGAAGCTGCCGCATATTTCCTTGATGAAAACGGTGATGCGAAGGCACCCGGCACACTTTTACA
AAACCCTGACTATGCAGAAACGATTCGTCTCATCTCTGAAGGTGGCCCCGATGCGTTCTACACGGGTGAGATTGCAGCAG
ACATCGTGGAACGCGCCACCCGTGAGGTTGACGGTTTCACACCATCACTGATGAGCACGGCAGATTTGGCTGCCTACACT
CCGGAAACTCGTGAAGCTTTGTGTGCTCCCTACCGCGACAAGATTGTTTGTGGCATGCCACCGTCATCATCGGGTGGCGT
CACAGTGATGGAAACCCTGGGTATCTTGAACAACTTTGATCTCGCCCAATACCCACCCACTGAGGTTGGTTTGGATGGCG
GATTGCCAAATGCGGAAGCTGTTCACCTGATTTCAGAGGCTGAGCGCCTGGCTTATGCTGATCGCGATGCTTACATCGGT
GATCCTGCTTTCGTGGAAGTTCCAGCAGGTGGTGTCGAAGAGTTGATCAGCGATGTCTACACGGGTGAACGCTCAGAACT
TATTGATCCAGAGCATTCAATGGGTCAGGCAACTGCTGGTCTGAGCCAGGAACCAGTCATGGCTGCCCTGCCGGAAAGTG
GCACCAGCCATATTTCCATCATCGATTCCTATGGCAACGCAGCATCGTTGACCACCAGTGTGGAAGCTGCTTTCGGTTCC
TTCCACTTCACCCGTGGTTTCATTTTGAATAATCAGCTGACAGATTTCTCCGCTGAACCACTTGATGAGGACGGCGAGCC
CGTGGCCAATCGTGTCGAGTCAGCAAAGCGCCCACGGTCTTCCATGTCGCCAATGCTAGTGTTCAACGCCAGTGGCGATG
GTGAAATCGCGGATCTGAATATGGTGCTGGGCTCCCCTGGCGGATCCTTGATTATTCAGTACGTGGTGAAAACCCTGGTC
AACATCATCGACTGGGATATGGATCCACAGCAGGCAGTGTCTGCGCCCAACTTTGGTGCGATGAACCAGCCTAAGACTGG
ACTGGGAAGCGAGCATCCGCTGATCGCCAATGATTCAGCAGAGCTTGTATCTGAACTGGAAAGCAAAGGCCACGAAGTTA
ATGTGGGCGAGCAATCCAGTGGCCTATCGGCGTTGGTGAAAAACGGCGACACCATTGTCGGTGGCGCCGATCCACGTAGA
GAAGGCGTGGTCTTGGGTGGCTAA

Upstream 100 bases:

>100_bases
ACTTCCCGCCGACGCTTCTGCTGAAGAGGAAGTAGAAGGCACTCACACAGGTGAAGATATTTCTGTTGCCCCGGAAATCG
GTACCGGCTACCGCGAGGGC

Downstream 100 bases:

>100_bases
TTAGCGCGCAGACCACGCAGTCCACAGTTGTTCATATCGGCCGCCGATCGCTCGAAGCTCTTCATGGGTTCCAGATTCTA
TGATTTCTCCGGAGTCCATG

Product: gamma-glutamyltranspeptidase precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MTPVQTQGYAVATANPIASEAACAVLREGGTAADALVTAQFVLGLTEPQSSGLGGGGYILYYDAEANAVTAIDGRETAPV
AADENYLIHVSAEDQTAPVPDARRSGRSIGVPGIVAALGQLHDSFGKTSWQDVLTTPQQLATDGFSISPRMSASIANSAE
DLSHDPEAAAYFLDENGDAKAPGTLLQNPDYAETIRLISEGGPDAFYTGEIAADIVERATREVDGFTPSLMSTADLAAYT
PETREALCAPYRDKIVCGMPPSSSGGVTVMETLGILNNFDLAQYPPTEVGLDGGLPNAEAVHLISEAERLAYADRDAYIG
DPAFVEVPAGGVEELISDVYTGERSELIDPEHSMGQATAGLSQEPVMAALPESGTSHISIIDSYGNAASLTTSVEAAFGS
FHFTRGFILNNQLTDFSAEPLDEDGEPVANRVESAKRPRSSMSPMLVFNASGDGEIADLNMVLGSPGGSLIIQYVVKTLV
NIIDWDMDPQQAVSAPNFGAMNQPKTGLGSEHPLIANDSAELVSELESKGHEVNVGEQSSGLSALVKNGDTIVGGADPRR
EGVVLGG

Sequences:

>Translated_567_residues
MTPVQTQGYAVATANPIASEAACAVLREGGTAADALVTAQFVLGLTEPQSSGLGGGGYILYYDAEANAVTAIDGRETAPV
AADENYLIHVSAEDQTAPVPDARRSGRSIGVPGIVAALGQLHDSFGKTSWQDVLTTPQQLATDGFSISPRMSASIANSAE
DLSHDPEAAAYFLDENGDAKAPGTLLQNPDYAETIRLISEGGPDAFYTGEIAADIVERATREVDGFTPSLMSTADLAAYT
PETREALCAPYRDKIVCGMPPSSSGGVTVMETLGILNNFDLAQYPPTEVGLDGGLPNAEAVHLISEAERLAYADRDAYIG
DPAFVEVPAGGVEELISDVYTGERSELIDPEHSMGQATAGLSQEPVMAALPESGTSHISIIDSYGNAASLTTSVEAAFGS
FHFTRGFILNNQLTDFSAEPLDEDGEPVANRVESAKRPRSSMSPMLVFNASGDGEIADLNMVLGSPGGSLIIQYVVKTLV
NIIDWDMDPQQAVSAPNFGAMNQPKTGLGSEHPLIANDSAELVSELESKGHEVNVGEQSSGLSALVKNGDTIVGGADPRR
EGVVLGG
>Mature_566_residues
TPVQTQGYAVATANPIASEAACAVLREGGTAADALVTAQFVLGLTEPQSSGLGGGGYILYYDAEANAVTAIDGRETAPVA
ADENYLIHVSAEDQTAPVPDARRSGRSIGVPGIVAALGQLHDSFGKTSWQDVLTTPQQLATDGFSISPRMSASIANSAED
LSHDPEAAAYFLDENGDAKAPGTLLQNPDYAETIRLISEGGPDAFYTGEIAADIVERATREVDGFTPSLMSTADLAAYTP
ETREALCAPYRDKIVCGMPPSSSGGVTVMETLGILNNFDLAQYPPTEVGLDGGLPNAEAVHLISEAERLAYADRDAYIGD
PAFVEVPAGGVEELISDVYTGERSELIDPEHSMGQATAGLSQEPVMAALPESGTSHISIIDSYGNAASLTTSVEAAFGSF
HFTRGFILNNQLTDFSAEPLDEDGEPVANRVESAKRPRSSMSPMLVFNASGDGEIADLNMVLGSPGGSLIIQYVVKTLVN
IIDWDMDPQQAVSAPNFGAMNQPKTGLGSEHPLIANDSAELVSELESKGHEVNVGEQSSGLSALVKNGDTIVGGADPRRE
GVVLGG

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=548, Percent_Identity=25.1824817518248, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI73915090, Length=548, Percent_Identity=25.1824817518248, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI73915096, Length=548, Percent_Identity=25.1824817518248, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI73915094, Length=548, Percent_Identity=25.1824817518248, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI113429324, Length=549, Percent_Identity=25.6830601092896, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI109148539, Length=572, Percent_Identity=26.048951048951, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI153266885, Length=497, Percent_Identity=25.7545271629779, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI113429326, Length=553, Percent_Identity=25.3164556962025, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI153266901, Length=498, Percent_Identity=25.5020080321285, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI153266907, Length=497, Percent_Identity=23.943661971831, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1789856, Length=573, Percent_Identity=34.0314136125654, Blast_Score=256, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI212646519, Length=526, Percent_Identity=30.7984790874525, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI72000294, Length=526, Percent_Identity=30.7984790874525, Blast_Score=192, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI193208245, Length=569, Percent_Identity=29.8769771528998, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193208247, Length=569, Percent_Identity=29.8769771528998, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17542894, Length=564, Percent_Identity=29.6099290780142, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17506189, Length=516, Percent_Identity=27.906976744186, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17564448, Length=463, Percent_Identity=26.3498920086393, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI72001497, Length=238, Percent_Identity=25.2100840336134, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI72001495, Length=238, Percent_Identity=25.2100840336134, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=482, Percent_Identity=24.0663900414938, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161077878, Length=572, Percent_Identity=28.3216783216783, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161077880, Length=572, Percent_Identity=28.3216783216783, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24642670, Length=572, Percent_Identity=28.3216783216783, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24642666, Length=572, Percent_Identity=28.3216783216783, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI45551474, Length=572, Percent_Identity=28.3216783216783, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI18859741, Length=571, Percent_Identity=26.9702276707531, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI18859893, Length=491, Percent_Identity=24.6435845213849, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI161077496, Length=552, Percent_Identity=24.8188405797101, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59097; Mature: 58966

Theoretical pI: Translated: 3.94; Mature: 3.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPVQTQGYAVATANPIASEAACAVLREGGTAADALVTAQFVLGLTEPQSSGLGGGGYIL
CCCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
YYDAEANAVTAIDGRETAPVAADENYLIHVSAEDQTAPVPDARRSGRSIGVPGIVAALGQ
EEECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHH
LHDSFGKTSWQDVLTTPQQLATDGFSISPRMSASIANSAEDLSHDPEAAAYFLDENGDAK
HHHHHCCCCHHHHHCCHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCCCEEEEEECCCCCC
APGTLLQNPDYAETIRLISEGGPDAFYTGEIAADIVERATREVDGFTPSLMSTADLAAYT
CCCCCCCCCCHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PETREALCAPYRDKIVCGMPPSSSGGVTVMETLGILNNFDLAQYPPTEVGLDGGLPNAEA
CHHHHHHHCCCCCCEEECCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
VHLISEAERLAYADRDAYIGDPAFVEVPAGGVEELISDVYTGERSELIDPEHSMGQATAG
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCHHCCCCCHHHCHHHCC
LSQEPVMAALPESGTSHISIIDSYGNAASLTTSVEAAFGSFHFTRGFILNNQLTDFSAEP
CCCCCCEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCC
LDEDGEPVANRVESAKRPRSSMSPMLVFNASGDGEIADLNMVLGSPGGSLIIQYVVKTLV
CCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHH
NIIDWDMDPQQAVSAPNFGAMNQPKTGLGSEHPLIANDSAELVSELESKGHEVNVGEQSS
HHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCEECCCCCCC
GLSALVKNGDTIVGGADPRREGVVLGG
CHHHHHHCCCEEECCCCCCCCCEEECC
>Mature Secondary Structure 
TPVQTQGYAVATANPIASEAACAVLREGGTAADALVTAQFVLGLTEPQSSGLGGGGYIL
CCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
YYDAEANAVTAIDGRETAPVAADENYLIHVSAEDQTAPVPDARRSGRSIGVPGIVAALGQ
EEECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHH
LHDSFGKTSWQDVLTTPQQLATDGFSISPRMSASIANSAEDLSHDPEAAAYFLDENGDAK
HHHHHCCCCHHHHHCCHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCCCEEEEEECCCCCC
APGTLLQNPDYAETIRLISEGGPDAFYTGEIAADIVERATREVDGFTPSLMSTADLAAYT
CCCCCCCCCCHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PETREALCAPYRDKIVCGMPPSSSGGVTVMETLGILNNFDLAQYPPTEVGLDGGLPNAEA
CHHHHHHHCCCCCCEEECCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
VHLISEAERLAYADRDAYIGDPAFVEVPAGGVEELISDVYTGERSELIDPEHSMGQATAG
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCHHCCCCCHHHCHHHCC
LSQEPVMAALPESGTSHISIIDSYGNAASLTTSVEAAFGSFHFTRGFILNNQLTDFSAEP
CCCCCCEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCC
LDEDGEPVANRVESAKRPRSSMSPMLVFNASGDGEIADLNMVLGSPGGSLIIQYVVKTLV
CCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHH
NIIDWDMDPQQAVSAPNFGAMNQPKTGLGSEHPLIANDSAELVSELESKGHEVNVGEQSS
HHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCEECCCCCCC
GLSALVKNGDTIVGGADPRREGVVLGG
CHHHHHHCCCEEECCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]