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The map label for this gene is mco [H]

Identifier: 62389836

GI number: 62389836

Start: 1002796

End: 1004337

Strand: Direct

Name: mco [H]

Synonym: cg1080

Alternate gene names: 62389836

Gene position: 1002796-1004337 (Clockwise)

Preceding gene: 62389831

Following gene: 62389837

Centisome position: 30.55

GC content: 56.81

Gene sequence:

>1542_bases
ATGTTGTTGCCAGAGTTGAATCGTCGGACTTTTTTCAAAGGGGCCGGGGTGCTGGCAGCAACGGTGGTGGGTGCGCAGGT
GCTGGTGGCGTGTTCCTCAGATGATGTGCGTGGTTATGGGGGAGAGCCGCGGACGTTGCCTATTCCACCAGCAGATTTAG
GTACGCGTGAGGGATCTAGCGTGCACTTTGCCCTGGAGGCTCAGACTGGGGAGAGTCAGATTTTGCCGGATGTCACAACG
AAGACGTGGGGTTTCAATGGCACTCATTTGGGGCCGACGTTGGTGGTGAAGAAAGGTGATGACGTCCACGTTGATGTGAT
AAACAATTTGGATGAAATGACCACTGTGCACTGGCATGGCATGAAGTTGCCGGCGATTGCTGATGGTGGTCCGCACTCAC
CGATCGGGCCTGGGCAGACGTGGTCACCAACGTGGACTGTGGCCAATGATGCAGCCACTTTGTGGTACCACCCGCACACT
CATGGCCTGACAGGTTTGCATGCGTACCGTGGTTTGGCGGGGATGATCATTGTGGAAGATGAAGCAACAGACAAGCTGGA
TCTGCCACGCGAGTACGGTGTGGACGATATTCCGCTGGTTTTAATGGATCACCGCTTCTTAGAAGACGGTTCCCTTGATG
AGGAAGACCTCCCCGATCTTGGGCTGTTGGGCGATACCCCCACTGCCAATGGCATTACCAATGCGCACTTTGATGCCACC
ACGCGCCGGGTTCGGTTCCGCGTGCTCAACGGCTCCAATATGCGGTTCTATAACTTGGCGTTTTCAGACACGCGCACCTT
CCAAGTCATTGCCAGCGATTCCGGTTTGCTGGATGAACCTCAAGACCGCACCACCTTGGCTATTGGCCCAGGCGAGCGGT
GGGAAATCGTCGTGGAGCTAGAGCCCGGCGAGGACGTCACCTTGGAATCTGTAGGTTTTGAGGACAACTACGGCGTCCCT
GATGATGAGTTCGTGCCCGATTTCGGCATGTCAGATTCCTTCCAGCTGCTCACCATCACCGGCCCTTCCGATGATGCTGC
GCAAGCACCTGCTTTGCCGGGCGTGCTGGTGAAATCCACCGAACCTGACGTCATCGATGCCACTGAACGCACCTTCATCA
TGAACACCTTCTCCATCAACGATCTACAGATGGACATGCAGCGCGTTGACGTGGTGATTGACCATGACCAGCCAGAAGTG
TGGATTGTCACCAACGACAACTCCGACTGGCCCCACAACTTCCATGTCCACGACGCCCGGTTTAAGGTGCTGAAATTTGA
AGGCACCGACGTAGAGCTCTTCAACGACGGCTGGAAAGACACCGTCGGCCTGCCACCGGGAGCAACCGCAACTTTAGCCG
TGGAATTTGGCCACTACCCAGACCCGCAATGGCCCTACATGTATCACTGCCACATGCTCTACCACGAGGATCAAGGCATG
ATGGGGCAGTTCGTCATCGTGGAGCCAGGCGACGAGCCGGCGGCGGTGCTGGGGTCGGGCACGGGCTCCAGCATTGACTC
CGCCGGCGGACATGCGCACTAG

Upstream 100 bases:

>100_bases
TCTGTGGGATTTGTCATGGGTGAAAGCTTAGAAGAACTACACCGTTTGGTTGATATGATGTGGGGTGTTTATGAAAATTT
GTTTGAGGGAGTGAAGGCGC

Downstream 100 bases:

>100_bases
GGGCGTGGGGCGGCGTCGATAAGCGAGATTTTTTAGCCCTTTAGAAGCCACATGACATATGTCATGAAAATTATGTGCAA
AGTGCAGTAATACTCCTGAC

Product: multicopper oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MLLPELNRRTFFKGAGVLAATVVGAQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSSVHFALEAQTGESQILPDVTT
KTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHGMKLPAIADGGPHSPIGPGQTWSPTWTVANDAATLWYHPHT
HGLTGLHAYRGLAGMIIVEDEATDKLDLPREYGVDDIPLVLMDHRFLEDGSLDEEDLPDLGLLGDTPTANGITNAHFDAT
TRRVRFRVLNGSNMRFYNLAFSDTRTFQVIASDSGLLDEPQDRTTLAIGPGERWEIVVELEPGEDVTLESVGFEDNYGVP
DDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKSTEPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEV
WIVTNDNSDWPHNFHVHDARFKVLKFEGTDVELFNDGWKDTVGLPPGATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
MGQFVIVEPGDEPAAVLGSGTGSSIDSAGGHAH

Sequences:

>Translated_513_residues
MLLPELNRRTFFKGAGVLAATVVGAQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSSVHFALEAQTGESQILPDVTT
KTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHGMKLPAIADGGPHSPIGPGQTWSPTWTVANDAATLWYHPHT
HGLTGLHAYRGLAGMIIVEDEATDKLDLPREYGVDDIPLVLMDHRFLEDGSLDEEDLPDLGLLGDTPTANGITNAHFDAT
TRRVRFRVLNGSNMRFYNLAFSDTRTFQVIASDSGLLDEPQDRTTLAIGPGERWEIVVELEPGEDVTLESVGFEDNYGVP
DDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKSTEPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEV
WIVTNDNSDWPHNFHVHDARFKVLKFEGTDVELFNDGWKDTVGLPPGATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
MGQFVIVEPGDEPAAVLGSGTGSSIDSAGGHAH
>Mature_513_residues
MLLPELNRRTFFKGAGVLAATVVGAQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSSVHFALEAQTGESQILPDVTT
KTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHGMKLPAIADGGPHSPIGPGQTWSPTWTVANDAATLWYHPHT
HGLTGLHAYRGLAGMIIVEDEATDKLDLPREYGVDDIPLVLMDHRFLEDGSLDEEDLPDLGLLGDTPTANGITNAHFDAT
TRRVRFRVLNGSNMRFYNLAFSDTRTFQVIASDSGLLDEPQDRTTLAIGPGERWEIVVELEPGEDVTLESVGFEDNYGVP
DDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKSTEPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEV
WIVTNDNSDWPHNFHVHDARFKVLKFEGTDVELFNDGWKDTVGLPPGATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
MGQFVIVEPGDEPAAVLGSGTGSSIDSAGGHAH

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=533, Percent_Identity=32.6454033771107, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1789394, Length=490, Percent_Identity=30.6122448979592, Blast_Score=220, Evalue=2e-58,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 56042; Mature: 56042

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPELNRRTFFKGAGVLAATVVGAQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSS
CCCCCCCCCEEECCCCHHHHHHHCEEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCE
VHFALEAQTGESQILPDVTTKTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHG
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCEEEEECCCCCHHEEEEECC
MKLPAIADGGPHSPIGPGQTWSPTWTVANDAATLWYHPHTHGLTGLHAYRGLAGMIIVED
EECCEECCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHCCCEEEEEEEC
EATDKLDLPREYGVDDIPLVLMDHRFLEDGSLDEEDLPDLGLLGDTPTANGITNAHFDAT
CCCCCCCCCHHCCCCCCEEEEECCEECCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCC
TRRVRFRVLNGSNMRFYNLAFSDTRTFQVIASDSGLLDEPQDRTTLAIGPGERWEIVVEL
EEEEEEEEECCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEE
EPGEDVTLESVGFEDNYGVPDDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKST
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECC
EPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEVWIVTNDNSDWPHNFHVHDAR
CCCEEECCCCEEEEEEEECCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCEEEEECCE
FKVLKFEGTDVELFNDGWKDTVGLPPGATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
EEEEEEECCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEECCCCC
MGQFVIVEPGDEPAAVLGSGTGSSIDSAGGHAH
CEEEEEEECCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLPELNRRTFFKGAGVLAATVVGAQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSS
CCCCCCCCCEEECCCCHHHHHHHCEEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCE
VHFALEAQTGESQILPDVTTKTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHG
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCEEEEECCCCCHHEEEEECC
MKLPAIADGGPHSPIGPGQTWSPTWTVANDAATLWYHPHTHGLTGLHAYRGLAGMIIVED
EECCEECCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHCCCEEEEEEEC
EATDKLDLPREYGVDDIPLVLMDHRFLEDGSLDEEDLPDLGLLGDTPTANGITNAHFDAT
CCCCCCCCCHHCCCCCCEEEEECCEECCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCC
TRRVRFRVLNGSNMRFYNLAFSDTRTFQVIASDSGLLDEPQDRTTLAIGPGERWEIVVEL
EEEEEEEEECCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEE
EPGEDVTLESVGFEDNYGVPDDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKST
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECC
EPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEVWIVTNDNSDWPHNFHVHDAR
CCCEEECCCCEEEEEEEECCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCEEEEECCE
FKVLKFEGTDVELFNDGWKDTVGLPPGATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
EEEEEEECCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEECCCCC
MGQFVIVEPGDEPAAVLGSGTGSSIDSAGGHAH
CEEEEEEECCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]