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The map label for this gene is pgi [H]

Identifier: 62389741

GI number: 62389741

Start: 909227

End: 910849

Strand: Reverse

Name: pgi [H]

Synonym: cg0973

Alternate gene names: 62389741

Gene position: 910849-909227 (Counterclockwise)

Preceding gene: 62389742

Following gene: 62389740

Centisome position: 27.75

GC content: 54.96

Gene sequence:

>1623_bases
ATGGCGGACATTTCGACCACCCAGGTTTGGCAAGACCTGACCGATCATTACTCAAACTTCCAGGCAACCACTCTGCGTGA
ACTTTTCAAGGAAGAAAACCGCGCCGAGAAGTACACCTTCTCCGCGGCTGGCCTCCACGTCGACCTGTCGAAGAATCTGC
TTGACGACGCCACCCTCACCAAGCTCCTTGCACTGACCGAAGAATCTGGCCTTCGCGAACGCATTGACGCGATGTTTGCC
GGTGAACACCTCAACAACACCGAAGACCGCGCTGTCCTCCACACCGCGCTGCGCCTTCCTGCCGAAGCTGATCTGTCAGT
AGATGGCCAAGATGTTGCTGCTGATGTCCACGAAGTTTTGGGACGCATGCGTGACTTCGCTACTGCGCTGCGCTCAGGCA
ACTGGTTGGGACACACCGGCCACACGATCAAGAAGATCGTCAACATTGGTATCGGTGGCTCTGACCTCGGACCAGCCATG
GCTACGAAGGCTCTGCGTGCATACGCGACCGCTGGTATCTCAGCAGAATTCGTCTCCAACGTCGACCCAGCAGACCTCGT
TTCTGTGTTGGAAGACCTCGATGCAGAATCCACATTGTTCGTGATCGCTTCGAAAACTTTCACCACCCAGGAGACGCTGT
CCAACGCTCGTGCAGCTCGTGCTTGGCTGGTAGAGAAGCTCGGTGAAGAGGCTGTCGCGAAGCACTTCGTCGCAGTGTCC
ACCAATGCTGAAAAGGTCGCAGAGTTCGGTATCGACACGGACAACATGTTCGGCTTCTGGGACTGGGTCGGAGGTCGTTA
CTCCGTGGACTCCGCAGTTGGTCTTTCCCTCATGGCAGTGATCGGCCCTCGCGACTTCATGCGTTTCCTCGGTGGATTCC
ACGCGATGGATGAACACTTCCGCACCACCAAGTTCGAAGAGAACGTTCCAATCTTGATGGCTCTGCTCGGTGTCTGGTAC
TCCGATTTCTATGGTGCAGAAACCCACGCTGTCCTACCTTATTCCGAGGATCTCAGCCGTTTTGCTGCTTACCTCCAGCA
GCTGACCATGGAATCAAATGGCAAGTCAGTCCACCGCGACGGCTCCCCTGTTTCCACTGGCACTGGCGAAATTTACTGGG
GTGAGCCTGGCACAAATGGCCAGCACGCTTTCTTCCAGCTGATCCACCAGGGCACTCGCCTTGTTCCAGCTGATTTCATT
GGTTTCGCTCGTCCAAAGCAGGATCTTCCTGCCGGTGAGCGCACCATGCATGACCTTTTGATGAGCAACTTCTTCGCACA
GACCAAGGTTTTGGCTTTCGGTAAGAACGCTGAAGAGATCGCTGCGGAAGGTGTCGCACCTGAGCTGGTCAACCACAAGG
TCATGCCAGGTAATCGCCCAACCACCACCATTTTGGCGGAGGAACTTACCCCTTCTATTCTCGGTGCGTTGATCGCTTTG
TACGAACACATCGTGATGGTTCAGGGCGTGATTTGGGACATCAACTCCTTCGACCAATGGGGTGTTGAACTGGGCAAACA
GCAGGCAAATGACCTCGCTCCGGCTGTCTCTGGTGAAGAGGATGTTGACTCGGGAGATTCTTCCACTGATTCACTGATTA
AGTGGTACCGCGCAAATAGGTAG

Upstream 100 bases:

>100_bases
TAAATTTGTCGTGTTTCCCACTTTGAACACTCTTCGATGCGCTTGGCCACAAAAGCAAGCTAACCTGAAGATGTTATTTA
ACGACAATAAAGGAGTTTTC

Downstream 100 bases:

>100_bases
TCGCTTGCTTATAGGGTCAGGGGCGTGAAGAATCCTCGCCTCATAGCACTGGCCGCTATCATCCTGACCTCGTTCAATCT
GCGAACAGCTATTACTGCTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MADISTTQVWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLTKLLALTEESGLRERIDAMFA
GEHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVLGRMRDFATALRSGNWLGHTGHTIKKIVNIGIGGSDLGPAM
ATKALRAYATAGISAEFVSNVDPADLVSVLEDLDAESTLFVIASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVS
TNAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHFRTTKFEENVPILMALLGVWY
SDFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRDGSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFI
GFARPKQDLPAGERTMHDLLMSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIAL
YEHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR

Sequences:

>Translated_540_residues
MADISTTQVWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLTKLLALTEESGLRERIDAMFA
GEHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVLGRMRDFATALRSGNWLGHTGHTIKKIVNIGIGGSDLGPAM
ATKALRAYATAGISAEFVSNVDPADLVSVLEDLDAESTLFVIASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVS
TNAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHFRTTKFEENVPILMALLGVWY
SDFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRDGSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFI
GFARPKQDLPAGERTMHDLLMSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIAL
YEHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR
>Mature_539_residues
ADISTTQVWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLTKLLALTEESGLRERIDAMFAG
EHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVLGRMRDFATALRSGNWLGHTGHTIKKIVNIGIGGSDLGPAMA
TKALRAYATAGISAEFVSNVDPADLVSVLEDLDAESTLFVIASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVST
NAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHFRTTKFEENVPILMALLGVWYS
DFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRDGSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFIG
FARPKQDLPAGERTMHDLLMSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIALY
EHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=555, Percent_Identity=49.009009009009, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI296080693, Length=555, Percent_Identity=45.7657657657658, Blast_Score=482, Evalue=1e-136,
Organism=Escherichia coli, GI1790457, Length=554, Percent_Identity=52.5270758122744, Blast_Score=551, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI71996708, Length=536, Percent_Identity=50.7462686567164, Blast_Score=522, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI71996703, Length=536, Percent_Identity=50.7462686567164, Blast_Score=522, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6319673, Length=538, Percent_Identity=49.4423791821561, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24651916, Length=546, Percent_Identity=52.014652014652, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24651914, Length=546, Percent_Identity=52.014652014652, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI17737445, Length=546, Percent_Identity=52.014652014652, Blast_Score=549, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 59167; Mature: 59036

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADISTTQVWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLT
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEEECCEEEECHHHHHHHHHHH
KLLALTEESGLRERIDAMFAGEHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVL
HHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
GRMRDFATALRSGNWLGHTGHTIKKIVNIGIGGSDLGPAMATKALRAYATAGISAEFVSN
HHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCC
VDPADLVSVLEDLDAESTLFVIASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVS
CCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TNAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHF
CCHHHHHHHCCCCCCCCCHHHCCCCCEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
RTTKFEENVPILMALLGVWYSDFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRD
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCEECCC
GSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFIGFARPKQDLPAGERTMHDLL
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
MSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIAL
HHHHHHHHHHHEECCCHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHH
YEHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ADISTTQVWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEEECCEEEECHHHHHHHHHHH
KLLALTEESGLRERIDAMFAGEHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVL
HHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
GRMRDFATALRSGNWLGHTGHTIKKIVNIGIGGSDLGPAMATKALRAYATAGISAEFVSN
HHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCC
VDPADLVSVLEDLDAESTLFVIASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVS
CCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TNAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHF
CCHHHHHHHCCCCCCCCCHHHCCCCCEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
RTTKFEENVPILMALLGVWYSDFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRD
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCEECCC
GSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFIGFARPKQDLPAGERTMHDLL
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
MSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIAL
HHHHHHHHHHHEECCCHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHH
YEHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA