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The map label for this gene is purE [H]

Identifier: 62389603

GI number: 62389603

Start: 736875

End: 737372

Strand: Direct

Name: purE [H]

Synonym: cg0820

Alternate gene names: 62389603

Gene position: 736875-737372 (Clockwise)

Preceding gene: 62389602

Following gene: 62389604

Centisome position: 22.45

GC content: 55.62

Gene sequence:

>498_bases
GTGGGTCCTCTAGTTGGTTTGATCATGGGTTCGGATTCGGATTGGGACACTGTAGCGCCAGCTGCAGAGGTACTCGCTGA
GTTTGGCATTCCTTTTGAAGTCGGAGTTGTCTCTGCACACCGCACCCCAGAGAAGATGCTCAACTACGCAAAGACTGCAC
ATGAGCGCGGCATCAAGACGATCATCGCGTGTGCTGGCGGCGCTGCACACCTGCCAGGCATGGTGGCTGCAGCAACTCCA
CTTCCAGTCATCGGTGTTCCACGCGCATTGAAGGATCTCGACGGTTTGGATTCCTTGCTGTCCATCGTCCAGATGCCAGG
CGGCGTTCCAGTCGCCACTGTCTCCATCGGTGGCGCGAAGAATGCAGGCCTACTTGCCGTTCGTATTCTCGGTGCTGGTG
ATCCTTCTTTGGTCACGAAGATGGCCGATTACCAAGAGAATATGGCGAAGGAAGTTGAAGCCAAGGACGAAGCACTGAAG
AAGCGCTTGCTCGGCTAA

Upstream 100 bases:

>100_bases
AAGCATTTCTCCAACACTTTTGATGGACAGATTAACGCTTAAAAGGCCTGTTATAGACTGATAAACCGATACGTAACTTT
CGCGCTTAAGGAGAATTTCA

Downstream 100 bases:

>100_bases
TGAATCCGATCGTGGTGCTGGGATCCAAAGTTGTTGATGGTCAAGTCACTGGCCTTTTGGCCTCAAGGCTGGAAAAGGCC
ATTGAGGTCTCATCTTTGAC

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MGPLVGLIMGSDSDWDTVAPAAEVLAEFGIPFEVGVVSAHRTPEKMLNYAKTAHERGIKTIIACAGGAAHLPGMVAAATP
LPVIGVPRALKDLDGLDSLLSIVQMPGGVPVATVSIGGAKNAGLLAVRILGAGDPSLVTKMADYQENMAKEVEAKDEALK
KRLLG

Sequences:

>Translated_165_residues
MGPLVGLIMGSDSDWDTVAPAAEVLAEFGIPFEVGVVSAHRTPEKMLNYAKTAHERGIKTIIACAGGAAHLPGMVAAATP
LPVIGVPRALKDLDGLDSLLSIVQMPGGVPVATVSIGGAKNAGLLAVRILGAGDPSLVTKMADYQENMAKEVEAKDEALK
KRLLG
>Mature_164_residues
GPLVGLIMGSDSDWDTVAPAAEVLAEFGIPFEVGVVSAHRTPEKMLNYAKTAHERGIKTIIACAGGAAHLPGMVAAATPL
PVIGVPRALKDLDGLDSLLSIVQMPGGVPVATVSIGGAKNAGLLAVRILGAGDPSLVTKMADYQENMAKEVEAKDEALKK
RLLG

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=56.3636363636364, Blast_Score=126, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=63.2911392405063, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16934; Mature: 16803

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPLVGLIMGSDSDWDTVAPAAEVLAEFGIPFEVGVVSAHRTPEKMLNYAKTAHERGIKT
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCHHE
IIACAGGAAHLPGMVAAATPLPVIGVPRALKDLDGLDSLLSIVQMPGGVPVATVSIGGAK
EEEECCCHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAVRILGAGDPSLVTKMADYQENMAKEVEAKDEALKKRLLG
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GPLVGLIMGSDSDWDTVAPAAEVLAEFGIPFEVGVVSAHRTPEKMLNYAKTAHERGIKT
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCHHE
IIACAGGAAHLPGMVAAATPLPVIGVPRALKDLDGLDSLLSIVQMPGGVPVATVSIGGAK
EEEECCCHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAVRILGAGDPSLVTKMADYQENMAKEVEAKDEALKKRLLG
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8998996 [H]