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The map label for this gene is lpdA [H]

Identifier: 62389577

GI number: 62389577

Start: 704878

End: 706287

Strand: Direct

Name: lpdA [H]

Synonym: cg0790

Alternate gene names: 62389577

Gene position: 704878-706287 (Clockwise)

Preceding gene: 62389576

Following gene: 62389578

Centisome position: 21.47

GC content: 55.6

Gene sequence:

>1410_bases
ATGGCAAAGAGGATCGTAATTATCGGCGGTGGACCTGCAGGCTATGAAGCCGCACTCGCAGGCGCTAAATACGGTGCAGA
AGTTACCGTTATTGAAGATGTCGGAGTTGGCGGATCCGCAGTCACCATGGACTGTGTACCTTCAAAGTCCTTCATCGCTG
GTACCGGTATCAAAACCGACCTCCGACGTGCTGATGACATGGGACTTAACCGTGGGCTTGGAAAAGCACACCTAGAAATC
GATGCACTGAACATCCGTGTGAAGGACCTTGCGAAAGCACAGTCCGAAGATATCTTGGGCCAGCTGCAGCGCTCAGATGT
CCGCATGATTAACGGTGTGGGCCGCTTTGATGATTACAACACCAAGCAAACCACCCACTACATTAAAGTCACCCACAGCG
ATGGCTCCGAAGAAACCGTTGAGTGCGATCTGGTGCTGGTTGCAACTGGTGCAACCCCCCGCATTCTTAAAGGTGCAGAG
CCAGACGGCGAGCGCATCTTGACCTGGCGTCAGGTCTACGACATTGAAGAACTCCCCACCCACCTTATCGTGGTTGGTTC
CGGTGTGACCGGTGCGGAATTTGTCTCTGCGTTTGCTGAACTCGGCGTCAAAGTCACCATGGTGGCATCCCGTGACCGCA
TTTTGCCTCACGATGACGCAGATGCCGCAGACGTGCTGGAAACCGTTCTGGCTGAGCGCGGAGTATCCCTGGAAAAGCAT
GCCCGCGTGGAGTCTGTCACCCGCACCGAAGACGGTGGCGTGTGTGTTCGCACTGCTGACGGACGAGAAATCTACGGTTC
TCACGCGTTGATGACTGTTGGTTCCATTCCAAACACGGCAGATCTTGGCCTGGAGAACATCGGTGTTGAGCTGGCACCAT
CCGGCCATATCAAGGTTGACCGCGTCTCCCGCACCAACATCCCCGGTGTGTACGCAGCAGGTGACTGTACTGACCTATTC
CCACTGGCGTCCGTTGCAGCGATGCAGGGCCGTATCGCCATGTATCACGCACTCGGTGAAGGCGTGAGCCCCATCCGTTT
GAAGACTGTTGCCACCGCAGTGTTTACCCGCCCAGAGATCGCAGCAGTAGGTATCACCCATGCACAAGTTGATTCCGGCG
AAGTGTCTGCTCGCGTGATTGTGCTTCCTTTGGCTACTAACCCACGCGCCAAGATGCGTTCCCTGCGCCACGGTTTTGTG
AAGCTGTTCTGCCGCCGTAACTCTGGCCTGATCATCGGTGGTGTCGTGGTGGCACCGACCGCGTCTGAGCTGATCCTACC
GATCGCTGTGGCAGTGACCAACCGTCTGACAGTTGCTGATCTGGCTGATACCTTCGCGGTGTACCCATCATTGTCAGGTT
CGATTACTGAAGCAGCACGTCAGCTGGTTCAACATGATGATCTAGGCTAA

Upstream 100 bases:

>100_bases
GTCACCCAGGCTAATTCAGCAGTAATCATTTAGACTTGGAACCGCTTACCAGTGGTTTCAACAATGCATTCACCCAGCTC
ACACGTGTGGAGGTGCCTTA

Downstream 100 bases:

>100_bases
TTTTTCTGAGTCTTAGATTTTGAGAAAACCCAGGATTGCTTTGTGCACTCCTGGGTTTTCACTTTGTTAAGCAGTTTTGG
GGAAAAGTGCAAAGTTTGCA

Product: flavoprotein disulfide reductase

Products: NA

Alternate protein names: NAD(P)H quinone reductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MAKRIVIIGGGPAGYEAALAGAKYGAEVTVIEDVGVGGSAVTMDCVPSKSFIAGTGIKTDLRRADDMGLNRGLGKAHLEI
DALNIRVKDLAKAQSEDILGQLQRSDVRMINGVGRFDDYNTKQTTHYIKVTHSDGSEETVECDLVLVATGATPRILKGAE
PDGERILTWRQVYDIEELPTHLIVVGSGVTGAEFVSAFAELGVKVTMVASRDRILPHDDADAADVLETVLAERGVSLEKH
ARVESVTRTEDGGVCVRTADGREIYGSHALMTVGSIPNTADLGLENIGVELAPSGHIKVDRVSRTNIPGVYAAGDCTDLF
PLASVAAMQGRIAMYHALGEGVSPIRLKTVATAVFTRPEIAAVGITHAQVDSGEVSARVIVLPLATNPRAKMRSLRHGFV
KLFCRRNSGLIIGGVVVAPTASELILPIAVAVTNRLTVADLADTFAVYPSLSGSITEAARQLVQHDDLG

Sequences:

>Translated_469_residues
MAKRIVIIGGGPAGYEAALAGAKYGAEVTVIEDVGVGGSAVTMDCVPSKSFIAGTGIKTDLRRADDMGLNRGLGKAHLEI
DALNIRVKDLAKAQSEDILGQLQRSDVRMINGVGRFDDYNTKQTTHYIKVTHSDGSEETVECDLVLVATGATPRILKGAE
PDGERILTWRQVYDIEELPTHLIVVGSGVTGAEFVSAFAELGVKVTMVASRDRILPHDDADAADVLETVLAERGVSLEKH
ARVESVTRTEDGGVCVRTADGREIYGSHALMTVGSIPNTADLGLENIGVELAPSGHIKVDRVSRTNIPGVYAAGDCTDLF
PLASVAAMQGRIAMYHALGEGVSPIRLKTVATAVFTRPEIAAVGITHAQVDSGEVSARVIVLPLATNPRAKMRSLRHGFV
KLFCRRNSGLIIGGVVVAPTASELILPIAVAVTNRLTVADLADTFAVYPSLSGSITEAARQLVQHDDLG
>Mature_468_residues
AKRIVIIGGGPAGYEAALAGAKYGAEVTVIEDVGVGGSAVTMDCVPSKSFIAGTGIKTDLRRADDMGLNRGLGKAHLEID
ALNIRVKDLAKAQSEDILGQLQRSDVRMINGVGRFDDYNTKQTTHYIKVTHSDGSEETVECDLVLVATGATPRILKGAEP
DGERILTWRQVYDIEELPTHLIVVGSGVTGAEFVSAFAELGVKVTMVASRDRILPHDDADAADVLETVLAERGVSLEKHA
RVESVTRTEDGGVCVRTADGREIYGSHALMTVGSIPNTADLGLENIGVELAPSGHIKVDRVSRTNIPGVYAAGDCTDLFP
LASVAAMQGRIAMYHALGEGVSPIRLKTVATAVFTRPEIAAVGITHAQVDSGEVSARVIVLPLATNPRAKMRSLRHGFVK
LFCRRNSGLIIGGVVVAPTASELILPIAVAVTNRLTVADLADTFAVYPSLSGSITEAARQLVQHDDLG

Specific function: May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NAD(P)H is the physiological reductant rather than NADH [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=26.8817204301075, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50301238, Length=456, Percent_Identity=26.7543859649123, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI291045266, Length=434, Percent_Identity=24.6543778801843, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI22035672, Length=461, Percent_Identity=24.0780911062907, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=25.2747252747253, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=25.2747252747253, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=25.2747252747253, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=25.2747252747253, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=25.2747252747253, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI291045268, Length=428, Percent_Identity=23.5981308411215, Blast_Score=93, Evalue=7e-19,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=25.7019438444924, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=28.2608695652174, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI87081717, Length=468, Percent_Identity=27.991452991453, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=25.6818181818182, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=25.9100642398287, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17557007, Length=478, Percent_Identity=27.6150627615063, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=447, Percent_Identity=27.2930648769575, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71983429, Length=447, Percent_Identity=27.2930648769575, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=444, Percent_Identity=24.0990990990991, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=238, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=28.5714285714286, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=452, Percent_Identity=23.8938053097345, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=21.8947368421053, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=29.1304347826087, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24640553, Length=481, Percent_Identity=25.5717255717256, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640549, Length=481, Percent_Identity=25.5717255717256, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=25.5717255717256, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17737741, Length=484, Percent_Identity=26.0330578512397, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.5.2 [H]

Molecular weight: Translated: 49541; Mature: 49410

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIVIIGGGPAGYEAALAGAKYGAEVTVIEDVGVGGSAVTMDCVPSKSFIAGTGIKTD
CCCEEEEECCCCCCHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEECCCCCHH
LRRADDMGLNRGLGKAHLEIDALNIRVKDLAKAQSEDILGQLQRSDVRMINGVGRFDDYN
HHHHHCCCCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
TKQTTHYIKVTHSDGSEETVECDLVLVATGATPRILKGAEPDGERILTWRQVYDIEELPT
CCCEEEEEEEEECCCCCCEEEEEEEEEECCCCCHHCCCCCCCCCEEEEHHHHHCHHHCCC
HLIVVGSGVTGAEFVSAFAELGVKVTMVASRDRILPHDDADAADVLETVLAERGVSLEKH
EEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
ARVESVTRTEDGGVCVRTADGREIYGSHALMTVGSIPNTADLGLENIGVELAPSGHIKVD
HHHHHHHCCCCCCEEEEECCCCEECCCEEEEEECCCCCHHHCCHHHCCEEECCCCCEEEE
RVSRTNIPGVYAAGDCTDLFPLASVAAMQGRIAMYHALGEGVSPIRLKTVATAVFTRPEI
EECCCCCCCEEECCCCCHHHHHHHHHHHCCCEEEEEHHCCCCCCEEHHHHHHHHHCCCCE
AAVGITHAQVDSGEVSARVIVLPLATNPRAKMRSLRHGFVKLFCRRNSGLIIGGVVVAPT
EEEEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHHEEEEECCCCEEEEEEEECCC
ASELILPIAVAVTNRLTVADLADTFAVYPSLSGSITEAARQLVQHDDLG
CHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKRIVIIGGGPAGYEAALAGAKYGAEVTVIEDVGVGGSAVTMDCVPSKSFIAGTGIKTD
CCEEEEECCCCCCHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCCCEEECCCCCHH
LRRADDMGLNRGLGKAHLEIDALNIRVKDLAKAQSEDILGQLQRSDVRMINGVGRFDDYN
HHHHHCCCCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
TKQTTHYIKVTHSDGSEETVECDLVLVATGATPRILKGAEPDGERILTWRQVYDIEELPT
CCCEEEEEEEEECCCCCCEEEEEEEEEECCCCCHHCCCCCCCCCEEEEHHHHHCHHHCCC
HLIVVGSGVTGAEFVSAFAELGVKVTMVASRDRILPHDDADAADVLETVLAERGVSLEKH
EEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
ARVESVTRTEDGGVCVRTADGREIYGSHALMTVGSIPNTADLGLENIGVELAPSGHIKVD
HHHHHHHCCCCCCEEEEECCCCEECCCEEEEEECCCCCHHHCCHHHCCEEECCCCCEEEE
RVSRTNIPGVYAAGDCTDLFPLASVAAMQGRIAMYHALGEGVSPIRLKTVATAVFTRPEI
EECCCCCCCEEECCCCCHHHHHHHHHHHCCCEEEEEHHCCCCCCEEHHHHHHHHHCCCCE
AAVGITHAQVDSGEVSARVIVLPLATNPRAKMRSLRHGFVKLFCRRNSGLIIGGVVVAPT
EEEEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHHEEEEECCCCEEEEEEEECCC
ASELILPIAVAVTNRLTVADLADTFAVYPSLSGSITEAARQLVQHDDLG
CHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]