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The map label for this gene is icd

Identifier: 62389553

GI number: 62389553

Start: 679301

End: 681517

Strand: Reverse

Name: icd

Synonym: cg0766

Alternate gene names: 62389553

Gene position: 681517-679301 (Counterclockwise)

Preceding gene: 62389554

Following gene: 62389552

Centisome position: 20.76

GC content: 57.47

Gene sequence:

>2217_bases
ATGGCTAAGATCATCTGGACCCGCACCGACGAAGCACCGCTGCTCGCGACCTACTCGCTGAAGCCGGTCGTCGAGGCATT
TGCTGCTACCGCGGGCATTGAGGTCGAGACCCGGGACATTTCACTCGCTGGACGCATCCTCGCCCAGTTCCCAGAGCGCC
TCACCGAAGATCAGAAGGTAGGCAACGCACTCGCAGAACTCGGCGAGCTTGCTAAGACTCCTGAAGCAAACATCATTAAG
CTTCCAAACATCTCCGCTTCTGTTCCACAGCTCAAGGCTGCTATTAAGGAACTGCAGGACCAGGGCTACGACATCCCAGA
ACTGCCTGATAACGCCACCACCGACGAGGAAAAAGACATCCTCGCACGCTACAACGCTGTTAAGGGTTCCGCTGTGAACC
CAGTGCTGCGTGAAGGCAACTCTGACCGCCGCGCACCAATCGCTGTCAAGAACTTTGTTAAGAAGTTCCCACACCGCATG
GGCGAGTGGTCTGCAGATTCCAAGACCAACGTTGCAACCATGGATGCAAACGACTTCCGCCACAACGAGAAGTCCATCAT
CCTCGACGCTGCTGATGAAGTTCAGATCAAGCACATCGCAGCTGACGGCACCGAGACCATCCTCAAGGACAGCCTCAAGC
TTCTTGAAGGCGAAGTTCTAGACGGAACCGTTCTGTCCGCAAAGGCACTGGACGCATTCCTTCTCGAGCAGGTCGCTCGC
GCAAAGGCAGAAGGTATCCTCTTCTCCGCACACCTGAAGGCCACCATGATGAAGGTCTCCGACCCAATCATCTTCGGCCA
CGTTGTGCGCGCTTACTTCGCAGACGTTTTCGCACAGTACGGTGAGCAGCTGCTCGCAGCTGGCCTCAACGGCGAAAACG
GCCTCGCTGCAATCCTCTCCGGCTTGGAGTCCCTGGACAACGGCGAAGAAATCAAGGCTGCATTCGAGAAGGGCTTGGAA
GACGGCCCAGACCTGGCCATGGTTAACTCCGCTCGCGGCATCACCAACCTGCATGTCCCTTCCGATGTCATCGTGGACGC
TTCCATGCCAGCAATGATTCGTACCTCCGGCCACATGTGGAACAAAGACGACCAGGAGCAGGACACCCTGGCAATCATCC
CAGACTCCTCCTACGCTGGCGTCTACCAGACCGTTATCGAAGACTGCCGCAAGAACGGCGCATTCGATCCAACCACCATG
GGTACCGTCCCTAACGTTGGTCTGATGGCTCAGAAGGCTGAAGAGTACGGCTCCCATGACAAGACCTTCCGCATCGAAGC
AGACGGTGTGGTTCAGGTTGTTTCCTCCAACGGCGACGTTCTCATCGAGCACGACGTTGAGGCAAATGACATCTGGCGTG
CATGCCAGGTCAAGGATGCCCCAATCCAGGATTGGGTAAAGCTTGCTGTCACCCGCTCCCGTCTCTCCGGAATGCCTGCA
GTGTTCTGGTTGGATCCAGAGCGCGCACACGACCGCAACCTGGCTTCCCTCGTTGAGAAGTACCTGGCTGACCACGACAC
CGAGGGCCTGGACATCCAGATCCTCTCCCCTGTTGAGGCAACCCAGCTCTCCATCGACCGCATCCGCCGTGGCGAGGACA
CCATCTCTGTCACCGGTAACGTTCTGCGTGACTACAACACCGACCTCTTCCCAATCCTGGAGCTGGGCACCTCTGCAAAG
ATGCTGTCTGTCGTTCCTTTGATGGCTGGCGGCGGACTGTTCGAGACCGGTGCTGGTGGATCTGCTCCTAAGCACGTCCA
GCAGGTTCAGGAAGAAAACCACCTGCGTTGGGATTCCCTCGGTGAGTTCCTCGCACTGGCTGAGTCCTTCCGCCACGAGC
TCAACAACAACGGCAACACCAAGGCCGGCGTTCTGGCTGACGCTCTGGACAAGGCAACTGAGAAGCTGCTGAACGAAGAG
AAGTCCCCATCCCGCAAGGTTGGCGAGATCGACAACCGTGGCTCCCACTTCTGGCTGACCAAGTTCTGGGCTGACGAGCT
CGCTGCTCAGACCGAGGACGCAGATCTGGCTGCTACCTTCGCACCAGTCGCAGAAGCACTGAACACAGGCGCTGCAGACA
TCGATGCTGCACTGCTCGCAGTTCAGGGTGGAGCAACTGACCTTGGTGGCTACTACTCCCCTAACGAGGAGAAGCTCACC
AACATCATGCGCCCAGTCGCACAGTTCAACGAGATCGTTGACGCACTGAAGAAGTAA

Upstream 100 bases:

>100_bases
TTTCCATGCGGGGCTGAAACTGCCACCATAGGCGCCAGCAATTAGTAGAACACTGTATTCTAGGTAGCTGAACAAAAGAG
CCCATCAACCAAGGAGACTC

Downstream 100 bases:

>100_bases
AGTCTCTTCACAAAAAGCGCTGTGCTTCCTCACATGGAAGCACAGCGCTTTTTCATATTTTTATTGCCATAATGGGCACA
TGCGTTTTTCTCGAGTTCTT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase

Number of amino acids: Translated: 738; Mature: 737

Protein sequence:

>738_residues
MAKIIWTRTDEAPLLATYSLKPVVEAFAATAGIEVETRDISLAGRILAQFPERLTEDQKVGNALAELGELAKTPEANIIK
LPNISASVPQLKAAIKELQDQGYDIPELPDNATTDEEKDILARYNAVKGSAVNPVLREGNSDRRAPIAVKNFVKKFPHRM
GEWSADSKTNVATMDANDFRHNEKSIILDAADEVQIKHIAADGTETILKDSLKLLEGEVLDGTVLSAKALDAFLLEQVAR
AKAEGILFSAHLKATMMKVSDPIIFGHVVRAYFADVFAQYGEQLLAAGLNGENGLAAILSGLESLDNGEEIKAAFEKGLE
DGPDLAMVNSARGITNLHVPSDVIVDASMPAMIRTSGHMWNKDDQEQDTLAIIPDSSYAGVYQTVIEDCRKNGAFDPTTM
GTVPNVGLMAQKAEEYGSHDKTFRIEADGVVQVVSSNGDVLIEHDVEANDIWRACQVKDAPIQDWVKLAVTRSRLSGMPA
VFWLDPERAHDRNLASLVEKYLADHDTEGLDIQILSPVEATQLSIDRIRRGEDTISVTGNVLRDYNTDLFPILELGTSAK
MLSVVPLMAGGGLFETGAGGSAPKHVQQVQEENHLRWDSLGEFLALAESFRHELNNNGNTKAGVLADALDKATEKLLNEE
KSPSRKVGEIDNRGSHFWLTKFWADELAAQTEDADLAATFAPVAEALNTGAADIDAALLAVQGGATDLGGYYSPNEEKLT
NIMRPVAQFNEIVDALKK

Sequences:

>Translated_738_residues
MAKIIWTRTDEAPLLATYSLKPVVEAFAATAGIEVETRDISLAGRILAQFPERLTEDQKVGNALAELGELAKTPEANIIK
LPNISASVPQLKAAIKELQDQGYDIPELPDNATTDEEKDILARYNAVKGSAVNPVLREGNSDRRAPIAVKNFVKKFPHRM
GEWSADSKTNVATMDANDFRHNEKSIILDAADEVQIKHIAADGTETILKDSLKLLEGEVLDGTVLSAKALDAFLLEQVAR
AKAEGILFSAHLKATMMKVSDPIIFGHVVRAYFADVFAQYGEQLLAAGLNGENGLAAILSGLESLDNGEEIKAAFEKGLE
DGPDLAMVNSARGITNLHVPSDVIVDASMPAMIRTSGHMWNKDDQEQDTLAIIPDSSYAGVYQTVIEDCRKNGAFDPTTM
GTVPNVGLMAQKAEEYGSHDKTFRIEADGVVQVVSSNGDVLIEHDVEANDIWRACQVKDAPIQDWVKLAVTRSRLSGMPA
VFWLDPERAHDRNLASLVEKYLADHDTEGLDIQILSPVEATQLSIDRIRRGEDTISVTGNVLRDYNTDLFPILELGTSAK
MLSVVPLMAGGGLFETGAGGSAPKHVQQVQEENHLRWDSLGEFLALAESFRHELNNNGNTKAGVLADALDKATEKLLNEE
KSPSRKVGEIDNRGSHFWLTKFWADELAAQTEDADLAATFAPVAEALNTGAADIDAALLAVQGGATDLGGYYSPNEEKLT
NIMRPVAQFNEIVDALKK
>Mature_737_residues
AKIIWTRTDEAPLLATYSLKPVVEAFAATAGIEVETRDISLAGRILAQFPERLTEDQKVGNALAELGELAKTPEANIIKL
PNISASVPQLKAAIKELQDQGYDIPELPDNATTDEEKDILARYNAVKGSAVNPVLREGNSDRRAPIAVKNFVKKFPHRMG
EWSADSKTNVATMDANDFRHNEKSIILDAADEVQIKHIAADGTETILKDSLKLLEGEVLDGTVLSAKALDAFLLEQVARA
KAEGILFSAHLKATMMKVSDPIIFGHVVRAYFADVFAQYGEQLLAAGLNGENGLAAILSGLESLDNGEEIKAAFEKGLED
GPDLAMVNSARGITNLHVPSDVIVDASMPAMIRTSGHMWNKDDQEQDTLAIIPDSSYAGVYQTVIEDCRKNGAFDPTTMG
TVPNVGLMAQKAEEYGSHDKTFRIEADGVVQVVSSNGDVLIEHDVEANDIWRACQVKDAPIQDWVKLAVTRSRLSGMPAV
FWLDPERAHDRNLASLVEKYLADHDTEGLDIQILSPVEATQLSIDRIRRGEDTISVTGNVLRDYNTDLFPILELGTSAKM
LSVVPLMAGGGLFETGAGGSAPKHVQQVQEENHLRWDSLGEFLALAESFRHELNNNGNTKAGVLADALDKATEKLLNEEK
SPSRKVGEIDNRGSHFWLTKFWADELAAQTEDADLAATFAPVAEALNTGAADIDAALLAVQGGATDLGGYYSPNEEKLTN
IMRPVAQFNEIVDALKK

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IDH_CORGL (P50216)

Other databases:

- EMBL:   X71489
- EMBL:   BA000036
- EMBL:   BX927149
- PIR:   I40719
- RefSeq:   NP_599896.1
- RefSeq:   YP_224955.1
- PDB:   2B0T
- PDBsum:   2B0T
- ProteinModelPortal:   P50216
- SMR:   P50216
- GeneID:   1018663
- GeneID:   3345662
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0766
- KEGG:   cgl:NCgl0634
- HOGENOM:   HBG286619
- OMA:   IRDLHAC
- ProtClustDB:   CLSK867411
- BioCyc:   CGLU196627:CG0766-MONOMER
- BRENDA:   1.1.1.42
- InterPro:   IPR001804
- InterPro:   IPR004436
- Gene3D:   G3DSA:3.40.718.10
- PIRSF:   PIRSF009407
- TIGRFAMs:   TIGR00178

Pfam domain/function: PF03971 IDH

EC number: =1.1.1.42

Molecular weight: Translated: 80082; Mature: 79951

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: BINDING 133-133 BINDING 143-143 BINDING 543-543 BINDING 585-585 BINDING 645-645

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIWTRTDEAPLLATYSLKPVVEAFAATAGIEVETRDISLAGRILAQFPERLTEDQKV
CCEEEEECCCCCCEEEECCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
GNALAELGELAKTPEANIIKLPNISASVPQLKAAIKELQDQGYDIPELPDNATTDEEKDI
HHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LARYNAVKGSAVNPVLREGNSDRRAPIAVKNFVKKFPHRMGEWSADSKTNVATMDANDFR
HHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHCC
HNEKSIILDAADEVQIKHIAADGTETILKDSLKLLEGEVLDGTVLSAKALDAFLLEQVAR
CCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AKAEGILFSAHLKATMMKVSDPIIFGHVVRAYFADVFAQYGEQLLAAGLNGENGLAAILS
HHHCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
GLESLDNGEEIKAAFEKGLEDGPDLAMVNSARGITNLHVPSDVIVDASMPAMIRTSGHMW
HHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCCCEEECCCCCEEECCCCCHHHCCCCCCC
NKDDQEQDTLAIIPDSSYAGVYQTVIEDCRKNGAFDPTTMGTVPNVGLMAQKAEEYGSHD
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
KTFRIEADGVVQVVSSNGDVLIEHDVEANDIWRACQVKDAPIQDWVKLAVTRSRLSGMPA
CEEEEECCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCE
VFWLDPERAHDRNLASLVEKYLADHDTEGLDIQILSPVEATQLSIDRIRRGEDTISVTGN
EEEECCHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECHH
VLRDYNTDLFPILELGTSAKMLSVVPLMAGGGLFETGAGGSAPKHVQQVQEENHLRWDSL
HHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCHHHH
GEFLALAESFRHELNNNGNTKAGVLADALDKATEKLLNEEKSPSRKVGEIDNRGSHFWLT
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEH
KFWADELAAQTEDADLAATFAPVAEALNTGAADIDAALLAVQGGATDLGGYYSPNEEKLT
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCCCCCCCCCHHHHH
NIMRPVAQFNEIVDALKK
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIIWTRTDEAPLLATYSLKPVVEAFAATAGIEVETRDISLAGRILAQFPERLTEDQKV
CEEEEECCCCCCEEEECCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
GNALAELGELAKTPEANIIKLPNISASVPQLKAAIKELQDQGYDIPELPDNATTDEEKDI
HHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LARYNAVKGSAVNPVLREGNSDRRAPIAVKNFVKKFPHRMGEWSADSKTNVATMDANDFR
HHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHCC
HNEKSIILDAADEVQIKHIAADGTETILKDSLKLLEGEVLDGTVLSAKALDAFLLEQVAR
CCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AKAEGILFSAHLKATMMKVSDPIIFGHVVRAYFADVFAQYGEQLLAAGLNGENGLAAILS
HHHCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
GLESLDNGEEIKAAFEKGLEDGPDLAMVNSARGITNLHVPSDVIVDASMPAMIRTSGHMW
HHHHCCCCHHHHHHHHCCCCCCCCEEEEECCCCCEEECCCCCEEECCCCCHHHCCCCCCC
NKDDQEQDTLAIIPDSSYAGVYQTVIEDCRKNGAFDPTTMGTVPNVGLMAQKAEEYGSHD
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
KTFRIEADGVVQVVSSNGDVLIEHDVEANDIWRACQVKDAPIQDWVKLAVTRSRLSGMPA
CEEEEECCCEEEEEECCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCE
VFWLDPERAHDRNLASLVEKYLADHDTEGLDIQILSPVEATQLSIDRIRRGEDTISVTGN
EEEECCHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECHH
VLRDYNTDLFPILELGTSAKMLSVVPLMAGGGLFETGAGGSAPKHVQQVQEENHLRWDSL
HHHHCCCCHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCHHHH
GEFLALAESFRHELNNNGNTKAGVLADALDKATEKLLNEEKSPSRKVGEIDNRGSHFWLT
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEH
KFWADELAAQTEDADLAATFAPVAEALNTGAADIDAALLAVQGGATDLGGYYSPNEEKLT
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCCCCCCCCCHHHHH
NIMRPVAQFNEIVDALKK
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7836312; 12948626