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The map label for this gene is papA [H]

Identifier: 62389480

GI number: 62389480

Start: 604429

End: 605712

Strand: Direct

Name: papA [H]

Synonym: cg0684

Alternate gene names: 62389480

Gene position: 604429-605712 (Clockwise)

Preceding gene: 62389479

Following gene: 62389481

Centisome position: 18.41

GC content: 55.06

Gene sequence:

>1284_bases
GTGGTGGGGGTGGTGTCCACCCCTGCGCGTAACCTGGGAAGCATGACTAAAACACTTGGTTCCCTTCAGCTGGAAGAAAT
CACGCTGACCCTCCCTCTGACTGAAGATGTGGCCGATGAACGCACCATTGATGTGTTCGCACGCATTGCCACACGCGTCG
GTGGGGAAGACCTTCCATATTTAGTATTCCTGCAGGGTGGGCCTGGCAATGAAGCTCCACGTCCAAGCCTTAATCCCCTC
AACCCCAATTGGTTGGGCGTGGCCTTGGAGGAATACCGCGTGGTCATGTTGGATCAACGTGGCACCGGCCGTTCCACCCC
AGTGGGTAATGATATTTTGGAAAAACCCACAGCAGAAGTAGTGGAGTACTTATCCCACCTGCGCGCAGATGGCATTGTGC
GAGATGCTGAAGCCCTGCGTAAGCATTTGGGTGTGAATCAGTGGAACCTTTTAGGCCAGTCCTTCGGAGGTTTCACCACC
CTGCATTACTTGTCCCGGCACGCCGATTCCTTGGACAACGTGTTTATTACCGGCGGTCTCAGCGCTATTGATCGCCCAGC
AGAAGACGTGTATGCCAACTGTTACAACCGCATGCGCCGAAACTCTGAGGAATTCTACCGTCGCTTCCCGCAATTACGGG
AAACTTTCCGAGGGTTGGTTAATCGTGCTCGCGCCGGGGAGATTGTGCTTCCCACCGGCGAAGTTGTGTCAGAAACCAGG
CTGCGATCCCTTGGTCACTTGTTGGGTAGCAATGACGGCTGGTTTGATCTGTACAACCTGCTGGAATTAGATCCCACCTC
CAACGCTTTTGTCCATGACCTGGCAGGACTTTTGCCTTTCGGCAACCGCAACCCAATTTATTACGTGCTCCATGAGTCCT
CTTACGCCGACGGTGTGGTGACAAATTGGGCAGCAGAGCGTGTGCTTCCAGAGGATTTCCGCGAGGATCCAACACTGCTC
ACCGGTGAGCACGTGTTCCAGGAGTGGACAGACACCGTGCCGTCGCTCAAGCCGTGGAAGGACGTTGCCCTGGCATTGGC
TCAGCAGGAATGGCCCAAGCTTTATGATGCGAAGGCATTGGAAAACTCACAGGCCAAGGGCGCTGCAGCAGTGTATGCCA
ATGACGTTTTCGTCCCAGTGGATTACTCTCTGGAAACCGCACAACACCTGCCCGGTGTGCAGCTGTTTATCACCAGCCAG
CATGAACACAATGGACTTCGTGCCAGCTCAGGCGCAGTACTGAAGCACCTTTTCGATCTGGCCCACGGCCGAGAGGTACG
CTGA

Upstream 100 bases:

>100_bases
TGCCAACAGGGGATATGCCACTGTGTACCCCACGGCGATGATCGGTAAAATCCTCGGCGCGCAGATATTGTTCTTGCTGC
TCTAAGGTGATTTTTGGGCA

Downstream 100 bases:

>100_bases
TTCCTCGTGTTAGTACTAGCCCTAGACACCTCAACCCCTGACCTGATCGTCGGCGTCGTCGACTCCGACACCGGAAACAC
CCGCGCCGAAACCATCATCG

Product: prolyl aminopeptidase A

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MVGVVSTPARNLGSMTKTLGSLQLEEITLTLPLTEDVADERTIDVFARIATRVGGEDLPYLVFLQGGPGNEAPRPSLNPL
NPNWLGVALEEYRVVMLDQRGTGRSTPVGNDILEKPTAEVVEYLSHLRADGIVRDAEALRKHLGVNQWNLLGQSFGGFTT
LHYLSRHADSLDNVFITGGLSAIDRPAEDVYANCYNRMRRNSEEFYRRFPQLRETFRGLVNRARAGEIVLPTGEVVSETR
LRSLGHLLGSNDGWFDLYNLLELDPTSNAFVHDLAGLLPFGNRNPIYYVLHESSYADGVVTNWAAERVLPEDFREDPTLL
TGEHVFQEWTDTVPSLKPWKDVALALAQQEWPKLYDAKALENSQAKGAAAVYANDVFVPVDYSLETAQHLPGVQLFITSQ
HEHNGLRASSGAVLKHLFDLAHGREVR

Sequences:

>Translated_427_residues
MVGVVSTPARNLGSMTKTLGSLQLEEITLTLPLTEDVADERTIDVFARIATRVGGEDLPYLVFLQGGPGNEAPRPSLNPL
NPNWLGVALEEYRVVMLDQRGTGRSTPVGNDILEKPTAEVVEYLSHLRADGIVRDAEALRKHLGVNQWNLLGQSFGGFTT
LHYLSRHADSLDNVFITGGLSAIDRPAEDVYANCYNRMRRNSEEFYRRFPQLRETFRGLVNRARAGEIVLPTGEVVSETR
LRSLGHLLGSNDGWFDLYNLLELDPTSNAFVHDLAGLLPFGNRNPIYYVLHESSYADGVVTNWAAERVLPEDFREDPTLL
TGEHVFQEWTDTVPSLKPWKDVALALAQQEWPKLYDAKALENSQAKGAAAVYANDVFVPVDYSLETAQHLPGVQLFITSQ
HEHNGLRASSGAVLKHLFDLAHGREVR
>Mature_427_residues
MVGVVSTPARNLGSMTKTLGSLQLEEITLTLPLTEDVADERTIDVFARIATRVGGEDLPYLVFLQGGPGNEAPRPSLNPL
NPNWLGVALEEYRVVMLDQRGTGRSTPVGNDILEKPTAEVVEYLSHLRADGIVRDAEALRKHLGVNQWNLLGQSFGGFTT
LHYLSRHADSLDNVFITGGLSAIDRPAEDVYANCYNRMRRNSEEFYRRFPQLRETFRGLVNRARAGEIVLPTGEVVSETR
LRSLGHLLGSNDGWFDLYNLLELDPTSNAFVHDLAGLLPFGNRNPIYYVLHESSYADGVVTNWAAERVLPEDFREDPTLL
TGEHVFQEWTDTVPSLKPWKDVALALAQQEWPKLYDAKALENSQAKGAAAVYANDVFVPVDYSLETAQHLPGVQLFITSQ
HEHNGLRASSGAVLKHLFDLAHGREVR

Specific function: Higher activity toward long peptides. Acts on hydroxyproline beta-naphthylamide with almost as high an activity as on proline beta-naphthylamide [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 47496; Mature: 47496

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGVVSTPARNLGSMTKTLGSLQLEEITLTLPLTEDVADERTIDVFARIATRVGGEDLPY
CCCCCCCCHHHHHHHHHHHHCEEEEEEEEEEECCHHHCCHHHHHHHHHHHHHCCCCCCCE
LVFLQGGPGNEAPRPSLNPLNPNWLGVALEEYRVVMLDQRGTGRSTPVGNDILEKPTAEV
EEEEECCCCCCCCCCCCCCCCCCCEEEEHHHEEEEEEECCCCCCCCCCCCHHHCCCHHHH
VEYLSHLRADGIVRDAEALRKHLGVNQWNLLGQSFGGFTTLHYLSRHADSLDNVFITGGL
HHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCH
SAIDRPAEDVYANCYNRMRRNSEEFYRRFPQLRETFRGLVNRARAGEIVLPTGEVVSETR
HHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHH
LRSLGHLLGSNDGWFDLYNLLELDPTSNAFVHDLAGLLPFGNRNPIYYVLHESSYADGVV
HHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHH
TNWAAERVLPEDFREDPTLLTGEHVFQEWTDTVPSLKPWKDVALALAQQEWPKLYDAKAL
HHHHHHHCCCHHHCCCCCEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ENSQAKGAAAVYANDVFVPVDYSLETAQHLPGVQLFITSQHEHNGLRASSGAVLKHLFDL
CCCCCCCCEEEEECCEEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
AHGREVR
HCCCCCC
>Mature Secondary Structure
MVGVVSTPARNLGSMTKTLGSLQLEEITLTLPLTEDVADERTIDVFARIATRVGGEDLPY
CCCCCCCCHHHHHHHHHHHHCEEEEEEEEEEECCHHHCCHHHHHHHHHHHHHCCCCCCCE
LVFLQGGPGNEAPRPSLNPLNPNWLGVALEEYRVVMLDQRGTGRSTPVGNDILEKPTAEV
EEEEECCCCCCCCCCCCCCCCCCCEEEEHHHEEEEEEECCCCCCCCCCCCHHHCCCHHHH
VEYLSHLRADGIVRDAEALRKHLGVNQWNLLGQSFGGFTTLHYLSRHADSLDNVFITGGL
HHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCH
SAIDRPAEDVYANCYNRMRRNSEEFYRRFPQLRETFRGLVNRARAGEIVLPTGEVVSETR
HHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHH
LRSLGHLLGSNDGWFDLYNLLELDPTSNAFVHDLAGLLPFGNRNPIYYVLHESSYADGVV
HHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHH
TNWAAERVLPEDFREDPTLLTGEHVFQEWTDTVPSLKPWKDVALALAQQEWPKLYDAKAL
HHHHHHHCCCHHHCCCCCEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ENSQAKGAAAVYANDVFVPVDYSLETAQHLPGVQLFITSQHEHNGLRASSGAVLKHLFDL
CCCCCCCCEEEEECCEEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
AHGREVR
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883756 [H]