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The map label for this gene is menB [H]

Identifier: 62389361

GI number: 62389361

Start: 484102

End: 485061

Strand: Reverse

Name: menB [H]

Synonym: cg0548

Alternate gene names: 62389361

Gene position: 485061-484102 (Counterclockwise)

Preceding gene: 62389362

Following gene: 62389360

Centisome position: 14.78

GC content: 59.58

Gene sequence:

>960_bases
ATGAGCAACTACAGCACCGACAACCCTTTTGATCCCACCCAATGGGCCACCGTTCCAGGTTTTGAAGAATTCACCGACAT
CACCTACCACCGCCACGTGGGCACCACCCGCGCCGATGGCATCGTGCGCATCGCCTTCGACCGCCCCGAAGTTCGCAATG
CTTTCCGCCCCCACACCGTCGACGAGCTTTACCAAGCCCTCGACCACGCGCGCCGCACCCCAGATGTTGGAACCATCCTG
CTCACCGGCAACGGCCCCAGCGAAAAAGACGGTGGCTGGGCGTTCTGCTCCGGCGGCGACCAACGCATCCGCGGCCGCTC
CGGCTACCAATACGCCACCGAACACGCGCGCGACGATGCCACCGCTGATGTCTCCACGGTAGATATTGCCCGCACCAAAG
TTGAAGGCGGACGCCTCCACATTTTGGAAGTCCAACGCCTCATCCGCACCATGCCTAAAGTTGTCATCGCAGTAGTCAAC
GGCTGGGCAGCCGGCGGTGGGCACTCCCTCCATGTCGTTTGCGACCTCACCATCGCTTCCCGCCAAGAAGCACGCTTCAA
GCAAACCGACGCTGACGTGGGATCCTTCGACGCTGGCTACGGCTCCGCCTACCTAGCGAAAATGGTCGGACAGAAAAACG
CCCGCGAAATCTTCTTCCTCGGACGCACCTACGACGCCGAACGCATGCAACAAATGGGCGCAGTCAACATCGTGGCCGAC
CACGGCGACCTAGAAAAAGAAGCCATCCAAGCAGCCCGCGAAATCAACACCAAATCCCCCACCGCGCAACGCATGCTGAA
ATTCGCCTTCAATCTCACCGACGATGGCCTCATGGGACAACAAGTCTTCGCCGGCGAAGCCACCCGCCTGGCCTACATGA
CGGATGAAGCCGTAGAGGGTAAGGAAGCATTCCTAGAAAAGCGCGAACCCAACTGGAATGAATTCCCTTACTACTACTAG

Upstream 100 bases:

>100_bases
ATGTGGGTGAGATAACCGACCGTGATGTCGCCCTAGCAAAAGTCATCGACGCCCACGCCAAGACCTTGGCCATTTCGGCA
GAGGCTTAAGGTTAAAGATT

Downstream 100 bases:

>100_bases
TGAGTTCATGGGGTCCTAAAACACTTACCGGGTACGAGCTCGGCTGTCTTAATTGTTTTTCATGCCCAGCCTCCGCCTCA
CTTTGAGAGGGGGAGGCTTG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSNYSTDNPFDPTQWATVPGFEEFTDITYHRHVGTTRADGIVRIAFDRPEVRNAFRPHTVDELYQALDHARRTPDVGTIL
LTGNGPSEKDGGWAFCSGGDQRIRGRSGYQYATEHARDDATADVSTVDIARTKVEGGRLHILEVQRLIRTMPKVVIAVVN
GWAAGGGHSLHVVCDLTIASRQEARFKQTDADVGSFDAGYGSAYLAKMVGQKNAREIFFLGRTYDAERMQQMGAVNIVAD
HGDLEKEAIQAAREINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVEGKEAFLEKREPNWNEFPYYY

Sequences:

>Translated_319_residues
MSNYSTDNPFDPTQWATVPGFEEFTDITYHRHVGTTRADGIVRIAFDRPEVRNAFRPHTVDELYQALDHARRTPDVGTIL
LTGNGPSEKDGGWAFCSGGDQRIRGRSGYQYATEHARDDATADVSTVDIARTKVEGGRLHILEVQRLIRTMPKVVIAVVN
GWAAGGGHSLHVVCDLTIASRQEARFKQTDADVGSFDAGYGSAYLAKMVGQKNAREIFFLGRTYDAERMQQMGAVNIVAD
HGDLEKEAIQAAREINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVEGKEAFLEKREPNWNEFPYYY
>Mature_318_residues
SNYSTDNPFDPTQWATVPGFEEFTDITYHRHVGTTRADGIVRIAFDRPEVRNAFRPHTVDELYQALDHARRTPDVGTILL
TGNGPSEKDGGWAFCSGGDQRIRGRSGYQYATEHARDDATADVSTVDIARTKVEGGRLHILEVQRLIRTMPKVVIAVVNG
WAAGGGHSLHVVCDLTIASRQEARFKQTDADVGSFDAGYGSAYLAKMVGQKNAREIFFLGRTYDAERMQQMGAVNIVADH
GDLEKEAIQAAREINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVEGKEAFLEKREPNWNEFPYYY

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=277, Percent_Identity=29.6028880866426, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI31542718, Length=293, Percent_Identity=27.3037542662116, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1788597, Length=306, Percent_Identity=45.7516339869281, Blast_Score=247, Evalue=7e-67,
Organism=Escherichia coli, GI87082183, Length=286, Percent_Identity=26.2237762237762, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787659, Length=285, Percent_Identity=27.0175438596491, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI221142681, Length=283, Percent_Identity=26.1484098939929, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787660, Length=274, Percent_Identity=28.4671532846715, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17540714, Length=265, Percent_Identity=27.5471698113208, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17554946, Length=273, Percent_Identity=26.7399267399267, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=292, Percent_Identity=29.1095890410959, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129971, Length=267, Percent_Identity=27.3408239700375, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653477, Length=267, Percent_Identity=27.3408239700375, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653139, Length=307, Percent_Identity=22.8013029315961, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 35540; Mature: 35409

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYSTDNPFDPTQWATVPGFEEFTDITYHRHVGTTRADGIVRIAFDRPEVRNAFRPHTV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHCCCCCCH
DELYQALDHARRTPDVGTILLTGNGPSEKDGGWAFCSGGDQRIRGRSGYQYATEHARDDA
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCC
TADVSTVDIARTKVEGGRLHILEVQRLIRTMPKVVIAVVNGWAAGGGHSLHVVCDLTIAS
CCCCEEEEHHHEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECC
RQEARFKQTDADVGSFDAGYGSAYLAKMVGQKNAREIFFLGRTYDAERMQQMGAVNIVAD
CHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHCCCEEEEEC
HGDLEKEAIQAAREINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVEG
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECCHHCCH
KEAFLEKREPNWNEFPYYY
HHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SNYSTDNPFDPTQWATVPGFEEFTDITYHRHVGTTRADGIVRIAFDRPEVRNAFRPHTV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHCCCCCCH
DELYQALDHARRTPDVGTILLTGNGPSEKDGGWAFCSGGDQRIRGRSGYQYATEHARDDA
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCC
TADVSTVDIARTKVEGGRLHILEVQRLIRTMPKVVIAVVNGWAAGGGHSLHVVCDLTIAS
CCCCEEEEHHHEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECC
RQEARFKQTDADVGSFDAGYGSAYLAKMVGQKNAREIFFLGRTYDAERMQQMGAVNIVAD
CHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHCCCEEEEEC
HGDLEKEAIQAAREINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVEG
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECCHHCCH
KEAFLEKREPNWNEFPYYY
HHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA