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The map label for this gene is ppx1 [C]

Identifier: 62389308

GI number: 62389308

Start: 433061

End: 433990

Strand: Direct

Name: ppx1 [C]

Synonym: cg0488

Alternate gene names: 62389308

Gene position: 433061-433990 (Clockwise)

Preceding gene: 62389305

Following gene: 62389309

Centisome position: 13.19

GC content: 58.92

Gene sequence:

>930_bases
GTGAGATTAGGTGTATTAGATGTGGGCAGCAATACTGTCCACCTAGTTGCAGTAGACGCGCGTCCCGGTGGACACCCCAC
CCCGATGAGCAATTGGCGTACCCCACTGCGCCTTGTTGAGCTTCTTGATGACTCCGGGGCGATCTCCGAAAAGGGCATCA
ACAAACTCACCTCAGCAGTCGGGGAAGCAGCAGACCTAGCGAAAACGCTCGGCTGCGCTGAACTGATGCCATTTGCTACA
TCGGCAGTCCGCTCCGCCACCAACAGCGAGGCAGTGCTCGACCACGTGGAGAAGGAAACCGGCGTCCGCCTGTCCATCCT
TTCCGGTGAAGACGAAGCACGCCAAACTTTCCTCGCAGTTCGACGTTGGTATGGATGGTCCGCAGGGCGCATAACTAACC
TCGACATCGGTGGCGGCTCCCTGGAACTATCCTCCGGAACCGACGAATCCCCAGACCTCGCGTTCTCACTGGATCTGGGT
GCGGGCCGCTTGACCCACAACTGGTTCGACACCGATCCACCGGCACGTAAGAAAATCAACCTCCTGCGCGATTATATCGA
TGCGGAACTTGCAGAACCCGCCCGCCAGATGCGCACCCTAGGGCCCGCGCGCCTGGCAGTGGGAACATCCAAAACTTTCC
GCACCCTGGCACGACTGACTGGTGCTGCGCCCTCATCCGCAGGACCACACGTCACCCGAACCCTCACCGCGCCGGGTCTG
CGCCAGCTGATCGCATTTATCTCACGAATGACTGCGGCGGACCGCGCTGAGCTGGAAGGTATCAGCTCGGATCGGTCACA
TCAGATCGTGGCAGGTGCGCTAGTTGCGGAAGCTGCGATGCGTGCGTTGGATATTGACAAGGTAGAAATTTGTCCGTGGG
CACTTCGTGAAGGTGTGATCCTCACCAGGATCGACAAAGGACTCGAGTAA

Upstream 100 bases:

>100_bases
TCGATGCCGCCGCTGGCGAAGACTCGGGGAAACCTAAAAATACCGAAGAAGAATTTGACCGATTCACACTTTGCCACCCT
AGACCGTCTAACCTTTAGGT

Downstream 100 bases:

>100_bases
CATTTACCCGGAAAGGAGTTGGCGAAAATGAGTGAAGAGAAACTCACAGTCGCTGAGCTGATGGCGCGTGCCGCGAAAGA
GGGACGCTCCACCGATGCTC

Product: exopolyphosphatase

Products: polyphosphate; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRLGVLDVGSNTVHLVAVDARPGGHPTPMSNWRTPLRLVELLDDSGAISEKGINKLTSAVGEAADLAKTLGCAELMPFAT
SAVRSATNSEAVLDHVEKETGVRLSILSGEDEARQTFLAVRRWYGWSAGRITNLDIGGGSLELSSGTDESPDLAFSLDLG
AGRLTHNWFDTDPPARKKINLLRDYIDAELAEPARQMRTLGPARLAVGTSKTFRTLARLTGAAPSSAGPHVTRTLTAPGL
RQLIAFISRMTAADRAELEGISSDRSHQIVAGALVAEAAMRALDIDKVEICPWALREGVILTRIDKGLE

Sequences:

>Translated_309_residues
MRLGVLDVGSNTVHLVAVDARPGGHPTPMSNWRTPLRLVELLDDSGAISEKGINKLTSAVGEAADLAKTLGCAELMPFAT
SAVRSATNSEAVLDHVEKETGVRLSILSGEDEARQTFLAVRRWYGWSAGRITNLDIGGGSLELSSGTDESPDLAFSLDLG
AGRLTHNWFDTDPPARKKINLLRDYIDAELAEPARQMRTLGPARLAVGTSKTFRTLARLTGAAPSSAGPHVTRTLTAPGL
RQLIAFISRMTAADRAELEGISSDRSHQIVAGALVAEAAMRALDIDKVEICPWALREGVILTRIDKGLE
>Mature_309_residues
MRLGVLDVGSNTVHLVAVDARPGGHPTPMSNWRTPLRLVELLDDSGAISEKGINKLTSAVGEAADLAKTLGCAELMPFAT
SAVRSATNSEAVLDHVEKETGVRLSILSGEDEARQTFLAVRRWYGWSAGRITNLDIGGGSLELSSGTDESPDLAFSLDLG
AGRLTHNWFDTDPPARKKINLLRDYIDAELAEPARQMRTLGPARLAVGTSKTFRTLARLTGAAPSSAGPHVTRTLTAPGL
RQLIAFISRMTAADRAELEGISSDRSHQIVAGALVAEAAMRALDIDKVEICPWALREGVILTRIDKGLE

Specific function: Degradation Of Inorganic Polyphosphates. Orthophosphate Is Released Progressively From The Ends Of Polyphosphate Of Circa 500 Residues Long, While Chains Of Circa 15 Residues Compete Poorly With Polyphosphate As Substrate. [C]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=304, Percent_Identity=23.0263157894737, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788848, Length=298, Percent_Identity=24.496644295302, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: 3.6.1.11 [C]

Molecular weight: Translated: 33038; Mature: 33038

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGVLDVGSNTVHLVAVDARPGGHPTPMSNWRTPLRLVELLDDSGAISEKGINKLTSAV
CEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
GEAADLAKTLGCAELMPFATSAVRSATNSEAVLDHVEKETGVRLSILSGEDEARQTFLAV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
RRWYGWSAGRITNLDIGGGSLELSSGTDESPDLAFSLDLGAGRLTHNWFDTDPPARKKIN
HHHCCCCCCCEEEEECCCCEEEECCCCCCCCCEEEEEECCCCCEECCCCCCCCCHHHHHH
LLRDYIDAELAEPARQMRTLGPARLAVGTSKTFRTLARLTGAAPSSAGPHVTRTLTAPGL
HHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCH
RQLIAFISRMTAADRAELEGISSDRSHQIVAGALVAEAAMRALDIDKVEICPWALREGVI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHCCEE
LTRIDKGLE
EEECCCCCC
>Mature Secondary Structure
MRLGVLDVGSNTVHLVAVDARPGGHPTPMSNWRTPLRLVELLDDSGAISEKGINKLTSAV
CEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
GEAADLAKTLGCAELMPFATSAVRSATNSEAVLDHVEKETGVRLSILSGEDEARQTFLAV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
RRWYGWSAGRITNLDIGGGSLELSSGTDESPDLAFSLDLGAGRLTHNWFDTDPPARKKIN
HHHCCCCCCCEEEEECCCCEEEECCCCCCCCCEEEEEECCCCCEECCCCCCCCCHHHHHH
LLRDYIDAELAEPARQMRTLGPARLAVGTSKTFRTLARLTGAAPSSAGPHVTRTLTAPGL
HHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCH
RQLIAFISRMTAADRAELEGISSDRSHQIVAGALVAEAAMRALDIDKVEICPWALREGVI
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHCCEE
LTRIDKGLE
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Polyphosphate; H2O [C]

Specific reaction: (Polyphosphate)n + H2O = (polyphosphate)n + phosphate [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]