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The map label for this gene is fadE [H]

Identifier: 62389185

GI number: 62389185

Start: 304070

End: 305266

Strand: Direct

Name: fadE [H]

Synonym: cg0346

Alternate gene names: 62389185

Gene position: 304070-305266 (Clockwise)

Preceding gene: 62389184

Following gene: 62389186

Centisome position: 9.26

GC content: 54.14

Gene sequence:

>1197_bases
ATGCGTGATCCCATTCAAGGTGCTGTTATTCCTTCTGATCTTTTTGGTTTCGCAGAAGTTCTCACCGAAGCCGAACGCGC
AGTTCTTCTGGAAACCCGCAGGGTGCTTGAGGAAGAGGTGAAGCCTTATATTAATGAGGCCTGGGATAAGGCAGTCTTCC
CCGATGAGATCGTGCAGCCCCTCCAAGATCTGCAATTGCTTGATCCGCCTGCACTTCGGGAAGCAGGGGAGTCGGTTCGA
GACATTTTCACTGGTTTCCGCAATTTTGAACTCGCGCGCTGTGACATCAATGTTGGTACCTATTACAACGCATCTGCTGG
TCTCTTCCGAACGGCCTGCATGGTTGGTGGCTCCCCGGAGCAGGCGCAGCGATTGGATGCGCAGATCAAATCTGGTGAGG
TCAAGGGCGTTTTTGCACTGACGGAACCTGATCATGGCTCTGATATCGCAGGTGGTCTGGCAACCACGGCCACTAAGGAC
GCAGACACCGGCGAGTGGATTATCAATGGTGAAAAACGGTGGATCGGTGGTGCTTCCACTGCTGATTTGATCGCTACCTT
CGCCAGGGATACAGCCGATAACCAGGTGAAATGCTTCCTCGTGGCACCTCAGGCAGAGGGCGTGTCCATGGAGATTATTG
ATCGCAAAGCCTCACTGCGCATCATGCAAAATGCACACATTACCTATAACAATGTCCGGGTGTCTGGGGATGCGCGGCTG
CACAACATCAATTCTTTCAAGGATGTTTCGGAATGCCTGCGCCGTATGCGTTCCGATGTGGCGTGGATGGCGGTCGGTGC
GCAGGCAGGTGCCTATGAAGCAGCCGTGAAGTATGTGCGCAGCAGGGAACAGTTTGGCCGTCCGATCGCGGGGTTCCAGT
TGATTCAGGAAAAGCTCGCGCTCATGCTGGGCAATCTCACGGCGTCGCTGGGCATGATGGTCAAACTCACCGATCAGCAG
CAGGCGGGAATTTTCAAAGAGGAAAACTCCGCGCTGGCGAAAATGTTTACCTCGCTCAAACTTCGGGAGACCGCTAGTTG
GGCGCGGGAAATCTGCGGAGGCAACGGCATCATTTTGGACAACGATGTTGCCCGGTTCCATGCCGATGCAGAAGCCGTCT
ATTCATATGAAGGCACCCACGAAATCAATGCACTCATCGTTGGTCGCGCCATCACGGGCGTCAGCGCTTTTATCTAA

Upstream 100 bases:

>100_bases
GATGAGGTTCGTCCGGGAATCCTCAAAGACAATGCGGTGAAGGTACTTGGCCTAGCCGCTAGCACTGAGCGCGGATCTCA
AGCAGAAAAGGTCGTGCAAC

Downstream 100 bases:

>100_bases
CACACTTTTAAGGAGAACATCATGACTACTTCCACCACCCCAAACACCATCGTTTCTTTCGAAGACGCACCAACCCTCAC
CGGCCAGGACCTGGGCTTTT

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRDPIQGAVIPSDLFGFAEVLTEAERAVLLETRRVLEEEVKPYINEAWDKAVFPDEIVQPLQDLQLLDPPALREAGESVR
DIFTGFRNFELARCDINVGTYYNASAGLFRTACMVGGSPEQAQRLDAQIKSGEVKGVFALTEPDHGSDIAGGLATTATKD
ADTGEWIINGEKRWIGGASTADLIATFARDTADNQVKCFLVAPQAEGVSMEIIDRKASLRIMQNAHITYNNVRVSGDARL
HNINSFKDVSECLRRMRSDVAWMAVGAQAGAYEAAVKYVRSREQFGRPIAGFQLIQEKLALMLGNLTASLGMMVKLTDQQ
QAGIFKEENSALAKMFTSLKLRETASWAREICGGNGIILDNDVARFHADAEAVYSYEGTHEINALIVGRAITGVSAFI

Sequences:

>Translated_398_residues
MRDPIQGAVIPSDLFGFAEVLTEAERAVLLETRRVLEEEVKPYINEAWDKAVFPDEIVQPLQDLQLLDPPALREAGESVR
DIFTGFRNFELARCDINVGTYYNASAGLFRTACMVGGSPEQAQRLDAQIKSGEVKGVFALTEPDHGSDIAGGLATTATKD
ADTGEWIINGEKRWIGGASTADLIATFARDTADNQVKCFLVAPQAEGVSMEIIDRKASLRIMQNAHITYNNVRVSGDARL
HNINSFKDVSECLRRMRSDVAWMAVGAQAGAYEAAVKYVRSREQFGRPIAGFQLIQEKLALMLGNLTASLGMMVKLTDQQ
QAGIFKEENSALAKMFTSLKLRETASWAREICGGNGIILDNDVARFHADAEAVYSYEGTHEINALIVGRAITGVSAFI
>Mature_398_residues
MRDPIQGAVIPSDLFGFAEVLTEAERAVLLETRRVLEEEVKPYINEAWDKAVFPDEIVQPLQDLQLLDPPALREAGESVR
DIFTGFRNFELARCDINVGTYYNASAGLFRTACMVGGSPEQAQRLDAQIKSGEVKGVFALTEPDHGSDIAGGLATTATKD
ADTGEWIINGEKRWIGGASTADLIATFARDTADNQVKCFLVAPQAEGVSMEIIDRKASLRIMQNAHITYNNVRVSGDARL
HNINSFKDVSECLRRMRSDVAWMAVGAQAGAYEAAVKYVRSREQFGRPIAGFQLIQEKLALMLGNLTASLGMMVKLTDQQ
QAGIFKEENSALAKMFTSLKLRETASWAREICGGNGIILDNDVARFHADAEAVYSYEGTHEINALIVGRAITGVSAFI

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=391, Percent_Identity=34.0153452685422, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI7669494, Length=371, Percent_Identity=31.8059299191375, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=28.8770053475936, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI76496475, Length=405, Percent_Identity=28.1481481481481, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI4557235, Length=405, Percent_Identity=28.1481481481481, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI4501857, Length=368, Percent_Identity=25, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI21361497, Length=362, Percent_Identity=25.414364640884, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4501859, Length=386, Percent_Identity=25.1295336787565, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=24.1469816272966, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4557231, Length=383, Percent_Identity=25.3263707571802, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI187960098, Length=383, Percent_Identity=25.3263707571802, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI226958414, Length=309, Percent_Identity=25.2427184466019, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI7656849, Length=284, Percent_Identity=24.6478873239437, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI218563752, Length=260, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786223, Length=361, Percent_Identity=28.2548476454294, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081958, Length=281, Percent_Identity=28.8256227758007, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=386, Percent_Identity=31.6062176165803, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=389, Percent_Identity=28.0205655526992, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17538396, Length=393, Percent_Identity=27.2264631043257, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=25.4641909814324, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=25.9640102827763, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=255, Percent_Identity=28.2352941176471, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534899, Length=285, Percent_Identity=28.7719298245614, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71985184, Length=344, Percent_Identity=24.4186046511628, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=377, Percent_Identity=25.1989389920424, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985192, Length=256, Percent_Identity=25.390625, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32563615, Length=212, Percent_Identity=28.3018867924528, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17533517, Length=269, Percent_Identity=27.5092936802974, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=281, Percent_Identity=25.9786476868327, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920834, Length=393, Percent_Identity=34.0966921119593, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=28.8311688311688, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=25, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356377, Length=386, Percent_Identity=26.9430051813472, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24646207, Length=382, Percent_Identity=27.7486910994764, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281363737, Length=413, Percent_Identity=24.6973365617433, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21355753, Length=309, Percent_Identity=27.1844660194175, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43529; Mature: 43529

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPIQGAVIPSDLFGFAEVLTEAERAVLLETRRVLEEEVKPYINEAWDKAVFPDEIVQP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LQDLQLLDPPALREAGESVRDIFTGFRNFELARCDINVGTYYNASAGLFRTACMVGGSPE
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEECCCCHHHHHHHHCCCCHH
QAQRLDAQIKSGEVKGVFALTEPDHGSDIAGGLATTATKDADTGEWIINGEKRWIGGAST
HHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEECCCEEEECCCCH
ADLIATFARDTADNQVKCFLVAPQAEGVSMEIIDRKASLRIMQNAHITYNNVRVSGDARL
HHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEECCHHHEEEEECCCEEEEEEEEECCCEE
HNINSFKDVSECLRRMRSDVAWMAVGAQAGAYEAAVKYVRSREQFGRPIAGFQLIQEKLA
ECCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LMLGNLTASLGMMVKLTDQQQAGIFKEENSALAKMFTSLKLRETASWAREICGGNGIILD
HHHHHHHHHHCEEEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
NDVARFHADAEAVYSYEGTHEINALIVGRAITGVSAFI
CCHHHHHCCHHHHEECCCCCCEEEEEEEHHHHHHHHCC
>Mature Secondary Structure
MRDPIQGAVIPSDLFGFAEVLTEAERAVLLETRRVLEEEVKPYINEAWDKAVFPDEIVQP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LQDLQLLDPPALREAGESVRDIFTGFRNFELARCDINVGTYYNASAGLFRTACMVGGSPE
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEECCCCHHHHHHHHCCCCHH
QAQRLDAQIKSGEVKGVFALTEPDHGSDIAGGLATTATKDADTGEWIINGEKRWIGGAST
HHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEECCCEEEECCCCH
ADLIATFARDTADNQVKCFLVAPQAEGVSMEIIDRKASLRIMQNAHITYNNVRVSGDARL
HHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEECCHHHEEEEECCCEEEEEEEEECCCEE
HNINSFKDVSECLRRMRSDVAWMAVGAQAGAYEAAVKYVRSREQFGRPIAGFQLIQEKLA
ECCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LMLGNLTASLGMMVKLTDQQQAGIFKEENSALAKMFTSLKLRETASWAREICGGNGIILD
HHHHHHHHHHCEEEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
NDVARFHADAEAVYSYEGTHEINALIVGRAITGVSAFI
CCHHHHHCCHHHHEECCCCCCEEEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]