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The map label for this gene is arsC1 [H]

Identifier: 62389160

GI number: 62389160

Start: 278814

End: 279896

Strand: Direct

Name: arsC1 [H]

Synonym: cg0318

Alternate gene names: 62389160

Gene position: 278814-279896 (Clockwise)

Preceding gene: 62389157

Following gene: 62389161

Centisome position: 8.49

GC content: 49.22

Gene sequence:

>1083_bases
ATGACCCTTACTAAAGAGCATTCGACACCTCGAGCGGCTGGCTCAATGTCGTTTCTTGACCGCTGGTTAGCTGCCTGGAT
TTTCTTGGCTATGGCTGCTGGGTTGTTAATCGGCAAGGTCTTTCCAGGAATTGGGGCGCTTTTGAGCGCGGTGGAAATTG
GTGGAATTTCCATTCCAATTGCTATCGGTTTGATCGTCATGATGTATCCACCTTTGGCCAAGGTGCGCTACGACAAAACT
AAAGAAATCAGCACAGACCGCGCTCTCATGGTGGTGTCGATTATGTTGAACTGGATCGTTGGACCAGCACTTATGTTTAG
CCTGGCGTGGCTGTTTCTTCCAGATCAACCAGAGCTTCGCACTGGGCTAATTATCGTGGGCCTTGCGCGCTGTATCGCGA
TGGTTTTGGTATGGAGTGATCTCGCTTGTGGTGACCGGGAAGCAACTGCTGTGCTGGTTGCAATCAACTCGGTGTTCCAG
ATCCTTATGTTCGGTGTGCTTGGTTGGTTTTACCTGCAGATTCTTCCCTCGTGGCTGGGATTAGACACCACGTCGGTGAC
TTTCTCTGTGGTATCAATCGTGACTTCCGTTCTCGTGTTCTTGGGCATACCACTTGTAGCTGGAGTTTTATCTCGCGTCA
TTGGTGAAAAAACAAAGGGACGGCGCTGGTACGAGGACACGTTCCTGCCTAAGATTTCACCCTTGGCGCTGATTGGCTTG
CTATACACAATTGTTCTGCTGTTTTCGTTGCAGGGGGATGAAATCACAGCGCAGCCTTGGACAGTAGCTCGTCTTGCATT
GCCGCTGCTGATGTACTTTGTGGGCATGTTTTTCATTTCCCTGGTGGTATCCAAACTGTCCGGGTTAACTTATGAGCGAG
CTGCTTCCGTGTCTTTTACTGCAGCAGGAAACAACTTTGAATTAGCGATTGCGGTATCGATCGGAACCTTTGGTGCGACA
TCACCGCAGGCATTAGCTGGAACGATCGGCCCTTTGATTGAAGTCCCAGTATTAGTCGGATTGGTTTATGTCATGTTGTG
GCTTGGACCAAAAATCTTTAAAAAGGAGAATGCAGGATCATGA

Upstream 100 bases:

>100_bases
GGTGGATGGGTGCGGTCATGTCCGTCATTATATATAGACGCACATCGATATTGAAGGTATTTTTATATCGGCAAACATCA
ATATGATTGAAGGCTGGCTC

Downstream 100 bases:

>100_bases
AATCAGTTTTGTTTGTGTGCGTCGGTAATGGCGGAAAATCACAGATGGCGGCGGCGCTGGCACAGAAGTATGCATCAGAT
TCAGTAGAGATCCATTCTGC

Product: heavy metal resistance membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTLTKEHSTPRAAGSMSFLDRWLAAWIFLAMAAGLLIGKVFPGIGALLSAVEIGGISIPIAIGLIVMMYPPLAKVRYDKT
KEISTDRALMVVSIMLNWIVGPALMFSLAWLFLPDQPELRTGLIIVGLARCIAMVLVWSDLACGDREATAVLVAINSVFQ
ILMFGVLGWFYLQILPSWLGLDTTSVTFSVVSIVTSVLVFLGIPLVAGVLSRVIGEKTKGRRWYEDTFLPKISPLALIGL
LYTIVLLFSLQGDEITAQPWTVARLALPLLMYFVGMFFISLVVSKLSGLTYERAASVSFTAAGNNFELAIAVSIGTFGAT
SPQALAGTIGPLIEVPVLVGLVYVMLWLGPKIFKKENAGS

Sequences:

>Translated_360_residues
MTLTKEHSTPRAAGSMSFLDRWLAAWIFLAMAAGLLIGKVFPGIGALLSAVEIGGISIPIAIGLIVMMYPPLAKVRYDKT
KEISTDRALMVVSIMLNWIVGPALMFSLAWLFLPDQPELRTGLIIVGLARCIAMVLVWSDLACGDREATAVLVAINSVFQ
ILMFGVLGWFYLQILPSWLGLDTTSVTFSVVSIVTSVLVFLGIPLVAGVLSRVIGEKTKGRRWYEDTFLPKISPLALIGL
LYTIVLLFSLQGDEITAQPWTVARLALPLLMYFVGMFFISLVVSKLSGLTYERAASVSFTAAGNNFELAIAVSIGTFGAT
SPQALAGTIGPLIEVPVLVGLVYVMLWLGPKIFKKENAGS
>Mature_359_residues
TLTKEHSTPRAAGSMSFLDRWLAAWIFLAMAAGLLIGKVFPGIGALLSAVEIGGISIPIAIGLIVMMYPPLAKVRYDKTK
EISTDRALMVVSIMLNWIVGPALMFSLAWLFLPDQPELRTGLIIVGLARCIAMVLVWSDLACGDREATAVLVAINSVFQI
LMFGVLGWFYLQILPSWLGLDTTSVTFSVVSIVTSVLVFLGIPLVAGVLSRVIGEKTKGRRWYEDTFLPKISPLALIGLL
YTIVLLFSLQGDEITAQPWTVARLALPLLMYFVGMFFISLVVSKLSGLTYERAASVSFTAAGNNFELAIAVSIGTFGATS
PQALAGTIGPLIEVPVLVGLVYVMLWLGPKIFKKENAGS

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=328, Percent_Identity=36.5853658536585, Blast_Score=177, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 38848; Mature: 38717

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTKEHSTPRAAGSMSFLDRWLAAWIFLAMAAGLLIGKVFPGIGALLSAVEIGGISIPI
CCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AIGLIVMMYPPLAKVRYDKTKEISTDRALMVVSIMLNWIVGPALMFSLAWLFLPDQPELR
HHHHHHHHCCCHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
TGLIIVGLARCIAMVLVWSDLACGDREATAVLVAINSVFQILMFGVLGWFYLQILPSWLG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDTTSVTFSVVSIVTSVLVFLGIPLVAGVLSRVIGEKTKGRRWYEDTFLPKISPLALIGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHH
LYTIVLLFSLQGDEITAQPWTVARLALPLLMYFVGMFFISLVVSKLSGLTYERAASVSFT
HHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEE
AAGNNFELAIAVSIGTFGATSPQALAGTIGPLIEVPVLVGLVYVMLWLGPKIFKKENAGS
ECCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCC
>Mature Secondary Structure 
TLTKEHSTPRAAGSMSFLDRWLAAWIFLAMAAGLLIGKVFPGIGALLSAVEIGGISIPI
CCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AIGLIVMMYPPLAKVRYDKTKEISTDRALMVVSIMLNWIVGPALMFSLAWLFLPDQPELR
HHHHHHHHCCCHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
TGLIIVGLARCIAMVLVWSDLACGDREATAVLVAINSVFQILMFGVLGWFYLQILPSWLG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDTTSVTFSVVSIVTSVLVFLGIPLVAGVLSRVIGEKTKGRRWYEDTFLPKISPLALIGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHH
LYTIVLLFSLQGDEITAQPWTVARLALPLLMYFVGMFFISLVVSKLSGLTYERAASVSFT
HHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEE
AAGNNFELAIAVSIGTFGATSPQALAGTIGPLIEVPVLVGLVYVMLWLGPKIFKKENAGS
ECCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]