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The map label for this gene is dnaZX [H]

Identifier: 62389140

GI number: 62389140

Start: 258552

End: 260879

Strand: Direct

Name: dnaZX [H]

Synonym: cg0296

Alternate gene names: 62389140

Gene position: 258552-260879 (Clockwise)

Preceding gene: 62389139

Following gene: 62389141

Centisome position: 7.88

GC content: 60.22

Gene sequence:

>2328_bases
GTGGCTTTGTATAGCAAGTATCGACCGGCAAGTTTTGGTGAACTAGTTGGGCAGTCGCAAGTGACTGACCCTCTGTCCGC
AGCTTTGGATAGCGGGCGCATCAACCATGCGTACCTTTTTTCGGGTCCGCGTGGTTGTGGCAAGACGTCGTCGGCACGCA
TCCTTGCCCGGTCCCTCAACTGCGTGGAAGGCCCAACTTCCACGCCGTGTGGGGTGTGTAATTCTTGCGTAGCGCTGGCC
CCGGGTGGCCCTGGAACCCTTGATGTAACAGAGCTCGACGCCGCGAGTAACAATGGTGTCGATGACATGCGTGAACTGCG
CGAACGCGCGAACTACGCCCCGGCGGAATCTCGCTACCGCGTGTTCATCATTGACGAAGCCCACATGATCAGTACCCAAG
GCTTCAACGCCTTGCTGAAAATCGTTGAAGAGCCACCAGCGCACCTGATTTTCATCTTCGCCACCACCGAGCCGGACAAA
ATGATCGGTACGATCCGTTCCCGCACGCACAATTACCCATTCCGCCTGCTCACCCCAGGGGATATGCGCAAAGTGCTGAA
AAATGCGGTCGATGGCGAAGGCGTCCACGTCGACGATTCCGTTTACCCACTGGTCATCCGCGCCGGCGGCGGCAGCCCCC
GCGACAGCCTCTCCATCCTCGACCAGCTCATCGCCGGCTCGGGCCCGGAGGGCTTGACATATGAGCGCGCCTTGCCGCTG
CTCGGTGTCACAAGCTTCACGCTTATCGACGATTCGATCCATGCCCTTGCATCTAAAGACAACGCAAGCATGTTCACCAC
GATCGATAACGTCATCGAAGAAGGCCTCGAACCGCGACGCTTCACGATCGACCTCCTCGACCGCCTCCGCGACTTGATGG
TCCTCCAAGCCGTCCCAGAAGCACTAAACCTCGGGCTTGTCGACGCCCCCACCGACCGCGCCGACGCCCTAATCGAACAA
TCCACCCTGTTCAAAGGCAACGAGCTCGCCAACCTAGCCTCCATGGTGAACTCCGGACTCGACGACATGCGTGGTGCCAC
CTCACCGCGCCTCCTTCTGGAAATCCTCTGCGCCCGACTGCTCCTGGCAAGCAATACCGTGGCAGGTCCAGCGGTCAGTA
GTTCGACTGACGCTGCGCCTGCAGCTACTCCGGGTGGTCTCACTGGTATTGCTGCTGCCCGCGCGAAAGCACGGGAGTAT
GGACAGAAGAAGGCAGCTCCAGCTCCTGCACCAACTCCTGCGCCCGAGCCAGTGCGCGAACAGTCTCTTGCACCAACGCC
TGAACCAACGCCAGCGGCTGAACCTACATCTCAGCCCGCGCCGGAACCGGAACCCGCCAGGGAACCAGTGGTGGAAGTGC
GGGAGGCGAGCGTCGAAAAGCAGCCTGCAAGCAGTGATCCCCTCGAAACCATTCGAAGCCGCTGGTCAGAGCTGCGCAAC
ATCGTGGAAAAACAAAGTGTGCGCACCTCAATCATGCTGACCGAAGCGCGAGTTTTGGGACTGCGAGGCGATACCCTCGT
GCTCGGTCACAGCACCGGGGCGTTGGCTGCGCGTTTGAACGCTGCTGATCACAACGGAATTTTGGTCAAGGTGTTGGCTG
AGGAAACTGGTCTGCAGCTCAAGGTCGAATGCATTGTGGGCACGAACCCAGCCGAAGCTGGATTTACCGCCCAGCCTGCT
GTGCAAAAGAGCACGTGGAACCCCAACTACGACTCCAAACCAGCCACTCCAAGTGCGCCTGCGCAGCCTCAGACGCCTAA
GCAAGAATCCGTGCCCACCGAGCCAGAGGAGCCTGAGAGTTCGGCTGAAACTTCGGGATGGGGGCAACCGGTAAAAATCG
GTGGGCCAGCACCTGAGGCACAGACTCCAACGCCTCCGCCTGCTCCGGTGGTTCCGGCTACTCCTGCTGCTCCGGCTGCG
GGTGCTGCGAAACCAGCGTGGAAGGAACGCGTCGAACAAGCCGCGGCAAATGCAGCGCAACAACGTCAGCATCGCCAGGG
CAGCTCCGAGCCCTTCGAGCGGGGTGTTCCGCTGCCACCAGAACCTGACCTGCCACCGGACCCCTATGGATACCCAGCTG
ACGAGGGTTTCCCCGAACGAAACCAAGGGTTCCAGCAACAGCCAGCGCCTCCCGTTGAGCAACCAGCTCCTGAGCCTGCG
ACGGAGCCAGTTCCAGCAGTTGCGCCTGAGCCGGAGGTCAGCCAGCTATCTGAAGAAGAGCAGCTGATCCGCGAAGCAGA
CGAAGAGCCAGGTGAAATGGATCGTCGTGATGCGAAAACCATCGCGATGGAACTGCTTGCTCAGGAACTCGGCGCGAAAC
CTTTGTAA

Upstream 100 bases:

>100_bases
CATCGCTCTCAACGAGGGCAGCGACGTCATGTTCGAACGAATGGCGGAGCAAGAAGTCGATCTTCTGGATCTGAAACGTT
AAGACGGTAGGCTCAATTCC

Downstream 100 bases:

>100_bases
GACTCGTTTGTAAGCCGAGAGCGAACCTGCCAAAAGTAAGGGGCGGGTTCGCGGTGACGTCGGTAGGATCGAGCGAAGAA
ACCAACAAACTTCTTAGGAG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 775; Mature: 774

Protein sequence:

>775_residues
MALYSKYRPASFGELVGQSQVTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALA
PGGPGTLDVTELDAASNNGVDDMRELRERANYAPAESRYRVFIIDEAHMISTQGFNALLKIVEEPPAHLIFIFATTEPDK
MIGTIRSRTHNYPFRLLTPGDMRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPL
LGVTSFTLIDDSIHALASKDNASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEALNLGLVDAPTDRADALIEQ
STLFKGNELANLASMVNSGLDDMRGATSPRLLLEILCARLLLASNTVAGPAVSSSTDAAPAATPGGLTGIAAARAKAREY
GQKKAAPAPAPTPAPEPVREQSLAPTPEPTPAAEPTSQPAPEPEPAREPVVEVREASVEKQPASSDPLETIRSRWSELRN
IVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGALAARLNAADHNGILVKVLAEETGLQLKVECIVGTNPAEAGFTAQPA
VQKSTWNPNYDSKPATPSAPAQPQTPKQESVPTEPEEPESSAETSGWGQPVKIGGPAPEAQTPTPPPAPVVPATPAAPAA
GAAKPAWKERVEQAAANAAQQRQHRQGSSEPFERGVPLPPEPDLPPDPYGYPADEGFPERNQGFQQQPAPPVEQPAPEPA
TEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMDRRDAKTIAMELLAQELGAKPL

Sequences:

>Translated_775_residues
MALYSKYRPASFGELVGQSQVTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALA
PGGPGTLDVTELDAASNNGVDDMRELRERANYAPAESRYRVFIIDEAHMISTQGFNALLKIVEEPPAHLIFIFATTEPDK
MIGTIRSRTHNYPFRLLTPGDMRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPL
LGVTSFTLIDDSIHALASKDNASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEALNLGLVDAPTDRADALIEQ
STLFKGNELANLASMVNSGLDDMRGATSPRLLLEILCARLLLASNTVAGPAVSSSTDAAPAATPGGLTGIAAARAKAREY
GQKKAAPAPAPTPAPEPVREQSLAPTPEPTPAAEPTSQPAPEPEPAREPVVEVREASVEKQPASSDPLETIRSRWSELRN
IVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGALAARLNAADHNGILVKVLAEETGLQLKVECIVGTNPAEAGFTAQPA
VQKSTWNPNYDSKPATPSAPAQPQTPKQESVPTEPEEPESSAETSGWGQPVKIGGPAPEAQTPTPPPAPVVPATPAAPAA
GAAKPAWKERVEQAAANAAQQRQHRQGSSEPFERGVPLPPEPDLPPDPYGYPADEGFPERNQGFQQQPAPPVEQPAPEPA
TEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMDRRDAKTIAMELLAQELGAKPL
>Mature_774_residues
ALYSKYRPASFGELVGQSQVTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLNCVEGPTSTPCGVCNSCVALAP
GGPGTLDVTELDAASNNGVDDMRELRERANYAPAESRYRVFIIDEAHMISTQGFNALLKIVEEPPAHLIFIFATTEPDKM
IGTIRSRTHNYPFRLLTPGDMRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPLL
GVTSFTLIDDSIHALASKDNASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPEALNLGLVDAPTDRADALIEQS
TLFKGNELANLASMVNSGLDDMRGATSPRLLLEILCARLLLASNTVAGPAVSSSTDAAPAATPGGLTGIAAARAKAREYG
QKKAAPAPAPTPAPEPVREQSLAPTPEPTPAAEPTSQPAPEPEPAREPVVEVREASVEKQPASSDPLETIRSRWSELRNI
VEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGALAARLNAADHNGILVKVLAEETGLQLKVECIVGTNPAEAGFTAQPAV
QKSTWNPNYDSKPATPSAPAQPQTPKQESVPTEPEEPESSAETSGWGQPVKIGGPAPEAQTPTPPPAPVVPATPAAPAAG
AAKPAWKERVEQAAANAAQQRQHRQGSSEPFERGVPLPPEPDLPPDPYGYPADEGFPERNQGFQQQPAPPVEQPAPEPAT
EPVPAVAPEPEVSQLSEEEQLIREADEEPGEMDRRDAKTIAMELLAQELGAKPL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=304, Percent_Identity=40.1315789473684, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1787341, Length=148, Percent_Identity=31.7567567567568, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 82164; Mature: 82033

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYSKYRPASFGELVGQSQVTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLN
CCCCCCCCCCHHHHHHCCHHCCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
CVEGPTSTPCGVCNSCVALAPGGPGTLDVTELDAASNNGVDDMRELRERANYAPAESRYR
HCCCCCCCCHHHHCCCEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEE
VFIIDEAHMISTQGFNALLKIVEEPPAHLIFIFATTEPDKMIGTIRSRTHNYPFRLLTPG
EEEEECCHHCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEECCH
DMRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPL
HHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCH
LGVTSFTLIDDSIHALASKDNASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPE
HCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHH
ALNLGLVDAPTDRADALIEQSTLFKGNELANLASMVNSGLDDMRGATSPRLLLEILCARL
HHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHH
LLASNTVAGPAVSSSTDAAPAATPGGLTGIAAARAKAREYGQKKAAPAPAPTPAPEPVRE
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
QSLAPTPEPTPAAEPTSQPAPEPEPAREPVVEVREASVEKQPASSDPLETIRSRWSELRN
HCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGALAARLNAADHNGILVKVLAEETGLQL
HHHHHHHHHHHEEEHHHHEECCCCEEEEECCCCCHHHEECCCCCCCEEEEEEECCCCCEE
KVECIVGTNPAEAGFTAQPAVQKSTWNPNYDSKPATPSAPAQPQTPKQESVPTEPEEPES
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SAETSGWGQPVKIGGPAPEAQTPTPPPAPVVPATPAAPAAGAAKPAWKERVEQAAANAAQ
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QRQHRQGSSEPFERGVPLPPEPDLPPDPYGYPADEGFPERNQGFQQQPAPPVEQPAPEPA
HHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMDRRDAKTIAMELLAQELGAKPL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALYSKYRPASFGELVGQSQVTDPLSAALDSGRINHAYLFSGPRGCGKTSSARILARSLN
CCCCCCCCCHHHHHHCCHHCCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
CVEGPTSTPCGVCNSCVALAPGGPGTLDVTELDAASNNGVDDMRELRERANYAPAESRYR
HCCCCCCCCHHHHCCCEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEE
VFIIDEAHMISTQGFNALLKIVEEPPAHLIFIFATTEPDKMIGTIRSRTHNYPFRLLTPG
EEEEECCHHCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEECCH
DMRKVLKNAVDGEGVHVDDSVYPLVIRAGGGSPRDSLSILDQLIAGSGPEGLTYERALPL
HHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCH
LGVTSFTLIDDSIHALASKDNASMFTTIDNVIEEGLEPRRFTIDLLDRLRDLMVLQAVPE
HCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHH
ALNLGLVDAPTDRADALIEQSTLFKGNELANLASMVNSGLDDMRGATSPRLLLEILCARL
HHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHH
LLASNTVAGPAVSSSTDAAPAATPGGLTGIAAARAKAREYGQKKAAPAPAPTPAPEPVRE
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
QSLAPTPEPTPAAEPTSQPAPEPEPAREPVVEVREASVEKQPASSDPLETIRSRWSELRN
HCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
IVEKQSVRTSIMLTEARVLGLRGDTLVLGHSTGALAARLNAADHNGILVKVLAEETGLQL
HHHHHHHHHHHEEEHHHHEECCCCEEEEECCCCCHHHEECCCCCCCEEEEEEECCCCCEE
KVECIVGTNPAEAGFTAQPAVQKSTWNPNYDSKPATPSAPAQPQTPKQESVPTEPEEPES
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SAETSGWGQPVKIGGPAPEAQTPTPPPAPVVPATPAAPAAGAAKPAWKERVEQAAANAAQ
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QRQHRQGSSEPFERGVPLPPEPDLPPDPYGYPADEGFPERNQGFQQQPAPPVEQPAPEPA
HHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TEPVPAVAPEPEVSQLSEEEQLIREADEEPGEMDRRDAKTIAMELLAQELGAKPL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]