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The map label for this gene is adhA [H]

Identifier: 62389120

GI number: 62389120

Start: 236327

End: 237346

Strand: Direct

Name: adhA [H]

Synonym: cg0273

Alternate gene names: 62389120

Gene position: 236327-237346 (Clockwise)

Preceding gene: 62389117

Following gene: 62389121

Centisome position: 7.2

GC content: 52.84

Gene sequence:

>1020_bases
ATGCCCAAATACATTGCCATGCAGGTATCCGAATCCGGTGCACCGTTAGCCGCGAATCTCGTGCAACCTGCTCCGTTGAA
ATCGAGGGAAGTCCGCGTGGAAATCGCTGCTAGTGGTGTGTGCCATGCAGATATTGGCACGGCAGCAGCATCGGGGAAGC
ACACTGTTTTTCCTGTTACCCCTGGTCATGAGATTGCAGGAACCATCGCGGAAATTGGTGAAAACGTATCTCGGTGGACG
GTTGGTGATCGCGTTGCAATCGGTTGGTTTGGTGGCAATTGCGGTGACTGCGCTTTTTGTCGTGCAGGTGATCCTGTGCA
TTGCAGAGAGCGGAAGATTCCTGGCGTTTCTTATGCGGGTGGTTGGGCACAGAATATTGTTGTTCCAGCGGAGGCTCTTG
CTGCGATTCCAGATGGCATGGACTTTTACGAGGCCGCCCCGATGGGCTGCGCAGGTGTGACAACATTCAATGCGTTGCGA
AACCTGAAGCTGGATCCCGGTGCGGCTGTCGCGGTCTTTGGAATCGGCGGTTTAGTGCGCCTAGCTATTCAGTTTGCTGC
GAAAATGGGTTATCGAACCATCACCATCGCCCGCGGTTTAGAGCGTGAGGAGCTAGCTAGGCAACTTGGCGCCAACCACT
ACATCGATAGCAATGATCTGCACCCTGGCCAGGCGTTATTTGAACTTGGCGGGGCTGACTTGATCTTGTCTACTGCGTCC
ACCACGGAGCCTCTTTCGGAGTTGTCTACCGGTCTTTCTATTGGCGGGCAGCTAACCATTATCGGAGTTGATGGGGGAGA
TATCACCGTTTCGGCAGCCCAATTGATGATGAACCGTCAGATCATCACAGGTCACCTCACTGGAAGTGCGAATGACACGG
AACAGACTATGAAATTTGCTCATCTCCATGGCGTGAAACCGCTTATTGAACGGATGCCTCTCGATCAAGCCAACGAGGCT
ATTGCACGTATTTCAGCTGGTAAACCACGTTTCCGTATTGTCTTGGAGCCGAATTCATAA

Upstream 100 bases:

>100_bases
CCCCCTTATTCAGAGTGATGGTCTACCGGAGAAGTACCCAGACCAATAGCATCGACCAACGATAGCGCGCTCAGAAGTTC
TTTAGTGAAAGCAGAACCAA

Downstream 100 bases:

>100_bases
TGCCAACAGCAAGCCCAATTTATGATGTCGTTGTCGTCGGAGCCGGCATTTCTGGCCTCATCGCCACGCAACTGTTGGAC
CGCGCAGGTCTAAACATCAA

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPKYIAMQVSESGAPLAANLVQPAPLKSREVRVEIAASGVCHADIGTAAASGKHTVFPVTPGHEIAGTIAEIGENVSRWT
VGDRVAIGWFGGNCGDCAFCRAGDPVHCRERKIPGVSYAGGWAQNIVVPAEALAAIPDGMDFYEAAPMGCAGVTTFNALR
NLKLDPGAAVAVFGIGGLVRLAIQFAAKMGYRTITIARGLEREELARQLGANHYIDSNDLHPGQALFELGGADLILSTAS
TTEPLSELSTGLSIGGQLTIIGVDGGDITVSAAQLMMNRQIITGHLTGSANDTEQTMKFAHLHGVKPLIERMPLDQANEA
IARISAGKPRFRIVLEPNS

Sequences:

>Translated_339_residues
MPKYIAMQVSESGAPLAANLVQPAPLKSREVRVEIAASGVCHADIGTAAASGKHTVFPVTPGHEIAGTIAEIGENVSRWT
VGDRVAIGWFGGNCGDCAFCRAGDPVHCRERKIPGVSYAGGWAQNIVVPAEALAAIPDGMDFYEAAPMGCAGVTTFNALR
NLKLDPGAAVAVFGIGGLVRLAIQFAAKMGYRTITIARGLEREELARQLGANHYIDSNDLHPGQALFELGGADLILSTAS
TTEPLSELSTGLSIGGQLTIIGVDGGDITVSAAQLMMNRQIITGHLTGSANDTEQTMKFAHLHGVKPLIERMPLDQANEA
IARISAGKPRFRIVLEPNS
>Mature_338_residues
PKYIAMQVSESGAPLAANLVQPAPLKSREVRVEIAASGVCHADIGTAAASGKHTVFPVTPGHEIAGTIAEIGENVSRWTV
GDRVAIGWFGGNCGDCAFCRAGDPVHCRERKIPGVSYAGGWAQNIVVPAEALAAIPDGMDFYEAAPMGCAGVTTFNALRN
LKLDPGAAVAVFGIGGLVRLAIQFAAKMGYRTITIARGLEREELARQLGANHYIDSNDLHPGQALFELGGADLILSTAST
TEPLSELSTGLSIGGQLTIIGVDGGDITVSAAQLMMNRQIITGHLTGSANDTEQTMKFAHLHGVKPLIERMPLDQANEAI
ARISAGKPRFRIVLEPNS

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=365, Percent_Identity=27.9452054794521, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI71565154, Length=251, Percent_Identity=30.6772908366534, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI156523966, Length=351, Percent_Identity=25.3561253561254, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4501939, Length=351, Percent_Identity=25.3561253561254, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501933, Length=363, Percent_Identity=26.4462809917355, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=26.3888888888889, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI262073058, Length=279, Percent_Identity=28.3154121863799, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI71743840, Length=279, Percent_Identity=28.3154121863799, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI4501929, Length=354, Percent_Identity=25.7062146892655, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786518, Length=355, Percent_Identity=30.9859154929577, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87082401, Length=332, Percent_Identity=28.3132530120482, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI87081918, Length=314, Percent_Identity=31.2101910828025, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788075, Length=319, Percent_Identity=27.8996865203762, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786552, Length=353, Percent_Identity=30.5949008498584, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788073, Length=288, Percent_Identity=27.4305555555556, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788407, Length=267, Percent_Identity=29.5880149812734, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082125, Length=320, Percent_Identity=27.5, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790045, Length=270, Percent_Identity=27.4074074074074, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787863, Length=303, Percent_Identity=26.4026402640264, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI226510992, Length=268, Percent_Identity=24.2537313432836, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=337, Percent_Identity=27.0029673590504, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=320, Percent_Identity=28.125, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71988145, Length=335, Percent_Identity=28.0597014925373, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=363, Percent_Identity=25.6198347107438, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=365, Percent_Identity=25.4794520547945, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=206, Percent_Identity=30.5825242718447, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324486, Length=320, Percent_Identity=30.3125, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323729, Length=320, Percent_Identity=30, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323961, Length=322, Percent_Identity=30.7453416149068, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319621, Length=324, Percent_Identity=30.5555555555556, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323980, Length=342, Percent_Identity=25.4385964912281, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=25.6716417910448, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=26.1333333333333, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17737895, Length=363, Percent_Identity=26.4462809917355, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 35529; Mature: 35398

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYIAMQVSESGAPLAANLVQPAPLKSREVRVEIAASGVCHADIGTAAASGKHTVFPVT
CCCEEEEEECCCCCCEEHHCCCCCCCCCCEEEEEEEECCEEECCCCCCCCCCCEEEEECC
PGHEIAGTIAEIGENVSRWTVGDRVAIGWFGGNCGDCAFCRAGDPVHCRERKIPGVSYAG
CCHHHHHHHHHHCCCCCEEECCCEEEEEEECCCCCCEEEECCCCCCCHHHCCCCCCCCCC
GWAQNIVVPAEALAAIPDGMDFYEAAPMGCAGVTTFNALRNLKLDPGAAVAVFGIGGLVR
CCCCCEEECHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
LAIQFAAKMGYRTITIARGLEREELARQLGANHYIDSNDLHPGQALFELGGADLILSTAS
HHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEECCC
TTEPLSELSTGLSIGGQLTIIGVDGGDITVSAAQLMMNRQIITGHLTGSANDTEQTMKFA
CCCHHHHHHHCCCCCCEEEEEEECCCCEEHHHHHHHHCCEEEEEEECCCCCCHHHHHHHH
HLHGVKPLIERMPLDQANEAIARISAGKPRFRIVLEPNS
HHCCCHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure 
PKYIAMQVSESGAPLAANLVQPAPLKSREVRVEIAASGVCHADIGTAAASGKHTVFPVT
CCEEEEEECCCCCCEEHHCCCCCCCCCCEEEEEEEECCEEECCCCCCCCCCCEEEEECC
PGHEIAGTIAEIGENVSRWTVGDRVAIGWFGGNCGDCAFCRAGDPVHCRERKIPGVSYAG
CCHHHHHHHHHHCCCCCEEECCCEEEEEEECCCCCCEEEECCCCCCCHHHCCCCCCCCCC
GWAQNIVVPAEALAAIPDGMDFYEAAPMGCAGVTTFNALRNLKLDPGAAVAVFGIGGLVR
CCCCCEEECHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
LAIQFAAKMGYRTITIARGLEREELARQLGANHYIDSNDLHPGQALFELGGADLILSTAS
HHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEECCC
TTEPLSELSTGLSIGGQLTIIGVDGGDITVSAAQLMMNRQIITGHLTGSANDTEQTMKFA
CCCHHHHHHHCCCCCCEEEEEEECCCCEEHHHHHHHHCCEEEEEEECCCCCCHHHHHHHH
HLHGVKPLIERMPLDQANEAIARISAGKPRFRIVLEPNS
HHCCCHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]