Click here to switch to the map view.

The map label for this gene is yrkH [H]

Identifier: 62388947

GI number: 62388947

Start: 54179

End: 55549

Strand: Direct

Name: yrkH [H]

Synonym: cg0071

Alternate gene names: 62388947

Gene position: 54179-55549 (Clockwise)

Preceding gene: 62388946

Following gene: 62388951

Centisome position: 1.65

GC content: 52.74

Gene sequence:

>1371_bases
GTGCTTATTGAACGCATCTACGACGAAGACCTTGCGCAGGCCAGCTATTTCATTGGCTGCCAAGCCCACAACACCGCAGT
CGTGGTTGATCCGCGTCGCGATATTGCCGTCTATCTGGACATGGCCAAGAAAAACGGAATGGAGATTGTTGGAGTTACCG
AAACCCATATCCATGCGGACTATTTGTCAGGAACCCGTGAGTTAGCTGCTGCAACTAATGCCACCATGTACGTCTCAGGG
GAGGGCGGCGCCGATTGGCAGTATGAATTCGACGCCGAGCGAATATGCGACGGCAGCGAGATTCGCCTGGGAAATCTGGT
GCTCACAGCTGTTCACACCCCAGGCCATACCCCGGAACACTTATCGTTCCTGCTGAAGGACGGCGCGTTCGCAGATGAGC
CAGGATTCATGCTCACTGGCGATTTCGTTTTCGCGGGTGATCTTGGCCGACCAGATTTGCTCGATGAAGCAGCTGGGGGA
GTGGACACTCGTTTTGAGGGGGCTCGCCAAATGTTCAAGAGCTTGAAGGAAAAATTCCTGACATTGCCTGATCACATCCA
GATCTTCCCTGGTCATGGTTCCGGTTCCGCGTGTGGCAAAGCCTTGGGTTCGGTTCCTTCAACAACACTTGGATATGAAC
GTCAATTTGCGTGGTGGGGAAAGTATCTGGAGGCAGATGATGAACAAGGATTCATTGATGAGCTTCTGGAAGGCCAACCT
GATGCACCTGCATACTTCGGCAGGATGAAGAGGCAAAATAGGCAAGGGCCCGCAATTATGGGCGCTCGCGAGCTGTTGCC
ACAGCTGGAAGCTTCTGATCTGCACGACGTCATTGTTGTTGATACCCGCTCAGCCGATGAAGTTCACCAGGGCACTGTAG
CTGGTGCAGTGAATATTCCTGCGGGCAATTCGATGGCGAAATTTGGCTCGTGGACCGTTGATCCCGAGAAGGATTCCCGA
GCTTTGGTTCTGCTCGCGGCAAGCCAAATTGGTGCCATGGAGATGTGGGACCACATGGTTCGCGTGGGAATCGATAATGT
TGCTGGTTTTATCACCAACTTTGATGGGGTGGACCTAGTTGCACCGCAAACTGTGTCCCCAGATCAGCTGGATGAATTGG
AATACGATCTACTTCTTGATGTCCGCAACCGCAGTGAAGTCGAAGAAGGCTACATCCCAGGAGCACTCCATATTAATGGT
GCATCCGTGCTGTGGAATCTGGAGAAACTGCCACGTGACGGAAAGATCGTGAGCTACTGCAAGAGTGGAACACGCAGCTC
AATCGCCGCAAGCACCCTGCGTAATGCTGGTTTTGATGTGGTGGAACTTCAAGGATCCTATGACAACTGGGTCCGGCACA
ACGCACAATAA

Upstream 100 bases:

>100_bases
AATGAGTGAACCTGCGCTTGAACTATACCCCCTGGGGTATTACTGTAGATTCTCAATACCCCGAGGGGTATCTAGTTTTT
ACGTTGAGAAGGAGAGCTCA

Downstream 100 bases:

>100_bases
ACAATAGTAAAAGGAACCCTCACGGATTGTGAGGGTTCCTTTTTTTGGGTTTCGCCGGAGGGAGACGTCGAAAAGCTTAT
AAAAGCTCCAAGCCGAGCAC

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLIERIYDEDLAQASYFIGCQAHNTAVVVDPRRDIAVYLDMAKKNGMEIVGVTETHIHADYLSGTRELAAATNATMYVSG
EGGADWQYEFDAERICDGSEIRLGNLVLTAVHTPGHTPEHLSFLLKDGAFADEPGFMLTGDFVFAGDLGRPDLLDEAAGG
VDTRFEGARQMFKSLKEKFLTLPDHIQIFPGHGSGSACGKALGSVPSTTLGYERQFAWWGKYLEADDEQGFIDELLEGQP
DAPAYFGRMKRQNRQGPAIMGARELLPQLEASDLHDVIVVDTRSADEVHQGTVAGAVNIPAGNSMAKFGSWTVDPEKDSR
ALVLLAASQIGAMEMWDHMVRVGIDNVAGFITNFDGVDLVAPQTVSPDQLDELEYDLLLDVRNRSEVEEGYIPGALHING
ASVLWNLEKLPRDGKIVSYCKSGTRSSIAASTLRNAGFDVVELQGSYDNWVRHNAQ

Sequences:

>Translated_456_residues
MLIERIYDEDLAQASYFIGCQAHNTAVVVDPRRDIAVYLDMAKKNGMEIVGVTETHIHADYLSGTRELAAATNATMYVSG
EGGADWQYEFDAERICDGSEIRLGNLVLTAVHTPGHTPEHLSFLLKDGAFADEPGFMLTGDFVFAGDLGRPDLLDEAAGG
VDTRFEGARQMFKSLKEKFLTLPDHIQIFPGHGSGSACGKALGSVPSTTLGYERQFAWWGKYLEADDEQGFIDELLEGQP
DAPAYFGRMKRQNRQGPAIMGARELLPQLEASDLHDVIVVDTRSADEVHQGTVAGAVNIPAGNSMAKFGSWTVDPEKDSR
ALVLLAASQIGAMEMWDHMVRVGIDNVAGFITNFDGVDLVAPQTVSPDQLDELEYDLLLDVRNRSEVEEGYIPGALHING
ASVLWNLEKLPRDGKIVSYCKSGTRSSIAASTLRNAGFDVVELQGSYDNWVRHNAQ
>Mature_456_residues
MLIERIYDEDLAQASYFIGCQAHNTAVVVDPRRDIAVYLDMAKKNGMEIVGVTETHIHADYLSGTRELAAATNATMYVSG
EGGADWQYEFDAERICDGSEIRLGNLVLTAVHTPGHTPEHLSFLLKDGAFADEPGFMLTGDFVFAGDLGRPDLLDEAAGG
VDTRFEGARQMFKSLKEKFLTLPDHIQIFPGHGSGSACGKALGSVPSTTLGYERQFAWWGKYLEADDEQGFIDELLEGQP
DAPAYFGRMKRQNRQGPAIMGARELLPQLEASDLHDVIVVDTRSADEVHQGTVAGAVNIPAGNSMAKFGSWTVDPEKDSR
ALVLLAASQIGAMEMWDHMVRVGIDNVAGFITNFDGVDLVAPQTVSPDQLDELEYDLLLDVRNRSEVEEGYIPGALHING
ASVLWNLEKLPRDGKIVSYCKSGTRSSIAASTLRNAGFDVVELQGSYDNWVRHNAQ

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=196, Percent_Identity=27.0408163265306, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI21703352, Length=205, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI116642887, Length=205, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787158, Length=220, Percent_Identity=26.8181818181818, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17538952, Length=186, Percent_Identity=29.0322580645161, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330176, Length=197, Percent_Identity=24.8730964467005, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 49800; Mature: 49800

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIERIYDEDLAQASYFIGCQAHNTAVVVDPRRDIAVYLDMAKKNGMEIVGVTETHIHAD
CCHHHHHHHHHHHCEEEEEEECCCEEEEEECCCCEEEEEEECCCCCCEEEEEEHHEEEHH
YLSGTRELAAATNATMYVSGEGGADWQYEFDAERICDGSEIRLGNLVLTAVHTPGHTPEH
HHCCHHHHHHHCCCEEEEECCCCCCCEEECCHHHCCCCCCEEECCEEEEEEECCCCCHHH
LSFLLKDGAFADEPGFMLTGDFVFAGDLGRPDLLDEAAGGVDTRFEGARQMFKSLKEKFL
HHHHHHCCCCCCCCCEEEECCEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHC
TLPDHIQIFPGHGSGSACGKALGSVPSTTLGYERQFAWWGKYLEADDEQGFIDELLEGQP
CCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCC
DAPAYFGRMKRQNRQGPAIMGARELLPQLEASDLHDVIVVDTRSADEVHQGTVAGAVNIP
CCCHHHHHHHHCCCCCCEEECHHHHHCCCCCCCCCCEEEEECCCCCHHHCCCEEEEEECC
AGNSMAKFGSWTVDPEKDSRALVLLAASQIGAMEMWDHMVRVGIDNVAGFITNFDGVDLV
CCCCHHHCCCEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
APQTVSPDQLDELEYDLLLDVRNRSEVEEGYIPGALHINGASVLWNLEKLPRDGKIVSYC
CCCCCCCHHHHHCCEEEEEEECCCCHHHHCCCCCEEEECCHHEEEEHHHCCCCCCEEHHH
KSGTRSSIAASTLRNAGFDVVELQGSYDNWVRHNAQ
HCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHCCCC
>Mature Secondary Structure
MLIERIYDEDLAQASYFIGCQAHNTAVVVDPRRDIAVYLDMAKKNGMEIVGVTETHIHAD
CCHHHHHHHHHHHCEEEEEEECCCEEEEEECCCCEEEEEEECCCCCCEEEEEEHHEEEHH
YLSGTRELAAATNATMYVSGEGGADWQYEFDAERICDGSEIRLGNLVLTAVHTPGHTPEH
HHCCHHHHHHHCCCEEEEECCCCCCCEEECCHHHCCCCCCEEECCEEEEEEECCCCCHHH
LSFLLKDGAFADEPGFMLTGDFVFAGDLGRPDLLDEAAGGVDTRFEGARQMFKSLKEKFL
HHHHHHCCCCCCCCCEEEECCEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHC
TLPDHIQIFPGHGSGSACGKALGSVPSTTLGYERQFAWWGKYLEADDEQGFIDELLEGQP
CCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCC
DAPAYFGRMKRQNRQGPAIMGARELLPQLEASDLHDVIVVDTRSADEVHQGTVAGAVNIP
CCCHHHHHHHHCCCCCCEEECHHHHHCCCCCCCCCCEEEEECCCCCHHHCCCEEEEEECC
AGNSMAKFGSWTVDPEKDSRALVLLAASQIGAMEMWDHMVRVGIDNVAGFITNFDGVDLV
CCCCHHHCCCEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
APQTVSPDQLDELEYDLLLDVRNRSEVEEGYIPGALHINGASVLWNLEKLPRDGKIVSYC
CCCCCCCHHHHHCCEEEEEEECCCCHHHHCCCCCEEEECCHHEEEEHHHCCCCCCEEHHH
KSGTRSSIAASTLRNAGFDVVELQGSYDNWVRHNAQ
HCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]