BacMap

Definition	Corynebacterium glutamicum ATCC 13032, complete genome.
Accession	NC_006958
Length	3,282,708

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The map label for this gene is ppiA [H]

Identifier: 62388929

GI number: 62388929

Start: 34378

End: 34902

Strand: Direct

Name: ppiA [H]

Synonym: cg0048

Alternate gene names: 62388929

Gene position: 34378-34902 (Clockwise)

Preceding gene: 62388927

Following gene: 62388930

Centisome position: 1.05

GC content: 58.1

Gene sequence:

>525_bases
ATGACTTCTAAGACCGCAACTGCGATTCTGCATACAAATCGCGGAGACATCACCATCGACCTGTTCGGCAACCACGCTCC
AGAGACCGTCGCTAACTTCGTTGGCCTGGCACAGGGCACCAAGGACTACCAGTCCGCAAACGCTCAGGGCGACAGCGAAG
GTCCGTTCTACAACGGATCTGTCTTCCACCGCGTCATCGACGGCTTCATGATCCAGGGTGGAGACCCAACCGGCACCGGC
CGTGGCGGCCCTGGCTACACCTTCGCTGATGAATTCCACCCAGAGCTGCGCTTCGACCGCGCATACCTGCTGGCAATGGC
AAATGCGGGCCCAGGCACCAACGGTTCCCAGTTCTTCATCACTGTGACCCCAACCCCTCACCTGAACAACGCTCACACCA
TCTTCGGTGAGGTCACTGACGCTGAGTCTCAGAAGGTTGTGGATGCAATTGCAACCACCGCAACCGATCGTTACGACCGC
CCAGCTGACGCAGTTGTCATCGAGTCTGTAGAGATCACCGCGTAA

Upstream 100 bases:

>100_bases
CAACTCTCCTTAAATTGGTCGCGTTCTTCTAAGACCCCACATTAGTAAAAGCATGGGACATGTGGTTGGCATTTCGCTCG
ATGTAGTTATGATGGGCGTT

Downstream 100 bases:

>100_bases
CAGCCACCTCTACGTACACTAATCTTCAGGTTATGCCGCAAGCCGGTATGACCTGATTTTTTTATGCCACAAAAACCTGT
TGAAAGACCAGTTGAAGATT

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase A; Rotamase A [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKDYQSANAQGDSEGPFYNGSVFHRVIDGFMIQGGDPTGTG
RGGPGYTFADEFHPELRFDRAYLLAMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQKVVDAIATTATDRYDR
PADAVVIESVEITA

Sequences:

>Translated_174_residues
MTSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKDYQSANAQGDSEGPFYNGSVFHRVIDGFMIQGGDPTGTG
RGGPGYTFADEFHPELRFDRAYLLAMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQKVVDAIATTATDRYDR
PADAVVIESVEITA
>Mature_173_residues
TSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKDYQSANAQGDSEGPFYNGSVFHRVIDGFMIQGGDPTGTGR
GGPGYTFADEFHPELRFDRAYLLAMANAGPGTNGSQFFITVTPTPHLNNAHTIFGEVTDAESQKVVDAIATTATDRYDRP
ADAVVIESVEITA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=48.2352941176471, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=47.8260869565217, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=41.9161676646707, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI19557636, Length=172, Percent_Identity=39.5348837209302, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4505991, Length=163, Percent_Identity=47.239263803681, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI6631100, Length=161, Percent_Identity=44.7204968944099, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI42560244, Length=166, Percent_Identity=39.7590361445783, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI4758950, Length=157, Percent_Identity=43.312101910828, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4826932, Length=159, Percent_Identity=41.5094339622642, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI22547212, Length=167, Percent_Identity=38.9221556886228, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI7657473, Length=167, Percent_Identity=38.9221556886228, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI10863927, Length=139, Percent_Identity=38.1294964028777, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI256017253, Length=139, Percent_Identity=41.726618705036, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI221139811, Length=139, Percent_Identity=41.726618705036, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI256017251, Length=139, Percent_Identity=41.726618705036, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=38.0368098159509, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI22547215, Length=167, Percent_Identity=38.9221556886228, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI178057341, Length=140, Percent_Identity=40.7142857142857, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI209417936, Length=139, Percent_Identity=38.1294964028777, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI30102944, Length=139, Percent_Identity=38.1294964028777, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI219842199, Length=139, Percent_Identity=38.1294964028777, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI310129267, Length=139, Percent_Identity=36.6906474820144, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI310120620, Length=139, Percent_Identity=36.6906474820144, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI20911035, Length=161, Percent_Identity=32.9192546583851, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI169163387, Length=139, Percent_Identity=36.6906474820144, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI169164185, Length=139, Percent_Identity=37.410071942446, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI169163623, Length=139, Percent_Identity=37.410071942446, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI150418007, Length=131, Percent_Identity=39.6946564885496, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=35.9712230215827, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI5031987, Length=157, Percent_Identity=37.5796178343949, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI310127646, Length=139, Percent_Identity=34.5323741007194, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI310114371, Length=139, Percent_Identity=34.5323741007194, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI310119221, Length=139, Percent_Identity=34.5323741007194, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI169214050, Length=139, Percent_Identity=35.2517985611511, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI5174637, Length=156, Percent_Identity=35.2564102564103, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI239751853, Length=139, Percent_Identity=35.2517985611511, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI113428306, Length=139, Percent_Identity=35.2517985611511, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI303305009, Length=129, Percent_Identity=37.984496124031, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI45439316, Length=129, Percent_Identity=37.984496124031, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI310132444, Length=139, Percent_Identity=33.8129496402878, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310113152, Length=139, Percent_Identity=33.8129496402878, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI27735045, Length=157, Percent_Identity=31.2101910828025, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310127745, Length=137, Percent_Identity=34.3065693430657, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI310119290, Length=137, Percent_Identity=34.3065693430657, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI310114540, Length=137, Percent_Identity=34.3065693430657, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786736, Length=178, Percent_Identity=35.9550561797753, Blast_Score=84, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=48.1481481481481, Blast_Score=141, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17506311, Length=170, Percent_Identity=47.6470588235294, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17551284, Length=159, Percent_Identity=45.9119496855346, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17551282, Length=159, Percent_Identity=45.9119496855346, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71997782, Length=140, Percent_Identity=42.1428571428571, Blast_Score=113, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17552784, Length=160, Percent_Identity=42.5, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980594, Length=171, Percent_Identity=39.1812865497076, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71980590, Length=158, Percent_Identity=39.873417721519, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17552780, Length=157, Percent_Identity=45.859872611465, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17506307, Length=157, Percent_Identity=45.859872611465, Blast_Score=102, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17532641, Length=173, Percent_Identity=38.150289017341, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17565860, Length=157, Percent_Identity=43.312101910828, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17559074, Length=165, Percent_Identity=35.7575757575758, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17566266, Length=132, Percent_Identity=40.1515151515151, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI32563659, Length=171, Percent_Identity=30.9941520467836, Blast_Score=83, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17532643, Length=157, Percent_Identity=37.5796178343949, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17539498, Length=162, Percent_Identity=36.4197530864198, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17552782, Length=162, Percent_Identity=36.4197530864198, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323246, Length=162, Percent_Identity=37.6543209876543, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323562, Length=169, Percent_Identity=42.0118343195266, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320510, Length=179, Percent_Identity=40.2234636871508, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320359, Length=162, Percent_Identity=40.7407407407407, Blast_Score=98, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6321848, Length=158, Percent_Identity=43.0379746835443, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322492, Length=169, Percent_Identity=36.6863905325444, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319914, Length=171, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=47.5903614457831, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922912, Length=168, Percent_Identity=46.4285714285714, Blast_Score=123, Evalue=8e-29,
Organism=Drosophila melanogaster, GI21357249, Length=176, Percent_Identity=39.2045454545455, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI19922376, Length=173, Percent_Identity=37.5722543352601, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24650807, Length=163, Percent_Identity=41.7177914110429, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20130249, Length=157, Percent_Identity=45.859872611465, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24652460, Length=137, Percent_Identity=39.4160583941606, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45549139, Length=130, Percent_Identity=43.0769230769231, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136360, Length=177, Percent_Identity=36.1581920903955, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24664125, Length=160, Percent_Identity=39.375, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357783, Length=160, Percent_Identity=39.375, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586038, Length=167, Percent_Identity=35.3293413173653, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647301, Length=159, Percent_Identity=33.9622641509434, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21355677, Length=177, Percent_Identity=30.5084745762712, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18497; Mature: 18366

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKDYQSANAQGDSEGPFYNGS
CCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHCCCCCCCCCCCEECCH
VFHRVIDGFMIQGGDPTGTGRGGPGYTFADEFHPELRFDRAYLLAMANAGPGTNGSQFFI
HHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEECEEEEEEEECCCCCCCCCEEEE
TVTPTPHLNNAHTIFGEVTDAESQKVVDAIATTATDRYDRPADAVVIESVEITA
EECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
TSKTATAILHTNRGDITIDLFGNHAPETVANFVGLAQGTKDYQSANAQGDSEGPFYNGS
CCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHCCCCCCCCCCCEECCH
VFHRVIDGFMIQGGDPTGTGRGGPGYTFADEFHPELRFDRAYLLAMANAGPGTNGSQFFI
HHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEECEEEEEEEECCCCCCCCCEEEE
TVTPTPHLNNAHTIFGEVTDAESQKVVDAIATTATDRYDRPADAVVIESVEITA
EECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]