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The map label for this gene is pepA

Identifier: 62185026

GI number: 62185026

Start: 455400

End: 456902

Strand: Direct

Name: pepA

Synonym: CAB397

Alternate gene names: 62185026

Gene position: 455400-456902 (Clockwise)

Preceding gene: 62185025

Following gene: 62185027

Centisome position: 39.79

GC content: 40.85

Gene sequence:

>1503_bases
GTGGTTCTATTTCACTCTCAAGCATCTTGTAGTAAACGAGTTAAGGCTGACGCGATTGTTCTTCCTTTTTGGAAGGTTAA
AAGTAAGCCTAAATGCGCAGCTTCCATTGCAAAGGAATATGAATCACTTTATCGCGTTGCCTTGGATAGCTTCTCTGGAG
AAAGAGGGGAAGTCGAGTTTATCTATAATTCTGGACAAGGGAAGGAAAAGCGTCTTTTAATTTTAGGATTAGGGAAGAAT
GAGGAGCTAACTTCTCAGGATGTTTTAGAGGTTTATGCTAAGGTAACACGCACATTACGTAAGGCAAAATGTACAACAGT
GAATGTGGTACTTCCTACAATTTCTGAGTTGCGTATTCCTGTGGAGGATTTCTTAACCAATCTGACTTCGGGAATCCTAT
CTTTGAACTATAATTACCCTAAGTATACGAAGGAAGCGAAAAAGACAGATCCTTTACTAACGAAAGTTACTGTATTGGGC
ATTGTACCTAAGATTGCCGATAGAATCTTTAGAAAAGAAGAGAGTATTTTTGAAGGCGTCTATCTGACACGAGATCTTGT
GAATGGGAATGCCGATGAGGTCACTCCCGAAAAATTAGCAAATATTGCTAAAGGATTAGCTAAGCAATTCCCTAGTGTTG
ACGCTAAGGTTTTGAATAAGGATGCTATTCTTAAAGAGAAGATGGGCTTGTTGGCCGCTGTGGCTAAAGGTTCAGCTGTA
GACCCTCGTTTTATTGTTTTAAGCTATCAAGGTAAGCCAAAATCTAAAGATCATACTGTACTTATAGGTAAAGGGGTAAC
TTTTGATTCTGGAGGCTTAGACCTGAAACCCGGCAAAGCCATGTTGACGATGAAGGAAGACATGGCAGGAGCCGCTACAG
TATTGGGTATTCTTTCTGGGGTGGCTGCTCTTGAGCTTCCTGTAAATGTTACCGCTCTTATTCCTGCCACAGAGAACGCT
ATAGATGCTGCTTCTTATAAGATGGGGGATGTTTACGTCGGGATGTCAGGACTCTCCGTAGAGATTGGTAGCACGGATGC
TGAGGGGCGTCTAATACTTGCTGATGCAATCACTTATGCTTTAAAATACTGCAAGCCTACGAGAATTATTGATTTTGCTA
CTTTAACAGGCGCTATGGTCGTTTCTTTAGGTGAGGATGTTGCTGGTTTCTTCTCAAATAATGATGTATTAGCTCAAGAT
CTTTTTGAAGCTTCTGCTGAAACTAGCGAATCTTTATGGCGCTTGCCGCTTGTTGAGAAATATGACAAAGCTTTGCATTC
CGATATTGCTGATATGAAAAATATTGGTAGTAACCGTGCAGGGGCGATTACAGCGGCACTTTTCTTAAAACGTTTTCTTG
AAGATCAACCGGTGGCGTGGGCTCATTTAGACATCGCAGGTACTGCGTATCGTGAAAAAGATGAAGATGCTTACCCAAAA
TATGCTTCTGGTTTTGGTGTTCGTTGTCTTATTTATTACATAGAAAAGTTCTTATCTAAGTAA

Upstream 100 bases:

>100_bases
AAAGATATGTATGCTGGTTATGGTCAAGGTCAGCAATATATATCTGAAGATGTGCCTTTTTAGTGGCTAACGAAATAACG
ATTTTTATAAAGAGGTAATT

Downstream 100 bases:

>100_bases
CTGTTTTTTAAACTCCTTCTAATTTAATAACGTGAATTTGTTTTTAATTTATTAAAATAAATGCGCGTTTTATTAAAGTT
TTTTCAATTTCCTGCCGATA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MVLFHSQASCSKRVKADAIVLPFWKVKSKPKCAASIAKEYESLYRVALDSFSGERGEVEFIYNSGQGKEKRLLILGLGKN
EELTSQDVLEVYAKVTRTLRKAKCTTVNVVLPTISELRIPVEDFLTNLTSGILSLNYNYPKYTKEAKKTDPLLTKVTVLG
IVPKIADRIFRKEESIFEGVYLTRDLVNGNADEVTPEKLANIAKGLAKQFPSVDAKVLNKDAILKEKMGLLAAVAKGSAV
DPRFIVLSYQGKPKSKDHTVLIGKGVTFDSGGLDLKPGKAMLTMKEDMAGAATVLGILSGVAALELPVNVTALIPATENA
IDAASYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYALKYCKPTRIIDFATLTGAMVVSLGEDVAGFFSNNDVLAQD
LFEASAETSESLWRLPLVEKYDKALHSDIADMKNIGSNRAGAITAALFLKRFLEDQPVAWAHLDIAGTAYREKDEDAYPK
YASGFGVRCLIYYIEKFLSK

Sequences:

>Translated_500_residues
MVLFHSQASCSKRVKADAIVLPFWKVKSKPKCAASIAKEYESLYRVALDSFSGERGEVEFIYNSGQGKEKRLLILGLGKN
EELTSQDVLEVYAKVTRTLRKAKCTTVNVVLPTISELRIPVEDFLTNLTSGILSLNYNYPKYTKEAKKTDPLLTKVTVLG
IVPKIADRIFRKEESIFEGVYLTRDLVNGNADEVTPEKLANIAKGLAKQFPSVDAKVLNKDAILKEKMGLLAAVAKGSAV
DPRFIVLSYQGKPKSKDHTVLIGKGVTFDSGGLDLKPGKAMLTMKEDMAGAATVLGILSGVAALELPVNVTALIPATENA
IDAASYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYALKYCKPTRIIDFATLTGAMVVSLGEDVAGFFSNNDVLAQD
LFEASAETSESLWRLPLVEKYDKALHSDIADMKNIGSNRAGAITAALFLKRFLEDQPVAWAHLDIAGTAYREKDEDAYPK
YASGFGVRCLIYYIEKFLSK
>Mature_500_residues
MVLFHSQASCSKRVKADAIVLPFWKVKSKPKCAASIAKEYESLYRVALDSFSGERGEVEFIYNSGQGKEKRLLILGLGKN
EELTSQDVLEVYAKVTRTLRKAKCTTVNVVLPTISELRIPVEDFLTNLTSGILSLNYNYPKYTKEAKKTDPLLTKVTVLG
IVPKIADRIFRKEESIFEGVYLTRDLVNGNADEVTPEKLANIAKGLAKQFPSVDAKVLNKDAILKEKMGLLAAVAKGSAV
DPRFIVLSYQGKPKSKDHTVLIGKGVTFDSGGLDLKPGKAMLTMKEDMAGAATVLGILSGVAALELPVNVTALIPATENA
IDAASYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYALKYCKPTRIIDFATLTGAMVVSLGEDVAGFFSNNDVLAQD
LFEASAETSESLWRLPLVEKYDKALHSDIADMKNIGSNRAGAITAALFLKRFLEDQPVAWAHLDIAGTAYREKDEDAYPK
YASGFGVRCLIYYIEKFLSK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=324, Percent_Identity=41.9753086419753, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI47155554, Length=323, Percent_Identity=30.3405572755418, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1790710, Length=431, Percent_Identity=34.338747099768, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87082123, Length=313, Percent_Identity=37.6996805111821, Blast_Score=185, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=315, Percent_Identity=32.0634920634921, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=328, Percent_Identity=27.7439024390244, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24661038, Length=324, Percent_Identity=36.7283950617284, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355725, Length=324, Percent_Identity=36.4197530864198, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI20129969, Length=298, Percent_Identity=31.8791946308725, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI161077148, Length=295, Percent_Identity=32.5423728813559, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI20130057, Length=295, Percent_Identity=32.5423728813559, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21357381, Length=321, Percent_Identity=31.4641744548287, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI221379063, Length=321, Percent_Identity=31.4641744548287, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI221379062, Length=321, Percent_Identity=31.4641744548287, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24662227, Length=258, Percent_Identity=31.0077519379845, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21355645, Length=295, Percent_Identity=29.4915254237288, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24662223, Length=295, Percent_Identity=29.4915254237288, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI20129963, Length=291, Percent_Identity=32.9896907216495, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19922386, Length=330, Percent_Identity=29.6969696969697, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646701, Length=422, Percent_Identity=27.4881516587678, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646703, Length=422, Percent_Identity=27.4881516587678, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21358201, Length=422, Percent_Identity=27.4881516587678, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CHLAB (Q5L681)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219811.1
- HSSP:   P00727
- ProteinModelPortal:   Q5L681
- SMR:   Q5L681
- GeneID:   3337398
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB397
- HOGENOM:   HBG742580
- OMA:   CKPTRII
- PhylomeDB:   Q5L681
- ProtClustDB:   PRK00913
- BioCyc:   CABO218497:CAB397-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54458; Mature: 54458

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 276-276 ACT_SITE 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLFHSQASCSKRVKADAIVLPFWKVKSKPKCAASIAKEYESLYRVALDSFSGERGEVEF
CEEECCCCHHHHCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
IYNSGQGKEKRLLILGLGKNEELTSQDVLEVYAKVTRTLRKAKCTTVNVVLPTISELRIP
EEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCCCC
VEDFLTNLTSGILSLNYNYPKYTKEAKKTDPLLTKVTVLGIVPKIADRIFRKEESIFEGV
HHHHHHHHHHHHEEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLTRDLVNGNADEVTPEKLANIAKGLAKQFPSVDAKVLNKDAILKEKMGLLAAVAKGSAV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHCCCCC
DPRFIVLSYQGKPKSKDHTVLIGKGVTFDSGGLDLKPGKAMLTMKEDMAGAATVLGILSG
CCEEEEEEECCCCCCCCCEEEEECCEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
VAALELPVNVTALIPATENAIDAASYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYA
HHHEEECCCEEEEECCCCCCHHHHHEECCEEEEECCCCEEEECCCCCCCCEEEHHHHHHH
LKYCKPTRIIDFATLTGAMVVSLGEDVAGFFSNNDVLAQDLFEASAETSESLWRLPLVEK
HHHCCCCCEEEHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
YDKALHSDIADMKNIGSNRAGAITAALFLKRFLEDQPVAWAHLDIAGTAYREKDEDAYPK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCC
YASGFGVRCLIYYIEKFLSK
HHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLFHSQASCSKRVKADAIVLPFWKVKSKPKCAASIAKEYESLYRVALDSFSGERGEVEF
CEEECCCCHHHHCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
IYNSGQGKEKRLLILGLGKNEELTSQDVLEVYAKVTRTLRKAKCTTVNVVLPTISELRIP
EEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCCCC
VEDFLTNLTSGILSLNYNYPKYTKEAKKTDPLLTKVTVLGIVPKIADRIFRKEESIFEGV
HHHHHHHHHHHHEEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLTRDLVNGNADEVTPEKLANIAKGLAKQFPSVDAKVLNKDAILKEKMGLLAAVAKGSAV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHCCCCC
DPRFIVLSYQGKPKSKDHTVLIGKGVTFDSGGLDLKPGKAMLTMKEDMAGAATVLGILSG
CCEEEEEEECCCCCCCCCEEEEECCEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
VAALELPVNVTALIPATENAIDAASYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYA
HHHEEECCCEEEEECCCCCCHHHHHEECCEEEEECCCCEEEECCCCCCCCEEEHHHHHHH
LKYCKPTRIIDFATLTGAMVVSLGEDVAGFFSNNDVLAQDLFEASAETSESLWRLPLVEK
HHHCCCCCEEEHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
YDKALHSDIADMKNIGSNRAGAITAALFLKRFLEDQPVAWAHLDIAGTAYREKDEDAYPK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCC
YASGFGVRCLIYYIEKFLSK
HHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA