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The map label for this gene is mutY [H]

Identifier: 62185010

GI number: 62185010

Start: 437579

End: 438688

Strand: Direct

Name: mutY [H]

Synonym: CAB380

Alternate gene names: 62185010

Gene position: 437579-438688 (Clockwise)

Preceding gene: 62185008

Following gene: 62185011

Centisome position: 38.24

GC content: 39.73

Gene sequence:

>1110_bases
ATGACAAAGATAGCTTTTTCTGAAAGGGCGAAGAATTTTCCTATAGGAAAGTTAAAACAATGGTTTATAGAGAATAAACG
TAGCTTTCCTTGGAGAGACGATCCTTCGCCTTACAACGTATGGGTTTCTGAAGTTATGCTTCAGCAAACTCGAGCGGAGG
TTGTAGTAAAATATTTTATTGAATGGATGAAAAAATTTCCTACCATAGAATCGTTAGCTACAGCTAATGAGGAGGACGTG
ATTAAGGCCTGGGAAGGCCTGGGATATTATACGCGAGTCCGAAATCTTTTGCATGGCGCGCGCATGGTCATGACAGATTT
TGGTGGGAAGCTTCCTGATGATCCTTTAGATTTAATGCAGATAAAAGGTTTAGGTCCTTATACAGTACACGCCATTCTAG
CATTTGCTTTTAAAAGAAGAACCGCAGCGGTCGATGGCAATGTACTACGTGTAATCAGTAGAGTATTTTTGATAGATGCT
TCTATAGATTTAGAGTCTACGAAAACATGGGTATTTAGAATTGTTTTGTCCTTTTTGCCTGCGGAAGATCCTCAAGTTAT
TGCTGAAGCTTTGATAGAACTCGGAGCGTGTATTTGTAAACGTGCTCCTAAGTGTGATATTTGTCCTTTACAGTCTATTT
GTGGCGCTTTTAAAGAAGGAAGACAAAAATCTCTTCCTGTACGTCATGCTAGGAAAAAAACTGTGACGCTATTTCGTTGG
GTAGCCATTGTTCTGTATAACGATTGTATTGTTCTTGAACAGAGAAAACCCGAGGAGATGATGGCCGGGTTGTACGAATT
CCCTTATATAGAGGTGAAGTCTTTGGAAGATCTTTCGGACATAGATGGATTAGTGCACGACATGGAAGAGTACGTACAGG
CTCCCTTGGTTTTTGCTGGGGAACTCGAAGAACAACGTCATGCATTTACTCACTATAAGGTACACCTGATTCCCAAAATT
TTTTATGCAAAATCCAAGCCAAAAGCAGAGCTTCTCTATCCTTTAGATAGTATAGATTCTTTACCTTTTTCTTCTGGGCA
TAGGAAAATCAAGGCATGGTTATTAGAGCATCCTTATGCTACCTTTCATTCTGAACTTATACAGGTTTGA

Upstream 100 bases:

>100_bases
AGAAAGATGACAATCTTTCTTCGTGCTGCGCAACCCATGAGAATTCTTCCATAAAGTGTGGCAAAAATTAAAACCTAGGT
AAAATTTTACGAGAATTTGT

Downstream 100 bases:

>100_bases
AGTTCATGAAAAATATAGATTTTTCTCAGTTGCTAAAGCTTGTTAGAAAAATGGTCTTAGATGGTGTCTGTCCTTGGACA
GATCGTCAAGATTTTGATTC

Product: putative A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTKIAFSERAKNFPIGKLKQWFIENKRSFPWRDDPSPYNVWVSEVMLQQTRAEVVVKYFIEWMKKFPTIESLATANEEDV
IKAWEGLGYYTRVRNLLHGARMVMTDFGGKLPDDPLDLMQIKGLGPYTVHAILAFAFKRRTAAVDGNVLRVISRVFLIDA
SIDLESTKTWVFRIVLSFLPAEDPQVIAEALIELGACICKRAPKCDICPLQSICGAFKEGRQKSLPVRHARKKTVTLFRW
VAIVLYNDCIVLEQRKPEEMMAGLYEFPYIEVKSLEDLSDIDGLVHDMEEYVQAPLVFAGELEEQRHAFTHYKVHLIPKI
FYAKSKPKAELLYPLDSIDSLPFSSGHRKIKAWLLEHPYATFHSELIQV

Sequences:

>Translated_369_residues
MTKIAFSERAKNFPIGKLKQWFIENKRSFPWRDDPSPYNVWVSEVMLQQTRAEVVVKYFIEWMKKFPTIESLATANEEDV
IKAWEGLGYYTRVRNLLHGARMVMTDFGGKLPDDPLDLMQIKGLGPYTVHAILAFAFKRRTAAVDGNVLRVISRVFLIDA
SIDLESTKTWVFRIVLSFLPAEDPQVIAEALIELGACICKRAPKCDICPLQSICGAFKEGRQKSLPVRHARKKTVTLFRW
VAIVLYNDCIVLEQRKPEEMMAGLYEFPYIEVKSLEDLSDIDGLVHDMEEYVQAPLVFAGELEEQRHAFTHYKVHLIPKI
FYAKSKPKAELLYPLDSIDSLPFSSGHRKIKAWLLEHPYATFHSELIQV
>Mature_368_residues
TKIAFSERAKNFPIGKLKQWFIENKRSFPWRDDPSPYNVWVSEVMLQQTRAEVVVKYFIEWMKKFPTIESLATANEEDVI
KAWEGLGYYTRVRNLLHGARMVMTDFGGKLPDDPLDLMQIKGLGPYTVHAILAFAFKRRTAAVDGNVLRVISRVFLIDAS
IDLESTKTWVFRIVLSFLPAEDPQVIAEALIELGACICKRAPKCDICPLQSICGAFKEGRQKSLPVRHARKKTVTLFRWV
AIVLYNDCIVLEQRKPEEMMAGLYEFPYIEVKSLEDLSDIDGLVHDMEEYVQAPLVFAGELEEQRHAFTHYKVHLIPKIF
YAKSKPKAELLYPLDSIDSLPFSSGHRKIKAWLLEHPYATFHSELIQV

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=360, Percent_Identity=32.2222222222222, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI115298652, Length=360, Percent_Identity=32.2222222222222, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI6912520, Length=360, Percent_Identity=32.2222222222222, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI190358497, Length=360, Percent_Identity=32.2222222222222, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI115298650, Length=360, Percent_Identity=32.2222222222222, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI115298648, Length=360, Percent_Identity=32.2222222222222, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1789331, Length=296, Percent_Identity=31.7567567567568, Blast_Score=173, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 42455; Mature: 42324

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIAFSERAKNFPIGKLKQWFIENKRSFPWRDDPSPYNVWVSEVMLQQTRAEVVVKYFI
CCCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EWMKKFPTIESLATANEEDVIKAWEGLGYYTRVRNLLHGARMVMTDFGGKLPDDPLDLMQ
HHHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
IKGLGPYTVHAILAFAFKRRTAAVDGNVLRVISRVFLIDASIDLESTKTWVFRIVLSFLP
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
AEDPQVIAEALIELGACICKRAPKCDICPLQSICGAFKEGRQKSLPVRHARKKTVTLFRW
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VAIVLYNDCIVLEQRKPEEMMAGLYEFPYIEVKSLEDLSDIDGLVHDMEEYVQAPLVFAG
HHHHHHCCEEEECCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCHHHHH
ELEEQRHAFTHYKVHLIPKIFYAKSKPKAELLYPLDSIDSLPFSSGHRKIKAWLLEHPYA
HHHHHHHHHHHHHHEEHHHHHHHCCCCCCEEECCCHHHCCCCCCCCCHHHHHHHHHCCHH
TFHSELIQV
HHHHHHHCC
>Mature Secondary Structure 
TKIAFSERAKNFPIGKLKQWFIENKRSFPWRDDPSPYNVWVSEVMLQQTRAEVVVKYFI
CCCCCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EWMKKFPTIESLATANEEDVIKAWEGLGYYTRVRNLLHGARMVMTDFGGKLPDDPLDLMQ
HHHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
IKGLGPYTVHAILAFAFKRRTAAVDGNVLRVISRVFLIDASIDLESTKTWVFRIVLSFLP
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
AEDPQVIAEALIELGACICKRAPKCDICPLQSICGAFKEGRQKSLPVRHARKKTVTLFRW
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VAIVLYNDCIVLEQRKPEEMMAGLYEFPYIEVKSLEDLSDIDGLVHDMEEYVQAPLVFAG
HHHHHHCCEEEECCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCHHHHH
ELEEQRHAFTHYKVHLIPKIFYAKSKPKAELLYPLDSIDSLPFSSGHRKIKAWLLEHPYA
HHHHHHHHHHHHHHEEHHHHHHHCCCCCCEEECCCHHHCCCCCCCCCHHHHHHHHHCCHH
TFHSELIQV
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]