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The map label for this gene is murA

Identifier: 62184812

GI number: 62184812

Start: 179419

End: 180753

Strand: Direct

Name: murA

Synonym: CAB168

Alternate gene names: 62184812

Gene position: 179419-180753 (Clockwise)

Preceding gene: 62184810

Following gene: 62184818

Centisome position: 15.68

GC content: 42.77

Gene sequence:

>1335_bases
ATGGCAGCAGCTGAAGTTTTTGGTGGTTGTGTGTTAGAAGGTTCTGTGCGGGTATCCGGGGCAAAAAACTCTACAACCAA
GTTGCTTGTTGCGTCATTATTATCGGATCGCAAATGCGTTTTGCGTAATGTCCCTGATATAGGAGATGTACGTTTAACTG
TTGAATTGTGCCGTTCTTTAGGTTCTATCGTACATTGGGATAAACAAGCAGAAGTCATAGAAATTCATACGCCTGAGATT
CATATGTCCGAAGTATCCGCACAGTTTTCTCGGGTAAATCGTATTCCTATTTTATTATTAGGAGCTTTACTTGCTCGTTG
TCCGGAAGGTGTCGTTGTTCCTTGTGTTGGGGGAGATGCTATAGGGGAAAGGACGCTAAATTTTCATTTTGAGGGTTTGG
AACAGCTAGGAGCCAAAGTTGCCTATGATGGGCATGGATACCAAGCTGCTGCTCCTAAAGGTCTTATCGGAGCTTATATT
ACTCTTCCTTATCCTTCCGTAGGAGCTACGGAGAATTTGATACTCGCTTCTGTCCGTGCTCAAGGCAGAACAATCATCAA
GAATGCTGCTTTAGAAGTAGAAATCTTGGATCTTATTTTGTTTTTACAAAAAGCAGGAGTGGAGATTACGACAGATAATG
ATAGGACTATAGAAATTTTTGGTTGTGAGGATTTTTATGAAGTAGATCATTGGGTGATCCCTGATAAGATAGAAGCCGCT
TCGTTTGGCATGGCTGCTGTACTTACCGGAGGGCGCGTTTTCGTAGAAAATGCCGAGCAACATCTGATGATTCCCTTTCT
TAAAACCTTACGCTCTATAGGAGGAGGGTTTTCAGTCACAGAAACAGGAATCGAATTTTTTTATAACGAACCATTAAAAG
GTGGTGTTGTATTAGAAACCGACGTACATCCTGGATTCCTTACAGATTGGCAACAACCTTTTTCAGTTCTTCTCTCCCAG
GCAGAAGGATCTTCTGTGATTCATGAAACTGTGCATGAGAACCGGCTAGGGTATTTACGCGGTTTACAGAAAATGGGAGC
CAATTGCGAACTGTTCTACCAGTGTTTAAGCTCAAAGGCTTGCCGTTATGCAACAGGCAATTTCCCCCATAGTGCGATCA
TTCACGGAGTCACACCATTGAAAGCTTCTCAACTTGTTATTCCCGATTTGCGTGCGGGTTTTGCCTATATTATGGCAGCG
CTCATTGCAGAGGGCGGCCCATCCTTAATCAAAAACACCCAGTTGTTAGATCGGGGATATTACAATTGGGTAGACAAACT
GAACTCTTTAGGAGCAAAAATCCACTTATTGTCTTTAGATCCCGTGGCTTTCTAA

Upstream 100 bases:

>100_bases
GATTTGTTTAAAAAAAATGAAAAGTTTGCATAGAAAAATAACTTTGGGTGGAGTTAACGTTTCTTTAAGATAAAGCGAAA
GCGATAATGAGGAGTAAGAA

Downstream 100 bases:

>100_bases
ACTTACAATCTATCTAAAGTTTGTAGCCCTAATAGATGCATACCCGTAGCTAGGGTCTTCTCAACAAGAGCACAAAGATA
GAGACGTTCTTTTTGATGAG

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MAAAEVFGGCVLEGSVRVSGAKNSTTKLLVASLLSDRKCVLRNVPDIGDVRLTVELCRSLGSIVHWDKQAEVIEIHTPEI
HMSEVSAQFSRVNRIPILLLGALLARCPEGVVVPCVGGDAIGERTLNFHFEGLEQLGAKVAYDGHGYQAAAPKGLIGAYI
TLPYPSVGATENLILASVRAQGRTIIKNAALEVEILDLILFLQKAGVEITTDNDRTIEIFGCEDFYEVDHWVIPDKIEAA
SFGMAAVLTGGRVFVENAEQHLMIPFLKTLRSIGGGFSVTETGIEFFYNEPLKGGVVLETDVHPGFLTDWQQPFSVLLSQ
AEGSSVIHETVHENRLGYLRGLQKMGANCELFYQCLSSKACRYATGNFPHSAIIHGVTPLKASQLVIPDLRAGFAYIMAA
LIAEGGPSLIKNTQLLDRGYYNWVDKLNSLGAKIHLLSLDPVAF

Sequences:

>Translated_444_residues
MAAAEVFGGCVLEGSVRVSGAKNSTTKLLVASLLSDRKCVLRNVPDIGDVRLTVELCRSLGSIVHWDKQAEVIEIHTPEI
HMSEVSAQFSRVNRIPILLLGALLARCPEGVVVPCVGGDAIGERTLNFHFEGLEQLGAKVAYDGHGYQAAAPKGLIGAYI
TLPYPSVGATENLILASVRAQGRTIIKNAALEVEILDLILFLQKAGVEITTDNDRTIEIFGCEDFYEVDHWVIPDKIEAA
SFGMAAVLTGGRVFVENAEQHLMIPFLKTLRSIGGGFSVTETGIEFFYNEPLKGGVVLETDVHPGFLTDWQQPFSVLLSQ
AEGSSVIHETVHENRLGYLRGLQKMGANCELFYQCLSSKACRYATGNFPHSAIIHGVTPLKASQLVIPDLRAGFAYIMAA
LIAEGGPSLIKNTQLLDRGYYNWVDKLNSLGAKIHLLSLDPVAF
>Mature_443_residues
AAAEVFGGCVLEGSVRVSGAKNSTTKLLVASLLSDRKCVLRNVPDIGDVRLTVELCRSLGSIVHWDKQAEVIEIHTPEIH
MSEVSAQFSRVNRIPILLLGALLARCPEGVVVPCVGGDAIGERTLNFHFEGLEQLGAKVAYDGHGYQAAAPKGLIGAYIT
LPYPSVGATENLILASVRAQGRTIIKNAALEVEILDLILFLQKAGVEITTDNDRTIEIFGCEDFYEVDHWVIPDKIEAAS
FGMAAVLTGGRVFVENAEQHLMIPFLKTLRSIGGGFSVTETGIEFFYNEPLKGGVVLETDVHPGFLTDWQQPFSVLLSQA
EGSSVIHETVHENRLGYLRGLQKMGANCELFYQCLSSKACRYATGNFPHSAIIHGVTPLKASQLVIPDLRAGFAYIMAAL
IAEGGPSLIKNTQLLDRGYYNWVDKLNSLGAKIHLLSLDPVAF

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=437, Percent_Identity=34.5537757437071, Blast_Score=210, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_CHLAB (Q5L6U5)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219597.1
- ProteinModelPortal:   Q5L6U5
- SMR:   Q5L6U5
- GeneID:   3337792
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB168
- HOGENOM:   HBG482701
- OMA:   LVPKAMV
- ProtClustDB:   PRK09369
- BioCyc:   CABO218497:CAB168-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 48147; Mature: 48016

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: ACT_SITE 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAEVFGGCVLEGSVRVSGAKNSTTKLLVASLLSDRKCVLRNVPDIGDVRLTVELCRSL
CCCHHHHCCEEEECCEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCCCEEEHHHHHHHH
GSIVHWDKQAEVIEIHTPEIHMSEVSAQFSRVNRIPILLLGALLARCPEGVVVPCVGGDA
HHHEECCCCCCEEEEECCCEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCC
IGERTLNFHFEGLEQLGAKVAYDGHGYQAAAPKGLIGAYITLPYPSVGATENLILASVRA
CCCCEEEEEEHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEHHH
QGRTIIKNAALEVEILDLILFLQKAGVEITTDNDRTIEIFGCEDFYEVDHWVIPDKIEAA
CCCEEEHHCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCHHHCCCCEECCCCCCHH
SFGMAAVLTGGRVFVENAEQHLMIPFLKTLRSIGGGFSVTETGIEFFYNEPLKGGVVLET
HCCEEEEEECCEEEEECCCCEEEHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCEEEEE
DVHPGFLTDWQQPFSVLLSQAEGSSVIHETVHENRLGYLRGLQKMGANCELFYQCLSSKA
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
CRYATGNFPHSAIIHGVTPLKASQLVIPDLRAGFAYIMAALIAEGGPSLIKNTQLLDRGY
CCCCCCCCCCHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCHHHHHCHHHHHCHH
YNWVDKLNSLGAKIHLLSLDPVAF
HHHHHHHHCCCCEEEEEECCCCCC
>Mature Secondary Structure 
AAAEVFGGCVLEGSVRVSGAKNSTTKLLVASLLSDRKCVLRNVPDIGDVRLTVELCRSL
CCHHHHCCEEEECCEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCCCEEEHHHHHHHH
GSIVHWDKQAEVIEIHTPEIHMSEVSAQFSRVNRIPILLLGALLARCPEGVVVPCVGGDA
HHHEECCCCCCEEEEECCCEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCC
IGERTLNFHFEGLEQLGAKVAYDGHGYQAAAPKGLIGAYITLPYPSVGATENLILASVRA
CCCCEEEEEEHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEHHH
QGRTIIKNAALEVEILDLILFLQKAGVEITTDNDRTIEIFGCEDFYEVDHWVIPDKIEAA
CCCEEEHHCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCHHHCCCCEECCCCCCHH
SFGMAAVLTGGRVFVENAEQHLMIPFLKTLRSIGGGFSVTETGIEFFYNEPLKGGVVLET
HCCEEEEEECCEEEEECCCCEEEHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCEEEEE
DVHPGFLTDWQQPFSVLLSQAEGSSVIHETVHENRLGYLRGLQKMGANCELFYQCLSSKA
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
CRYATGNFPHSAIIHGVTPLKASQLVIPDLRAGFAYIMAALIAEGGPSLIKNTQLLDRGY
CCCCCCCCCCHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCHHHHHCHHHHHCHH
YNWVDKLNSLGAKIHLLSLDPVAF
HHHHHHHHCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA