Click here to switch to the map view.

The map label for this gene is csd [H]

Identifier: 62184701

GI number: 62184701

Start: 68050

End: 69270

Strand: Direct

Name: csd [H]

Synonym: CAB054

Alternate gene names: 62184701

Gene position: 68050-69270 (Clockwise)

Preceding gene: 62184700

Following gene: 62184704

Centisome position: 5.95

GC content: 43.24

Gene sequence:

>1221_bases
ATGGTGTGTAGGATCAAAGAAGACTTTCCTATTTTTTCTAATAAAAAGCTTCAGGGGGAGTCCTACATTTATCTTGACTC
TGCGGCTACTACGCATAAACCTAAGAAAGTGATAGACGCAATTACGGATTTTTACAGTAGTAGCTATGCTACCGTAAATC
GTAATGTCTATACTTCTTCGCAGGTAACGACGGCAAATTATAACGCTGTTCGTGGGAAAGTTCGTGCATGGATACAAGCT
GCATATGATGAAGAGATCGTTTTTACTCGGGGAACTACAGCCGCATTGAATCTATTAGCCATATCCGCAAATGACGCTTT
CATTCCTGAGGGTGGTGTGGTGTTAGTTTCTGAAGTAGAGCATCATGCAAATGTATTGTCATGGGAATTAGCCTGCCGTA
GGCGTGGATCTTGTGTTAAAAAAATTGCTGTTGATCATTTGGGATATATAGATTTAGAACACCTAGAGGTCTTACTCAAA
GCAGGAGCTGTGTTTGTAAGCATAGCCCACGTGAGTAATGTTACAGGGTGTATCCAACCTCTAAAGGAAATCGCAAGTCT
CGCTCACCAATATGGTGCGTATGTCGCTGTGGACGGAGCCCAGGGAGTAGCTCATACCTCTGTAGATGTTGTTGATTGGG
ATGTAGATTTCTATGCTTTTTCGGGCCATAAAATGTATGCACCCACAGGTTTAGGGGTGTTGTATGGTAAGAAGGCATTG
TTAGAAAAGCTTCCTCCTGTAGAAGGTGGAGGCGATATGGTCTCCATTTATGATAGTGAACATCCAGAATATCTTCCTGC
ACCGTTAAAATTTGAAGCAGGAACGCCGCCTATAGCTTCTATCTTAGGATTAGGAGCCGCTATAGATTACTTACAATCTT
TGCCAGACTCCGTATACCAGGAAGAAGAAGAGTTGACACAGTATTTGTACAACGAATTGCTAACGATTCCGGGTATGCAG
ATATTAGGTCCAGAGGTAGGTCACCCTCGCGGAGCTTTGATAAGTTTCAAGGTGGAAGGTGCGCATCCTTTCGATATAGG
GTGTTTATTGGATCTTCAAGGGATCGCTGTCCGTACAGGGCATCAATGTGCACAACCTGCCATGACCCGCTGGGATTTGG
GTCATGTGCTTAGAGTGTCACTGGGATTATATAATGATAAGGAAGATGTGGATGCTTTCTTGTCGGCTTTACGTGTTATT
TTGAATAAAGTCCGAGTATAG

Upstream 100 bases:

>100_bases
CTAGTTCAAGGATTTTTATCTATAGAACCTAGTCAAGAAGCTTTCCCTAAACTGTCCGAGCAAATGTAATCTCAAGATAT
GACTAAGGAGTATTCTATAG

Downstream 100 bases:

>100_bases
TCCTTATTGTGAGGAGCTTCCTTGAAATTCGATGTGTTCTTTAGAATAAGGGTACCAACGTAAACGCATTTGTTGACATC
TATCTATTAGCCAGTTTTTG

Product: putative cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVCRIKEDFPIFSNKKLQGESYIYLDSAATTHKPKKVIDAITDFYSSSYATVNRNVYTSSQVTTANYNAVRGKVRAWIQA
AYDEEIVFTRGTTAALNLLAISANDAFIPEGGVVLVSEVEHHANVLSWELACRRRGSCVKKIAVDHLGYIDLEHLEVLLK
AGAVFVSIAHVSNVTGCIQPLKEIASLAHQYGAYVAVDGAQGVAHTSVDVVDWDVDFYAFSGHKMYAPTGLGVLYGKKAL
LEKLPPVEGGGDMVSIYDSEHPEYLPAPLKFEAGTPPIASILGLGAAIDYLQSLPDSVYQEEEELTQYLYNELLTIPGMQ
ILGPEVGHPRGALISFKVEGAHPFDIGCLLDLQGIAVRTGHQCAQPAMTRWDLGHVLRVSLGLYNDKEDVDAFLSALRVI
LNKVRV

Sequences:

>Translated_406_residues
MVCRIKEDFPIFSNKKLQGESYIYLDSAATTHKPKKVIDAITDFYSSSYATVNRNVYTSSQVTTANYNAVRGKVRAWIQA
AYDEEIVFTRGTTAALNLLAISANDAFIPEGGVVLVSEVEHHANVLSWELACRRRGSCVKKIAVDHLGYIDLEHLEVLLK
AGAVFVSIAHVSNVTGCIQPLKEIASLAHQYGAYVAVDGAQGVAHTSVDVVDWDVDFYAFSGHKMYAPTGLGVLYGKKAL
LEKLPPVEGGGDMVSIYDSEHPEYLPAPLKFEAGTPPIASILGLGAAIDYLQSLPDSVYQEEEELTQYLYNELLTIPGMQ
ILGPEVGHPRGALISFKVEGAHPFDIGCLLDLQGIAVRTGHQCAQPAMTRWDLGHVLRVSLGLYNDKEDVDAFLSALRVI
LNKVRV
>Mature_406_residues
MVCRIKEDFPIFSNKKLQGESYIYLDSAATTHKPKKVIDAITDFYSSSYATVNRNVYTSSQVTTANYNAVRGKVRAWIQA
AYDEEIVFTRGTTAALNLLAISANDAFIPEGGVVLVSEVEHHANVLSWELACRRRGSCVKKIAVDHLGYIDLEHLEVLLK
AGAVFVSIAHVSNVTGCIQPLKEIASLAHQYGAYVAVDGAQGVAHTSVDVVDWDVDFYAFSGHKMYAPTGLGVLYGKKAL
LEKLPPVEGGGDMVSIYDSEHPEYLPAPLKFEAGTPPIASILGLGAAIDYLQSLPDSVYQEEEELTQYLYNELLTIPGMQ
ILGPEVGHPRGALISFKVEGAHPFDIGCLLDLQGIAVRTGHQCAQPAMTRWDLGHVLRVSLGLYNDKEDVDAFLSALRVI
LNKVRV

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=383, Percent_Identity=26.1096605744125, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1787970, Length=401, Percent_Identity=42.14463840399, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1789175, Length=398, Percent_Identity=37.1859296482412, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI48994898, Length=403, Percent_Identity=27.0471464019851, Blast_Score=118, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI25143064, Length=403, Percent_Identity=25.8064516129032, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=339, Percent_Identity=27.4336283185841, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319831, Length=394, Percent_Identity=26.9035532994924, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129463, Length=398, Percent_Identity=27.3869346733668, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44309; Mature: 44309

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCRIKEDFPIFSNKKLQGESYIYLDSAATTHKPKKVIDAITDFYSSSYATVNRNVYTSS
CEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCEEECC
QVTTANYNAVRGKVRAWIQAAYDEEIVFTRGTTAALNLLAISANDAFIPEGGVVLVSEVE
CEEECCCHHHHHHHHHHHHHHCCCCEEEECCCHHEEEEEEEECCCCCCCCCCEEEEEEHH
HHANVLSWELACRRRGSCVKKIAVDHLGYIDLEHLEVLLKAGAVFVSIAHVSNVTGCIQP
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHEEEHHHHHHHHHHHHH
LKEIASLAHQYGAYVAVDGAQGVAHTSVDVVDWDVDFYAFSGHKMYAPTGLGVLYGKKAL
HHHHHHHHHHHCCEEEEECCCCCEECEEEEEEECEEEEEECCCEEECCCCCHHHHHHHHH
LEKLPPVEGGGDMVSIYDSEHPEYLPAPLKFEAGTPPIASILGLGAAIDYLQSLPDSVYQ
HHHCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHH
EEEELTQYLYNELLTIPGMQILGPEVGHPRGALISFKVEGAHPFDIGCLLDLQGIAVRTG
HHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCEEEECC
HQCAQPAMTRWDLGHVLRVSLGLYNDKEDVDAFLSALRVILNKVRV
CHHHCCCHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVCRIKEDFPIFSNKKLQGESYIYLDSAATTHKPKKVIDAITDFYSSSYATVNRNVYTSS
CEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCEEECC
QVTTANYNAVRGKVRAWIQAAYDEEIVFTRGTTAALNLLAISANDAFIPEGGVVLVSEVE
CEEECCCHHHHHHHHHHHHHHCCCCEEEECCCHHEEEEEEEECCCCCCCCCCEEEEEEHH
HHANVLSWELACRRRGSCVKKIAVDHLGYIDLEHLEVLLKAGAVFVSIAHVSNVTGCIQP
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHEEEHHHHHHHHHHHHH
LKEIASLAHQYGAYVAVDGAQGVAHTSVDVVDWDVDFYAFSGHKMYAPTGLGVLYGKKAL
HHHHHHHHHHHCCEEEEECCCCCEECEEEEEEECEEEEEECCCEEECCCCCHHHHHHHHH
LEKLPPVEGGGDMVSIYDSEHPEYLPAPLKFEAGTPPIASILGLGAAIDYLQSLPDSVYQ
HHHCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHH
EEEELTQYLYNELLTIPGMQILGPEVGHPRGALISFKVEGAHPFDIGCLLDLQGIAVRTG
HHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCEEEECC
HQCAQPAMTRWDLGHVLRVSLGLYNDKEDVDAFLSALRVILNKVRV
CHHHCCCHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]