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The map label for this gene is dmsA [H]

Identifier: 59714173

GI number: 59714173

Start: 1109616

End: 1112264

Strand: Reverse

Name: dmsA [H]

Synonym: VF_A0990

Alternate gene names: 59714173

Gene position: 1112264-1109616 (Counterclockwise)

Preceding gene: 59714174

Following gene: 59714172

Centisome position: 83.61

GC content: 41.34

Gene sequence:

>2649_bases
ATGACTCTTTCTCGACGTACTTTTTTAAAAACCTCCATTGCGACTGCTATTGTTGCGGGTGGTGGTTTAATGGTTTATCC
CGCTTCTAAATTTTTTGATGATGAGGATGTAGAAGTCATTCCTCATGCTAGCCATTGGGGACCATTTAACGCAATTGTAA
AGGCGGGTGTTCTTGTTGGTATTCAACCTCGTAAAGAGCTCGATGCTATGCCTACCGAAATGCTGACAGAAGGTTTAATC
GGTCGAGTTTATGATAAAACTCGCGTTAAATACCCGATGGTAAGGGCTTCCTATTTAGCCGATCCAAAAGGGGATACGAA
ACCGCACTTGCGTGGTAAAGAACCTTTTGTGCGAGTTAGCTGGGATACCGCTTTATCTTTGGTTGCTGATGCAATTCAAA
CTACTGCAACAGAACATGGGAATGAAGCTATTTTCAGTAGTTCTTATGGTGGATGGTCGCATGCTGGTTTAATGCGTCCT
CAAGTATTACAAGGGCGTTTTTTCAATCTAATTGGTGGACAGAGTACGACGACGGGTGATTATTCTGGTGGTGCCTCACA
AGTTATTCTTCCTCATGTTATTGGTGATATGGAAGTATACTCACCACAAACCGCATGGCCTGTAATTCAAGAGAACACAG
AAATCTTTGTTCTGATAGGCTGTGATCCTTGGAAAAACAACCGCATTGAATTTCGTGTTGCGGATCATCAAATGTATTCT
CATTGGAAGCAGTTTGCTGAAAATGGCATTCAGTTTATTTCAATTAACCCACAACAGACCCGTACCGATGATGAATTGGA
TGCGGAGTGGGTGAAAATTGTTCCAAATACAGATACCGCTTTATTTTTAGCCATGGCACAGCATGTTTATGTTAACGATC
TTCATGATACCGCTTATTTGGCTCGTTATACCGTAGGGGCTGACAAATACATCGACCATTTAATGGGAAAAAATGATGGC
ATCGTAAAATCACCAGAATGGGCTGCAAAGATCACGGGTATTCCTGCTGAGGATATTCAAAAAATGGCCATTCGATTCGC
AACCAGTAAAACCCAATTTGCGGCGGGTTGGTCATTACAAAGAGCCGATCATGGTGAGATGATCCATTGGGCGATCATTA
ATTTTGCAGCTATGCTAGGCAAAATTGGTAAGCCGGGAGAAGGGGTTGGCTTTAGTTGGCATTATGGTAATGGTGGTATG
CCACAATCAGGGAAAACACTTCCTATTGGCTTATCTCAAGGTAAAAATCCAGTGAGTGCGATTTGTCCTGCATCTCGTAT
TTCTGAAATGCTGATGAATCCAGGAAAAAGCTTTACTAGAGATGGTATTGAATACACGTACCCTGATATCAAAATGGTGT
ATAACGCAGGCAATAATCTTCTTTCTCATCAGCAAGATACGAATGAACTTATTAATGCACTTAATGAAAAGGTTGAAACG
TTTGTCTGCCAAGACCCATGGTGGTGTGCTTCTTCTCGATATGCCGATATTGTATTGCCTGCAACCAGTACGTTAGAGCG
TAATGATCTTTCTTCTGGTGGTACGTACAGTAACGATAAAATTTATGCTATGCGTCAGGTCATTAAGCCTTACGGTGAAA
GTCTTGATGATTTCGAAATCTTTCGTAAATTAGCCGAGATATTCAATGTTGAAGAGAAATTTACAGATGGTTTAGCGTTT
GATGATATTTTGAAACGTGCTTATCACGCCTCATCAGCAACCTTATCATTTGATGAGTTTTGGAAAAATGGAGTCGCTTT
ATTACCTGTACCTCAAGAGGCAAATCAGTGGGTAAGACATGGTGATTTTTATCAAGATCCAGATAAGCATCCTTTGCATA
CCACATCAGGAAAAATAGAGCTTTACTGCCAAGATATTGCAAATTTTGATGTGAAAAATTGTCCACCAATGCCAACATTT
TTAGAACCGTTTGAATATTTAGGAAACGCAAAACCAAACCAAGTTCATGTTGTGAGCCCTCATCCTTACATGCGATTACA
CTCCCAGCTGGCAAATACAGAGGTTCGTAAATATGAAAGTGTTCAAGGACGTCAGTATGTACTGATTAATGACATGGATG
CACAAAAACACGGTATTCGTTCAGGGCAGTTAGTGGAAATCTACAATGAGCGAGGACGTGTTATTGCGGGTGCAAAAGTA
TCTGATCAGATCATGCCCGGAGTCATTAGTTTAGAAGAGGGAGCTTGGCTGCAATTTGATAGTCAAGGGCGATGCAATAG
TGGTTCTATTAATGTATTAACATCAAGCCAAGCATGCAGTGATTTAAGTCAGGCAAACAGTGCCAATACCTGCTTAGCTT
ATATTCAGCGTTGTCGTGATCCTGAGTCATCTAACTTGGCCTTTGAACCTCCAAGAACGGTGACGGTAGACAGTGATATT
CGTGTCGATAAAGTGAATACCACCCTTGGTGAAGCAAATACAAGTTCGAGTGAAACCAAACAGAGTGTTGGTGAAGCTCT
GTTTTATCAACGTTGTACTATGTGTCATTCTGCAAAAGATCCGAAGCAGTACACTAAATCGCAATGGCATGGTATTACCA
AAAGTATGTTCCCTCGTGCCGGGTTAAACCCATTAGAGCGAGAAGAGGTAATGGCATTTCTTGAAGCTAACGCTAAAGAC
GCGCAGTAA

Upstream 100 bases:

>100_bases
ATGTGCATATAAAATGAATCTTTATAGGTTTAGAATGCATCTGTTAAGGATTTATTCACTATTGATAAGTGATAAATAGA
CTAAAAATACGGAATGCATT

Downstream 100 bases:

>100_bases
TGTAAATAATTTCTCGTTTTATTTAAGCCCAAATAGCATGGCTGCTGTTTGGGCTTTTTTATGCATAATGATTAATAAAA
CAAACAATGAAAGGTTTCGA

Product: trimethylamine-N-oxide reductase

Products: Biotin [C]

Alternate protein names: DMSO reductase; DMSOR [H]

Number of amino acids: Translated: 882; Mature: 881

Protein sequence:

>882_residues
MTLSRRTFLKTSIATAIVAGGGLMVYPASKFFDDEDVEVIPHASHWGPFNAIVKAGVLVGIQPRKELDAMPTEMLTEGLI
GRVYDKTRVKYPMVRASYLADPKGDTKPHLRGKEPFVRVSWDTALSLVADAIQTTATEHGNEAIFSSSYGGWSHAGLMRP
QVLQGRFFNLIGGQSTTTGDYSGGASQVILPHVIGDMEVYSPQTAWPVIQENTEIFVLIGCDPWKNNRIEFRVADHQMYS
HWKQFAENGIQFISINPQQTRTDDELDAEWVKIVPNTDTALFLAMAQHVYVNDLHDTAYLARYTVGADKYIDHLMGKNDG
IVKSPEWAAKITGIPAEDIQKMAIRFATSKTQFAAGWSLQRADHGEMIHWAIINFAAMLGKIGKPGEGVGFSWHYGNGGM
PQSGKTLPIGLSQGKNPVSAICPASRISEMLMNPGKSFTRDGIEYTYPDIKMVYNAGNNLLSHQQDTNELINALNEKVET
FVCQDPWWCASSRYADIVLPATSTLERNDLSSGGTYSNDKIYAMRQVIKPYGESLDDFEIFRKLAEIFNVEEKFTDGLAF
DDILKRAYHASSATLSFDEFWKNGVALLPVPQEANQWVRHGDFYQDPDKHPLHTTSGKIELYCQDIANFDVKNCPPMPTF
LEPFEYLGNAKPNQVHVVSPHPYMRLHSQLANTEVRKYESVQGRQYVLINDMDAQKHGIRSGQLVEIYNERGRVIAGAKV
SDQIMPGVISLEEGAWLQFDSQGRCNSGSINVLTSSQACSDLSQANSANTCLAYIQRCRDPESSNLAFEPPRTVTVDSDI
RVDKVNTTLGEANTSSSETKQSVGEALFYQRCTMCHSAKDPKQYTKSQWHGITKSMFPRAGLNPLEREEVMAFLEANAKD
AQ

Sequences:

>Translated_882_residues
MTLSRRTFLKTSIATAIVAGGGLMVYPASKFFDDEDVEVIPHASHWGPFNAIVKAGVLVGIQPRKELDAMPTEMLTEGLI
GRVYDKTRVKYPMVRASYLADPKGDTKPHLRGKEPFVRVSWDTALSLVADAIQTTATEHGNEAIFSSSYGGWSHAGLMRP
QVLQGRFFNLIGGQSTTTGDYSGGASQVILPHVIGDMEVYSPQTAWPVIQENTEIFVLIGCDPWKNNRIEFRVADHQMYS
HWKQFAENGIQFISINPQQTRTDDELDAEWVKIVPNTDTALFLAMAQHVYVNDLHDTAYLARYTVGADKYIDHLMGKNDG
IVKSPEWAAKITGIPAEDIQKMAIRFATSKTQFAAGWSLQRADHGEMIHWAIINFAAMLGKIGKPGEGVGFSWHYGNGGM
PQSGKTLPIGLSQGKNPVSAICPASRISEMLMNPGKSFTRDGIEYTYPDIKMVYNAGNNLLSHQQDTNELINALNEKVET
FVCQDPWWCASSRYADIVLPATSTLERNDLSSGGTYSNDKIYAMRQVIKPYGESLDDFEIFRKLAEIFNVEEKFTDGLAF
DDILKRAYHASSATLSFDEFWKNGVALLPVPQEANQWVRHGDFYQDPDKHPLHTTSGKIELYCQDIANFDVKNCPPMPTF
LEPFEYLGNAKPNQVHVVSPHPYMRLHSQLANTEVRKYESVQGRQYVLINDMDAQKHGIRSGQLVEIYNERGRVIAGAKV
SDQIMPGVISLEEGAWLQFDSQGRCNSGSINVLTSSQACSDLSQANSANTCLAYIQRCRDPESSNLAFEPPRTVTVDSDI
RVDKVNTTLGEANTSSSETKQSVGEALFYQRCTMCHSAKDPKQYTKSQWHGITKSMFPRAGLNPLEREEVMAFLEANAKD
AQ
>Mature_881_residues
TLSRRTFLKTSIATAIVAGGGLMVYPASKFFDDEDVEVIPHASHWGPFNAIVKAGVLVGIQPRKELDAMPTEMLTEGLIG
RVYDKTRVKYPMVRASYLADPKGDTKPHLRGKEPFVRVSWDTALSLVADAIQTTATEHGNEAIFSSSYGGWSHAGLMRPQ
VLQGRFFNLIGGQSTTTGDYSGGASQVILPHVIGDMEVYSPQTAWPVIQENTEIFVLIGCDPWKNNRIEFRVADHQMYSH
WKQFAENGIQFISINPQQTRTDDELDAEWVKIVPNTDTALFLAMAQHVYVNDLHDTAYLARYTVGADKYIDHLMGKNDGI
VKSPEWAAKITGIPAEDIQKMAIRFATSKTQFAAGWSLQRADHGEMIHWAIINFAAMLGKIGKPGEGVGFSWHYGNGGMP
QSGKTLPIGLSQGKNPVSAICPASRISEMLMNPGKSFTRDGIEYTYPDIKMVYNAGNNLLSHQQDTNELINALNEKVETF
VCQDPWWCASSRYADIVLPATSTLERNDLSSGGTYSNDKIYAMRQVIKPYGESLDDFEIFRKLAEIFNVEEKFTDGLAFD
DILKRAYHASSATLSFDEFWKNGVALLPVPQEANQWVRHGDFYQDPDKHPLHTTSGKIELYCQDIANFDVKNCPPMPTFL
EPFEYLGNAKPNQVHVVSPHPYMRLHSQLANTEVRKYESVQGRQYVLINDMDAQKHGIRSGQLVEIYNERGRVIAGAKVS
DQIMPGVISLEEGAWLQFDSQGRCNSGSINVLTSSQACSDLSQANSANTCLAYIQRCRDPESSNLAFEPPRTVTVDSDIR
VDKVNTTLGEANTSSSETKQSVGEALFYQRCTMCHSAKDPKQYTKSQWHGITKSMFPRAGLNPLEREEVMAFLEANAKDA
Q

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081994, Length=816, Percent_Identity=38.4803921568627, Blast_Score=544, Evalue=1e-155,
Organism=Escherichia coli, GI145693196, Length=768, Percent_Identity=38.5416666666667, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1787231, Length=795, Percent_Identity=39.2452830188679, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI87081797, Length=745, Percent_Identity=31.1409395973154, Blast_Score=285, Evalue=1e-77,
Organism=Escherichia coli, GI1787870, Length=745, Percent_Identity=28.993288590604, Blast_Score=242, Evalue=8e-65,
Organism=Escherichia coli, GI171474008, Length=840, Percent_Identity=27.7380952380952, Blast_Score=232, Evalue=7e-62,
Organism=Escherichia coli, GI3868721, Length=668, Percent_Identity=21.4071856287425, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.7.2.3 [C]

Molecular weight: Translated: 98218; Mature: 98087

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSRRTFLKTSIATAIVAGGGLMVYPASKFFDDEDVEVIPHASHWGPFNAIVKAGVLVG
CCCCHHHHHHHHHHHHHHCCCCEEEEECHHCCCCCCCEEECCCCCCCHHHHHHHCCEEEE
IQPRKELDAMPTEMLTEGLIGRVYDKTRVKYPMVRASYLADPKGDTKPHLRGKEPFVRVS
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEE
WDTALSLVADAIQTTATEHGNEAIFSSSYGGWSHAGLMRPQVLQGRFFNLIGGQSTTTGD
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHCCCHHHHCCCCCCCCCC
YSGGASQVILPHVIGDMEVYSPQTAWPVIQENTEIFVLIGCDPWKNNRIEFRVADHQMYS
CCCCCCCEEHHHHHCCCEECCCCCCCCEEECCCEEEEEECCCCCCCCEEEEEECHHHHHH
HWKQFAENGIQFISINPQQTRTDDELDAEWVKIVPNTDTALFLAMAQHVYVNDLHDTAYL
HHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHH
ARYTVGADKYIDHLMGKNDGIVKSPEWAAKITGIPAEDIQKMAIRFATSKTQFAAGWSLQ
HHEECCHHHHHHHHHCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHHCCCCCEECCCCCC
RADHGEMIHWAIINFAAMLGKIGKPGEGVGFSWHYGNGGMPQSGKTLPIGLSQGKNPVSA
CCCCCCEEHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCHHH
ICPASRISEMLMNPGKSFTRDGIEYTYPDIKMVYNAGNNLLSHQQDTNELINALNEKVET
HCCHHHHHHHHHCCCCCHHHCCCEEECCCEEEEEECCCCHHCCCCHHHHHHHHHHHHHHE
FVCQDPWWCASSRYADIVLPATSTLERNDLSSGGTYSNDKIYAMRQVIKPYGESLDDFEI
EECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
FRKLAEIFNVEEKFTDGLAFDDILKRAYHASSATLSFDEFWKNGVALLPVPQEANQWVRH
HHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHCCEEEEECCHHHHHHHHC
GDFYQDPDKHPLHTTSGKIELYCQDIANFDVKNCPPMPTFLEPFEYLGNAKPNQVHVVSP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECC
HPYMRLHSQLANTEVRKYESVQGRQYVLINDMDAQKHGIRSGQLVEIYNERGRVIAGAKV
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCCCEEEEECCCCCEEECCCC
SDQIMPGVISLEEGAWLQFDSQGRCNSGSINVLTSSQACSDLSQANSANTCLAYIQRCRD
CCCCCCCEEEECCCCEEEECCCCCCCCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHCC
PESSNLAFEPPRTVTVDSDIRVDKVNTTLGEANTSSSETKQSVGEALFYQRCTMCHSAKD
CCCCCEEECCCCEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PKQYTKSQWHGITKSMFPRAGLNPLEREEVMAFLEANAKDAQ
HHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLSRRTFLKTSIATAIVAGGGLMVYPASKFFDDEDVEVIPHASHWGPFNAIVKAGVLVG
CCCHHHHHHHHHHHHHHCCCCEEEEECHHCCCCCCCEEECCCCCCCHHHHHHHCCEEEE
IQPRKELDAMPTEMLTEGLIGRVYDKTRVKYPMVRASYLADPKGDTKPHLRGKEPFVRVS
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEE
WDTALSLVADAIQTTATEHGNEAIFSSSYGGWSHAGLMRPQVLQGRFFNLIGGQSTTTGD
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHCCCHHHHCCCCCCCCCC
YSGGASQVILPHVIGDMEVYSPQTAWPVIQENTEIFVLIGCDPWKNNRIEFRVADHQMYS
CCCCCCCEEHHHHHCCCEECCCCCCCCEEECCCEEEEEECCCCCCCCEEEEEECHHHHHH
HWKQFAENGIQFISINPQQTRTDDELDAEWVKIVPNTDTALFLAMAQHVYVNDLHDTAYL
HHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHH
ARYTVGADKYIDHLMGKNDGIVKSPEWAAKITGIPAEDIQKMAIRFATSKTQFAAGWSLQ
HHEECCHHHHHHHHHCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHHCCCCCEECCCCCC
RADHGEMIHWAIINFAAMLGKIGKPGEGVGFSWHYGNGGMPQSGKTLPIGLSQGKNPVSA
CCCCCCEEHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCHHH
ICPASRISEMLMNPGKSFTRDGIEYTYPDIKMVYNAGNNLLSHQQDTNELINALNEKVET
HCCHHHHHHHHHCCCCCHHHCCCEEECCCEEEEEECCCCHHCCCCHHHHHHHHHHHHHHE
FVCQDPWWCASSRYADIVLPATSTLERNDLSSGGTYSNDKIYAMRQVIKPYGESLDDFEI
EECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
FRKLAEIFNVEEKFTDGLAFDDILKRAYHASSATLSFDEFWKNGVALLPVPQEANQWVRH
HHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHCCEEEEECCHHHHHHHHC
GDFYQDPDKHPLHTTSGKIELYCQDIANFDVKNCPPMPTFLEPFEYLGNAKPNQVHVVSP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECC
HPYMRLHSQLANTEVRKYESVQGRQYVLINDMDAQKHGIRSGQLVEIYNERGRVIAGAKV
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCCCCCCEEEEECCCCCEEECCCC
SDQIMPGVISLEEGAWLQFDSQGRCNSGSINVLTSSQACSDLSQANSANTCLAYIQRCRD
CCCCCCCEEEECCCCEEEECCCCCCCCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHHCC
PESSNLAFEPPRTVTVDSDIRVDKVNTTLGEANTSSSETKQSVGEALFYQRCTMCHSAKD
CCCCCEEECCCCEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PKQYTKSQWHGITKSMFPRAGLNPLEREEVMAFLEANAKDAQ
HHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds) [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8645727; 8534974; 7625833; 8658134 [H]