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The map label for this gene is csd [H]

Identifier: 59713951

GI number: 59713951

Start: 862836

End: 864068

Strand: Reverse

Name: csd [H]

Synonym: VF_A0768

Alternate gene names: 59713951

Gene position: 864068-862836 (Counterclockwise)

Preceding gene: 59713952

Following gene: 59713949

Centisome position: 64.95

GC content: 38.52

Gene sequence:

>1233_bases
ATGAATTTCACTCCTAATAACGTTAGAACACAGTTTCTTTCTTTAACGCAAGAGGTAGACAATAAACCCGTTATTTTTTT
TGATGGACCGGGTGGCTCACAAGTACCTCAAAGTGTGATTGATTCCATGTCTCGCTATCTTGGTTTTTCCAATTCAAATT
TGGGCGGACACTTTTTTTCCAGTAAAAATACAAATAATGTATTAAATCAAGCTCGACTTTCATGTGCGGCATTGCTCAAT
GCGAAGAGCGAAGAAAACATCATATTTGGCCCTAACATGACCTCACTTACTTTTCAGCTGAGTCGTGCCATTAGCCGAGA
CTGGAAAAGAGGGGATGAGATTATTGTCACTGCACTTGATCACTATTCAAACGTATCAAGTTGGCAGCAAGCTGCAGAAG
ATAAAGGGGTGATTGTTCATCAAGTAAGAGTTAAAGAAGATGACTGTACTTTGGATATGGAACACCTTTATTCATTGTTA
ACAGAAAAAACGAAATTAGTCGCAACCACTTATGCTTCTAATACCACAGGTTCAATTGTTGATGTGAAATCAATTGTTGA
AGCAGCACATAATGTGAACGCTATGGTTTATGTGGATGCTGTTCATTATGCCCCTCATCATCTTATCGATGTTCAAGCGC
TTGGATGTGACTTTTTAGCGTGTTCAGCATATAAATTTTTTGGGCCTCATGTGGGCATTGCTTATGTATCACCAAAATGG
ATGTACGCTTTATTTCCCTATAAAGTTGAGCCTGCGACAAATGTTGGTCCCGGTCGCTTTGAGACTGGGACTCAAAGTTT
TGAAGCTTTAGCCGGTTTAACCAGTGCTGTTGAATATTTGGCTCAATGGGGAAGAAAGTCTCTCTCTTTAAGGGATAGGC
TGAAAAAGAGCTTTGAGCAATACCAAATACATGAAGATGAATTAACACAGCATTTTTTAAATAAACTTGCGGTACGTCCG
TGGATACATTTATATGGCATTAATGATAAGAACAAATTGACTGAGCGTACCCCGACATTTGCACTTCGTATTGATGGCAT
AAAGCCTGAAGAGATAGCCAAAGTATTAGCTGAATATAATGTGTGTGTGTGGAGCGGACATTTTTATGCGATTGGTTTAA
TTAAACAGCTAGGTTTTTATGAGCGAGGAGGTGTTGTCCGCATTGGTTTTATGCATTACAACACCATAGAAGAAATTGAT
TATTTATTTTTGCTTTTAGATGCATTTGCATAG

Upstream 100 bases:

>100_bases
GATAGAAAACTTTGGCACAACGGTAAACCAATCCGTTTAATTGATCAGCAGAAAGAAGGGCATATGGACGTTTTTGTTTT
AACCGCTAAGGATAATGTTG

Downstream 100 bases:

>100_bases
AAAGCGGCAATGTCTCTTAAGTCTTGATCATTTAATCGTTGTAATTGGGCCTTCATCATTTGTGCTAGAGGGCCTTTCCT
TTCATCGTTTTGATAGGATT

Product: cysteine desulfhydrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNFTPNNVRTQFLSLTQEVDNKPVIFFDGPGGSQVPQSVIDSMSRYLGFSNSNLGGHFFSSKNTNNVLNQARLSCAALLN
AKSEENIIFGPNMTSLTFQLSRAISRDWKRGDEIIVTALDHYSNVSSWQQAAEDKGVIVHQVRVKEDDCTLDMEHLYSLL
TEKTKLVATTYASNTTGSIVDVKSIVEAAHNVNAMVYVDAVHYAPHHLIDVQALGCDFLACSAYKFFGPHVGIAYVSPKW
MYALFPYKVEPATNVGPGRFETGTQSFEALAGLTSAVEYLAQWGRKSLSLRDRLKKSFEQYQIHEDELTQHFLNKLAVRP
WIHLYGINDKNKLTERTPTFALRIDGIKPEEIAKVLAEYNVCVWSGHFYAIGLIKQLGFYERGGVVRIGFMHYNTIEEID
YLFLLLDAFA

Sequences:

>Translated_410_residues
MNFTPNNVRTQFLSLTQEVDNKPVIFFDGPGGSQVPQSVIDSMSRYLGFSNSNLGGHFFSSKNTNNVLNQARLSCAALLN
AKSEENIIFGPNMTSLTFQLSRAISRDWKRGDEIIVTALDHYSNVSSWQQAAEDKGVIVHQVRVKEDDCTLDMEHLYSLL
TEKTKLVATTYASNTTGSIVDVKSIVEAAHNVNAMVYVDAVHYAPHHLIDVQALGCDFLACSAYKFFGPHVGIAYVSPKW
MYALFPYKVEPATNVGPGRFETGTQSFEALAGLTSAVEYLAQWGRKSLSLRDRLKKSFEQYQIHEDELTQHFLNKLAVRP
WIHLYGINDKNKLTERTPTFALRIDGIKPEEIAKVLAEYNVCVWSGHFYAIGLIKQLGFYERGGVVRIGFMHYNTIEEID
YLFLLLDAFA
>Mature_410_residues
MNFTPNNVRTQFLSLTQEVDNKPVIFFDGPGGSQVPQSVIDSMSRYLGFSNSNLGGHFFSSKNTNNVLNQARLSCAALLN
AKSEENIIFGPNMTSLTFQLSRAISRDWKRGDEIIVTALDHYSNVSSWQQAAEDKGVIVHQVRVKEDDCTLDMEHLYSLL
TEKTKLVATTYASNTTGSIVDVKSIVEAAHNVNAMVYVDAVHYAPHHLIDVQALGCDFLACSAYKFFGPHVGIAYVSPKW
MYALFPYKVEPATNVGPGRFETGTQSFEALAGLTSAVEYLAQWGRKSLSLRDRLKKSFEQYQIHEDELTQHFLNKLAVRP
WIHLYGINDKNKLTERTPTFALRIDGIKPEEIAKVLAEYNVCVWSGHFYAIGLIKQLGFYERGGVVRIGFMHYNTIEEID
YLFLLLDAFA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI156713448, Length=306, Percent_Identity=22.5490196078431, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787970, Length=422, Percent_Identity=28.436018957346, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789175, Length=422, Percent_Identity=25.3554502369668, Blast_Score=132, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46105; Mature: 46105

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFTPNNVRTQFLSLTQEVDNKPVIFFDGPGGSQVPQSVIDSMSRYLGFSNSNLGGHFFS
CCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEC
SKNTNNVLNQARLSCAALLNAKSEENIIFGPNMTSLTFQLSRAISRDWKRGDEIIVTALD
CCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEH
HYSNVSSWQQAAEDKGVIVHQVRVKEDDCTLDMEHLYSLLTEKTKLVATTYASNTTGSIV
HHCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCHHEEEEEECCCCCCCHH
DVKSIVEAAHNVNAMVYVDAVHYAPHHLIDVQALGCDFLACSAYKFFGPHVGIAYVSPKW
HHHHHHHHHHCCCEEEEEEEECCCCCCEEEEHHCCCCHHHHHHHHHCCCCCEEEEECCCE
MYALFPYKVEPATNVGPGRFETGTQSFEALAGLTSAVEYLAQWGRKSLSLRDRLKKSFEQ
EEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
YQIHEDELTQHFLNKLAVRPWIHLYGINDKNKLTERTPTFALRIDGIKPEEIAKVLAEYN
HCCCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHCC
VCVWSGHFYAIGLIKQLGFYERGGVVRIGFMHYNTIEEIDYLFLLLDAFA
EEEECCCHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFTPNNVRTQFLSLTQEVDNKPVIFFDGPGGSQVPQSVIDSMSRYLGFSNSNLGGHFFS
CCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEC
SKNTNNVLNQARLSCAALLNAKSEENIIFGPNMTSLTFQLSRAISRDWKRGDEIIVTALD
CCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEH
HYSNVSSWQQAAEDKGVIVHQVRVKEDDCTLDMEHLYSLLTEKTKLVATTYASNTTGSIV
HHCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCHHEEEEEECCCCCCCHH
DVKSIVEAAHNVNAMVYVDAVHYAPHHLIDVQALGCDFLACSAYKFFGPHVGIAYVSPKW
HHHHHHHHHHCCCEEEEEEEECCCCCCEEEEHHCCCCHHHHHHHHHCCCCCEEEEECCCE
MYALFPYKVEPATNVGPGRFETGTQSFEALAGLTSAVEYLAQWGRKSLSLRDRLKKSFEQ
EEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
YQIHEDELTQHFLNKLAVRPWIHLYGINDKNKLTERTPTFALRIDGIKPEEIAKVLAEYN
HCCCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHCC
VCVWSGHFYAIGLIKQLGFYERGGVVRIGFMHYNTIEEIDYLFLLLDAFA
EEEECCCHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]