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The map label for this gene is bioC [H]

Identifier: 59713929

GI number: 59713929

Start: 842105

End: 842926

Strand: Reverse

Name: bioC [H]

Synonym: VF_A0746

Alternate gene names: 59713929

Gene position: 842926-842105 (Counterclockwise)

Preceding gene: 172087813

Following gene: 59713928

Centisome position: 63.36

GC content: 38.93

Gene sequence:

>822_bases
ATGGTGAATCCAGCAGTTGCCATCGATATGTTTAATTCAACATCAAATAAAGAAAAACAAGCGATTCAAGCTGCATTTAG
TAAAGCGGCGCATACCTATGATCGTTCAGCAGAATTTCAACGCCAAGTGGCAGATACGCTTTTGTCTTATTTACCAACCG
ATCTAACTGGACTACGAATTTTAGATGTGGGGTGTGGAACTGGTTATTGTTGCGAAGCCTTGTTAAAACGGGGAGCATGC
GTCGTAGCGTTTGATTTATCGTCTGTCATGTTAGAGAAAGCGAAAGAACGATGTGGTGATCACAATATTACCTATATTCA
AGGTGATGCTGAAGATCTTCCGTTCATGGATGATGAATTTGATGGTGTCGTATCCAGTTTAGCGCTGCAATGGTGCCAAG
ATTTATCGGTCCCATTAAGAGAAATGAAACGAATTAGCCATAATAAAAGCAAGGTTATTTTCTCAACTTTGTTAGATGGC
TCACTGTTTGAATTGAAAAAGGCATGGTCAAAGGTTGATTTATATCAACATGTTAACGATTTTATTACGCCATCTATGGT
AAAAATTGCGTTAGCGCAATCTGAATGCAACAACTTTACACTACACTGCACGTCTGTCGAGATGACGTATTCTTCCGCTC
TTGCTTTAATGAAAGATTTAAAAGGAATTGGAGCAACGCATTTACCTAATGGTCGCAGCTCAGGATTATTGAGCAAAGAA
AAGCTATTAGCAGTGGAAGAAGCGTATCAACTATTTAGAAGTGAATTAAACCACTTACCTGCTACATATCAGGTAGGCTA
CGGAGTTATAAGTAATGATTGA

Upstream 100 bases:

>100_bases
AGTCGGTTCAGCTCGAATAAGAGTGACCTTAAGTGCCAATCATTCATCAGCAGATATTTCAGCGCTGACACAAGCGATAA
ACGAATTAGGATGAGGTGTT

Downstream 100 bases:

>100_bases
TGCATTTTTTATTGCAGGAACAGATACAGATGTGGGTAAAACCGTTGCTTCAAAAGCGATTTTAGATGCGTTAAACATGA
AAGGTTTACGAACTGCTGCT

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MVNPAVAIDMFNSTSNKEKQAIQAAFSKAAHTYDRSAEFQRQVADTLLSYLPTDLTGLRILDVGCGTGYCCEALLKRGAC
VVAFDLSSVMLEKAKERCGDHNITYIQGDAEDLPFMDDEFDGVVSSLALQWCQDLSVPLREMKRISHNKSKVIFSTLLDG
SLFELKKAWSKVDLYQHVNDFITPSMVKIALAQSECNNFTLHCTSVEMTYSSALALMKDLKGIGATHLPNGRSSGLLSKE
KLLAVEEAYQLFRSELNHLPATYQVGYGVISND

Sequences:

>Translated_273_residues
MVNPAVAIDMFNSTSNKEKQAIQAAFSKAAHTYDRSAEFQRQVADTLLSYLPTDLTGLRILDVGCGTGYCCEALLKRGAC
VVAFDLSSVMLEKAKERCGDHNITYIQGDAEDLPFMDDEFDGVVSSLALQWCQDLSVPLREMKRISHNKSKVIFSTLLDG
SLFELKKAWSKVDLYQHVNDFITPSMVKIALAQSECNNFTLHCTSVEMTYSSALALMKDLKGIGATHLPNGRSSGLLSKE
KLLAVEEAYQLFRSELNHLPATYQVGYGVISND
>Mature_273_residues
MVNPAVAIDMFNSTSNKEKQAIQAAFSKAAHTYDRSAEFQRQVADTLLSYLPTDLTGLRILDVGCGTGYCCEALLKRGAC
VVAFDLSSVMLEKAKERCGDHNITYIQGDAEDLPFMDDEFDGVVSSLALQWCQDLSVPLREMKRISHNKSKVIFSTLLDG
SLFELKKAWSKVDLYQHVNDFITPSMVKIALAQSECNNFTLHCTSVEMTYSSALALMKDLKGIGATHLPNGRSSGLLSKE
KLLAVEEAYQLFRSELNHLPATYQVGYGVISND

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=261, Percent_Identity=26.8199233716475, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786994, Length=242, Percent_Identity=38.0165289256198, Blast_Score=163, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17535003, Length=240, Percent_Identity=25.4166666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922210, Length=282, Percent_Identity=26.5957446808511, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 30168; Mature: 30168

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNPAVAIDMFNSTSNKEKQAIQAAFSKAAHTYDRSAEFQRQVADTLLSYLPTDLTGLRI
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
LDVGCGTGYCCEALLKRGACVVAFDLSSVMLEKAKERCGDHNITYIQGDAEDLPFMDDEF
EEECCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHH
DGVVSSLALQWCQDLSVPLREMKRISHNKSKVIFSTLLDGSLFELKKAWSKVDLYQHVND
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FITPSMVKIALAQSECNNFTLHCTSVEMTYSSALALMKDLKGIGATHLPNGRSSGLLSKE
HCCHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
KLLAVEEAYQLFRSELNHLPATYQVGYGVISND
HHHHHHHHHHHHHHHHHCCCCEEEECCEEECCC
>Mature Secondary Structure
MVNPAVAIDMFNSTSNKEKQAIQAAFSKAAHTYDRSAEFQRQVADTLLSYLPTDLTGLRI
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
LDVGCGTGYCCEALLKRGACVVAFDLSSVMLEKAKERCGDHNITYIQGDAEDLPFMDDEF
EEECCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHH
DGVVSSLALQWCQDLSVPLREMKRISHNKSKVIFSTLLDGSLFELKKAWSKVDLYQHVND
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FITPSMVKIALAQSECNNFTLHCTSVEMTYSSALALMKDLKGIGATHLPNGRSSGLLSKE
HCCHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
KLLAVEEAYQLFRSELNHLPATYQVGYGVISND
HHHHHHHHHHHHHHHHHCCCCEEEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]