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The map label for this gene is lsrR [H]

Identifier: 59713583

GI number: 59713583

Start: 454430

End: 455410

Strand: Reverse

Name: lsrR [H]

Synonym: VF_A0400

Alternate gene names: 59713583

Gene position: 455410-454430 (Counterclockwise)

Preceding gene: 59713584

Following gene: 59713582

Centisome position: 34.23

GC content: 41.79

Gene sequence:

>981_bases
ATGACGATGTCACCCTCTCAAGATCAAACAGAAAACACAGATATGTTGACTGAAATTGCGATTCTTTATTATCAAGAAGG
CGCAACTCAGGAGGAAATATCAAAAAAGTTTGGTTTATCTCGAGCGAAAGTTGGTCGCATGCTAAGAAAGGCGCGAGAAG
AAGGCATTGTTGAAATAACCGTAAAATTTCACCCTGTATACAGTGTTCAGCTTGAACAAAAACTGGTTGAAAAATTTAAC
CTAAAACGTGCATTAATTTCGTTAGACCAACCCAATACAAATGAACAACGAAAACAAGTTGCAGCACTTGTAAGTTCATA
CCTTAACAATAACTTACAAGAAGGAATGGCTGTTGCTGTTGGTCAAGGCCAAAATGTTGCAGCAGTAGCAGATCATGCAG
GCATCGTTACGCAACGTAATGCACGCTTCGTATCGGCGATAGGTGGAACCCATCGCAGTGGTGATATTATTAATGCTGAT
CATATCTGCCGTCGTCTAGCCAAAAAATACGGTGGAAGCAGCGAAACCTTATACGCTCCAGCTTATGTAAATGACCCAAG
CTTACGATCAGCATTTATGGAGCATGCCACCATCAAAGAGACATTAAGCCAAGCTAGAAAAGCGGAATTTGCCTTAGTTG
GTATTGGTGATATGGACGAAAATAGTCATATGGTCAAACTCGGGTTCTTCACACCTAAAGAATTTGTTGAAGCCCGATTA
AACGATGGCATCGTGGGTGATATTGGCGGTTTTGATTTCTTCAAACTTGATGGTACGGACGCAGACACTCTTATGCGAGG
CCGTGTTATTGGTCTTGAAATGGAAGACCTACGTCAAATTCCAAATGTTGTGGCAATGGCCAGCGAAAGTCGTAAAGCCT
TATCAATTATGGGAGCTTTACGCACAGGCGTTATAGACGTACTTGCTACCAGCGTAAGCTGTGCCATGGCTTTATTGAAT
TTAGCGGAAAATGAAGAGTAA

Upstream 100 bases:

>100_bases
ATTTATGTCATCAAGATAAACTAGGCATAACTCCGGCACAAAAGTTAGGGTTAATATCAAAACCAATTACACTTGCAGAA
TTATTAAGTTAGGACAAGTT

Downstream 100 bases:

>100_bases
CCCACACTTATTCCCTTTCACAATATAACATACTGTAGCACGATCGCAGTTCTATAATTTAGTTCGTGACATCAATAGAT
TAGCAAGATTATATTGATGT

Product: transcriptional repressor

Products: protein histidine; sugar phosphate

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTMSPSQDQTENTDMLTEIAILYYQEGATQEEISKKFGLSRAKVGRMLRKAREEGIVEITVKFHPVYSVQLEQKLVEKFN
LKRALISLDQPNTNEQRKQVAALVSSYLNNNLQEGMAVAVGQGQNVAAVADHAGIVTQRNARFVSAIGGTHRSGDIINAD
HICRRLAKKYGGSSETLYAPAYVNDPSLRSAFMEHATIKETLSQARKAEFALVGIGDMDENSHMVKLGFFTPKEFVEARL
NDGIVGDIGGFDFFKLDGTDADTLMRGRVIGLEMEDLRQIPNVVAMASESRKALSIMGALRTGVIDVLATSVSCAMALLN
LAENEE

Sequences:

>Translated_326_residues
MTMSPSQDQTENTDMLTEIAILYYQEGATQEEISKKFGLSRAKVGRMLRKAREEGIVEITVKFHPVYSVQLEQKLVEKFN
LKRALISLDQPNTNEQRKQVAALVSSYLNNNLQEGMAVAVGQGQNVAAVADHAGIVTQRNARFVSAIGGTHRSGDIINAD
HICRRLAKKYGGSSETLYAPAYVNDPSLRSAFMEHATIKETLSQARKAEFALVGIGDMDENSHMVKLGFFTPKEFVEARL
NDGIVGDIGGFDFFKLDGTDADTLMRGRVIGLEMEDLRQIPNVVAMASESRKALSIMGALRTGVIDVLATSVSCAMALLN
LAENEE
>Mature_325_residues
TMSPSQDQTENTDMLTEIAILYYQEGATQEEISKKFGLSRAKVGRMLRKAREEGIVEITVKFHPVYSVQLEQKLVEKFNL
KRALISLDQPNTNEQRKQVAALVSSYLNNNLQEGMAVAVGQGQNVAAVADHAGIVTQRNARFVSAIGGTHRSGDIINADH
ICRRLAKKYGGSSETLYAPAYVNDPSLRSAFMEHATIKETLSQARKAEFALVGIGDMDENSHMVKLGFFTPKEFVEARLN
DGIVGDIGGFDFFKLDGTDADTLMRGRVIGLEMEDLRQIPNVVAMASESRKALSIMGALRTGVIDVLATSVSCAMALLNL
AENEE

Specific function: Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI- 2, lsrR is inactivated by binding phospho-AI-2, leading to the trans

COG id: COG2390

COG function: function code K; Transcriptional regulator, contains sigma factor-related N-terminal domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sorC transcriptional regulatory family [H]

Homologues:

Organism=Escherichia coli, GI87082414, Length=326, Percent_Identity=26.9938650306748, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787791, Length=315, Percent_Identity=26.984126984127, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007324
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04198 Sugar-bind [H]

EC number: 2.7.1.69

Molecular weight: Translated: 35720; Mature: 35589

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMSPSQDQTENTDMLTEIAILYYQEGATQEEISKKFGLSRAKVGRMLRKAREEGIVEIT
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEE
VKFHPVYSVQLEQKLVEKFNLKRALISLDQPNTNEQRKQVAALVSSYLNNNLQEGMAVAV
EEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEE
GQGQNVAAVADHAGIVTQRNARFVSAIGGTHRSGDIINADHICRRLAKKYGGSSETLYAP
CCCCCEEEEHHCCCCEEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEC
AYVNDPSLRSAFMEHATIKETLSQARKAEFALVGIGDMDENSHMVKLGFFTPKEFVEARL
EECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHH
NDGIVGDIGGFDFFKLDGTDADTLMRGRVIGLEMEDLRQIPNVVAMASESRKALSIMGAL
CCCCEECCCCCEEEEECCCCHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTGVIDVLATSVSCAMALLNLAENEE
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TMSPSQDQTENTDMLTEIAILYYQEGATQEEISKKFGLSRAKVGRMLRKAREEGIVEIT
CCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEE
VKFHPVYSVQLEQKLVEKFNLKRALISLDQPNTNEQRKQVAALVSSYLNNNLQEGMAVAV
EEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEE
GQGQNVAAVADHAGIVTQRNARFVSAIGGTHRSGDIINADHICRRLAKKYGGSSETLYAP
CCCCCEEEEHHCCCCEEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEC
AYVNDPSLRSAFMEHATIKETLSQARKAEFALVGIGDMDENSHMVKLGFFTPKEFVEARL
EECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHH
NDGIVGDIGGFDFFKLDGTDADTLMRGRVIGLEMEDLRQIPNVVAMASESRKALSIMGAL
CCCCEECCCCCEEEEECCCCHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTGVIDVLATSVSCAMALLNLAENEE
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N(pi)-phosphohistidine; sugar

Specific reaction: protein N(pi)-phosphohistidine + sugar = protein histidine + sugar phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA