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The map label for this gene is aslA [H]

Identifier: 59713396

GI number: 59713396

Start: 236799

End: 238337

Strand: Reverse

Name: aslA [H]

Synonym: VF_A0213

Alternate gene names: 59713396

Gene position: 238337-236799 (Counterclockwise)

Preceding gene: 172087795

Following gene: 59713391

Centisome position: 17.92

GC content: 40.48

Gene sequence:

>1539_bases
ATGAAAACAAAAACGTTAGCCAAAACAGCACTAGCTCTTGCCGTTACCTCATTTGGAACTCATGCAGCACAAACTCAACC
GAACATAGTGACCATAATGGTTGATGACGTTAGCCCTATGGATATTTCAGCTTATCATCGAGGGTTAGGCGCAATTAACA
CGCCAAATATTGATCGTATAGCTAAACGAGGCATGATGGTAAGTGATTATTATGCACAAGGAAGCTCTACTGCAGGACGA
AGCGCCTTTATTACAGGGCAATATCCATTTAGAACTGGATTAACAACTGTTGGTCAACCTGGCTCTAATATTGGTTTACA
AAAAGAAGACCCCACTCTTGCTGACATGTTAAAAGCAAAAGGTTACGACACCATACATGTTGGGAAAAGCCATTTAGGCG
ACCGCAATAAATTTTTACCAACGGTTCATGGCTTTGATGAATTTTATGGTTTTCTTTATCACTTAAATGTAATGGAAATG
CCAGAGCAACCTAATTTCCCCAAAGACCCTGACTTTATTGGCCGTCCGCGAAATATGCTTCACAGCTTCGCCACAGAGAG
TTACGACAAAACCGTACAACCACGTTGGGGGGAAATTGGTAAACAGCGCATCGAAGATAAAGGGCCTCTTGGCTCTGAGC
GAATGAAAACCATTGATGATGAATACGTTGAGTTCACAACGCAATGGCTAGAAAAGCATGAAGCGCAAACACCAAATAAG
CCTTTTTTCTTGTGGTTTAATCCATCTCGTATGCATCAACAAATACACGTAAAAGATGAATATTTAGGAGTCAGTGGTCA
CACCGAATATTTTGATGCGTTAAAAGAGTTAGATGACCAAATAGGTGTATTACTAAATAAATTAGATGCTCTAGGTGAAA
CAGACAACACCATCATCATGTTTACGTCTGATAACGGTATTAACCTTGATCACTGGCCAATGGCTGGTACTGCCGCTTTC
CGTAGTCAAAAAGGAACAACGTGGGATGGAGCATTCCGAGTGCCTATGCTGATCAGCTGGCCTGGACATATACCTGAAGG
CGAATATACCGATGGATTTATGACATCAGAAGATTGGGTTCCAACCTTAATGGCTGCTGCAACTGGTGATACCAAAATTA
AGCAAGAGCTACTAAAAGGCAAAGAAATTAATGGAACAAAATACAAGGCTCATTTAGATGGCTATAACCAGATGGACATG
CTAACTAAAAAAGGCCCAAGCAAGCGTCATGAATTCTTCTATTACAATGAACAAGATTTGAATGCTATCCGCGTAGACAA
TTGGAAAGTGCATTTAAAAACTAAAACAGAATGGACTGAACCAGCAAAAGCATGGCCTCTTGGTATTATCCTAGATATCA
AAGCGGATCCATGGGAGCGAAGCGTTGATACTAATGGTTGGTTCTTATGGATGAAAGAACGCTCCTGGATAGTCCCTACA
CTACAGAAAAAGATTGGTGAATATAAAAAATCATTGAAAGTTTTCCCACCACGCCAAAAATCAGGTGGTATTGGAATGTC
TGATAATTCTGTGAAATAA

Upstream 100 bases:

>100_bases
TTAGTTCGCATGGAACAAATAGTTCGAAAATATACAGATATGTCTCAGCCACAAATTAAACAACACCATATAAATAAATT
TTTACTGCAAGGTAATAAAT

Downstream 100 bases:

>100_bases
ATTTGATACTCTAGCCAATCAATATAAAAGAGGAGCGTTCATCGCTCCTCTTTTATATTTCATTTTAACTTATTGCTCTT
TTGGGATGATGACATTAAAT

Product: sulfatase family protein

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MKTKTLAKTALALAVTSFGTHAAQTQPNIVTIMVDDVSPMDISAYHRGLGAINTPNIDRIAKRGMMVSDYYAQGSSTAGR
SAFITGQYPFRTGLTTVGQPGSNIGLQKEDPTLADMLKAKGYDTIHVGKSHLGDRNKFLPTVHGFDEFYGFLYHLNVMEM
PEQPNFPKDPDFIGRPRNMLHSFATESYDKTVQPRWGEIGKQRIEDKGPLGSERMKTIDDEYVEFTTQWLEKHEAQTPNK
PFFLWFNPSRMHQQIHVKDEYLGVSGHTEYFDALKELDDQIGVLLNKLDALGETDNTIIMFTSDNGINLDHWPMAGTAAF
RSQKGTTWDGAFRVPMLISWPGHIPEGEYTDGFMTSEDWVPTLMAAATGDTKIKQELLKGKEINGTKYKAHLDGYNQMDM
LTKKGPSKRHEFFYYNEQDLNAIRVDNWKVHLKTKTEWTEPAKAWPLGIILDIKADPWERSVDTNGWFLWMKERSWIVPT
LQKKIGEYKKSLKVFPPRQKSGGIGMSDNSVK

Sequences:

>Translated_512_residues
MKTKTLAKTALALAVTSFGTHAAQTQPNIVTIMVDDVSPMDISAYHRGLGAINTPNIDRIAKRGMMVSDYYAQGSSTAGR
SAFITGQYPFRTGLTTVGQPGSNIGLQKEDPTLADMLKAKGYDTIHVGKSHLGDRNKFLPTVHGFDEFYGFLYHLNVMEM
PEQPNFPKDPDFIGRPRNMLHSFATESYDKTVQPRWGEIGKQRIEDKGPLGSERMKTIDDEYVEFTTQWLEKHEAQTPNK
PFFLWFNPSRMHQQIHVKDEYLGVSGHTEYFDALKELDDQIGVLLNKLDALGETDNTIIMFTSDNGINLDHWPMAGTAAF
RSQKGTTWDGAFRVPMLISWPGHIPEGEYTDGFMTSEDWVPTLMAAATGDTKIKQELLKGKEINGTKYKAHLDGYNQMDM
LTKKGPSKRHEFFYYNEQDLNAIRVDNWKVHLKTKTEWTEPAKAWPLGIILDIKADPWERSVDTNGWFLWMKERSWIVPT
LQKKIGEYKKSLKVFPPRQKSGGIGMSDNSVK
>Mature_512_residues
MKTKTLAKTALALAVTSFGTHAAQTQPNIVTIMVDDVSPMDISAYHRGLGAINTPNIDRIAKRGMMVSDYYAQGSSTAGR
SAFITGQYPFRTGLTTVGQPGSNIGLQKEDPTLADMLKAKGYDTIHVGKSHLGDRNKFLPTVHGFDEFYGFLYHLNVMEM
PEQPNFPKDPDFIGRPRNMLHSFATESYDKTVQPRWGEIGKQRIEDKGPLGSERMKTIDDEYVEFTTQWLEKHEAQTPNK
PFFLWFNPSRMHQQIHVKDEYLGVSGHTEYFDALKELDDQIGVLLNKLDALGETDNTIIMFTSDNGINLDHWPMAGTAAF
RSQKGTTWDGAFRVPMLISWPGHIPEGEYTDGFMTSEDWVPTLMAAATGDTKIKQELLKGKEINGTKYKAHLDGYNQMDM
LTKKGPSKRHEFFYYNEQDLNAIRVDNWKVHLKTKTEWTEPAKAWPLGIILDIKADPWERSVDTNGWFLWMKERSWIVPT
LQKKIGEYKKSLKVFPPRQKSGGIGMSDNSVK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=425, Percent_Identity=29.8823529411765, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI146229329, Length=425, Percent_Identity=29.8823529411765, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI6005990, Length=425, Percent_Identity=29.8823529411765, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI146229324, Length=425, Percent_Identity=29.8823529411765, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI4503899, Length=441, Percent_Identity=29.0249433106576, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI31742482, Length=475, Percent_Identity=26.9473684210526, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI45430057, Length=390, Percent_Identity=27.9487179487179, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI157266309, Length=574, Percent_Identity=25.7839721254355, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI58743319, Length=480, Percent_Identity=25.8333333333333, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI146229327, Length=350, Percent_Identity=28.2857142857143, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI109389362, Length=515, Percent_Identity=26.6019417475728, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI38569407, Length=405, Percent_Identity=26.6666666666667, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI38569405, Length=405, Percent_Identity=26.6666666666667, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI59797060, Length=504, Percent_Identity=26.3888888888889, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI53831991, Length=144, Percent_Identity=38.8888888888889, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI71852586, Length=153, Percent_Identity=34.640522875817, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI71852584, Length=153, Percent_Identity=34.640522875817, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1790233, Length=503, Percent_Identity=29.6222664015905, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081924, Length=404, Percent_Identity=24.009900990099, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533416, Length=432, Percent_Identity=27.0833333333333, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI115533418, Length=394, Percent_Identity=27.4111675126904, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17559078, Length=131, Percent_Identity=35.8778625954198, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366397, Length=395, Percent_Identity=27.3417721518987, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281366395, Length=395, Percent_Identity=27.3417721518987, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24666163, Length=395, Percent_Identity=27.3417721518987, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24666109, Length=362, Percent_Identity=28.1767955801105, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24666175, Length=385, Percent_Identity=25.4545454545455, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281363223, Length=382, Percent_Identity=26.1780104712042, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 58045; Mature: 58045

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKTLAKTALALAVTSFGTHAAQTQPNIVTIMVDDVSPMDISAYHRGLGAINTPNIDRI
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHH
AKRGMMVSDYYAQGSSTAGRSAFITGQYPFRTGLTTVGQPGSNIGLQKEDPTLADMLKAK
HHCCCEEEEHHCCCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
GYDTIHVGKSHLGDRNKFLPTVHGFDEFYGFLYHLNVMEMPEQPNFPKDPDFIGRPRNML
CCCEEECCHHHCCCCCCCCCCCCCHHHHHHHHHEEEHEECCCCCCCCCCCCCCCCCHHHH
HSFATESYDKTVQPRWGEIGKQRIEDKGPLGSERMKTIDDEYVEFTTQWLEKHEAQTPNK
HHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PFFLWFNPSRMHQQIHVKDEYLGVSGHTEYFDALKELDDQIGVLLNKLDALGETDNTIIM
CEEEEECHHHHCCEEEEEHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
FTSDNGINLDHWPMAGTAAFRSQKGTTWDGAFRVPMLISWPGHIPEGEYTDGFMTSEDWV
EECCCCCCCCCCCCCCHHHHHCCCCCCCCCCEECCEEEECCCCCCCCCCCCCCCCCCCCH
PTLMAAATGDTKIKQELLKGKEINGTKYKAHLDGYNQMDMLTKKGPSKRHEFFYYNEQDL
HHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEECCCCC
NAIRVDNWKVHLKTKTEWTEPAKAWPLGIILDIKADPWERSVDTNGWFLWMKERSWIVPT
CEEEECCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCHH
LQKKIGEYKKSLKVFPPRQKSGGIGMSDNSVK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTKTLAKTALALAVTSFGTHAAQTQPNIVTIMVDDVSPMDISAYHRGLGAINTPNIDRI
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHH
AKRGMMVSDYYAQGSSTAGRSAFITGQYPFRTGLTTVGQPGSNIGLQKEDPTLADMLKAK
HHCCCEEEEHHCCCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
GYDTIHVGKSHLGDRNKFLPTVHGFDEFYGFLYHLNVMEMPEQPNFPKDPDFIGRPRNML
CCCEEECCHHHCCCCCCCCCCCCCHHHHHHHHHEEEHEECCCCCCCCCCCCCCCCCHHHH
HSFATESYDKTVQPRWGEIGKQRIEDKGPLGSERMKTIDDEYVEFTTQWLEKHEAQTPNK
HHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PFFLWFNPSRMHQQIHVKDEYLGVSGHTEYFDALKELDDQIGVLLNKLDALGETDNTIIM
CEEEEECHHHHCCEEEEEHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
FTSDNGINLDHWPMAGTAAFRSQKGTTWDGAFRVPMLISWPGHIPEGEYTDGFMTSEDWV
EECCCCCCCCCCCCCCHHHHHCCCCCCCCCCEECCEEEECCCCCCCCCCCCCCCCCCCCH
PTLMAAATGDTKIKQELLKGKEINGTKYKAHLDGYNQMDMLTKKGPSKRHEFFYYNEQDL
HHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEECCCCC
NAIRVDNWKVHLKTKTEWTEPAKAWPLGIILDIKADPWERSVDTNGWFLWMKERSWIVPT
CEEEECCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCHH
LQKKIGEYKKSLKVFPPRQKSGGIGMSDNSVK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]