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The map label for this gene is purE

Identifier: 59713144

GI number: 59713144

Start: 2858240

End: 2858725

Strand: Direct

Name: purE

Synonym: VF_2537

Alternate gene names: 59713144

Gene position: 2858240-2858725 (Clockwise)

Preceding gene: 59713140

Following gene: 59713145

Centisome position: 98.64

GC content: 43.83

Gene sequence:

>486_bases
ATGAAAGTCGGTATTATCATGGGTTCAAAATCAGACTGGCCAACAATGAAACTAGCCGCTGAGATGCTTGACCGCTTTAA
TGTGCCTTATGAGACAAAAGTGGTTTCTGCTCATAGAACACCTCAGTTACTTGCCGATTATGCAACTCAAGCAAAAGATC
GTGGCATCAAAGTAATTATCGCAGGTGCGGGTGGTGCAGCACACCTTCCTGGAATGGCAGCAGCATTCACAAGTGTTCCT
GTTTTAGGTGTTCCAGTACAATCTCGTGCACTTAAAGGTATGGATTCATTACTTTCAATTGTACAGATGCCAAAAGGTAT
TGCTGTTGGTACTCTTGCGATAGGTGAAGCGGGAGCGGCTAATGCAGGTATCCTTGCAGCTCAAATCATTGGAACATCAA
ACGAAGAAGTAATGGCTGCGGTTGAAGCTTTCCGTAAAGAACAAACTGAAATGGTGTTAGAGAACCCAGATCCATCAGAG
GATTAA

Upstream 100 bases:

>100_bases
TTTAGCTTTTCCTTACGCAAACGTTTTCCTTAATAAAAAATAACCGTATAATGCGGATAACTTTTCTATATTGCCAATAT
CTTTATTTAAGGAGTTCACA

Downstream 100 bases:

>100_bases
TCATGAATGTTCTTATTTTAGGTTCAGGTCAATTAGCACGAATGATGTCTTTAGCTAGTGCTCCATTAAATATTGATGTG
ATCGCTTATGATGTTAATAG

Product: N5-carboxyaminoimidazole ribonucleotide mutase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MKVGIIMGSKSDWPTMKLAAEMLDRFNVPYETKVVSAHRTPQLLADYATQAKDRGIKVIIAGAGGAAHLPGMAAAFTSVP
VLGVPVQSRALKGMDSLLSIVQMPKGIAVGTLAIGEAGAANAGILAAQIIGTSNEEVMAAVEAFRKEQTEMVLENPDPSE
D

Sequences:

>Translated_161_residues
MKVGIIMGSKSDWPTMKLAAEMLDRFNVPYETKVVSAHRTPQLLADYATQAKDRGIKVIIAGAGGAAHLPGMAAAFTSVP
VLGVPVQSRALKGMDSLLSIVQMPKGIAVGTLAIGEAGAANAGILAAQIIGTSNEEVMAAVEAFRKEQTEMVLENPDPSE
D
>Mature_161_residues
MKVGIIMGSKSDWPTMKLAAEMLDRFNVPYETKVVSAHRTPQLLADYATQAKDRGIKVIIAGAGGAAHLPGMAAAFTSVP
VLGVPVQSRALKGMDSLLSIVQMPKGIAVGTLAIGEAGAANAGILAAQIIGTSNEEVMAAVEAFRKEQTEMVLENPDPSE
D

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=64.968152866242, Blast_Score=173, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=53.6423841059603, Blast_Score=158, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURE_VIBF1 (Q5E1R4)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205920.1
- ProteinModelPortal:   Q5E1R4
- SMR:   Q5E1R4
- STRING:   Q5E1R4
- GeneID:   3279682
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2537
- NMPDR:   fig|312309.3.peg.2537
- eggNOG:   COG0041
- HOGENOM:   HBG301965
- OMA:   GVVMGSS
- PhylomeDB:   Q5E1R4
- ProtClustDB:   CLSK2396259
- BioCyc:   VFIS312309:VF2537-MONOMER
- InterPro:   IPR000031
- Gene3D:   G3DSA:3.40.50.7700
- PANTHER:   PTHR23046
- TIGRFAMs:   TIGR01162

Pfam domain/function: PF00731 AIRC; SSF52255 AIR_carboxyl

EC number: =5.4.99.18

Molecular weight: Translated: 16774; Mature: 16774

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: BINDING 9-9 BINDING 12-12 BINDING 39-39

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGIIMGSKSDWPTMKLAAEMLDRFNVPYETKVVSAHRTPQLLADYATQAKDRGIKVII
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEE
AGAGGAAHLPGMAAAFTSVPVLGVPVQSRALKGMDSLLSIVQMPKGIAVGTLAIGEAGAA
ECCCCCCCCCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
NAGILAAQIIGTSNEEVMAAVEAFRKEQTEMVLENPDPSED
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHEEECCCCCCCC
>Mature Secondary Structure
MKVGIIMGSKSDWPTMKLAAEMLDRFNVPYETKVVSAHRTPQLLADYATQAKDRGIKVII
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEE
AGAGGAAHLPGMAAAFTSVPVLGVPVQSRALKGMDSLLSIVQMPKGIAVGTLAIGEAGAA
ECCCCCCCCCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
NAGILAAQIIGTSNEEVMAAVEAFRKEQTEMVLENPDPSED
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA