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The map label for this gene is sthA [H]

Identifier: 59713046

GI number: 59713046

Start: 2738879

End: 2740357

Strand: Direct

Name: sthA [H]

Synonym: VF_2439

Alternate gene names: 59713046

Gene position: 2738879-2740357 (Clockwise)

Preceding gene: 59713043

Following gene: 59713050

Centisome position: 94.52

GC content: 39.89

Gene sequence:

>1479_bases
ATGAAAAGGTTAAAATACTTTGTTAGCAATGTTGCGATATTGATAATAATTAAGGCGCTAATAATGACTAATTCAACCCC
AATACGTTCAACCCATTTTGATGCCATTGTAATTGGTAGTGGCCCAGGGGGTGAAGGGGCTGCAATGGGTCTTACTAAAG
CTAACTTAAATGTCGCAATTATAGAAAGAGAACCAAGTGTCGGTGGCGGTTGTACACACTGGGGAACCATTCCATCGAAA
GCACTTCGTCATGCCGTTAGCCGTATTATCGAGTTTAACTCAAACCCTCTTTACTGTAAGAATAATACCAGTCTTCATTC
TACTTTTTCGGATATTTTAGGTCATGCGAAAAGTGTAATAGATAAGCAAACTCGTATGAGACAAGGGTTCTACGATCGCA
ACCAATGCTCACTCATCTTTGGAGAAGCGAGTTTCGTAGAAAAAAATACCGTTGCTGTTACAGCAAAAGATGGCTCTATT
GAAACCTACACCGCCGACAAATTTATTATCGCTACTGGCTCTCGTCCATATCGACCTGAAGGCATTAATTTTAACCATAG
TCGTGTTTACGACAGTGATTCTATCTTATCCCTTAAGCACGATCCTCGTCATATCATTATTTACGGTGCTGGTGTTATTG
GTAGTGAATACGCTTCTATTTTTCGAGGGTTAGGTGTAAAGGTAGATTTAGTAAATACTCGAGATCGCCTACTTTCCTTT
TTAGATAATGAAATGTCAGATGCACTTTCCTATCATTTTTGGAACAGTGGTATCGTCACTCGCAATGATGAAAATTTTGA
GCACATCGAAGCAAACGATGACGGTGTAATCATGCATTTAGAATCAGGCAAAAAAATGAAAGCCGATTGCATACTTTTTG
CAAATGGACGAACAGGTAATACGGACAAGCTAAACCTTTCAGCTGTTGGTCTTGAAGCTGATTCTCGTGGTCAATTAAAA
GTAAATGATAATTACCAAACAGACGTCGAGCACATTTATGCGGTTGGTGATGTGATTGGATACCCAAGCTTAGCCAGTGC
CGCCTATGACCAAGGACGATTTACCGCTCAAGCCATTACTAAAGGCAAAGCAGAAGCTAGACTCATCGATCATATTCCTA
CTGGAATTTACACCATCCCAGAAATTAGCTCTGTAGGAAAAACGGAACAAGAACTTACCGCTGCAAAAGTACCTTACGAG
GTTGGCCGCTCATCATTTAAACATTTAGCACGAGCACAAATTGCAGGTAAAGATATAGGTAGCCTAAAAATATTATTCCA
TCGTGAAACCAAGGAGATATTGGGCATTCATTGCTTTGGTGAACGTGCGGCTGAAATCATTCATATCGGTCAAGCCATTA
TGGAGCAAAAAGGCGAAGCTAATACTATTGAGTATTTTGTTAATACCACATTTAACTACCCTACTATGGCAGAAGCTTAT
CGAGTTGCCGCACTCAATGGTCTAAATAGATTATTCTAA

Upstream 100 bases:

>100_bases
TCTACTTACCTATGTAAATAATGAAATCACTAATACGACAGATTTCCATAAACAACGTGATCCTCTCCACTCTATCTTAA
TCACTTGATTTACCAAACGA

Downstream 100 bases:

>100_bases
TTATAAAAAAGGGCTGCATGCTGCAGCCATTTTTTTGTATAACTATCAATTAGGTAACGCATTTGGCCTATGATAGGAAA
ATTGCTTTTTTCCATTGATA

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKRLKYFVSNVAILIIIKALIMTNSTPIRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAIIEREPSVGGGCTHWGTIPSK
ALRHAVSRIIEFNSNPLYCKNNTSLHSTFSDILGHAKSVIDKQTRMRQGFYDRNQCSLIFGEASFVEKNTVAVTAKDGSI
ETYTADKFIIATGSRPYRPEGINFNHSRVYDSDSILSLKHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLVNTRDRLLSF
LDNEMSDALSYHFWNSGIVTRNDENFEHIEANDDGVIMHLESGKKMKADCILFANGRTGNTDKLNLSAVGLEADSRGQLK
VNDNYQTDVEHIYAVGDVIGYPSLASAAYDQGRFTAQAITKGKAEARLIDHIPTGIYTIPEISSVGKTEQELTAAKVPYE
VGRSSFKHLARAQIAGKDIGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAY
RVAALNGLNRLF

Sequences:

>Translated_492_residues
MKRLKYFVSNVAILIIIKALIMTNSTPIRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAIIEREPSVGGGCTHWGTIPSK
ALRHAVSRIIEFNSNPLYCKNNTSLHSTFSDILGHAKSVIDKQTRMRQGFYDRNQCSLIFGEASFVEKNTVAVTAKDGSI
ETYTADKFIIATGSRPYRPEGINFNHSRVYDSDSILSLKHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLVNTRDRLLSF
LDNEMSDALSYHFWNSGIVTRNDENFEHIEANDDGVIMHLESGKKMKADCILFANGRTGNTDKLNLSAVGLEADSRGQLK
VNDNYQTDVEHIYAVGDVIGYPSLASAAYDQGRFTAQAITKGKAEARLIDHIPTGIYTIPEISSVGKTEQELTAAKVPYE
VGRSSFKHLARAQIAGKDIGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAY
RVAALNGLNRLF
>Mature_492_residues
MKRLKYFVSNVAILIIIKALIMTNSTPIRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAIIEREPSVGGGCTHWGTIPSK
ALRHAVSRIIEFNSNPLYCKNNTSLHSTFSDILGHAKSVIDKQTRMRQGFYDRNQCSLIFGEASFVEKNTVAVTAKDGSI
ETYTADKFIIATGSRPYRPEGINFNHSRVYDSDSILSLKHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLVNTRDRLLSF
LDNEMSDALSYHFWNSGIVTRNDENFEHIEANDDGVIMHLESGKKMKADCILFANGRTGNTDKLNLSAVGLEADSRGQLK
VNDNYQTDVEHIYAVGDVIGYPSLASAAYDQGRFTAQAITKGKAEARLIDHIPTGIYTIPEISSVGKTEQELTAAKVPYE
VGRSSFKHLARAQIAGKDIGSLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAY
RVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=473, Percent_Identity=29.8097251585624, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=26.2472885032538, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI22035672, Length=318, Percent_Identity=30.8176100628931, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI291045266, Length=437, Percent_Identity=25.1716247139588, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI33519430, Length=402, Percent_Identity=25.6218905472637, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI33519428, Length=402, Percent_Identity=25.6218905472637, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI33519426, Length=402, Percent_Identity=25.6218905472637, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI148277065, Length=402, Percent_Identity=25.6218905472637, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI148277071, Length=402, Percent_Identity=25.6218905472637, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI291045268, Length=311, Percent_Identity=26.6881028938907, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=75.5939524838013, Blast_Score=747, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=469, Percent_Identity=29.8507462686567, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1789915, Length=432, Percent_Identity=29.1666666666667, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081717, Length=465, Percent_Identity=26.2365591397849, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=31.4775160599572, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=25.987525987526, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=396, Percent_Identity=26.010101010101, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=396, Percent_Identity=26.010101010101, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71982272, Length=373, Percent_Identity=26.5415549597855, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559934, Length=257, Percent_Identity=25.6809338521401, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=487, Percent_Identity=27.9260780287474, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=26.4392324093817, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325166, Length=478, Percent_Identity=28.0334728033473, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21358499, Length=474, Percent_Identity=31.2236286919831, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24640553, Length=510, Percent_Identity=28.6274509803922, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24640549, Length=490, Percent_Identity=28.5714285714286, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24640551, Length=491, Percent_Identity=28.9205702647658, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=24.6406570841889, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 54104; Mature: 54104

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLKYFVSNVAILIIIKALIMTNSTPIRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEE
IEREPSVGGGCTHWGTIPSKALRHAVSRIIEFNSNPLYCKNNTSLHSTFSDILGHAKSVI
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHH
DKQTRMRQGFYDRNQCSLIFGEASFVEKNTVAVTAKDGSIETYTADKFIIATGSRPYRPE
HHHHHHHHCCCCCCCEEEEECCCCEEECCEEEEEECCCCEEEEECCEEEEEECCCCCCCC
GINFNHSRVYDSDSILSLKHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLVNTRDRLLSF
CCCCCCCEEECCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCHHHHHHH
LDNEMSDALSYHFWNSGIVTRNDENFEHIEANDDGVIMHLESGKKMKADCILFANGRTGN
HHHHHHHHHHEEEECCCEEECCCCCCEEEECCCCCEEEEECCCCCEEEEEEEEECCCCCC
TDKLNLSAVGLEADSRGQLKVNDNYQTDVEHIYAVGDVIGYPSLASAAYDQGRFTAQAIT
CCEEEEEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEEHHHH
KGKAEARLIDHIPTGIYTIPEISSVGKTEQELTAAKVPYEVGRSSFKHLARAQIAGKDIG
CCCHHHHHHHHCCCCEEECCCCHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
SLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAY
CEEEEEEECCCHHEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHH
RVAALNGLNRLF
HHHHHHHHHHCC
>Mature Secondary Structure
MKRLKYFVSNVAILIIIKALIMTNSTPIRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAI
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEE
IEREPSVGGGCTHWGTIPSKALRHAVSRIIEFNSNPLYCKNNTSLHSTFSDILGHAKSVI
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHH
DKQTRMRQGFYDRNQCSLIFGEASFVEKNTVAVTAKDGSIETYTADKFIIATGSRPYRPE
HHHHHHHHCCCCCCCEEEEECCCCEEECCEEEEEECCCCEEEEECCEEEEEECCCCCCCC
GINFNHSRVYDSDSILSLKHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLVNTRDRLLSF
CCCCCCCEEECCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCEEEEECCHHHHHHH
LDNEMSDALSYHFWNSGIVTRNDENFEHIEANDDGVIMHLESGKKMKADCILFANGRTGN
HHHHHHHHHHEEEECCCEEECCCCCCEEEECCCCCEEEEECCCCCEEEEEEEEECCCCCC
TDKLNLSAVGLEADSRGQLKVNDNYQTDVEHIYAVGDVIGYPSLASAAYDQGRFTAQAIT
CCEEEEEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCEEEHHHH
KGKAEARLIDHIPTGIYTIPEISSVGKTEQELTAAKVPYEVGRSSFKHLARAQIAGKDIG
CCCHHHHHHHHCCCCEEECCCCHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
SLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAY
CEEEEEEECCCHHEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHH
RVAALNGLNRLF
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA