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The map label for this gene is mutL [H]

Identifier: 59712932

GI number: 59712932

Start: 2611702

End: 2613684

Strand: Reverse

Name: mutL [H]

Synonym: VF_2325

Alternate gene names: 59712932

Gene position: 2613684-2611702 (Counterclockwise)

Preceding gene: 59712933

Following gene: 59712931

Centisome position: 90.2

GC content: 38.83

Gene sequence:

>1983_bases
ATGCCAATTCAAATCTTACCAGCACGATTAGCCAACCAAATTGCGGCGGGTGAGGTTGTGGAGCGTCCGGCTTCTGTTGT
TAAAGAATTGGTAGAAAACAGTATCGATGCGGGAGCAACTCGCATCGATATTGATATCGAAAAAGGTGGCAGTAAGTTAA
TCCGAATCCGTGATAATGGATCGGGGATCCCAAAAGATGAACTGACCTTAGCCTTAAGCCGTCATGCCACATCAAAAATC
ACTTCATTAGACGATCTTGAAGCCATTGTTAGTTTGGGGTTTCGAGGTGAAGCTCTTGCTTCTATTAGTTCTGTTTCACG
TTTAACACTAACTTCTCGTACTGTTGCCCAAGAAGAGGCATGGTCTGCTTATGCGGAAGGTCGAGAAATGAATGTGAAAT
TAAAGCCAGCAGCTCATCCCATCGGAACGACTATCGATGTGGTTGATCTGTTTTTTAATACTCCAGCACGTCGTAAGTTC
CTGCGAGCAGATAAAACAGAATTTACTCATATTGATGAACTATTAAAGCGTATTGCATTAAGTCGATTGGATGTGACGAT
TAATTTACGTCATAACGGTAAGATGGTTCGTCAATATCGAGCAGCACAAACTAAACCTCAAATAGAAAAACGTTTAGCGG
CCGTATGTGGTGCAAATTTCTTGCAACATGCATTAGAAGTCGAGTTAGAGCATGGAGAGTTGAAGTTTCACGGTTGGATA
TCGTCTCCAGAAGGAGCAAGAGCACAGGGTGATATTCAATACTGTTATGTGAACGGGCGTATGATGAAAGATAAGCTAAT
CAATCATGCTATCCGTCAAGGTTATGAATCATCTTTGCCTGCAAACCAATATGCAGCGTATATTTTATTTATTGAGATCA
ATCCACATGATGTTGATGTTAACGTACACCCAGCAAAACACGAGGTACGTTTTCATCAAGCACGATTAGTGCATGATTTT
ATTTACCAAGCCATTTTTGGGGCATTACAGCAAGGCGCATCATTACCTGATGTGGTTGGTCATATTCAGTCTGAGGCTGA
AGAGCAACAACTTGAGAGCAAAGAATCGTATTTTCCACCAATGAAAGAATATGTACGACAGCCTCAACAAACACATTATC
CTAAATCTGAACAATTAAGAGCTGCGGTAGAATCTACGCCAAGTTATCCAAATAAGGCGCCATTAGATTCATGGATACCG
AAAGGAAACGTTGGGAGTTCATCTTCAAATTCCACTGCACCATCTCGTTCATTCCATACTGATAAACCAACGAAAAAAGC
ACTTTCTAATTACAATGAACTGCTTACCACCCAAAATAGAGAGCAGAGAGAAAGTACCTCTCAGGTGAATGAGCAATCAC
ATACATTCAGATCCACTCAACAAATTGAGCGAGTTGCACCTCAAGTTACTCAGGTGTCTAAAAATGGCATCACATTAGGC
AAAGTATTAAGTGTTGTTGAATCGACCTTTGCATTACTGCAACAAGGAAAGCAACTTCAGTTATTGAACTTACGCTATGC
TGAGTTTGTCAAAATCTACGGTCAGTTAAGTTCGGTTAATGTTGAGCCGTTGAAACCTCAACCTTTATTGATACCGCTTT
CTGTTGGTATTGATGAGTCAATTTGTAACAATTTATCTAATTACGCCTCTTTGTTGAAATCTTTAGGTATTGATCTTAAA
GTTAAAAATAGAACAAATATTATCGTAATGGCTGTTTGTCAACCAATCAGACAGCAGAACTTACAACAATTGATCCCGAA
TCTGTTAAGGTATCTAGAACAAATTAATCCATCATTAGAGCAAGTAATAAAATGGCTTTCTCATCAAATTCAACATGATG
AAGTAAGTTATACTACTGCTCAAGCTATTCAATTAGTGATGGAATTAGAGCAATTATGGGGAGATGAATTGAATAATTTC
TACCCTAAATTATTAAAAGACATCGATATTACACAAGTGATACAAGCATTTAGTCATGAATAA

Upstream 100 bases:

>100_bases
GCGTATCTGTTTCCAGCTTAAGAAAAGCAAACAAGTTACGTTCAGATGAGCTTGCTATAGGGCAGGTGCTCATTATTCCA
ACCAGTTAAGGAACAAGGTT

Downstream 100 bases:

>100_bases
ACCATTACCAAAAGCCATCTTTTTGATGGGACCAACAGCGTCAGGGAAAACAAACTTAGCAATTGAATTGCGAAAACGTT
TTCCTGTGGAGTTGATTAGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MPIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNGSGIPKDELTLALSRHATSKI
TSLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAYAEGREMNVKLKPAAHPIGTTIDVVDLFFNTPARRKF
LRADKTEFTHIDELLKRIALSRLDVTINLRHNGKMVRQYRAAQTKPQIEKRLAAVCGANFLQHALEVELEHGELKFHGWI
SSPEGARAQGDIQYCYVNGRMMKDKLINHAIRQGYESSLPANQYAAYILFIEINPHDVDVNVHPAKHEVRFHQARLVHDF
IYQAIFGALQQGASLPDVVGHIQSEAEEQQLESKESYFPPMKEYVRQPQQTHYPKSEQLRAAVESTPSYPNKAPLDSWIP
KGNVGSSSSNSTAPSRSFHTDKPTKKALSNYNELLTTQNREQRESTSQVNEQSHTFRSTQQIERVAPQVTQVSKNGITLG
KVLSVVESTFALLQQGKQLQLLNLRYAEFVKIYGQLSSVNVEPLKPQPLLIPLSVGIDESICNNLSNYASLLKSLGIDLK
VKNRTNIIVMAVCQPIRQQNLQQLIPNLLRYLEQINPSLEQVIKWLSHQIQHDEVSYTTAQAIQLVMELEQLWGDELNNF
YPKLLKDIDITQVIQAFSHE

Sequences:

>Translated_660_residues
MPIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNGSGIPKDELTLALSRHATSKI
TSLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAYAEGREMNVKLKPAAHPIGTTIDVVDLFFNTPARRKF
LRADKTEFTHIDELLKRIALSRLDVTINLRHNGKMVRQYRAAQTKPQIEKRLAAVCGANFLQHALEVELEHGELKFHGWI
SSPEGARAQGDIQYCYVNGRMMKDKLINHAIRQGYESSLPANQYAAYILFIEINPHDVDVNVHPAKHEVRFHQARLVHDF
IYQAIFGALQQGASLPDVVGHIQSEAEEQQLESKESYFPPMKEYVRQPQQTHYPKSEQLRAAVESTPSYPNKAPLDSWIP
KGNVGSSSSNSTAPSRSFHTDKPTKKALSNYNELLTTQNREQRESTSQVNEQSHTFRSTQQIERVAPQVTQVSKNGITLG
KVLSVVESTFALLQQGKQLQLLNLRYAEFVKIYGQLSSVNVEPLKPQPLLIPLSVGIDESICNNLSNYASLLKSLGIDLK
VKNRTNIIVMAVCQPIRQQNLQQLIPNLLRYLEQINPSLEQVIKWLSHQIQHDEVSYTTAQAIQLVMELEQLWGDELNNF
YPKLLKDIDITQVIQAFSHE
>Mature_659_residues
PIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNGSGIPKDELTLALSRHATSKIT
SLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAYAEGREMNVKLKPAAHPIGTTIDVVDLFFNTPARRKFL
RADKTEFTHIDELLKRIALSRLDVTINLRHNGKMVRQYRAAQTKPQIEKRLAAVCGANFLQHALEVELEHGELKFHGWIS
SPEGARAQGDIQYCYVNGRMMKDKLINHAIRQGYESSLPANQYAAYILFIEINPHDVDVNVHPAKHEVRFHQARLVHDFI
YQAIFGALQQGASLPDVVGHIQSEAEEQQLESKESYFPPMKEYVRQPQQTHYPKSEQLRAAVESTPSYPNKAPLDSWIPK
GNVGSSSSNSTAPSRSFHTDKPTKKALSNYNELLTTQNREQRESTSQVNEQSHTFRSTQQIERVAPQVTQVSKNGITLGK
VLSVVESTFALLQQGKQLQLLNLRYAEFVKIYGQLSSVNVEPLKPQPLLIPLSVGIDESICNNLSNYASLLKSLGIDLKV
KNRTNIIVMAVCQPIRQQNLQQLIPNLLRYLEQINPSLEQVIKWLSHQIQHDEVSYTTAQAIQLVMELEQLWGDELNNFY
PKLLKDIDITQVIQAFSHE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=316, Percent_Identity=36.7088607594937, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4505911, Length=316, Percent_Identity=29.746835443038, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI189458898, Length=316, Percent_Identity=29.746835443038, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI189458896, Length=310, Percent_Identity=30, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=27.1428571428571, Blast_Score=124, Evalue=4e-28,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=27.1428571428571, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI263191589, Length=222, Percent_Identity=31.981981981982, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI91992160, Length=364, Percent_Identity=25, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI91992162, Length=364, Percent_Identity=25, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310128480, Length=303, Percent_Identity=24.4224422442244, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790612, Length=665, Percent_Identity=49.1729323308271, Blast_Score=592, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71991825, Length=443, Percent_Identity=30.4740406320542, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=28.7790697674419, Blast_Score=131, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=319, Percent_Identity=37.3040752351097, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=339, Percent_Identity=28.6135693215339, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=385, Percent_Identity=26.4935064935065, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=215, Percent_Identity=29.3023255813954, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136968, Length=548, Percent_Identity=29.014598540146, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=27.4509803921569, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 74084; Mature: 73953

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKDELTLALSRHATSKITSLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEA
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WSAYAEGREMNVKLKPAAHPIGTTIDVVDLFFNTPARRKFLRADKTEFTHIDELLKRIAL
HHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
SRLDVTINLRHNGKMVRQYRAAQTKPQIEKRLAAVCGANFLQHALEVELEHGELKFHGWI
HHCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEEC
SSPEGARAQGDIQYCYVNGRMMKDKLINHAIRQGYESSLPANQYAAYILFIEINPHDVDV
CCCCCCCCCCCEEEEEECCEEHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQAIFGALQQGASLPDVVGHIQSEAEEQQLESKESYFPP
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
MKEYVRQPQQTHYPKSEQLRAAVESTPSYPNKAPLDSWIPKGNVGSSSSNSTAPSRSFHT
HHHHHCCCHHCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCC
DKPTKKALSNYNELLTTQNREQRESTSQVNEQSHTFRSTQQIERVAPQVTQVSKNGITLG
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KVLSVVESTFALLQQGKQLQLLNLRYAEFVKIYGQLSSVNVEPLKPQPLLIPLSVGIDES
HHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHH
ICNNLSNYASLLKSLGIDLKVKNRTNIIVMAVCQPIRQQNLQQLIPNLLRYLEQINPSLE
HHHHHHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
QVIKWLSHQIQHDEVSYTTAQAIQLVMELEQLWGDELNNFYPKLLKDIDITQVIQAFSHE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
PIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNG
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKDELTLALSRHATSKITSLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEA
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WSAYAEGREMNVKLKPAAHPIGTTIDVVDLFFNTPARRKFLRADKTEFTHIDELLKRIAL
HHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
SRLDVTINLRHNGKMVRQYRAAQTKPQIEKRLAAVCGANFLQHALEVELEHGELKFHGWI
HHCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEEC
SSPEGARAQGDIQYCYVNGRMMKDKLINHAIRQGYESSLPANQYAAYILFIEINPHDVDV
CCCCCCCCCCCEEEEEECCEEHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQAIFGALQQGASLPDVVGHIQSEAEEQQLESKESYFPP
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
MKEYVRQPQQTHYPKSEQLRAAVESTPSYPNKAPLDSWIPKGNVGSSSSNSTAPSRSFHT
HHHHHCCCHHCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCC
DKPTKKALSNYNELLTTQNREQRESTSQVNEQSHTFRSTQQIERVAPQVTQVSKNGITLG
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KVLSVVESTFALLQQGKQLQLLNLRYAEFVKIYGQLSSVNVEPLKPQPLLIPLSVGIDES
HHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHH
ICNNLSNYASLLKSLGIDLKVKNRTNIIVMAVCQPIRQQNLQQLIPNLLRYLEQINPSLE
HHHHHHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
QVIKWLSHQIQHDEVSYTTAQAIQLVMELEQLWGDELNNFYPKLLKDIDITQVIQAFSHE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA