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The map label for this gene is rnr [H]

Identifier: 59712921

GI number: 59712921

Start: 2599850

End: 2602357

Strand: Reverse

Name: rnr [H]

Synonym: VF_2314

Alternate gene names: 59712921

Gene position: 2602357-2599850 (Counterclockwise)

Preceding gene: 59712922

Following gene: 59712920

Centisome position: 89.81

GC content: 41.99

Gene sequence:

>2508_bases
ATGTCTAAGATTATTCAAAACGATCCTTTTCAAGATCGAGAAGCTGAAAAATACGAGAATCCAATTCCAAGCCGTGAATT
TATTCTGGAATTTTTTGAAAAAGCCGATGCACCGTTAAATCGTAATGACTTATTCGAAGCCCTAGGTTTATCTGGTGAAG
ATAGCTATGAAGGTTTACGTCGTCGTTTACGTGCAATGGAGCGTGACGGTCAGTTAGTATTTACTCGTCGTCAATGTTAT
GCACTGCCTGAACGCATCGAAATGTTAAAAGGTGTGGTATTAGGTCATCGTGATGGTTTCGGTTGGATTCGTCCAGAAGG
TAGCCTAGGTAAAGATAACGATGTACTGCTTCCTTTCCACCAAATGAAGAAAGTGATTCATGGTGATGTGGTATTAGTAC
AACCAACAGGAACGGATAAACGAGGCCGAAAAGAAGGCCGAGTTGTTCGTGTATTAGAGCCTCGTAACGAAGGTATTGTT
GGTCGATTCTTTATTGAAGACGGTATGGGGTTTGTTGTTCCTGACGATTCTCGTATTAGTCAAGATATCTTCATTCCTAA
AGAGCATAAAATGGGTGCCCGAATGGGTAACGTTGTCGTTATGGATATCACAGATCGTGGTAGCCGTGCTCGAGGTATGA
CAGGTAAAATTACGGAAGTTCTTGGTGAAAATATGGCGCCAGGAATGGAAATTGATATTGCACTTCGTACACATAATATT
CCACACGTATGGCCAGCAGCGGTTGAAAAACAAGTTGAAGGGCTAGGTGAGGAAGTGCCAGAAGAAGCAAAAGAAGGCCG
TGTCGATTTACGTGAATTACCATTGGTTACGATTGATGGTGAAGATGCACGAGATTTTGATGATGCCGTATTCTGTCAAG
CTAAAGCTTCTGGTGGTTGGCGTTTATGGGTGGCGATTGCTGATGTAAGTTACTACGTTCGCCCTGATAATGCATTAGAT
AAAGAAGCGATTCAGCGTGGTAACTCGGTTTACTTCCCTGCGCAAGTGGTTCCAATGTTGCCAGAGGTTCTCTCTAATGG
ACTATGTTCATTGAACCCACAAGTTGATCGTTTATGTATGGTGTGTGAGATGACTATCTCTGCATCAGGTAAGCTTTCTG
GCTACAAACATTATGAAGCGGTGATGAATTCACACGCTCGTCTTACTTACAATAAAGTAAGTGATATTCTTGATGGTGAT
GAAGAACTGACTCAGCGTTATGAGCCTTTAGTTCCACACTTAAAAGAGCTTCACAATATGTATCAGGTGCTAAAAACAGC
ACGTGAAGCGCGTGGAGCAATTGAGTTTGAAACCATTGAAACCAAATTTATCTTCAATGCGGATCGTAAGATTGACAGCA
TTGAGCCAGTGATACGTAATGATGCACATAAGATCATCGAAGAGTGTATGATTTTAGCTAACATTGCATCGGCTACTTTT
GTTGAAAAAGCCAAAGAGCCAGCTTTGTATCGTGTGCATGAATCTCCGGGTGAAGAACGCCTGCAAGGGTTCCGTGACTT
CTTAGGAGAGCTAGGTTTAAGCCTATCTGGTGGATTAACACCATCACCAACGGATTACGGTCAATTGGTGCATGTGATTG
CTGATCGCCCAGATAAAGAATTGATTCAAACTATGCTGCTACGCTCAATGAAGCAGGCGGTATATAACGCAGATAATGCT
GGGCATTTTGGTTTGGCATTGAAACGTTACGCACACTTTACGTCACCAATTCGTCGTTACCCAGACTTATTGCTGCACCG
TGCAATTAAGTATCTTATTGCAAAAGAAAAAGGTCAGAATAACGATCGTTGGACACCAACAGGTGGTTACCATTATTCAT
TCGATGATATGGATGTATTTGGTGAGCAATGTTCAATGACAGAGCGCCGTGCTGACGATGCGACACGTGATGTATCTGAT
TGGCTGAAATGTGAATACATGCAAGATCATATCGGTGAAGAGCTTGAAGGTGTGATTGCTAATGTCACAGGCTTTGGTTT
CTTTGTTCGATTAAATGATCTTCATATTGATGGTTTAGTTCATATTTCATCACTAGCTAATGACTACTACCAGTTTGATC
CAGCTGGTCAGCGTTTGACAGGTGAAAGTTCTGGTCAAATTTTCCGTCTTGGCGATCAAGTTACGGTCAAAGTTGTTGCG
GTAAACCTTGATGATCGTAATATCGATTTCGAGTGCACTAGCTCAATGCGTAAAGCTCGTGGACATGGTAAAACAGCAAA
AGAAAATGCGAAAAAACGTGGTGCAAAAGAGCCACGTCGTGATCCTAATTTCAAGCCAAAGAAAAAAGGTGATAAGTCTG
AACCTAAAGGTTTAGGTCAACTTGGCGAACGAAAATCTAAGGGTAAAAAAGGCAAGGTAAAATCAAAAGCACAAGCGATG
GTTGAACCAACAAAGCGCCCTGACGGCTCAACAGAAGGTGTGAAAGCTAAGAAAAAGCCGAAGCACAAGAAAAAAGTTAG
AGCAAGAAAGCCAAAGGCAAATAAGTAA

Upstream 100 bases:

>100_bases
AATTTAAGACTTGAATTCCAGATCCTTTCCTATCTGTTATAGGCATACTCAGGTACAATATAACTATATTTCTTGTCTCT
CCGACTAAGCAGGTCAGCCT

Downstream 100 bases:

>100_bases
TTTCGATAATGGGGCGGTTATAGCCCCATTTAGATAAACAAATAAGTAAAGAAAAGAAGCGACAGCATGAGTAATGATTA
TATTTTTGGTATCCACGCAG

Product: exoribonuclease R, RNase R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 835; Mature: 834

Protein sequence:

>835_residues
MSKIIQNDPFQDREAEKYENPIPSREFILEFFEKADAPLNRNDLFEALGLSGEDSYEGLRRRLRAMERDGQLVFTRRQCY
ALPERIEMLKGVVLGHRDGFGWIRPEGSLGKDNDVLLPFHQMKKVIHGDVVLVQPTGTDKRGRKEGRVVRVLEPRNEGIV
GRFFIEDGMGFVVPDDSRISQDIFIPKEHKMGARMGNVVVMDITDRGSRARGMTGKITEVLGENMAPGMEIDIALRTHNI
PHVWPAAVEKQVEGLGEEVPEEAKEGRVDLRELPLVTIDGEDARDFDDAVFCQAKASGGWRLWVAIADVSYYVRPDNALD
KEAIQRGNSVYFPAQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISASGKLSGYKHYEAVMNSHARLTYNKVSDILDGD
EELTQRYEPLVPHLKELHNMYQVLKTAREARGAIEFETIETKFIFNADRKIDSIEPVIRNDAHKIIEECMILANIASATF
VEKAKEPALYRVHESPGEERLQGFRDFLGELGLSLSGGLTPSPTDYGQLVHVIADRPDKELIQTMLLRSMKQAVYNADNA
GHFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKEKGQNNDRWTPTGGYHYSFDDMDVFGEQCSMTERRADDATRDVSD
WLKCEYMQDHIGEELEGVIANVTGFGFFVRLNDLHIDGLVHISSLANDYYQFDPAGQRLTGESSGQIFRLGDQVTVKVVA
VNLDDRNIDFECTSSMRKARGHGKTAKENAKKRGAKEPRRDPNFKPKKKGDKSEPKGLGQLGERKSKGKKGKVKSKAQAM
VEPTKRPDGSTEGVKAKKKPKHKKKVRARKPKANK

Sequences:

>Translated_835_residues
MSKIIQNDPFQDREAEKYENPIPSREFILEFFEKADAPLNRNDLFEALGLSGEDSYEGLRRRLRAMERDGQLVFTRRQCY
ALPERIEMLKGVVLGHRDGFGWIRPEGSLGKDNDVLLPFHQMKKVIHGDVVLVQPTGTDKRGRKEGRVVRVLEPRNEGIV
GRFFIEDGMGFVVPDDSRISQDIFIPKEHKMGARMGNVVVMDITDRGSRARGMTGKITEVLGENMAPGMEIDIALRTHNI
PHVWPAAVEKQVEGLGEEVPEEAKEGRVDLRELPLVTIDGEDARDFDDAVFCQAKASGGWRLWVAIADVSYYVRPDNALD
KEAIQRGNSVYFPAQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISASGKLSGYKHYEAVMNSHARLTYNKVSDILDGD
EELTQRYEPLVPHLKELHNMYQVLKTAREARGAIEFETIETKFIFNADRKIDSIEPVIRNDAHKIIEECMILANIASATF
VEKAKEPALYRVHESPGEERLQGFRDFLGELGLSLSGGLTPSPTDYGQLVHVIADRPDKELIQTMLLRSMKQAVYNADNA
GHFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKEKGQNNDRWTPTGGYHYSFDDMDVFGEQCSMTERRADDATRDVSD
WLKCEYMQDHIGEELEGVIANVTGFGFFVRLNDLHIDGLVHISSLANDYYQFDPAGQRLTGESSGQIFRLGDQVTVKVVA
VNLDDRNIDFECTSSMRKARGHGKTAKENAKKRGAKEPRRDPNFKPKKKGDKSEPKGLGQLGERKSKGKKGKVKSKAQAM
VEPTKRPDGSTEGVKAKKKPKHKKKVRARKPKANK
>Mature_834_residues
SKIIQNDPFQDREAEKYENPIPSREFILEFFEKADAPLNRNDLFEALGLSGEDSYEGLRRRLRAMERDGQLVFTRRQCYA
LPERIEMLKGVVLGHRDGFGWIRPEGSLGKDNDVLLPFHQMKKVIHGDVVLVQPTGTDKRGRKEGRVVRVLEPRNEGIVG
RFFIEDGMGFVVPDDSRISQDIFIPKEHKMGARMGNVVVMDITDRGSRARGMTGKITEVLGENMAPGMEIDIALRTHNIP
HVWPAAVEKQVEGLGEEVPEEAKEGRVDLRELPLVTIDGEDARDFDDAVFCQAKASGGWRLWVAIADVSYYVRPDNALDK
EAIQRGNSVYFPAQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISASGKLSGYKHYEAVMNSHARLTYNKVSDILDGDE
ELTQRYEPLVPHLKELHNMYQVLKTAREARGAIEFETIETKFIFNADRKIDSIEPVIRNDAHKIIEECMILANIASATFV
EKAKEPALYRVHESPGEERLQGFRDFLGELGLSLSGGLTPSPTDYGQLVHVIADRPDKELIQTMLLRSMKQAVYNADNAG
HFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKEKGQNNDRWTPTGGYHYSFDDMDVFGEQCSMTERRADDATRDVSDW
LKCEYMQDHIGEELEGVIANVTGFGFFVRLNDLHIDGLVHISSLANDYYQFDPAGQRLTGESSGQIFRLGDQVTVKVVAV
NLDDRNIDFECTSSMRKARGHGKTAKENAKKRGAKEPRRDPNFKPKKKGDKSEPKGLGQLGERKSKGKKGKVKSKAQAMV
EPTKRPDGSTEGVKAKKKPKHKKKVRARKPKANK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=488, Percent_Identity=28.8934426229508, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI190014625, Length=488, Percent_Identity=28.8934426229508, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI134288890, Length=362, Percent_Identity=32.8729281767956, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI219521928, Length=710, Percent_Identity=25.9154929577465, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI19115966, Length=710, Percent_Identity=25.9154929577465, Blast_Score=157, Evalue=4e-38,
Organism=Escherichia coli, GI87082383, Length=744, Percent_Identity=66.9354838709677, Blast_Score=1055, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=655, Percent_Identity=26.1068702290076, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17553506, Length=460, Percent_Identity=31.0869565217391, Blast_Score=181, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI212645896, Length=413, Percent_Identity=30.5084745762712, Blast_Score=171, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324552, Length=452, Percent_Identity=27.4336283185841, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323943, Length=357, Percent_Identity=24.6498599439776, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24649634, Length=456, Percent_Identity=30.7017543859649, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19922976, Length=363, Percent_Identity=28.6501377410468, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24654597, Length=363, Percent_Identity=28.6501377410468, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24654592, Length=363, Percent_Identity=28.6501377410468, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 94121; Mature: 93989

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIIQNDPFQDREAEKYENPIPSREFILEFFEKADAPLNRNDLFEALGLSGEDSYEGLR
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHH
RRLRAMERDGQLVFTRRQCYALPERIEMLKGVVLGHRDGFGWIRPEGSLGKDNDVLLPFH
HHHHHHHCCCCEEEEHHHHHHCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEECHH
QMKKVIHGDVVLVQPTGTDKRGRKEGRVVRVLEPRNEGIVGRFFIEDGMGFVVPDDSRIS
HHHHHHCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCEEEECCCCCCC
QDIFIPKEHKMGARMGNVVVMDITDRGSRARGMTGKITEVLGENMAPGMEIDIALRTHNI
CCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEEECCC
PHVWPAAVEKQVEGLGEEVPEEAKEGRVDLRELPLVTIDGEDARDFDDAVFCQAKASGGW
CCCCHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCEEEECCCCCCCCCCCEEEEEECCCCE
RLWVAIADVSYYVRPDNALDKEAIQRGNSVYFPAQVVPMLPEVLSNGLCSLNPQVDRLCM
EEEEEEEEEEEEECCCCCCCHHHHHCCCCEEECHHHHHHHHHHHCCCCCCCCCHHHHHHH
VCEMTISASGKLSGYKHYEAVMNSHARLTYNKVSDILDGDEELTQRYEPLVPHLKELHNM
HHHHHHCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
YQVLKTAREARGAIEFETIETKFIFNADRKIDSIEPVIRNDAHKIIEECMILANIASATF
HHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEKAKEPALYRVHESPGEERLQGFRDFLGELGLSLSGGLTPSPTDYGQLVHVIADRPDKE
HHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHH
LIQTMLLRSMKQAVYNADNAGHFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKEKGQN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NDRWTPTGGYHYSFDDMDVFGEQCSMTERRADDATRDVSDWLKCEYMQDHIGEELEGVIA
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHH
NVTGFGFFVRLNDLHIDGLVHISSLANDYYQFDPAGQRLTGESSGQIFRLGDQVTVKVVA
HHCCCEEEEEEECEEECHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEECCEEEEEEEE
VNLDDRNIDFECTSSMRKARGHGKTAKENAKKRGAKEPRRDPNFKPKKKGDKSEPKGLGQ
EECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LGERKSKGKKGKVKSKAQAMVEPTKRPDGSTEGVKAKKKPKHKKKVRARKPKANK
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKIIQNDPFQDREAEKYENPIPSREFILEFFEKADAPLNRNDLFEALGLSGEDSYEGLR
CCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHH
RRLRAMERDGQLVFTRRQCYALPERIEMLKGVVLGHRDGFGWIRPEGSLGKDNDVLLPFH
HHHHHHHCCCCEEEEHHHHHHCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEECHH
QMKKVIHGDVVLVQPTGTDKRGRKEGRVVRVLEPRNEGIVGRFFIEDGMGFVVPDDSRIS
HHHHHHCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCEEEECCCCCCC
QDIFIPKEHKMGARMGNVVVMDITDRGSRARGMTGKITEVLGENMAPGMEIDIALRTHNI
CCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEEECCC
PHVWPAAVEKQVEGLGEEVPEEAKEGRVDLRELPLVTIDGEDARDFDDAVFCQAKASGGW
CCCCHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCEEEECCCCCCCCCCCEEEEEECCCCE
RLWVAIADVSYYVRPDNALDKEAIQRGNSVYFPAQVVPMLPEVLSNGLCSLNPQVDRLCM
EEEEEEEEEEEEECCCCCCCHHHHHCCCCEEECHHHHHHHHHHHCCCCCCCCCHHHHHHH
VCEMTISASGKLSGYKHYEAVMNSHARLTYNKVSDILDGDEELTQRYEPLVPHLKELHNM
HHHHHHCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
YQVLKTAREARGAIEFETIETKFIFNADRKIDSIEPVIRNDAHKIIEECMILANIASATF
HHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEKAKEPALYRVHESPGEERLQGFRDFLGELGLSLSGGLTPSPTDYGQLVHVIADRPDKE
HHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCHHH
LIQTMLLRSMKQAVYNADNAGHFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKEKGQN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NDRWTPTGGYHYSFDDMDVFGEQCSMTERRADDATRDVSDWLKCEYMQDHIGEELEGVIA
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHH
NVTGFGFFVRLNDLHIDGLVHISSLANDYYQFDPAGQRLTGESSGQIFRLGDQVTVKVVA
HHCCCEEEEEEECEEECHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEECCEEEEEEEE
VNLDDRNIDFECTSSMRKARGHGKTAKENAKKRGAKEPRRDPNFKPKKKGDKSEPKGLGQ
EECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LGERKSKGKKGKVKSKAQAMVEPTKRPDGSTEGVKAKKKPKHKKKVRARKPKANK
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]