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The map label for this gene is yegE [H]

Identifier: 59712868

GI number: 59712868

Start: 2536490

End: 2538385

Strand: Reverse

Name: yegE [H]

Synonym: VF_2261

Alternate gene names: 59712868

Gene position: 2538385-2536490 (Counterclockwise)

Preceding gene: 59712869

Following gene: 59712867

Centisome position: 87.6

GC content: 33.49

Gene sequence:

>1896_bases
ATGCATTATAAAAAAACGAAAGCTGTAACTTATTCAGCTGCTGTATATATGATATTTTCCTTATTTATTTTTTTATATCT
ATATAGTGATTATCAAAAAAAGAAATTGGTTGCCGTTGAACAAATTCAGAGTGAATCAACACGTCAATTAGCTTATACAC
ATAATGAATTTAATGAGTTATCGAACCGGATATCTAATACATTAGAGCTTCTTGCTGATAGTCGACCTTTATATGATTAT
TTTATACATCCTTCAGAAAGAGTAACAAATACTGTCGAATCATCATGGTTGAAATTGGTGGTATTGGAAAAGTTTTTTTC
CCGATTAGAGCTCATTGATGATGAAGGAAATTATTTACTTTCTATTGTTTATTCAAATGATAATAAGCAAGCAGTGAAAC
AACTCCCCACTTCTCTTTCTGTTAATCATTCTTTGCTTGATAAGTTAACTTTATTACCTAAAGGGCAAGCTTTCTCTGAA
GGCGTAAGATTAAATGAAGCATTAGCTGTTTCTGGGGTTTATGAGCCGCTAATGCAAGTTGCTATACCTATTGATATATC
AGGGAAGAGAAAGGGATATATTCTTGCAGAGCTGAATGCATCCATCATTATCAACGTAGTAAAGTTCTCTCCTACATTGA
GTATCTCACCAGCCATGATAAATCAAGATGGCTATTATCTTTTATCTGATGATAATCAGAACATGCTTGGTCATCTTGTT
AGTGAACGAGTGGGTAAAACACTAAAAATTCAAAAGCCTGCATTATGGAGTGTAATGTCGAAGCAAAAAGAAGGAAGCTT
ATCACTTGATGATGGTATTTATTCTTTTTATCGTTTTGATATGAAAAAAGAAATTCCAAATAAAAAAATGTATTTTTTGC
TCTATTACCCCACTTATGAAGTGAATGTTTTATTTGAATTAATTCGTGTTGAAATAATGGAAGAAGCGGCAATTATTTTT
CTATTATTAAGTCTTATTGTTATTCCTTTTGGGATTCTACTTAGTTTTTGGGATAACTCTAATTTAGAAAGTCAGTTAGC
TAAATCTGCATTAGAGGGTATGTCTGCTGTTGTTATCACTGATAGACATAGAAGAATTTTAAAGGTGAACCCAGCATTTA
CTTCAATTAGTGGTTTCTCTGCAAATGAAGTCATCGGAAAAAATACTTTCGATGTATTGCTATCTGAGAGCGAAAATATT
GATAAACGTTTAACTACATGGAAGCAAGTTGAAGAGCTTGGTGCCTGGCAAGGGGAACTAGATGTACTGAGTAAAAATAA
GAGAAAGCTAAGTCTATTGGTTCGTATTCAATCTGTTAAAAGTAAAAGAAAAGCGACTCAGTATTATATTATTTCTTACA
TTGATATTACTAAGCGTAAAGAGCTAGAAAAGGAATTGCGCTATTTAAGCGAAAAAGATGTACTTTCTGGTTGTTGGAAT
CGTAGAAAATTTGAATTTGAATTAGAAAATCAGACTTTATTAACTCAGCGTTATTACCCAGCGCATCAGTGTTGTCTTGC
TATATTAGATATTGATCTGTTTAAACGAATTAATGATACAAAAGGACATGACGTTGGTGACCAAGTTATACGTTTAGTTT
CTGATATCTTAAATAATGGAAGTCGAGAAACGGATTTTGTGGCTAGGATTGGTGGGGAAGAGTTTGCCATTATAATGCCT
CATACCACGTTGATGGACGCCGAAATGGTGGTAAATAGATTGCGAGTAGCTGTCTCTCAATTAGAGGAATATCACGTAAC
AATAAGTGGCGGCCTAACCGATTTAGGTCATTCAAAAAAAGACGCTTATAAGTGTGCAGATCTGGCTCTATATGAATCAA
AAACGAATGGACGAAACCAAGTCTCTATTTGCTCTAGTTTAGAGGACTTAGCATAG

Upstream 100 bases:

>100_bases
TAAAGCCCTTCTCAGAAGGGTTTTATTTTATCTTGTGTAATATAAAATGATTATATAGAATTTCGTACCGCGGGCTATTC
ATGAAATCATAAGGTAAAGT

Downstream 100 bases:

>100_bases
AGGGATAAAAGAGTTATTAGACTAAAGTCTAACCTTGTCTATACTTACCATTACCGATACATAAGTCTAATTAGACATTA
CTTGATTAAGTAACATTAAA

Product: GGDEF domain-containing protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MHYKKTKAVTYSAAVYMIFSLFIFLYLYSDYQKKKLVAVEQIQSESTRQLAYTHNEFNELSNRISNTLELLADSRPLYDY
FIHPSERVTNTVESSWLKLVVLEKFFSRLELIDDEGNYLLSIVYSNDNKQAVKQLPTSLSVNHSLLDKLTLLPKGQAFSE
GVRLNEALAVSGVYEPLMQVAIPIDISGKRKGYILAELNASIIINVVKFSPTLSISPAMINQDGYYLLSDDNQNMLGHLV
SERVGKTLKIQKPALWSVMSKQKEGSLSLDDGIYSFYRFDMKKEIPNKKMYFLLYYPTYEVNVLFELIRVEIMEEAAIIF
LLLSLIVIPFGILLSFWDNSNLESQLAKSALEGMSAVVITDRHRRILKVNPAFTSISGFSANEVIGKNTFDVLLSESENI
DKRLTTWKQVEELGAWQGELDVLSKNKRKLSLLVRIQSVKSKRKATQYYIISYIDITKRKELEKELRYLSEKDVLSGCWN
RRKFEFELENQTLLTQRYYPAHQCCLAILDIDLFKRINDTKGHDVGDQVIRLVSDILNNGSRETDFVARIGGEEFAIIMP
HTTLMDAEMVVNRLRVAVSQLEEYHVTISGGLTDLGHSKKDAYKCADLALYESKTNGRNQVSICSSLEDLA

Sequences:

>Translated_631_residues
MHYKKTKAVTYSAAVYMIFSLFIFLYLYSDYQKKKLVAVEQIQSESTRQLAYTHNEFNELSNRISNTLELLADSRPLYDY
FIHPSERVTNTVESSWLKLVVLEKFFSRLELIDDEGNYLLSIVYSNDNKQAVKQLPTSLSVNHSLLDKLTLLPKGQAFSE
GVRLNEALAVSGVYEPLMQVAIPIDISGKRKGYILAELNASIIINVVKFSPTLSISPAMINQDGYYLLSDDNQNMLGHLV
SERVGKTLKIQKPALWSVMSKQKEGSLSLDDGIYSFYRFDMKKEIPNKKMYFLLYYPTYEVNVLFELIRVEIMEEAAIIF
LLLSLIVIPFGILLSFWDNSNLESQLAKSALEGMSAVVITDRHRRILKVNPAFTSISGFSANEVIGKNTFDVLLSESENI
DKRLTTWKQVEELGAWQGELDVLSKNKRKLSLLVRIQSVKSKRKATQYYIISYIDITKRKELEKELRYLSEKDVLSGCWN
RRKFEFELENQTLLTQRYYPAHQCCLAILDIDLFKRINDTKGHDVGDQVIRLVSDILNNGSRETDFVARIGGEEFAIIMP
HTTLMDAEMVVNRLRVAVSQLEEYHVTISGGLTDLGHSKKDAYKCADLALYESKTNGRNQVSICSSLEDLA
>Mature_631_residues
MHYKKTKAVTYSAAVYMIFSLFIFLYLYSDYQKKKLVAVEQIQSESTRQLAYTHNEFNELSNRISNTLELLADSRPLYDY
FIHPSERVTNTVESSWLKLVVLEKFFSRLELIDDEGNYLLSIVYSNDNKQAVKQLPTSLSVNHSLLDKLTLLPKGQAFSE
GVRLNEALAVSGVYEPLMQVAIPIDISGKRKGYILAELNASIIINVVKFSPTLSISPAMINQDGYYLLSDDNQNMLGHLV
SERVGKTLKIQKPALWSVMSKQKEGSLSLDDGIYSFYRFDMKKEIPNKKMYFLLYYPTYEVNVLFELIRVEIMEEAAIIF
LLLSLIVIPFGILLSFWDNSNLESQLAKSALEGMSAVVITDRHRRILKVNPAFTSISGFSANEVIGKNTFDVLLSESENI
DKRLTTWKQVEELGAWQGELDVLSKNKRKLSLLVRIQSVKSKRKATQYYIISYIDITKRKELEKELRYLSEKDVLSGCWN
RRKFEFELENQTLLTQRYYPAHQCCLAILDIDLFKRINDTKGHDVGDQVIRLVSDILNNGSRETDFVARIGGEEFAIIMP
HTTLMDAEMVVNRLRVAVSQLEEYHVTISGGLTDLGHSKKDAYKCADLALYESKTNGRNQVSICSSLEDLA

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=290, Percent_Identity=27.2413793103448, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1786584, Length=183, Percent_Identity=34.9726775956284, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1787262, Length=166, Percent_Identity=37.3493975903614, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081881, Length=172, Percent_Identity=35.4651162790698, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1787541, Length=281, Percent_Identity=26.6903914590747, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI145693134, Length=181, Percent_Identity=32.0441988950276, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788085, Length=190, Percent_Identity=30, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082007, Length=187, Percent_Identity=28.3422459893048, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787802, Length=179, Percent_Identity=27.9329608938547, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081974, Length=150, Percent_Identity=31.3333333333333, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787816, Length=168, Percent_Identity=33.9285714285714, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 72067; Mature: 72067

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYKKTKAVTYSAAVYMIFSLFIFLYLYSDYQKKKLVAVEQIQSESTRQLAYTHNEFNEL
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
SNRISNTLELLADSRPLYDYFIHPSERVTNTVESSWLKLVVLEKFFSRLELIDDEGNYLL
HHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEE
SIVYSNDNKQAVKQLPTSLSVNHSLLDKLTLLPKGQAFSEGVRLNEALAVSGVYEPLMQV
EEEEECCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHHHHH
AIPIDISGKRKGYILAELNASIIINVVKFSPTLSISPAMINQDGYYLLSDDNQNMLGHLV
EECEEECCCCCCEEEEECCCEEEEEEEEECCCCCCCCEEECCCCEEEEECCCCHHHHHHH
SERVGKTLKIQKPALWSVMSKQKEGSLSLDDGIYSFYRFDMKKEIPNKKMYFLLYYPTYE
HHHCCCEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCH
VNVLFELIRVEIMEEAAIIFLLLSLIVIPFGILLSFWDNSNLESQLAKSALEGMSAVVIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEE
DRHRRILKVNPAFTSISGFSANEVIGKNTFDVLLSESENIDKRLTTWKQVEELGAWQGEL
CCCCEEEEECCCCEECCCCCCCHHCCCCHHHHEECCCCCHHHHHHHHHHHHHHCCCCCCH
DVLSKNKRKLSLLVRIQSVKSKRKATQYYIISYIDITKRKELEKELRYLSEKDVLSGCWN
HHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
RRKFEFELENQTLLTQRYYPAHQCCLAILDIDLFKRINDTKGHDVGDQVIRLVSDILNNG
CCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
SRETDFVARIGGEEFAIIMPHTTLMDAEMVVNRLRVAVSQLEEYHVTISGGLTDLGHSKK
CCCCCHHEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCH
DAYKCADLALYESKTNGRNQVSICSSLEDLA
HHHHHHHHHEEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MHYKKTKAVTYSAAVYMIFSLFIFLYLYSDYQKKKLVAVEQIQSESTRQLAYTHNEFNEL
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
SNRISNTLELLADSRPLYDYFIHPSERVTNTVESSWLKLVVLEKFFSRLELIDDEGNYLL
HHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEE
SIVYSNDNKQAVKQLPTSLSVNHSLLDKLTLLPKGQAFSEGVRLNEALAVSGVYEPLMQV
EEEEECCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHHHHHHHH
AIPIDISGKRKGYILAELNASIIINVVKFSPTLSISPAMINQDGYYLLSDDNQNMLGHLV
EECEEECCCCCCEEEEECCCEEEEEEEEECCCCCCCCEEECCCCEEEEECCCCHHHHHHH
SERVGKTLKIQKPALWSVMSKQKEGSLSLDDGIYSFYRFDMKKEIPNKKMYFLLYYPTYE
HHHCCCEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCH
VNVLFELIRVEIMEEAAIIFLLLSLIVIPFGILLSFWDNSNLESQLAKSALEGMSAVVIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEE
DRHRRILKVNPAFTSISGFSANEVIGKNTFDVLLSESENIDKRLTTWKQVEELGAWQGEL
CCCCEEEEECCCCEECCCCCCCHHCCCCHHHHEECCCCCHHHHHHHHHHHHHHCCCCCCH
DVLSKNKRKLSLLVRIQSVKSKRKATQYYIISYIDITKRKELEKELRYLSEKDVLSGCWN
HHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
RRKFEFELENQTLLTQRYYPAHQCCLAILDIDLFKRINDTKGHDVGDQVIRLVSDILNNG
CCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
SRETDFVARIGGEEFAIIMPHTTLMDAEMVVNRLRVAVSQLEEYHVTISGGLTDLGHSKK
CCCCCHHEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCH
DAYKCADLALYESKTNGRNQVSICSSLEDLA
HHHHHHHHHEEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]