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The map label for this gene is folB [H]

Identifier: 59712854

GI number: 59712854

Start: 2523321

End: 2523674

Strand: Reverse

Name: folB [H]

Synonym: VF_2247

Alternate gene names: 59712854

Gene position: 2523674-2523321 (Counterclockwise)

Preceding gene: 59712856

Following gene: 59712853

Centisome position: 87.1

GC content: 37.29

Gene sequence:

>354_bases
ATGGATTTAGTATTTATAAAACAGCTTGAAGTAATTACCACCATTGGTGTTTATGAATGGGAACAGGGAATTAAACAAAA
GCTCGTATTAGATATTGATATGGCTCACGATAACAAACCAGCAGCAAAATCCGACGATGTTGAGCATTGTTTAAATTATG
CAGAAGTGAGCGAAGCAGTAACAGAGTATATTCAAAATGGTCGATTTTTATTAGTTGAACGTGTAGCTGAAGAAATTGCC
GAGCTAATCATGACTCGTTTTTCTGTTCCTTGGGTTCGAATTCATTTATCTAAACCTGGTGCAGTTGTAAATGCGCATAG
CGTCGGTGTTGTGATTGAGCGAGGAAGTAAATGA

Upstream 100 bases:

>100_bases
TTATAGTATATTGCTCGACACATTGAGCAAAGTAATATCAATATTACGTTGTTTTTCTTTTGATGGGTATCCGACCTCTT
AATAAAAAGTGTGATCAAAG

Downstream 100 bases:

>100_bases
TCACAACTTATATTGGCATTGGCTCCAATATTGAACCAGAAAAGCATGTAAAGGCTGCGATAGATGAGTTAAAGCTGTTA
GGAAGCATTACTCAAATATC

Product: bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 117; Mature: 117

Protein sequence:

>117_residues
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAAKSDDVEHCLNYAEVSEAVTEYIQNGRFLLVERVAEEIA
ELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK

Sequences:

>Translated_117_residues
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAAKSDDVEHCLNYAEVSEAVTEYIQNGRFLLVERVAEEIA
ELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK
>Mature_117_residues
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAAKSDDVEHCLNYAEVSEAVTEYIQNGRFLLVERVAEEIA
ELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=117, Percent_Identity=65.8119658119658, Blast_Score=167, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324073, Length=88, Percent_Identity=32.9545454545455, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13190; Mature: 13190

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAAKSDDVEHCLNYAEVSEAV
CCEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
TEYIQNGRFLLVERVAEEIAELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK
HHHHHCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCEEEEEECCCC
>Mature Secondary Structure
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAAKSDDVEHCLNYAEVSEAV
CCEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
TEYIQNGRFLLVERVAEEIAELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK
HHHHHCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]