Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 59712791

GI number: 59712791

Start: 2455275

End: 2456174

Strand: Direct

Name: nadC [H]

Synonym: VF_2184

Alternate gene names: 59712791

Gene position: 2455275-2456174 (Clockwise)

Preceding gene: 59712784

Following gene: 59712792

Centisome position: 84.74

GC content: 41.89

Gene sequence:

>900_bases
ATGGACTTCATCATGATCAAAACTCACGACAGCGCATCTCGTCTTGAATATTTACAACAGCAACTTCCTACTGAAATTAC
TCGTGCCGTTGCAGATACCCTACGTGAAGATTTAGGCGGTACATTAGATGTAAGTACAGACATCACAGCGAGCCTAATTG
CTGAAGACACGCAATCTGTTGCAACGATTATTACTCGTGAGCATGGTGTTTTCTGTGGCCAAATGTGGGCTGATGAAGTG
TTCAAACAACTGGGTGGCACAGTAAGCATTGAATGGCATGTTAAAGATGGCGATAAAGTTGAACCAAACCAAACGCTATG
TACCTTAACAGGACCTGCTCGCACACTATTAACTGGTGAGCGAAATGCAATGAACTTTATTCAAACGCTATCTGGTTGCT
CAACAGTAACAGCAACCTACGCTGAAAAAATTGCACACACTAACTGTCGTCTACTTGATACTCGTAAAACCATTCCAGGT
TTGCGCAGTGCATTAAAATATGCTGTAGCGTGTGGTGGTGGCTTCAATCACCGTATTGGCGTGTTCGATGCTTACCTAAT
TAAAGAAAACCATATCATTGCGTGCGGCGGAATTGAAAAAGCTATCTCAACAGCAAAAGAGCTTAACCCTGGTAAACCAG
TAGAAGTTGAAACTGAAAGTCTAGAAGAGCTACAGCAAGCGATTGATGCTGGTGCTGACATTATTATGTTAGATAACTTC
ACCACAGACATGATGCGTGAAGCAGTAAAAATTAACGCTGGTCGTGCTGCACTAGAAAACTCAGGTAACGTGACTTTAGA
TACGATTGCTGAATATGCAGAAACAGGCGTTGATTACATCTCTGTTGGTGCATTAACCAAGCATCTTAAAGCCATGGATT
TATCGATGCGTTTTAAATAA

Upstream 100 bases:

>100_bases
TTCATTCCTGCGTAAATTGAAGTAACTTTGAGTATCTTATGATGAAATTCTACTCTAGCGCGAGTATTATTATTGCCATA
AACGTATTTCAAATAATTCA

Downstream 100 bases:

>100_bases
ATCGCAGAATTATCGATAAACAAAAAGCCAGTAAATTTGCTGGCTTTTTTATTTTTAACACACAACTCCTCTCTTATATC
TTTGATACTATTCACATAAT

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MDFIMIKTHDSASRLEYLQQQLPTEITRAVADTLREDLGGTLDVSTDITASLIAEDTQSVATIITREHGVFCGQMWADEV
FKQLGGTVSIEWHVKDGDKVEPNQTLCTLTGPARTLLTGERNAMNFIQTLSGCSTVTATYAEKIAHTNCRLLDTRKTIPG
LRSALKYAVACGGGFNHRIGVFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
TTDMMREAVKINAGRAALENSGNVTLDTIAEYAETGVDYISVGALTKHLKAMDLSMRFK

Sequences:

>Translated_299_residues
MDFIMIKTHDSASRLEYLQQQLPTEITRAVADTLREDLGGTLDVSTDITASLIAEDTQSVATIITREHGVFCGQMWADEV
FKQLGGTVSIEWHVKDGDKVEPNQTLCTLTGPARTLLTGERNAMNFIQTLSGCSTVTATYAEKIAHTNCRLLDTRKTIPG
LRSALKYAVACGGGFNHRIGVFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
TTDMMREAVKINAGRAALENSGNVTLDTIAEYAETGVDYISVGALTKHLKAMDLSMRFK
>Mature_299_residues
MDFIMIKTHDSASRLEYLQQQLPTEITRAVADTLREDLGGTLDVSTDITASLIAEDTQSVATIITREHGVFCGQMWADEV
FKQLGGTVSIEWHVKDGDKVEPNQTLCTLTGPARTLLTGERNAMNFIQTLSGCSTVTATYAEKIAHTNCRLLDTRKTIPG
LRSALKYAVACGGGFNHRIGVFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
TTDMMREAVKINAGRAALENSGNVTLDTIAEYAETGVDYISVGALTKHLKAMDLSMRFK

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=293, Percent_Identity=34.4709897610922, Blast_Score=153, Evalue=2e-37,
Organism=Escherichia coli, GI1786299, Length=294, Percent_Identity=60.2040816326531, Blast_Score=343, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6321162, Length=285, Percent_Identity=31.9298245614035, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32547; Mature: 32547

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFIMIKTHDSASRLEYLQQQLPTEITRAVADTLREDLGGTLDVSTDITASLIAEDTQSV
CCEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHH
ATIITREHGVFCGQMWADEVFKQLGGTVSIEWHVKDGDKVEPNQTLCTLTGPARTLLTGE
HHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEEEECCCCHHEECCC
RNAMNFIQTLSGCSTVTATYAEKIAHTNCRLLDTRKTIPGLRSALKYAVACGGGFNHRIG
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECHHCCHHHHHHHHHHHHCCCCCCCCCC
VFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
CEEEEEEECCCEEEECCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEECCC
TTDMMREAVKINAGRAALENSGNVTLDTIAEYAETGVDYISVGALTKHLKAMDLSMRFK
CHHHHHHHHHCCCCHHHHCCCCCEEHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDFIMIKTHDSASRLEYLQQQLPTEITRAVADTLREDLGGTLDVSTDITASLIAEDTQSV
CCEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHH
ATIITREHGVFCGQMWADEVFKQLGGTVSIEWHVKDGDKVEPNQTLCTLTGPARTLLTGE
HHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEEEECCCCHHEECCC
RNAMNFIQTLSGCSTVTATYAEKIAHTNCRLLDTRKTIPGLRSALKYAVACGGGFNHRIG
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECHHCCHHHHHHHHHHHHCCCCCCCCCC
VFDAYLIKENHIIACGGIEKAISTAKELNPGKPVEVETESLEELQQAIDAGADIIMLDNF
CEEEEEEECCCEEEECCHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEECCC
TTDMMREAVKINAGRAALENSGNVTLDTIAEYAETGVDYISVGALTKHLKAMDLSMRFK
CHHHHHHHHHCCCCHHHHCCCCCEEHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]