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The map label for this gene is lpxB [H]

Identifier: 59712556

GI number: 59712556

Start: 2178462

End: 2179613

Strand: Reverse

Name: lpxB [H]

Synonym: VF_1949

Alternate gene names: 59712556

Gene position: 2179613-2178462 (Counterclockwise)

Preceding gene: 59712557

Following gene: 59712555

Centisome position: 75.22

GC content: 38.98

Gene sequence:

>1152_bases
ATGACCAAACCATTACGAATCGGAATTGTTGCAGGTGAATTATCTGGAGATACTCTAGGTGAAGGCTTTATTAAGTCAAT
CAAAGCACAATATCCAGATGCAGAGTTCGTTGGGATCGGTGGACCTAAGATGATAGCTCAGGGCTGTGATTCTTTATTTG
ATATGGAAGAGTTAGCCGTAATGGGATTGGTTGAAGTACTTGGTCGCTTACCTCGTTTATTGAAGGTAAAGGCGGAATTA
GTACGTTACTTCACTCAAAATCCACCAGATGTATTCATTGGTATTGATGCTCCTGATTTTAACCTTCGTCTTGAAAAAAC
ACTAAAAGATAACGGTATTAAAACGGTTCATTACGTTAGTCCATCAGTATGGGCATGGCGACCAAAGCGTATTTTTAAAA
TCGATGCTGCTACGGATCTTGTATTAGCCTTTCTGCCTTTTGAAAAAGCATTTTATGATAAATACAATGTCGCTTGTGAG
TTTATTGGTCATACATTAGCTGATGCTATTCCAATGGAAACGGATAAAATTGCCGCTCGTGATTTATTAGGTTTAGAGCA
AGAGCGTGAATGGCTTGCTGTATTGCCAGGAAGTCGTGGTGGTGAAGTAGCATTAATAGCCAAACCCTTTATTGAAACTT
GTCAGCGCATCCATAAGCAGCATCCCAACATGGGCTTTGTTGTTGCAGCGGTAAATGAAAAACGCCGTGAGCAATTTGAA
ACCATTTGGAAAGCAACGGCACCAGAGCTTGATTTTGTTATTATTCAAGATACAGCTCGAAATGTGATGACAGCAGCTGA
TGCCGTGTTACTTGCTTCAGGTACGGTTGCTTTAGAATGTATGCTTGTTAAGCGTCCAATGGTCGTAGGTTATCAAGTGA
ATAAACTTACGGGATGGATAGCTCAAAAACTGTCGATTACTGAATTTGTCTCGCTTCCTAATGTATTGGCAGGAAAAGAG
CTAGTTCAAGAGTTTATTCAAGAAGAGTGTCATCCAGATTTTCTTTATCCCGCAATGGAAAAAGTATTAAATAATGATAA
TCGTGAATTAATTGAAAAATTCACAGAAATGCATCAATGGATTAGAAAAGATGCAGATAAACAAGCCGCCAATGCCGTAT
TACGCCTAATTAATAAAGAAACAGCAGAATAA

Upstream 100 bases:

>100_bases
TTGAGAAATCAACGCGCGGTATTATTCGTTAATAACGGCATTAAAAACAGTTAAAGTATATAAGGCCTATTCATGTAGGC
CTTTTTTATTTGGAGTAAGT

Downstream 100 bases:

>100_bases
CCAGATGACAAAAAAAGCAGAATCAAAAGAATTACCGCCATTTGAGTATCCAGAAGGATATCAACTTTTCGCTGGAGTTG
ATGAAGTTGGTCGTGGCCCT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MTKPLRIGIVAGELSGDTLGEGFIKSIKAQYPDAEFVGIGGPKMIAQGCDSLFDMEELAVMGLVEVLGRLPRLLKVKAEL
VRYFTQNPPDVFIGIDAPDFNLRLEKTLKDNGIKTVHYVSPSVWAWRPKRIFKIDAATDLVLAFLPFEKAFYDKYNVACE
FIGHTLADAIPMETDKIAARDLLGLEQEREWLAVLPGSRGGEVALIAKPFIETCQRIHKQHPNMGFVVAAVNEKRREQFE
TIWKATAPELDFVIIQDTARNVMTAADAVLLASGTVALECMLVKRPMVVGYQVNKLTGWIAQKLSITEFVSLPNVLAGKE
LVQEFIQEECHPDFLYPAMEKVLNNDNRELIEKFTEMHQWIRKDADKQAANAVLRLINKETAE

Sequences:

>Translated_383_residues
MTKPLRIGIVAGELSGDTLGEGFIKSIKAQYPDAEFVGIGGPKMIAQGCDSLFDMEELAVMGLVEVLGRLPRLLKVKAEL
VRYFTQNPPDVFIGIDAPDFNLRLEKTLKDNGIKTVHYVSPSVWAWRPKRIFKIDAATDLVLAFLPFEKAFYDKYNVACE
FIGHTLADAIPMETDKIAARDLLGLEQEREWLAVLPGSRGGEVALIAKPFIETCQRIHKQHPNMGFVVAAVNEKRREQFE
TIWKATAPELDFVIIQDTARNVMTAADAVLLASGTVALECMLVKRPMVVGYQVNKLTGWIAQKLSITEFVSLPNVLAGKE
LVQEFIQEECHPDFLYPAMEKVLNNDNRELIEKFTEMHQWIRKDADKQAANAVLRLINKETAE
>Mature_382_residues
TKPLRIGIVAGELSGDTLGEGFIKSIKAQYPDAEFVGIGGPKMIAQGCDSLFDMEELAVMGLVEVLGRLPRLLKVKAELV
RYFTQNPPDVFIGIDAPDFNLRLEKTLKDNGIKTVHYVSPSVWAWRPKRIFKIDAATDLVLAFLPFEKAFYDKYNVACEF
IGHTLADAIPMETDKIAARDLLGLEQEREWLAVLPGSRGGEVALIAKPFIETCQRIHKQHPNMGFVVAAVNEKRREQFET
IWKATAPELDFVIIQDTARNVMTAADAVLLASGTVALECMLVKRPMVVGYQVNKLTGWIAQKLSITEFVSLPNVLAGKEL
VQEFIQEECHPDFLYPAMEKVLNNDNRELIEKFTEMHQWIRKDADKQAANAVLRLINKETAE

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=376, Percent_Identity=57.4468085106383, Blast_Score=443, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42958; Mature: 42827

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPLRIGIVAGELSGDTLGEGFIKSIKAQYPDAEFVGIGGPKMIAQGCDSLFDMEELAV
CCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
MGLVEVLGRLPRLLKVKAELVRYFTQNPPDVFIGIDAPDFNLRLEKTLKDNGIKTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEHHHCCCCEEEEEEC
PSVWAWRPKRIFKIDAATDLVLAFLPFEKAFYDKYNVACEFIGHTLADAIPMETDKIAAR
CCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DLLGLEQEREWLAVLPGSRGGEVALIAKPFIETCQRIHKQHPNMGFVVAAVNEKRREQFE
HHHCCHHCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHH
TIWKATAPELDFVIIQDTARNVMTAADAVLLASGTVALECMLVKRPMVVGYQVNKLTGWI
HHHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHEEEEEECCCEEEEEEHHHHHHHH
AQKLSITEFVSLPNVLAGKELVQEFIQEECHPDFLYPAMEKVLNNDNRELIEKFTEMHQW
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
IRKDADKQAANAVLRLINKETAE
HHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKPLRIGIVAGELSGDTLGEGFIKSIKAQYPDAEFVGIGGPKMIAQGCDSLFDMEELAV
CCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
MGLVEVLGRLPRLLKVKAELVRYFTQNPPDVFIGIDAPDFNLRLEKTLKDNGIKTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEHHHCCCCEEEEEEC
PSVWAWRPKRIFKIDAATDLVLAFLPFEKAFYDKYNVACEFIGHTLADAIPMETDKIAAR
CCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DLLGLEQEREWLAVLPGSRGGEVALIAKPFIETCQRIHKQHPNMGFVVAAVNEKRREQFE
HHHCCHHCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHH
TIWKATAPELDFVIIQDTARNVMTAADAVLLASGTVALECMLVKRPMVVGYQVNKLTGWI
HHHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHEEEEEECCCEEEEEEHHHHHHHH
AQKLSITEFVSLPNVLAGKELVQEFIQEECHPDFLYPAMEKVLNNDNRELIEKFTEMHQW
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
IRKDADKQAANAVLRLINKETAE
HHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA